Browse SLC6A4

Summary
SymbolSLC6A4
Namesolute carrier family 6 (neurotransmitter transporter), member 4
Aliases 5-HTT; SERT1; serotonin transporter 1; OCD1; solute carrier family 6 (neurotransmitter transporter, serotoni ......
Chromosomal Location17q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane Multi-pass membrane protein Endomembrane system Multi-pass membrane protein Endosome membrane Multi-pass membrane protein Note=Could be part of recycling endosomes (PubMed:18227069, PubMed:16870614). Density of transporter molecules on the plasma membrane is itself regulated by STX1A (By similarity). Density of transporter molecules on the plasma membrane is also regulated by serotonin (PubMed:17506858) (PubMed:18227069).
Domain PF03491 Serotonin (5-HT) neurotransmitter transporter
PF00209 Sodium
Function

Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.

> Gene Ontology
 
Biological Process GO:0001101 response to acid chemical
GO:0001504 neurotransmitter uptake
GO:0001505 regulation of neurotransmitter levels
GO:0001666 response to hypoxia
GO:0001963 synaptic transmission, dopaminergic
GO:0003013 circulatory system process
GO:0003018 vascular process in circulatory system
GO:0006836 neurotransmitter transport
GO:0006837 serotonin transport
GO:0007270 neuron-neuron synaptic transmission
GO:0007320 insemination
GO:0007584 response to nutrient
GO:0007611 learning or memory
GO:0007613 memory
GO:0007618 mating
GO:0007620 copulation
GO:0007623 circadian rhythm
GO:0008015 blood circulation
GO:0009636 response to toxic substance
GO:0009991 response to extracellular stimulus
GO:0010721 negative regulation of cell development
GO:0014074 response to purine-containing compound
GO:0015844 monoamine transport
GO:0015850 organic hydroxy compound transport
GO:0021534 cell proliferation in hindbrain
GO:0021536 diencephalon development
GO:0021794 thalamus development
GO:0021924 cell proliferation in external granule layer
GO:0021930 cerebellar granule cell precursor proliferation
GO:0021936 regulation of cerebellar granule cell precursor proliferation
GO:0021941 negative regulation of cerebellar granule cell precursor proliferation
GO:0030900 forebrain development
GO:0030902 hindbrain development
GO:0031667 response to nutrient levels
GO:0032225 regulation of synaptic transmission, dopaminergic
GO:0032227 negative regulation of synaptic transmission, dopaminergic
GO:0032355 response to estradiol
GO:0032526 response to retinoic acid
GO:0035150 regulation of tube size
GO:0035176 social behavior
GO:0035265 organ growth
GO:0036293 response to decreased oxygen levels
GO:0042310 vasoconstriction
GO:0042493 response to drug
GO:0042713 sperm ejaculation
GO:0044706 multi-multicellular organism process
GO:0044708 single-organism behavior
GO:0045665 negative regulation of neuron differentiation
GO:0045787 positive regulation of cell cycle
GO:0045926 negative regulation of growth
GO:0046620 regulation of organ growth
GO:0046621 negative regulation of organ growth
GO:0046683 response to organophosphorus
GO:0048511 rhythmic process
GO:0048638 regulation of developmental growth
GO:0048640 negative regulation of developmental growth
GO:0048854 brain morphogenesis
GO:0050768 negative regulation of neurogenesis
GO:0050804 modulation of synaptic transmission
GO:0050805 negative regulation of synaptic transmission
GO:0050880 regulation of blood vessel size
GO:0050890 cognition
GO:0051259 protein oligomerization
GO:0051260 protein homooligomerization
GO:0051610 serotonin uptake
GO:0051703 intraspecies interaction between organisms
GO:0051705 multi-organism behavior
GO:0051961 negative regulation of nervous system development
GO:0061351 neural precursor cell proliferation
GO:0070305 response to cGMP
GO:0070482 response to oxygen levels
GO:0071229 cellular response to acid chemical
GO:0071300 cellular response to retinoic acid
GO:0071321 cellular response to cGMP
GO:0071396 cellular response to lipid
GO:0071407 cellular response to organic cyclic compound
GO:0071417 cellular response to organonitrogen compound
GO:0090066 regulation of anatomical structure size
GO:0098657 import into cell
GO:0098810 neurotransmitter reuptake
GO:2000177 regulation of neural precursor cell proliferation
GO:2000178 negative regulation of neural precursor cell proliferation
Molecular Function GO:0000149 SNARE binding
GO:0003779 actin binding
GO:0005326 neurotransmitter transporter activity
GO:0005328 neurotransmitter:sodium symporter activity
GO:0005335 serotonin:sodium symporter activity
GO:0008144 drug binding
GO:0008504 monoamine transmembrane transporter activity
GO:0015077 monovalent inorganic cation transmembrane transporter activity
GO:0015081 sodium ion transmembrane transporter activity
GO:0015222 serotonin transmembrane transporter activity
GO:0015291 secondary active transmembrane transporter activity
GO:0015293 symporter activity
GO:0015294 solute:cation symporter activity
GO:0015370 solute:sodium symporter activity
GO:0017016 Ras GTPase binding
GO:0017022 myosin binding
GO:0017075 syntaxin-1 binding
GO:0017137 Rab GTPase binding
GO:0019811 cocaine binding
GO:0019905 syntaxin binding
GO:0022804 active transmembrane transporter activity
GO:0031267 small GTPase binding
GO:0046873 metal ion transmembrane transporter activity
GO:0050998 nitric-oxide synthase binding
GO:0051015 actin filament binding
GO:0051020 GTPase binding
GO:1901618 organic hydroxy compound transmembrane transporter activity
Cellular Component GO:0010008 endosome membrane
GO:0044440 endosomal part
GO:0045121 membrane raft
GO:0098589 membrane region
GO:0098793 presynapse
GO:0098857 membrane microdomain
> KEGG and Reactome Pathway
 
KEGG hsa04726 Serotonergic synapse
Reactome R-HSA-112316: Neuronal System
R-HSA-112311: Neurotransmitter Clearance In The Synaptic Cleft
R-HSA-380615: Serotonin clearance from the synaptic cleft
R-HSA-112315: Transmission across Chemical Synapses
Summary
SymbolSLC6A4
Namesolute carrier family 6 (neurotransmitter transporter), member 4
Aliases 5-HTT; SERT1; serotonin transporter 1; OCD1; solute carrier family 6 (neurotransmitter transporter, serotoni ......
Chromosomal Location17q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between SLC6A4 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolSLC6A4
Namesolute carrier family 6 (neurotransmitter transporter), member 4
Aliases 5-HTT; SERT1; serotonin transporter 1; OCD1; solute carrier family 6 (neurotransmitter transporter, serotoni ......
Chromosomal Location17q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of SLC6A4 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolSLC6A4
Namesolute carrier family 6 (neurotransmitter transporter), member 4
Aliases 5-HTT; SERT1; serotonin transporter 1; OCD1; solute carrier family 6 (neurotransmitter transporter, serotoni ......
Chromosomal Location17q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of SLC6A4 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)141201
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)6501
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)8701
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.4240.479
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.5560.621
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.2610.849
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.3470.43
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.5580.508
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.2050.836
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.0570.874
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.0570.92
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682301.0380.00174
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of SLC6A4 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.41.460.177
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.41.75.70.231
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21179.55.93.61
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131115.49.16.31
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolSLC6A4
Namesolute carrier family 6 (neurotransmitter transporter), member 4
Aliases 5-HTT; SERT1; serotonin transporter 1; OCD1; solute carrier family 6 (neurotransmitter transporter, serotoni ......
Chromosomal Location17q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SLC6A4. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolSLC6A4
Namesolute carrier family 6 (neurotransmitter transporter), member 4
Aliases 5-HTT; SERT1; serotonin transporter 1; OCD1; solute carrier family 6 (neurotransmitter transporter, serotoni ......
Chromosomal Location17q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SLC6A4. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SLC6A4.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolSLC6A4
Namesolute carrier family 6 (neurotransmitter transporter), member 4
Aliases 5-HTT; SERT1; serotonin transporter 1; OCD1; solute carrier family 6 (neurotransmitter transporter, serotoni ......
Chromosomal Location17q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SLC6A4. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolSLC6A4
Namesolute carrier family 6 (neurotransmitter transporter), member 4
Aliases 5-HTT; SERT1; serotonin transporter 1; OCD1; solute carrier family 6 (neurotransmitter transporter, serotoni ......
Chromosomal Location17q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of SLC6A4 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolSLC6A4
Namesolute carrier family 6 (neurotransmitter transporter), member 4
Aliases 5-HTT; SERT1; serotonin transporter 1; OCD1; solute carrier family 6 (neurotransmitter transporter, serotoni ......
Chromosomal Location17q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between SLC6A4 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolSLC6A4
Namesolute carrier family 6 (neurotransmitter transporter), member 4
Aliases 5-HTT; SERT1; serotonin transporter 1; OCD1; solute carrier family 6 (neurotransmitter transporter, serotoni ......
Chromosomal Location17q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting SLC6A4 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting SLC6A4.
ID Name Drug Type Targets #Targets
DB00176FluvoxamineSmall MoleculeKCNH2, SLC6A42
DB00182AmphetamineSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB ......19
DB00191PhentermineSmall MoleculeMAOA, MAOB, SLC6A2, SLC6A3, SLC6A45
DB00193TramadolSmall MoleculeCHRM3, GRIN3A, HTR2C, OPRD1, OPRK1, OPRM1, SLC6A2, SLC6A48
DB00215CitalopramSmall MoleculeADRA1A, CHRM1, HRH1, HTR2C, SLC6A45
DB00285VenlafaxineSmall MoleculeSLC6A2, SLC6A3, SLC6A43
DB00289AtomoxetineSmall MoleculeGRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, SLC6A2, SLC ......10
DB00321AmitriptylineSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, ......35
DB00344ProtriptylineSmall MoleculeSLC6A2, SLC6A42
DB00370MirtazapineSmall MoleculeADRA1A, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, DRD1 ......23
DB00408LoxapineSmall MoleculeADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, CHRM1, CHRM2, CHRM3 ......34
DB00422MethylphenidateSmall MoleculeSLC6A2, SLC6A3, SLC6A43
DB00454PethidineSmall MoleculeCES1, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, GRIN1, GRIN2A, GRIN2B, GR ......16
DB00458ImipramineSmall MoleculeADRA1A, ADRA1B, ADRA1D, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, D ......25
DB00472FluoxetineSmall MoleculeCKS1B, HTR2C, KCNH2, SLC6A44
DB00476DuloxetineSmall MoleculeSLC6A2, SLC6A3, SLC6A43
DB00514DextromethorphanSmall MoleculeCHRNA2, CHRNA3, CHRNA4, CHRNA7, CHRNB2, CHRNB4, CYBA, CYBB, GRIN3A ......21
DB00540NortriptylineSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB ......24
DB00543AmoxapineSmall MoleculeADRA1A, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2A, ADRA2B, ADRA2C, CH ......48
DB00574FenfluramineSmall MoleculeHTR2A, HTR2B, HTR2C, SLC6A44
DB00579MazindolSmall MoleculeSLC18A2, SLC6A2, SLC6A3, SLC6A44
DB00656TrazodoneSmall MoleculeADRA1A, ADRA2A, HRH1, HTR1A, HTR2A, HTR2C, SLC6A47
DB00661VerapamilSmall MoleculeADRA1A, ADRA1B, ADRA1D, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1 ......19
DB00715ParoxetineSmall MoleculeCHRM1, CHRM2, CHRM3, CHRM4, CHRM5, HTR2A, SLC6A2, SLC6A48
DB00726TrimipramineSmall MoleculeADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, ......24
DB00805MinaprineSmall MoleculeACHE, CHRM1, DRD1, DRD2, HTR2A, HTR2B, HTR2C, MAOA, SLC6A49
DB00852PseudoephedrineSmall MoleculeADRA1A, ADRA2A, ADRB1, ADRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATF6, ......20
DB00907CocaineSmall MoleculeCES1, CHRM1, CHRM2, SCN10A, SCN11A, SCN5A, SIGMAR1, SLC6A2, SLC6A3 ......10
DB00988DopamineSmall MoleculeDBH, DRD1, DRD1, DRD2, DRD3, DRD4, DRD5, DRD5, HTR1A, HTR3A, HTR3B ......17
DB01104SertralineSmall MoleculePGRMC1, SIGMAR1, SLC6A3, SLC6A44
DB01105SibutramineSmall MoleculeSLC6A2, SLC6A3, SLC6A43
DB01114ChlorphenamineSmall MoleculeHRH1, SLC6A2, SLC6A3, SLC6A44
DB01142DoxepinSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, CHRM1, CHRM2, CHRM ......23
DB01149NefazodoneSmall MoleculeADRA1A, ADRA1B, ADRA2A, HTR1A, HTR2A, HTR2C, KCNH2, SLC6A2, SLC6A3 ......10
DB01151DesipramineSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, CHRM ......21
DB01175EscitalopramSmall MoleculeADRA1A, CHRM1, HRH1, SLC6A2, SLC6A3, SLC6A46
DB01191DexfenfluramineSmall MoleculeHTR2C, SLC6A42
DB01242ClomipramineSmall MoleculeGSTP1, HTR2A, HTR2B, HTR2C, SLC6A2, SLC6A46
DB01363EphedraSmall MoleculeADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, MAOA, MAOB, SLC18A1, ......13
DB01442MMDASmall MoleculeHTR2A, MAOA, MAOB, SLC18A1, SLC18A2, SLC6A2, SLC6A3, SLC6A48
DB01454MidomafetamineSmall MoleculeHTR2A, HTR2B, HTR2C, SLC18A2, SLC6A2, SLC6A3, SLC6A47
DB014724-MethoxyamphetamineSmall MoleculeADRA1A, ADRA2A, MAOA, MAOB, SLC18A2, SLC6A3, SLC6A47
DB01577MethamphetamineSmall MoleculeADRA2A, ADRA2B, ADRA2C, MAOA, MAOB, SLC18A1, SLC18A2, SLC6A2, SLC6 ......11
DB04821NomifensineSmall MoleculeMAOA, MAOB, MPO, SLC18A2, SLC6A2, SLC6A3, SLC6A47
DB04832ZimelidineSmall MoleculeMAOA, MAOB, SLC6A43
DB04836AmineptineSmall MoleculeSLC6A2, SLC6A42
DB04889BicifadineSmall MoleculeDRD2, SLC6A2, SLC6A43
DB04896MilnacipranSmall MoleculeGRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, SLC6A2, SLC ......9
DB05422OPC-14523Small MoleculeSLC6A41
DB05688CRx-119Small MoleculeSLC6A2, SLC6A42
DB06148MianserinSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, DRD1, DRD2, DRD3, ......23
DB06156TesofensineSmall MoleculeSLC6A2, SLC6A3, SLC6A43
DB06204TapentadolSmall MoleculeHTR3A, OPRD1, OPRK1, OPRM1, SLC6A2, SLC6A46
DB06700DesvenlafaxineSmall MoleculeSLC6A2, SLC6A42
DB06701DexmethylphenidateSmall MoleculeSLC6A2, SLC6A3, SLC6A43
DB08839SerotoninSmall MoleculeHTR2A, HTR3A, HTR3B, SLC18A2, SLC6A45
DB08918LevomilnacipranSmall MoleculeSLC6A2, SLC6A42
DB09016ButriptylineSmall MoleculeHRH1, HTR2A, SLC6A43
DB09068VortioxetineSmall MoleculeADRB1, HTR1A, HTR1B, HTR3A, HTR7, SLC6A46
DB09167DosulepinSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, CHRM1, CHRM2, CHRM ......16
DB09186NisoxetineSmall MoleculeSLC6A41
DB09195LorpiprazoleSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, HRH1, HTR2A, HTR2C ......10
DB09225ZotepineSmall MoleculeDRD1, DRD2, DRD5, HTR2A, HTR6, HTR7, SLC6A2, SLC6A48
DB09289TianeptineSmall MoleculeGRIA1, HTR1A, SLC6A43
DB12305DasotralineSmall MoleculeSLC6A2, SLC6A3, SLC6A43