Browse SLC7A4

Summary
SymbolSLC7A4
Namesolute carrier family 7, member 4
Aliases HCAT3; CAT-4; solute carrier family 7 (cationic amino acid transporter, y+ system), member 4; solute carrier ......
Chromosomal Location22q11.21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Membrane Multi-pass membrane protein
Domain PF13520 Amino acid permease
PF13906 C-terminus of AA_permease
Function

Involved in the transport of the cationic amino acids (arginine, lysine and ornithine).

> Gene Ontology
 
Biological Process GO:0003333 amino acid transmembrane transport
GO:0006520 cellular amino acid metabolic process
GO:0006820 anion transport
GO:0006865 amino acid transport
GO:0015711 organic anion transport
GO:0015802 basic amino acid transport
GO:0015807 L-amino acid transport
GO:0015849 organic acid transport
GO:0046942 carboxylic acid transport
GO:1902475 L-alpha-amino acid transmembrane transport
GO:1903825 organic acid transmembrane transport
GO:1905039 carboxylic acid transmembrane transport
GO:1990822 basic amino acid transmembrane transport
Molecular Function GO:0005342 organic acid transmembrane transporter activity
GO:0015171 amino acid transmembrane transporter activity
GO:0015174 basic amino acid transmembrane transporter activity
GO:0015179 L-amino acid transmembrane transporter activity
GO:0015291 secondary active transmembrane transporter activity
GO:0015297 antiporter activity
GO:0022804 active transmembrane transporter activity
GO:0046943 carboxylic acid transmembrane transporter activity
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolSLC7A4
Namesolute carrier family 7, member 4
Aliases HCAT3; CAT-4; solute carrier family 7 (cationic amino acid transporter, y+ system), member 4; solute carrier ......
Chromosomal Location22q11.21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between SLC7A4 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolSLC7A4
Namesolute carrier family 7, member 4
Aliases HCAT3; CAT-4; solute carrier family 7 (cationic amino acid transporter, y+ system), member 4; solute carrier ......
Chromosomal Location22q11.21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of SLC7A4 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolSLC7A4
Namesolute carrier family 7, member 4
Aliases HCAT3; CAT-4; solute carrier family 7 (cationic amino acid transporter, y+ system), member 4; solute carrier ......
Chromosomal Location22q11.21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of SLC7A4 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.220.771
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.7720.495
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.2120.844
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-1.5150.0476
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-2.5540.0458
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.2130.882
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.2070.821
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.6940.598
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.4190.76
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.1450.714
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.1450.811
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.5070.172
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of SLC7A4 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277311.1011.10.0181
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275911.1011.10.0286
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21179.55.93.61
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)86016.7-16.70.429
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131115.4015.40.482
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38277.907.90.26
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22139.109.10.519
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolSLC7A4
Namesolute carrier family 7, member 4
Aliases HCAT3; CAT-4; solute carrier family 7 (cationic amino acid transporter, y+ system), member 4; solute carrier ......
Chromosomal Location22q11.21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SLC7A4. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolSLC7A4
Namesolute carrier family 7, member 4
Aliases HCAT3; CAT-4; solute carrier family 7 (cationic amino acid transporter, y+ system), member 4; solute carrier ......
Chromosomal Location22q11.21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SLC7A4. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SLC7A4.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolSLC7A4
Namesolute carrier family 7, member 4
Aliases HCAT3; CAT-4; solute carrier family 7 (cationic amino acid transporter, y+ system), member 4; solute carrier ......
Chromosomal Location22q11.21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SLC7A4. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolSLC7A4
Namesolute carrier family 7, member 4
Aliases HCAT3; CAT-4; solute carrier family 7 (cationic amino acid transporter, y+ system), member 4; solute carrier ......
Chromosomal Location22q11.21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of SLC7A4 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolSLC7A4
Namesolute carrier family 7, member 4
Aliases HCAT3; CAT-4; solute carrier family 7 (cationic amino acid transporter, y+ system), member 4; solute carrier ......
Chromosomal Location22q11.21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between SLC7A4 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolSLC7A4
Namesolute carrier family 7, member 4
Aliases HCAT3; CAT-4; solute carrier family 7 (cationic amino acid transporter, y+ system), member 4; solute carrier ......
Chromosomal Location22q11.21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting SLC7A4 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting SLC7A4.
ID Name Drug Type Targets #Targets
DB00123L-LysineSmall MoleculeKARS, SLC7A1, SLC7A2, SLC7A3, SLC7A45
DB00125L-ArginineSmall MoleculeARG2, ASL, ASS1, AZIN2, NOS2, NOS3, SLC7A1, SLC7A3, SLC7A49
DB00129OrnithineSmall MoleculeARG1, ARG2, GATM, OAT, OAZ1, OAZ2, OAZ3, OTC, SLC25A15, SLC25A2, S ......14