TISIDB

Summary
Symbol	SNAI1
Name	snail family zinc finger 1
Aliases	SNA; SLUGH2; SNAH; SNAIL1; SNAIL; snail 1 (drosophila homolog), zinc finger protein; snail homolog 1 (Drosop ......
Chromosomal Location	20q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Nucleus Cytoplasm. Note=Once phosphorylated (probably on Ser-107, Ser-111, Ser-115 and Ser-119) it is exported from the nucleus to the cytoplasm where subsequent phosphorylation of the destruction motif and ubiquitination involving BTRC occurs.
Domain	-
Function	Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. During EMT, involved with LOXL2 in negatively regulating pericentromeric heterochromatin transcription (By similarity). SNAI1 recruits LOXL2 to pericentromeric regions to oxidize histone H3 and repress transcription which leads to release of heterochromatin component CBX5/HP1A, enabling chromatin reorganization and acquisition of mesenchymal traits (By similarity). Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself.

> Gene Ontology [ TOP ]
Biological Process	GO:0001501 skeletal system development GO:0001503 ossification GO:0001649 osteoblast differentiation GO:0001701 in utero embryonic development GO:0001704 formation of primary germ layer GO:0001707 mesoderm formation GO:0001837 epithelial to mesenchymal transition GO:0001890 placenta development GO:0001892 embryonic placenta development GO:0001942 hair follicle development GO:0003002 regionalization GO:0003007 heart morphogenesis GO:0003197 endocardial cushion development GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003203 endocardial cushion morphogenesis GO:0003272 endocardial cushion formation GO:0006694 steroid biosynthetic process GO:0006766 vitamin metabolic process GO:0006775 fat-soluble vitamin metabolic process GO:0007043 cell-cell junction assembly GO:0007219 Notch signaling pathway GO:0007369 gastrulation GO:0007389 pattern specification process GO:0007498 mesoderm development GO:0007507 heart development GO:0008202 steroid metabolic process GO:0008544 epidermis development GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage GO:0009110 vitamin biosynthetic process GO:0010717 regulation of epithelial to mesenchymal transition GO:0010718 positive regulation of epithelial to mesenchymal transition GO:0010894 negative regulation of steroid biosynthetic process GO:0010957 negative regulation of vitamin D biosynthetic process GO:0019216 regulation of lipid metabolic process GO:0019218 regulation of steroid metabolic process GO:0022404 molting cycle process GO:0022405 hair cycle process GO:0030330 DNA damage response, signal transduction by p53 class mediator GO:0030335 positive regulation of cell migration GO:0030656 regulation of vitamin metabolic process GO:0031069 hair follicle morphogenesis GO:0034329 cell junction assembly GO:0034330 cell junction organization GO:0040017 positive regulation of locomotion GO:0042303 molting cycle GO:0042359 vitamin D metabolic process GO:0042362 fat-soluble vitamin biosynthetic process GO:0042368 vitamin D biosynthetic process GO:0042633 hair cycle GO:0042770 signal transduction in response to DNA damage GO:0043297 apical junction assembly GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator GO:0043588 skin development GO:0044283 small molecule biosynthetic process GO:0045216 cell-cell junction organization GO:0045833 negative regulation of lipid metabolic process GO:0045939 negative regulation of steroid metabolic process GO:0045992 negative regulation of embryonic development GO:0045995 regulation of embryonic development GO:0046137 negative regulation of vitamin metabolic process GO:0046890 regulation of lipid biosynthetic process GO:0048332 mesoderm morphogenesis GO:0048568 embryonic organ development GO:0048608 reproductive structure development GO:0048730 epidermis morphogenesis GO:0048762 mesenchymal cell differentiation GO:0050810 regulation of steroid biosynthetic process GO:0051055 negative regulation of lipid biosynthetic process GO:0051216 cartilage development GO:0051272 positive regulation of cellular component movement GO:0060021 palate development GO:0060317 cardiac epithelial to mesenchymal transition GO:0060485 mesenchyme development GO:0060536 cartilage morphogenesis GO:0060556 regulation of vitamin D biosynthetic process GO:0060706 cell differentiation involved in embryonic placenta development GO:0060707 trophoblast giant cell differentiation GO:0060800 regulation of cell differentiation involved in embryonic placenta development GO:0060806 negative regulation of cell differentiation involved in embryonic placenta development GO:0060972 left/right pattern formation GO:0061311 cell surface receptor signaling pathway involved in heart development GO:0061314 Notch signaling involved in heart development GO:0061448 connective tissue development GO:0061458 reproductive system development GO:0070830 bicellular tight junction assembly GO:0072132 mesenchyme morphogenesis GO:0072331 signal transduction by p53 class mediator GO:0097193 intrinsic apoptotic signaling pathway GO:0098773 skin epidermis development GO:1901615 organic hydroxy compound metabolic process GO:1901617 organic hydroxy compound biosynthetic process GO:1901796 regulation of signal transduction by p53 class mediator GO:1901797 negative regulation of signal transduction by p53 class mediator GO:1901888 regulation of cell junction assembly GO:1902229 regulation of intrinsic apoptotic signaling pathway in response to DNA damage GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage GO:1902532 negative regulation of intracellular signal transduction GO:2000147 positive regulation of cell motility GO:2000241 regulation of reproductive process GO:2000242 negative regulation of reproductive process GO:2000810 regulation of bicellular tight junction assembly GO:2001020 regulation of response to DNA damage stimulus GO:2001021 negative regulation of response to DNA damage stimulus GO:2001233 regulation of apoptotic signaling pathway GO:2001234 negative regulation of apoptotic signaling pathway GO:2001242 regulation of intrinsic apoptotic signaling pathway GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Molecular Function	GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
Cellular Component	-

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04520 Adherens junction
Reactome	-

Summary
Symbol	SNAI1
Name	snail family zinc finger 1
Aliases	SNA; SLUGH2; SNAH; SNAIL1; SNAIL; snail 1 (drosophila homolog), zinc finger protein; snail homolog 1 (Drosop ......
Chromosomal Location	20q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between SNAI1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining

[ TOP ]

Literatures describing the relation between SNAI1 and anti-tumor immunity in human cancer.

PMID	Cancer type	Relation to immunity	Evidence sentences
28574228	Cholangiocarcinoma	Inhibit immunity	Our findings further indicated that CCA cells with EMT-like features appear to generate immunosuppressive natural T regulatory-like cluster of differentiation 4-positive (CD4+)CD25-cells rather than to increase CD4+CD25+natural T regulatory cells, in part by mediating T regulatory-inducible cytokines such as transforming growth factor β1 and interleukin 2.These results demonstrate that aPKC-ι promotes EMT and induces immunosuppression through the aPKC-ι/P-Sp1/Snail signaling pathway and may be a potential therapeutic target for CCA.
23509364	Colorectal Carcinoma	Promote immunity	NK group 2, member D (NKG2D) is an NK cell-activating receptor crucially involved in cancer immunosurveillance. In this study, we show that induction of EMT by TGF-β stimulation of human keratinocytes, by glycogen synthase kinase-3β inhibition in several epithelial tumor cell lines, and by Snail1 overexpression in colorectal cancer cells strongly upregulated the expression of NKG2D ligands (NKG2DLs), MHC class I chain-related molecules A and B (MICA/B) and ULBP1-3.
29632713	breast carcinoma	Inhibit immunity	The phagocytosis of EMT-activated cells was rescued by using CD47 blocking antibody or by genetic targeting of SNAI1, ZEB1 or CD47.

Summary
Symbol	SNAI1
Name	snail family zinc finger 1
Aliases	SNA; SLUGH2; SNAH; SNAIL1; SNAIL; snail 1 (drosophila homolog), zinc finger protein; snail homolog 1 (Drosop ......
Chromosomal Location	20q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of SNAI1 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	SNAI1
Name	snail family zinc finger 1
Aliases	SNA; SLUGH2; SNAH; SNAIL1; SNAIL; snail 1 (drosophila homolog), zinc finger protein; snail homolog 1 (Drosop ......
Chromosomal Location	20q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the expression difference of SNAI1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-0.747	0.172
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-1.333	0.266
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.323	0.749
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-1.01	0.0321
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.961	0.399
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	-1.063	0.487
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.051	0.924
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-0.179	0.836
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.474	0.575
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	1.145	0.26
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	2.367	0.0673
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.421	0.009

> Mutation difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the mutation difference of SNAI1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	0	0	1
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	0	0	1
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	5.9	-5.9	0.447
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	9.1	-9.1	0.458
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	6.2	-6.2	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	11.1	-11.1	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	0	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	1

Summary
Symbol	SNAI1
Name	snail family zinc finger 1
Aliases	SNA; SLUGH2; SNAH; SNAIL1; SNAIL; snail 1 (drosophila homolog), zinc finger protein; snail homolog 1 (Drosop ......
Chromosomal Location	20q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SNAI1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	SNAI1
Name	snail family zinc finger 1
Aliases	SNA; SLUGH2; SNAH; SNAIL1; SNAIL; snail 1 (drosophila homolog), zinc finger protein; snail homolog 1 (Drosop ......
Chromosomal Location	20q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SNAI1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SNAI1. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	SNAI1
Name	snail family zinc finger 1
Aliases	SNA; SLUGH2; SNAH; SNAIL1; SNAIL; snail 1 (drosophila homolog), zinc finger protein; snail homolog 1 (Drosop ......
Chromosomal Location	20q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SNAI1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	SNAI1
Name	snail family zinc finger 1
Aliases	SNA; SLUGH2; SNAH; SNAIL1; SNAIL; snail 1 (drosophila homolog), zinc finger protein; snail homolog 1 (Drosop ......
Chromosomal Location	20q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of SNAI1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	SNAI1
Name	snail family zinc finger 1
Aliases	SNA; SLUGH2; SNAH; SNAIL1; SNAIL; snail 1 (drosophila homolog), zinc finger protein; snail homolog 1 (Drosop ......
Chromosomal Location	20q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between SNAI1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	SNAI1
Name	snail family zinc finger 1
Aliases	SNA; SLUGH2; SNAH; SNAIL1; SNAIL; snail 1 (drosophila homolog), zinc finger protein; snail homolog 1 (Drosop ......
Chromosomal Location	20q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting SNAI1 collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

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