| Summary | |
|---|---|
| Symbol | SNAPIN |
| Name | SNAP-associated protein |
| Aliases | BLOC1S7; BORCS3; SNAP-25-binding protein; biogenesis of lysosomal organelles complex-1, subunit 7; SNAPAP; B ...... |
| Chromosomal Location | 1q22 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
| Subcellular Location | Membrane Peripheral membrane protein Cytoplasmic side Cytoplasm, cytosol Cytoplasm, perinuclear region Golgi apparatus membrane Lysosome membrane Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane Note=Colocalizes with NANOS1 and PUM2 in the perinuclear region of germ cells. |
| Domain |
PF14712 Snapin/Pallidin |
| Function |
Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling. May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release through its ability to potentiate the interaction of synaptotagmin with the SNAREs and the plasma-membrane-associated protein SNAP25. Its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis. May also have a role in the mechanisms of SNARE-mediated membrane fusion in non-neuronal cells (PubMed:17182842, PubMed:18167355). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (PubMed:25898167). |
| Biological Process |
GO:0001505 regulation of neurotransmitter levels GO:0006836 neurotransmitter transport GO:0006885 regulation of pH GO:0006887 exocytosis GO:0006906 vesicle fusion GO:0006914 autophagy GO:0007018 microtubule-based movement GO:0007033 vacuole organization GO:0007034 vacuolar transport GO:0007035 vacuolar acidification GO:0007040 lysosome organization GO:0007041 lysosomal transport GO:0007042 lysosomal lumen acidification GO:0007269 neurotransmitter secretion GO:0008088 axo-dendritic transport GO:0008089 anterograde axonal transport GO:0008090 retrograde axonal transport GO:0008333 endosome to lysosome transport GO:0010721 negative regulation of cell development GO:0010970 transport along microtubule GO:0010975 regulation of neuron projection development GO:0010977 negative regulation of neuron projection development GO:0016050 vesicle organization GO:0016079 synaptic vesicle exocytosis GO:0016188 synaptic vesicle maturation GO:0016197 endosomal transport GO:0016236 macroautophagy GO:0017156 calcium ion regulated exocytosis GO:0021700 developmental maturation GO:0023061 signal release GO:0030004 cellular monovalent inorganic cation homeostasis GO:0030641 regulation of cellular pH GO:0030705 cytoskeleton-dependent intracellular transport GO:0031345 negative regulation of cell projection organization GO:0031503 protein complex localization GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane GO:0032418 lysosome localization GO:0032438 melanosome organization GO:0033059 cellular pigmentation GO:0034629 cellular protein complex localization GO:0035751 regulation of lysosomal lumen pH GO:0043393 regulation of protein binding GO:0043473 pigmentation GO:0044801 single-organism membrane fusion GO:0045026 plasma membrane fusion GO:0045055 regulated exocytosis GO:0045324 late endosome to vacuole transport GO:0045665 negative regulation of neuron differentiation GO:0045851 pH reduction GO:0047496 vesicle transport along microtubule GO:0048284 organelle fusion GO:0048489 synaptic vesicle transport GO:0048490 anterograde synaptic vesicle transport GO:0048753 pigment granule organization GO:0050768 negative regulation of neurogenesis GO:0050808 synapse organization GO:0051098 regulation of binding GO:0051452 intracellular pH reduction GO:0051453 regulation of intracellular pH GO:0051604 protein maturation GO:0051640 organelle localization GO:0051648 vesicle localization GO:0051650 establishment of vesicle localization GO:0051656 establishment of organelle localization GO:0051961 negative regulation of nervous system development GO:0055067 monovalent inorganic cation homeostasis GO:0061025 membrane fusion GO:0072384 organelle transport along microtubule GO:0072553 terminal button organization GO:0080171 lytic vacuole organization GO:0090174 organelle membrane fusion GO:0097352 autophagosome maturation GO:0097479 synaptic vesicle localization GO:0097480 establishment of synaptic vesicle localization GO:0097576 vacuole fusion GO:0098930 axonal transport GO:0099003 vesicle-mediated transport in synapse GO:0099500 vesicle fusion to plasma membrane GO:0099504 synaptic vesicle cycle GO:0099514 synaptic vesicle cytoskeletal transport GO:0099517 synaptic vesicle transport along microtubule GO:0099518 vesicle cytoskeletal trafficking GO:0099531 presynaptic process involved in chemical synaptic transmission GO:0099643 signal release from synapse GO:1902774 late endosome to lysosome transport GO:1902822 regulation of late endosome to lysosome transport GO:1902824 positive regulation of late endosome to lysosome transport GO:1903335 regulation of vacuolar transport GO:1903337 positive regulation of vacuolar transport |
| Molecular Function |
GO:0000149 SNARE binding |
| Cellular Component |
GO:0005765 lysosomal membrane GO:0008021 synaptic vesicle GO:0030133 transport vesicle GO:0030141 secretory granule GO:0030424 axon GO:0030658 transport vesicle membrane GO:0030659 cytoplasmic vesicle membrane GO:0030672 synaptic vesicle membrane GO:0031082 BLOC complex GO:0031083 BLOC-1 complex GO:0032838 cell projection cytoplasm GO:0033267 axon part GO:0044445 cytosolic part GO:0070382 exocytic vesicle GO:0098793 presynapse GO:0098852 lytic vacuole membrane GO:0099078 BORC complex GO:0099501 exocytic vesicle membrane GO:0099503 secretory vesicle GO:0099568 cytoplasmic region GO:1904115 axon cytoplasm |
| KEGG | - |
| Reactome |
R-HSA-421837: Clathrin derived vesicle budding R-HSA-432722: Golgi Associated Vesicle Biogenesis R-HSA-199991: Membrane Trafficking R-HSA-5653656: Vesicle-mediated transport R-HSA-199992: trans-Golgi Network Vesicle Budding |
| Summary | |
|---|---|
| Symbol | SNAPIN |
| Name | SNAP-associated protein |
| Aliases | BLOC1S7; BORCS3; SNAP-25-binding protein; biogenesis of lysosomal organelles complex-1, subunit 7; SNAPAP; B ...... |
| Chromosomal Location | 1q22 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content | Literatures that report relations between SNAPIN and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
|
There is no record. |
| Summary | |
|---|---|
| Symbol | SNAPIN |
| Name | SNAP-associated protein |
| Aliases | BLOC1S7; BORCS3; SNAP-25-binding protein; biogenesis of lysosomal organelles complex-1, subunit 7; SNAPAP; B ...... |
| Chromosomal Location | 1q22 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
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> High-throughput Screening
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Statistical results of SNAPIN in screening data sets for detecting immune reponses.
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| Summary | |
|---|---|
| Symbol | SNAPIN |
| Name | SNAP-associated protein |
| Aliases | BLOC1S7; BORCS3; SNAP-25-binding protein; biogenesis of lysosomal organelles complex-1, subunit 7; SNAPAP; B ...... |
| Chromosomal Location | 1q22 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
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Points in the above scatter plot represent the expression difference of SNAPIN in various data sets.
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Points in the above scatter plot represent the mutation difference of SNAPIN in various data sets.
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| Summary | |
|---|---|
| Symbol | SNAPIN |
| Name | SNAP-associated protein |
| Aliases | BLOC1S7; BORCS3; SNAP-25-binding protein; biogenesis of lysosomal organelles complex-1, subunit 7; SNAPAP; B ...... |
| Chromosomal Location | 1q22 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SNAPIN. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
| Summary | |
|---|---|
| Symbol | SNAPIN |
| Name | SNAP-associated protein |
| Aliases | BLOC1S7; BORCS3; SNAP-25-binding protein; biogenesis of lysosomal organelles complex-1, subunit 7; SNAPAP; B ...... |
| Chromosomal Location | 1q22 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SNAPIN. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SNAPIN. > Immunoinhibitor > Immunostimulator > MHC molecule |
| Summary | |
|---|---|
| Symbol | SNAPIN |
| Name | SNAP-associated protein |
| Aliases | BLOC1S7; BORCS3; SNAP-25-binding protein; biogenesis of lysosomal organelles complex-1, subunit 7; SNAPAP; B ...... |
| Chromosomal Location | 1q22 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SNAPIN. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
| Summary | |
|---|---|
| Symbol | SNAPIN |
| Name | SNAP-associated protein |
| Aliases | BLOC1S7; BORCS3; SNAP-25-binding protein; biogenesis of lysosomal organelles complex-1, subunit 7; SNAPAP; B ...... |
| Chromosomal Location | 1q22 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Distribution of SNAPIN expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
| Summary | |
|---|---|
| Symbol | SNAPIN |
| Name | SNAP-associated protein |
| Aliases | BLOC1S7; BORCS3; SNAP-25-binding protein; biogenesis of lysosomal organelles complex-1, subunit 7; SNAPAP; B ...... |
| Chromosomal Location | 1q22 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Associations between SNAPIN and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
| Summary | |
|---|---|
| Symbol | SNAPIN |
| Name | SNAP-associated protein |
| Aliases | BLOC1S7; BORCS3; SNAP-25-binding protein; biogenesis of lysosomal organelles complex-1, subunit 7; SNAPAP; B ...... |
| Chromosomal Location | 1q22 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content | Drugs targeting SNAPIN collected from DrugBank database. |
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There is no record. |