Browse ST8SIA2

Summary
SymbolST8SIA2
NameST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
Aliases STX; ST8SIA-II; HsT19690; SIAT8B; sialyltransferase 8 (alpha-2, 8-sialytransferase) B; SIAT8-B; ST8SiaII; al ......
Chromosomal Location15q26
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Golgi apparatus membrane Single-pass type II membrane protein
Domain PF00777 Glycosyltransferase family 29 (sialyltransferase)
Function

May transfer sialic acid through alpha-2,8-linkages to the alpha-2,3-linked and alpha-2,6-linked sialic acid of N-linked oligosaccharides of glycoproteins and may be involved in PSA (polysialic acid) expression.

> Gene Ontology
 
Biological Process GO:0001573 ganglioside metabolic process
GO:0001574 ganglioside biosynthetic process
GO:0006486 protein glycosylation
GO:0006487 protein N-linked glycosylation
GO:0006491 N-glycan processing
GO:0006643 membrane lipid metabolic process
GO:0006664 glycolipid metabolic process
GO:0006665 sphingolipid metabolic process
GO:0006672 ceramide metabolic process
GO:0006687 glycosphingolipid metabolic process
GO:0006688 glycosphingolipid biosynthetic process
GO:0009100 glycoprotein metabolic process
GO:0009101 glycoprotein biosynthetic process
GO:0009247 glycolipid biosynthetic process
GO:0009311 oligosaccharide metabolic process
GO:0030148 sphingolipid biosynthetic process
GO:0043413 macromolecule glycosylation
GO:0044723 single-organism carbohydrate metabolic process
GO:0046467 membrane lipid biosynthetic process
GO:0046513 ceramide biosynthetic process
GO:0070085 glycosylation
GO:0097503 sialylation
GO:1903509 liposaccharide metabolic process
Molecular Function GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity
GO:0008373 sialyltransferase activity
GO:0016757 transferase activity, transferring glycosyl groups
GO:0031406 carboxylic acid binding
GO:0033691 sialic acid binding
GO:0043168 anion binding
Cellular Component GO:0005769 early endosome
GO:0030173 integral component of Golgi membrane
GO:0031228 intrinsic component of Golgi membrane
GO:0031300 intrinsic component of organelle membrane
GO:0031301 integral component of organelle membrane
GO:0055037 recycling endosome
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-446203: Asparagine N-linked glycosylation
R-HSA-422475: Axon guidance
R-HSA-446193: Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
R-HSA-1266738: Developmental Biology
R-HSA-392499: Metabolism of proteins
R-HSA-975577: N-Glycan antennae elongation
R-HSA-975576: N-glycan antennae elongation in the medial/trans-Golgi
R-HSA-375165: NCAM signaling for neurite out-growth
R-HSA-419037: NCAM1 interactions
R-HSA-597592: Post-translational protein modification
R-HSA-4085001: Sialic acid metabolism
R-HSA-446219: Synthesis of substrates in N-glycan biosythesis
R-HSA-948021: Transport to the Golgi and subsequent modification
Summary
SymbolST8SIA2
NameST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
Aliases STX; ST8SIA-II; HsT19690; SIAT8B; sialyltransferase 8 (alpha-2, 8-sialytransferase) B; SIAT8-B; ST8SiaII; al ......
Chromosomal Location15q26
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between ST8SIA2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolST8SIA2
NameST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
Aliases STX; ST8SIA-II; HsT19690; SIAT8B; sialyltransferase 8 (alpha-2, 8-sialytransferase) B; SIAT8-B; ST8SiaII; al ......
Chromosomal Location15q26
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of ST8SIA2 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolST8SIA2
NameST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
Aliases STX; ST8SIA-II; HsT19690; SIAT8B; sialyltransferase 8 (alpha-2, 8-sialytransferase) B; SIAT8-B; ST8SiaII; al ......
Chromosomal Location15q26
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of ST8SIA2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.0870.811
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.3780.568
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.1380.779
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.1850.734
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.3990.664
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.0780.941
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.1490.876
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.1880.896
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.4850.755
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.0630.88
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.0630.92
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.8330.013
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of ST8SIA2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.41.460.177
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.41.75.70.231
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolST8SIA2
NameST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
Aliases STX; ST8SIA-II; HsT19690; SIAT8B; sialyltransferase 8 (alpha-2, 8-sialytransferase) B; SIAT8-B; ST8SiaII; al ......
Chromosomal Location15q26
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ST8SIA2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolST8SIA2
NameST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
Aliases STX; ST8SIA-II; HsT19690; SIAT8B; sialyltransferase 8 (alpha-2, 8-sialytransferase) B; SIAT8-B; ST8SiaII; al ......
Chromosomal Location15q26
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ST8SIA2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ST8SIA2.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolST8SIA2
NameST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
Aliases STX; ST8SIA-II; HsT19690; SIAT8B; sialyltransferase 8 (alpha-2, 8-sialytransferase) B; SIAT8-B; ST8SiaII; al ......
Chromosomal Location15q26
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ST8SIA2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolST8SIA2
NameST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
Aliases STX; ST8SIA-II; HsT19690; SIAT8B; sialyltransferase 8 (alpha-2, 8-sialytransferase) B; SIAT8-B; ST8SiaII; al ......
Chromosomal Location15q26
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of ST8SIA2 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolST8SIA2
NameST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
Aliases STX; ST8SIA-II; HsT19690; SIAT8B; sialyltransferase 8 (alpha-2, 8-sialytransferase) B; SIAT8-B; ST8SiaII; al ......
Chromosomal Location15q26
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between ST8SIA2 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolST8SIA2
NameST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
Aliases STX; ST8SIA-II; HsT19690; SIAT8B; sialyltransferase 8 (alpha-2, 8-sialytransferase) B; SIAT8-B; ST8SiaII; al ......
Chromosomal Location15q26
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting ST8SIA2 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.