Browse STRA6

Summary
SymbolSTRA6
Namestimulated by retinoic acid 6
Aliases FLJ12541; retinol binding protein 4 receptor; stimulated by retinoic acid gene 6 homolog (mouse); stimulated ......
Chromosomal Location15q24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane Multi-pass membrane protein Note=In the retinal pigment epithelium localizes to the basolateral membrane.
Domain -
Function

Functions as retinol transporter. Accepts all-trans retinol from the extracellular retinol-binding protein RBP4, facilitates retinol transport across the cell membrane, and then transfers retinol to the cytoplasmic retinol-binding protein RBP1 (PubMed:9452451, PubMed:18316031, PubMed:22665496). Retinol uptake is enhanced by LRAT, an enzyme that converts retinol to all-trans retinyl esters, the storage forms of vitamin A (PubMed:18316031, PubMed:22665496). Contributes to the activation of a signaling cascade that depends on retinol transport and LRAT-dependent generation of retinol metabolites that then trigger activation of JAK2 and its target STAT5, and ultimately increase the expression of SOCS3 and inhibit cellular responses to insulin (PubMed:21368206, PubMed:22665496). Important for the homeostasis of vitamin A and its derivatives, such as retinoic acid (PubMed:18316031). STRA6-mediated transport is particularly important in the eye, and under conditions of dietary vitamin A deficiency (Probable). Does not transport retinoic acid (PubMed:18316031).

> Gene Ontology
 
Biological Process GO:0001523 retinoid metabolic process
GO:0001654 eye development
GO:0001655 urogenital system development
GO:0001822 kidney development
GO:0003170 heart valve development
GO:0003177 pulmonary valve development
GO:0003179 heart valve morphogenesis
GO:0003184 pulmonary valve morphogenesis
GO:0003205 cardiac chamber development
GO:0003231 cardiac ventricle development
GO:0003279 cardiac septum development
GO:0003281 ventricular septum development
GO:0006720 isoprenoid metabolic process
GO:0006721 terpenoid metabolic process
GO:0007423 sensory organ development
GO:0007507 heart development
GO:0007517 muscle organ development
GO:0007548 sex differentiation
GO:0007611 learning or memory
GO:0007612 learning
GO:0007631 feeding behavior
GO:0007638 mechanosensory behavior
GO:0009612 response to mechanical stimulus
GO:0010171 body morphogenesis
GO:0010996 response to auditory stimulus
GO:0016101 diterpenoid metabolic process
GO:0030323 respiratory tube development
GO:0030324 lung development
GO:0030325 adrenal gland development
GO:0030540 female genitalia development
GO:0031076 embryonic camera-type eye development
GO:0031223 auditory behavior
GO:0035239 tube morphogenesis
GO:0035270 endocrine system development
GO:0042297 vocal learning
GO:0043010 camera-type eye development
GO:0043583 ear development
GO:0043584 nose development
GO:0043585 nose morphogenesis
GO:0044708 single-organism behavior
GO:0046660 female sex differentiation
GO:0048048 embryonic eye morphogenesis
GO:0048286 lung alveolus development
GO:0048514 blood vessel morphogenesis
GO:0048520 positive regulation of behavior
GO:0048546 digestive tract morphogenesis
GO:0048562 embryonic organ morphogenesis
GO:0048565 digestive tract development
GO:0048566 embryonic digestive tract development
GO:0048568 embryonic organ development
GO:0048592 eye morphogenesis
GO:0048593 camera-type eye morphogenesis
GO:0048596 embryonic camera-type eye morphogenesis
GO:0048608 reproductive structure development
GO:0048732 gland development
GO:0048745 smooth muscle tissue development
GO:0048806 genitalia development
GO:0048844 artery morphogenesis
GO:0050795 regulation of behavior
GO:0050890 cognition
GO:0050905 neuromuscular process
GO:0051180 vitamin transport
GO:0055123 digestive system development
GO:0060065 uterus development
GO:0060323 head morphogenesis
GO:0060324 face development
GO:0060325 face morphogenesis
GO:0060426 lung vasculature development
GO:0060428 lung epithelium development
GO:0060430 lung saccule development
GO:0060537 muscle tissue development
GO:0060538 skeletal muscle organ development
GO:0060539 diaphragm development
GO:0060541 respiratory system development
GO:0060840 artery development
GO:0060900 embryonic camera-type eye formation
GO:0061029 eyelid development in camera-type eye
GO:0061038 uterus morphogenesis
GO:0061143 alveolar primary septum development
GO:0061156 pulmonary artery morphogenesis
GO:0061205 paramesonephric duct development
GO:0061458 reproductive system development
GO:0072001 renal system development
GO:0090596 sensory organ morphogenesis
GO:0097070 ductus arteriosus closure
GO:0098596 imitative learning
GO:0098597 observational learning
GO:0098598 learned vocalization behavior or vocal learning
GO:1905314 semi-lunar valve development
Molecular Function GO:0051183 vitamin transporter activity
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-1643685: Disease
R-HSA-2474795: Diseases associated with visual transduction
R-HSA-5663202: Diseases of signal transduction
R-HSA-2453864: Retinoid cycle disease events
R-HSA-162582: Signal Transduction
R-HSA-2453902: The canonical retinoid cycle in rods (twilight vision)
R-HSA-2187338: Visual phototransduction
Summary
SymbolSTRA6
Namestimulated by retinoic acid 6
Aliases FLJ12541; retinol binding protein 4 receptor; stimulated by retinoic acid gene 6 homolog (mouse); stimulated ......
Chromosomal Location15q24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between STRA6 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolSTRA6
Namestimulated by retinoic acid 6
Aliases FLJ12541; retinol binding protein 4 receptor; stimulated by retinoic acid gene 6 homolog (mouse); stimulated ......
Chromosomal Location15q24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of STRA6 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolSTRA6
Namestimulated by retinoic acid 6
Aliases FLJ12541; retinol binding protein 4 receptor; stimulated by retinoic acid gene 6 homolog (mouse); stimulated ......
Chromosomal Location15q24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of STRA6 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-1.5220.0297
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.8530.154
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-1.2860.249
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.020.958
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.2320.889
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.3520.884
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.2790.752
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.8780.506
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.550.68
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.9680.219
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.9810.0449
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.3650.0882
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of STRA6 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277314.81.413.40.0181
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275914.8014.80.00826
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.811.8-70.577
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)1311018.2-18.20.199
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.63.7-1.11
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161407.1-7.10.467
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolSTRA6
Namestimulated by retinoic acid 6
Aliases FLJ12541; retinol binding protein 4 receptor; stimulated by retinoic acid gene 6 homolog (mouse); stimulated ......
Chromosomal Location15q24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of STRA6. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolSTRA6
Namestimulated by retinoic acid 6
Aliases FLJ12541; retinol binding protein 4 receptor; stimulated by retinoic acid gene 6 homolog (mouse); stimulated ......
Chromosomal Location15q24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of STRA6. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by STRA6.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolSTRA6
Namestimulated by retinoic acid 6
Aliases FLJ12541; retinol binding protein 4 receptor; stimulated by retinoic acid gene 6 homolog (mouse); stimulated ......
Chromosomal Location15q24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of STRA6. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolSTRA6
Namestimulated by retinoic acid 6
Aliases FLJ12541; retinol binding protein 4 receptor; stimulated by retinoic acid gene 6 homolog (mouse); stimulated ......
Chromosomal Location15q24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of STRA6 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolSTRA6
Namestimulated by retinoic acid 6
Aliases FLJ12541; retinol binding protein 4 receptor; stimulated by retinoic acid gene 6 homolog (mouse); stimulated ......
Chromosomal Location15q24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between STRA6 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolSTRA6
Namestimulated by retinoic acid 6
Aliases FLJ12541; retinol binding protein 4 receptor; stimulated by retinoic acid gene 6 homolog (mouse); stimulated ......
Chromosomal Location15q24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting STRA6 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.