Browse TBP

Summary
SymbolTBP
NameTATA box binding protein
Aliases TFIID; GTF2D1; SCA17; GTF2D; HDL4; TATA sequence-binding protein; TATA-box binding protein N-terminal domain ......
Chromosomal Location6q27
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus
Domain PF00352 Transcription factor TFIID (or TATA-binding protein
Function

General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID (PubMed:2374612, PubMed:2363050, PubMed:2194289, PubMed:9836642, PubMed:27193682). Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II (PubMed:2374612, PubMed:2363050, PubMed:2194289, PubMed:9836642, PubMed:27193682). Component of a BRF2-containing transcription factor complex that regulates transcription mediated by RNA polymerase III (PubMed:26638071). Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription (PubMed:15970593). The rate of PIC formation probably is primarily dependent on the rate of association of SL1 with the rDNA promoter. SL1 is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA.

> Gene Ontology
 
Biological Process GO:0006352 DNA-templated transcription, initiation
GO:0006353 DNA-templated transcription, termination
GO:0006354 DNA-templated transcription, elongation
GO:0006360 transcription from RNA polymerase I promoter
GO:0006361 transcription initiation from RNA polymerase I promoter
GO:0006362 transcription elongation from RNA polymerase I promoter
GO:0006363 termination of RNA polymerase I transcription
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006368 transcription elongation from RNA polymerase II promoter
GO:0006383 transcription from RNA polymerase III promoter
GO:0007283 spermatogenesis
GO:0009301 snRNA transcription
GO:0016073 snRNA metabolic process
GO:0040029 regulation of gene expression, epigenetic
GO:0042795 snRNA transcription from RNA polymerase II promoter
GO:0045815 positive regulation of gene expression, epigenetic
GO:0048232 male gamete generation
GO:0072331 signal transduction by p53 class mediator
GO:0098781 ncRNA transcription
GO:1901796 regulation of signal transduction by p53 class mediator
Molecular Function GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0000987 core promoter proximal region sequence-specific DNA binding
GO:0001046 core promoter sequence-specific DNA binding
GO:0001047 core promoter binding
GO:0001085 RNA polymerase II transcription factor binding
GO:0001103 RNA polymerase II repressing transcription factor binding
GO:0001159 core promoter proximal region DNA binding
GO:0008134 transcription factor binding
GO:0070491 repressing transcription factor binding
Cellular Component GO:0000428 DNA-directed RNA polymerase complex
GO:0000785 chromatin
GO:0000790 nuclear chromatin
GO:0000791 euchromatin
GO:0001939 female pronucleus
GO:0001940 male pronucleus
GO:0005667 transcription factor complex
GO:0005669 transcription factor TFIID complex
GO:0005672 transcription factor TFIIA complex
GO:0005719 nuclear euchromatin
GO:0016591 DNA-directed RNA polymerase II, holoenzyme
GO:0030880 RNA polymerase complex
GO:0044454 nuclear chromosome part
GO:0044798 nuclear transcription factor complex
GO:0045120 pronucleus
GO:0055029 nuclear DNA-directed RNA polymerase complex
GO:0061695 transferase complex, transferring phosphorus-containing groups
GO:0090575 RNA polymerase II transcription factor complex
> KEGG and Reactome Pathway
 
KEGG hsa03022 Basal transcription factors
Reactome R-HSA-5250924: B-WICH complex positively regulates rRNA expression
R-HSA-1643685: Disease
R-HSA-212165: Epigenetic regulation of gene expression
R-HSA-74160: Gene Expression
R-HSA-212436: Generic Transcription Pathway
R-HSA-162906: HIV Infection
R-HSA-162587: HIV Life Cycle
R-HSA-167161: HIV Transcription Initiation
R-HSA-5663205: Infectious disease
R-HSA-162599: Late Phase of HIV Life Cycle
R-HSA-5250941: Negative epigenetic regulation of rRNA expression
R-HSA-427413: NoRC negatively regulates rRNA expression
R-HSA-5250913: Positive epigenetic regulation of rRNA expression
R-HSA-73777: RNA Polymerase I Chain Elongation
R-HSA-73854: RNA Polymerase I Promoter Clearance
R-HSA-73772: RNA Polymerase I Promoter Escape
R-HSA-73864: RNA Polymerase I Transcription
R-HSA-73762: RNA Polymerase I Transcription Initiation
R-HSA-73863: RNA Polymerase I Transcription Termination
R-HSA-504046: RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
R-HSA-167162: RNA Polymerase II HIV Promoter Escape
R-HSA-674695: RNA Polymerase II Pre-transcription Events
R-HSA-73776: RNA Polymerase II Promoter Escape
R-HSA-73857: RNA Polymerase II Transcription
R-HSA-75953: RNA Polymerase II Transcription Initiation
R-HSA-76042: RNA Polymerase II Transcription Initiation And Promoter Clearance
R-HSA-73779: RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-HSA-749476: RNA Polymerase III Abortive And Retractive Initiation
R-HSA-74158: RNA Polymerase III Transcription
R-HSA-76046: RNA Polymerase III Transcription Initiation
R-HSA-76061: RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-HSA-76066: RNA Polymerase III Transcription Initiation From Type 2 Promoter
R-HSA-76071: RNA Polymerase III Transcription Initiation From Type 3 Promoter
R-HSA-6807505: RNA polymerase II transcribes snRNA genes
R-HSA-5633007: Regulation of TP53 Activity
R-HSA-6804756: Regulation of TP53 Activity through Phosphorylation
R-HSA-427359: SIRT1 negatively regulates rRNA Expression
R-HSA-167172: Transcription of the HIV genome
R-HSA-3700989: Transcriptional Regulation by TP53
Summary
SymbolTBP
NameTATA box binding protein
Aliases TFIID; GTF2D1; SCA17; GTF2D; HDL4; TATA sequence-binding protein; TATA-box binding protein N-terminal domain ......
Chromosomal Location6q27
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between TBP and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolTBP
NameTATA box binding protein
Aliases TFIID; GTF2D1; SCA17; GTF2D; HDL4; TATA sequence-binding protein; TATA-box binding protein N-terminal domain ......
Chromosomal Location6q27
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of TBP in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.66 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolTBP
NameTATA box binding protein
Aliases TFIID; GTF2D1; SCA17; GTF2D; HDL4; TATA sequence-binding protein; TATA-box binding protein N-terminal domain ......
Chromosomal Location6q27
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of TBP in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.3050.0507
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.5870.668
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.0980.923
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.1010.732
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.0440.976
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.2820.885
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.0140.961
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.0380.973
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.1040.933
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.0080.992
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.5430.635
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0490.312
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolTBP
NameTATA box binding protein
Aliases TFIID; GTF2D1; SCA17; GTF2D; HDL4; TATA sequence-binding protein; TATA-box binding protein N-terminal domain ......
Chromosomal Location6q27
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TBP. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolTBP
NameTATA box binding protein
Aliases TFIID; GTF2D1; SCA17; GTF2D; HDL4; TATA sequence-binding protein; TATA-box binding protein N-terminal domain ......
Chromosomal Location6q27
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TBP. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TBP.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolTBP
NameTATA box binding protein
Aliases TFIID; GTF2D1; SCA17; GTF2D; HDL4; TATA sequence-binding protein; TATA-box binding protein N-terminal domain ......
Chromosomal Location6q27
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TBP. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolTBP
NameTATA box binding protein
Aliases TFIID; GTF2D1; SCA17; GTF2D; HDL4; TATA sequence-binding protein; TATA-box binding protein N-terminal domain ......
Chromosomal Location6q27
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of TBP expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolTBP
NameTATA box binding protein
Aliases TFIID; GTF2D1; SCA17; GTF2D; HDL4; TATA sequence-binding protein; TATA-box binding protein N-terminal domain ......
Chromosomal Location6q27
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between TBP and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolTBP
NameTATA box binding protein
Aliases TFIID; GTF2D1; SCA17; GTF2D; HDL4; TATA sequence-binding protein; TATA-box binding protein N-terminal domain ......
Chromosomal Location6q27
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting TBP collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.