TISIDB

Summary
Symbol	TENM2
Name	teneurin transmembrane protein 2
Aliases	KIAA1127; Ten-M2; ODZ2; odz, odd Oz/ten-m homolog 2 (Drosophila); TNM2; neurestin alpha; odd Oz/ten-m homolo ......
Chromosomal Location	5q35
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Cell membrane Single-pass membrane protein Endoplasmic reticulum Golgi apparatus Cell junction, synapse Cell projection, dendritic spine Cell projection, filopodium Cell projection, growth cone Cell junction, synapse, postsynaptic cell membrane Single-pass membrane protein Cell junction, synapse, synaptosome Note=Colocalizes with ADGRL1 across intercellular junctions. ; SUBCELLULAR LOCATION: Isoform 2: Cell membrane. Note=Colocalizes with ADGRL1 across intercellular junctions.; SUBCELLULAR LOCATION: Ten-2 intracellular domain: Nucleus, PML body
Domain	PF06484 Teneurin Intracellular Region PF15636 GHH signature containing HNH/Endo VII superfamily nuclease toxin
Function	Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Induces homophilic cell-cell adhesion (By similarity). May function as a cellular signal transducer. ; FUNCTION: Isoform 2: Acts as a ligand of the ADGRL1 receptor. Mediates axon guidance and heterophilic cell-cell adhesion. ; FUNCTION: Ten-2 intracellular domain: Induces gene transcription inhibition.

> Gene Ontology [ TOP ]
Biological Process	GO:0030031 cell projection assembly GO:0031346 positive regulation of cell projection organization GO:0044089 positive regulation of cellular component biogenesis GO:0046847 filopodium assembly GO:0051489 regulation of filopodium assembly GO:0051491 positive regulation of filopodium assembly GO:0060491 regulation of cell projection assembly GO:0097264 self proteolysis
Molecular Function	GO:0046982 protein heterodimerization activity
Cellular Component	GO:0016604 nuclear body GO:0016605 PML body GO:0030175 filopodium GO:0030425 dendrite GO:0030426 growth cone GO:0030427 site of polarized growth GO:0043197 dendritic spine GO:0044309 neuron spine GO:0045211 postsynaptic membrane GO:0097060 synaptic membrane GO:0098794 postsynapse GO:0098858 actin-based cell projection

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	-

Summary
Symbol	TENM2
Name	teneurin transmembrane protein 2
Aliases	KIAA1127; Ten-M2; ODZ2; odz, odd Oz/ten-m homolog 2 (Drosophila); TNM2; neurestin alpha; odd Oz/ten-m homolo ......
Chromosomal Location	5q35
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between TENM2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	TENM2
Name	teneurin transmembrane protein 2
Aliases	KIAA1127; Ten-M2; ODZ2; odz, odd Oz/ten-m homolog 2 (Drosophila); TNM2; neurestin alpha; odd Oz/ten-m homolo ......
Chromosomal Location	5q35
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of TENM2 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	TENM2
Name	teneurin transmembrane protein 2
Aliases	KIAA1127; Ten-M2; ODZ2; odz, odd Oz/ten-m homolog 2 (Drosophila); TNM2; neurestin alpha; odd Oz/ten-m homolo ......
Chromosomal Location	5q35
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the expression difference of TENM2 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.035	0.917
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-0.53	0.383
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	0.449	0.386
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.147	0.74
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.141	0.934
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.509	0.807
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	-1.251	0.149
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-1.297	0.313
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-1.2	0.382
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	-0.006	0.989
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0.272	0.659
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-1.049	0.00532

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of TENM2 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	14.3	0	14.3	0.196
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	10	0	10	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	25	0	25	0.222
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	22.2	12.3	9.9	0.224
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	22.2	15.3	6.9	0.542
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	28.6	17.6	11	0.476
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	25	0	25	0.473
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	30.8	27.3	3.5	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	11.1	12.5	-1.4	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	22.2	-22.2	0.505
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	25	0	25	0.364
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	23.7	3.7	20	0.037
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	18.2	0	18.2	0.274
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	31.2	7.1	24.1	0.175
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	7.7	-7.7	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	8.3	-8.3	1

Summary
Symbol	TENM2
Name	teneurin transmembrane protein 2
Aliases	KIAA1127; Ten-M2; ODZ2; odz, odd Oz/ten-m homolog 2 (Drosophila); TNM2; neurestin alpha; odd Oz/ten-m homolo ......
Chromosomal Location	5q35
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TENM2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	TENM2
Name	teneurin transmembrane protein 2
Aliases	KIAA1127; Ten-M2; ODZ2; odz, odd Oz/ten-m homolog 2 (Drosophila); TNM2; neurestin alpha; odd Oz/ten-m homolo ......
Chromosomal Location	5q35
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TENM2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TENM2. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	TENM2
Name	teneurin transmembrane protein 2
Aliases	KIAA1127; Ten-M2; ODZ2; odz, odd Oz/ten-m homolog 2 (Drosophila); TNM2; neurestin alpha; odd Oz/ten-m homolo ......
Chromosomal Location	5q35
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TENM2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	TENM2
Name	teneurin transmembrane protein 2
Aliases	KIAA1127; Ten-M2; ODZ2; odz, odd Oz/ten-m homolog 2 (Drosophila); TNM2; neurestin alpha; odd Oz/ten-m homolo ......
Chromosomal Location	5q35
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of TENM2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	TENM2
Name	teneurin transmembrane protein 2
Aliases	KIAA1127; Ten-M2; ODZ2; odz, odd Oz/ten-m homolog 2 (Drosophila); TNM2; neurestin alpha; odd Oz/ten-m homolo ......
Chromosomal Location	5q35
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between TENM2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	TENM2
Name	teneurin transmembrane protein 2
Aliases	KIAA1127; Ten-M2; ODZ2; odz, odd Oz/ten-m homolog 2 (Drosophila); TNM2; neurestin alpha; odd Oz/ten-m homolo ......
Chromosomal Location	5q35
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting TENM2 collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

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