Browse TIRAP

Summary
SymbolTIRAP
Nametoll-interleukin 1 receptor (TIR) domain containing adaptor protein
Aliases wyatt; MyD88 adapter-like; Toll-interleukin 1 receptor (TIR) domain-containing adaptor protein; BACTS1; MyD8 ......
Chromosomal Location11q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm Cell membrane Membrane Note=Colocalizes with DAB2IP at the plasma membrane.
Domain PF13676 TIR domain
Function

Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6.

> Gene Ontology
 
Biological Process GO:0001819 positive regulation of cytokine production
GO:0002218 activation of innate immune response
GO:0002221 pattern recognition receptor signaling pathway
GO:0002224 toll-like receptor signaling pathway
GO:0002237 response to molecule of bacterial origin
GO:0002685 regulation of leukocyte migration
GO:0002687 positive regulation of leukocyte migration
GO:0002688 regulation of leukocyte chemotaxis
GO:0002690 positive regulation of leukocyte chemotaxis
GO:0002694 regulation of leukocyte activation
GO:0002696 positive regulation of leukocyte activation
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0002757 immune response-activating signal transduction
GO:0002758 innate immune response-activating signal transduction
GO:0002764 immune response-regulating signaling pathway
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007250 activation of NF-kappaB-inducing kinase activity
GO:0007254 JNK cascade
GO:0010608 posttranscriptional regulation of gene expression
GO:0030099 myeloid cell differentiation
GO:0030335 positive regulation of cell migration
GO:0030593 neutrophil chemotaxis
GO:0030595 leukocyte chemotaxis
GO:0030888 regulation of B cell proliferation
GO:0030890 positive regulation of B cell proliferation
GO:0031098 stress-activated protein kinase signaling cascade
GO:0031349 positive regulation of defense response
GO:0032092 positive regulation of protein binding
GO:0032103 positive regulation of response to external stimulus
GO:0032147 activation of protein kinase activity
GO:0032479 regulation of type I interferon production
GO:0032493 response to bacterial lipoprotein
GO:0032496 response to lipopolysaccharide
GO:0032602 chemokine production
GO:0032606 type I interferon production
GO:0032608 interferon-beta production
GO:0032615 interleukin-12 production
GO:0032618 interleukin-15 production
GO:0032635 interleukin-6 production
GO:0032637 interleukin-8 production
GO:0032640 tumor necrosis factor production
GO:0032642 regulation of chemokine production
GO:0032648 regulation of interferon-beta production
GO:0032655 regulation of interleukin-12 production
GO:0032658 regulation of interleukin-15 production
GO:0032675 regulation of interleukin-6 production
GO:0032677 regulation of interleukin-8 production
GO:0032680 regulation of tumor necrosis factor production
GO:0032722 positive regulation of chemokine production
GO:0032735 positive regulation of interleukin-12 production
GO:0032738 positive regulation of interleukin-15 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032872 regulation of stress-activated MAPK cascade
GO:0032874 positive regulation of stress-activated MAPK cascade
GO:0032943 mononuclear cell proliferation
GO:0032944 regulation of mononuclear cell proliferation
GO:0032946 positive regulation of mononuclear cell proliferation
GO:0033674 positive regulation of kinase activity
GO:0034121 regulation of toll-like receptor signaling pathway
GO:0034123 positive regulation of toll-like receptor signaling pathway
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034135 regulation of toll-like receptor 2 signaling pathway
GO:0034137 positive regulation of toll-like receptor 2 signaling pathway
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034139 regulation of toll-like receptor 3 signaling pathway
GO:0034141 positive regulation of toll-like receptor 3 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034143 regulation of toll-like receptor 4 signaling pathway
GO:0034145 positive regulation of toll-like receptor 4 signaling pathway
GO:0035664 TIRAP-dependent toll-like receptor signaling pathway
GO:0035665 TIRAP-dependent toll-like receptor 4 signaling pathway
GO:0038061 NIK/NF-kappaB signaling
GO:0040017 positive regulation of locomotion
GO:0042035 regulation of cytokine biosynthetic process
GO:0042089 cytokine biosynthetic process
GO:0042100 B cell proliferation
GO:0042107 cytokine metabolic process
GO:0042108 positive regulation of cytokine biosynthetic process
GO:0042113 B cell activation
GO:0042226 interleukin-6 biosynthetic process
GO:0042742 defense response to bacterium
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043393 regulation of protein binding
GO:0043410 positive regulation of MAPK cascade
GO:0043487 regulation of RNA stability
GO:0043488 regulation of mRNA stability
GO:0043489 RNA stabilization
GO:0043496 regulation of protein homodimerization activity
GO:0043900 regulation of multi-organism process
GO:0043901 negative regulation of multi-organism process
GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism
GO:0044110 growth involved in symbiotic interaction
GO:0044116 growth of symbiont involved in interaction with host
GO:0044117 growth of symbiont in host
GO:0044126 regulation of growth of symbiont in host
GO:0044130 negative regulation of growth of symbiont in host
GO:0044144 modulation of growth of symbiont involved in interaction with host
GO:0044146 negative regulation of growth of symbiont involved in interaction with host
GO:0045088 regulation of innate immune response
GO:0045089 positive regulation of innate immune response
GO:0045408 regulation of interleukin-6 biosynthetic process
GO:0045410 positive regulation of interleukin-6 biosynthetic process
GO:0045860 positive regulation of protein kinase activity
GO:0045926 negative regulation of growth
GO:0046328 regulation of JNK cascade
GO:0046330 positive regulation of JNK cascade
GO:0046651 lymphocyte proliferation
GO:0048255 mRNA stabilization
GO:0050670 regulation of lymphocyte proliferation
GO:0050671 positive regulation of lymphocyte proliferation
GO:0050830 defense response to Gram-positive bacterium
GO:0050864 regulation of B cell activation
GO:0050865 regulation of cell activation
GO:0050867 positive regulation of cell activation
GO:0050871 positive regulation of B cell activation
GO:0050900 leukocyte migration
GO:0050920 regulation of chemotaxis
GO:0050921 positive regulation of chemotaxis
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051098 regulation of binding
GO:0051099 positive regulation of binding
GO:0051249 regulation of lymphocyte activation
GO:0051251 positive regulation of lymphocyte activation
GO:0051272 positive regulation of cellular component movement
GO:0051403 stress-activated MAPK cascade
GO:0060326 cell chemotaxis
GO:0070302 regulation of stress-activated protein kinase signaling cascade
GO:0070304 positive regulation of stress-activated protein kinase signaling cascade
GO:0070339 response to bacterial lipopeptide
GO:0070371 ERK1 and ERK2 cascade
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070391 response to lipoteichoic acid
GO:0070661 leukocyte proliferation
GO:0070663 regulation of leukocyte proliferation
GO:0070665 positive regulation of leukocyte proliferation
GO:0070935 3'-UTR-mediated mRNA stabilization
GO:0071216 cellular response to biotic stimulus
GO:0071219 cellular response to molecule of bacterial origin
GO:0071220 cellular response to bacterial lipoprotein
GO:0071221 cellular response to bacterial lipopeptide
GO:0071223 cellular response to lipoteichoic acid
GO:0071621 granulocyte chemotaxis
GO:0071622 regulation of granulocyte chemotaxis
GO:0071624 positive regulation of granulocyte chemotaxis
GO:0071706 tumor necrosis factor superfamily cytokine production
GO:0071900 regulation of protein serine/threonine kinase activity
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0072566 chemokine (C-X-C motif) ligand 1 production
GO:0072567 chemokine (C-X-C motif) ligand 2 production
GO:0090022 regulation of neutrophil chemotaxis
GO:0090023 positive regulation of neutrophil chemotaxis
GO:0090073 positive regulation of protein homodimerization activity
GO:0097529 myeloid leukocyte migration
GO:0097530 granulocyte migration
GO:0098542 defense response to other organism
GO:1901222 regulation of NIK/NF-kappaB signaling
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1902622 regulation of neutrophil migration
GO:1902624 positive regulation of neutrophil migration
GO:1903555 regulation of tumor necrosis factor superfamily cytokine production
GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production
GO:1990266 neutrophil migration
GO:2000147 positive regulation of cell motility
GO:2000338 regulation of chemokine (C-X-C motif) ligand 1 production
GO:2000340 positive regulation of chemokine (C-X-C motif) ligand 1 production
GO:2000341 regulation of chemokine (C-X-C motif) ligand 2 production
GO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production
Molecular Function GO:0005080 protein kinase C binding
GO:0005543 phospholipid binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0030674 protein binding, bridging
GO:0035091 phosphatidylinositol binding
GO:0035325 Toll-like receptor binding
GO:0035662 Toll-like receptor 4 binding
GO:0035663 Toll-like receptor 2 binding
GO:0046982 protein heterodimerization activity
GO:0060090 binding, bridging
GO:1901981 phosphatidylinositol phosphate binding
GO:1902936 phosphatidylinositol bisphosphate binding
Cellular Component GO:0001726 ruffle
GO:0030139 endocytic vesicle
GO:0031252 cell leading edge
GO:0031253 cell projection membrane
GO:0031256 leading edge membrane
GO:0032587 ruffle membrane
GO:0045171 intercellular bridge
> KEGG and Reactome Pathway
 
KEGG hsa04064 NF-kappa B signaling pathway
hsa04620 Toll-like receptor signaling pathway
Reactome R-HSA-166054: Activated TLR4 signalling
R-HSA-1280218: Adaptive Immune System
R-HSA-1236975: Antigen processing-Cross presentation
R-HSA-983169: Class I MHC mediated antigen processing & presentation
R-HSA-1643685: Disease
R-HSA-5602358: Diseases associated with the TLR signaling cascade
R-HSA-5260271: Diseases of Immune System
R-HSA-1236974: ER-Phagosome pathway
R-HSA-5603041: IRAK4 deficiency (TLR2/4)
R-HSA-168256: Immune System
R-HSA-168249: Innate Immune System
R-HSA-5602498: MyD88 deficiency (TLR2/4)
R-HSA-166058: MyD88
R-HSA-181438: Toll Like Receptor 2 (TLR2) Cascade
R-HSA-166016: Toll Like Receptor 4 (TLR4) Cascade
R-HSA-168179: Toll Like Receptor TLR1
R-HSA-168188: Toll Like Receptor TLR6
R-HSA-168898: Toll-Like Receptors Cascades
Summary
SymbolTIRAP
Nametoll-interleukin 1 receptor (TIR) domain containing adaptor protein
Aliases wyatt; MyD88 adapter-like; Toll-interleukin 1 receptor (TIR) domain-containing adaptor protein; BACTS1; MyD8 ......
Chromosomal Location11q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between TIRAP and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolTIRAP
Nametoll-interleukin 1 receptor (TIR) domain containing adaptor protein
Aliases wyatt; MyD88 adapter-like; Toll-interleukin 1 receptor (TIR) domain-containing adaptor protein; BACTS1; MyD8 ......
Chromosomal Location11q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of TIRAP in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolTIRAP
Nametoll-interleukin 1 receptor (TIR) domain containing adaptor protein
Aliases wyatt; MyD88 adapter-like; Toll-interleukin 1 receptor (TIR) domain-containing adaptor protein; BACTS1; MyD8 ......
Chromosomal Location11q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of TIRAP in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.1350.509
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.1920.851
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.3710.643
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.8550.0234
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.7090.618
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 471.0470.593
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.1980.353
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.0950.917
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.3540.739
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.2540.798
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.4460.751
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0190.785
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of TIRAP in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277301.4-1.41
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275901.7-1.71
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.1011.10.36
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59200200.357
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolTIRAP
Nametoll-interleukin 1 receptor (TIR) domain containing adaptor protein
Aliases wyatt; MyD88 adapter-like; Toll-interleukin 1 receptor (TIR) domain-containing adaptor protein; BACTS1; MyD8 ......
Chromosomal Location11q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TIRAP. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolTIRAP
Nametoll-interleukin 1 receptor (TIR) domain containing adaptor protein
Aliases wyatt; MyD88 adapter-like; Toll-interleukin 1 receptor (TIR) domain-containing adaptor protein; BACTS1; MyD8 ......
Chromosomal Location11q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TIRAP. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TIRAP.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolTIRAP
Nametoll-interleukin 1 receptor (TIR) domain containing adaptor protein
Aliases wyatt; MyD88 adapter-like; Toll-interleukin 1 receptor (TIR) domain-containing adaptor protein; BACTS1; MyD8 ......
Chromosomal Location11q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TIRAP. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolTIRAP
Nametoll-interleukin 1 receptor (TIR) domain containing adaptor protein
Aliases wyatt; MyD88 adapter-like; Toll-interleukin 1 receptor (TIR) domain-containing adaptor protein; BACTS1; MyD8 ......
Chromosomal Location11q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of TIRAP expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolTIRAP
Nametoll-interleukin 1 receptor (TIR) domain containing adaptor protein
Aliases wyatt; MyD88 adapter-like; Toll-interleukin 1 receptor (TIR) domain-containing adaptor protein; BACTS1; MyD8 ......
Chromosomal Location11q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between TIRAP and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolTIRAP
Nametoll-interleukin 1 receptor (TIR) domain containing adaptor protein
Aliases wyatt; MyD88 adapter-like; Toll-interleukin 1 receptor (TIR) domain-containing adaptor protein; BACTS1; MyD8 ......
Chromosomal Location11q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting TIRAP collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.