Browse TKTL1

Summary
SymbolTKTL1
Nametransketolase-like 1
Aliases TKR; TKT2; TK 2; transketolase-2; transketolase-related protein; Transketolase 2; Transketolase-like protein ......
Chromosomal LocationXq28
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm Nucleus Note=Predominantly cytoplasmic and to a lesser extent also nuclear (PubMed:16969476).
Domain PF02779 Transketolase
PF02780 Transketolase
PF00456 Transketolase
Function

Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.

> Gene Ontology
 
Biological Process GO:0005996 monosaccharide metabolic process
GO:0006006 glucose metabolic process
GO:0006007 glucose catabolic process
GO:0006766 vitamin metabolic process
GO:0006767 water-soluble vitamin metabolic process
GO:0006772 thiamine metabolic process
GO:0006790 sulfur compound metabolic process
GO:0016052 carbohydrate catabolic process
GO:0019318 hexose metabolic process
GO:0019320 hexose catabolic process
GO:0042723 thiamine-containing compound metabolic process
GO:0044282 small molecule catabolic process
GO:0044723 single-organism carbohydrate metabolic process
GO:0044724 single-organism carbohydrate catabolic process
GO:0046365 monosaccharide catabolic process
GO:0072527 pyrimidine-containing compound metabolic process
Molecular Function GO:0004802 transketolase activity
GO:0016744 transferase activity, transferring aldehyde or ketonic groups
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa00030 Pentose phosphate pathway
hsa01100 Metabolic pathways
hsa01200 Carbon metabolism
hsa01230 Biosynthesis of amino acids
Reactome -
Summary
SymbolTKTL1
Nametransketolase-like 1
Aliases TKR; TKT2; TK 2; transketolase-2; transketolase-related protein; Transketolase 2; Transketolase-like protein ......
Chromosomal LocationXq28
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between TKTL1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolTKTL1
Nametransketolase-like 1
Aliases TKR; TKT2; TK 2; transketolase-2; transketolase-related protein; Transketolase 2; Transketolase-like protein ......
Chromosomal LocationXq28
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of TKTL1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolTKTL1
Nametransketolase-like 1
Aliases TKR; TKT2; TK 2; transketolase-2; transketolase-related protein; Transketolase 2; Transketolase-like protein ......
Chromosomal LocationXq28
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of TKTL1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.3870.503
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.8330.356
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.0440.957
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-2.5120.00333
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-2.40.0631
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-2.6480.0723
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-1.4790.039
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-1.9620.0592
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.8330.448
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.960.32
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.6720.178
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.2790.489
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of TKTL1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.41.460.177
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.41.75.70.231
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)2117011.8-11.80.193
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)1311018.2-18.20.199
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916012.5-12.50.52
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47014.3-14.31
1329033130MelanomaallAnti-PD-1 (nivolumab) 382703.7-3.70.415
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221307.7-7.70.371
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolTKTL1
Nametransketolase-like 1
Aliases TKR; TKT2; TK 2; transketolase-2; transketolase-related protein; Transketolase 2; Transketolase-like protein ......
Chromosomal LocationXq28
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TKTL1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolTKTL1
Nametransketolase-like 1
Aliases TKR; TKT2; TK 2; transketolase-2; transketolase-related protein; Transketolase 2; Transketolase-like protein ......
Chromosomal LocationXq28
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TKTL1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TKTL1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolTKTL1
Nametransketolase-like 1
Aliases TKR; TKT2; TK 2; transketolase-2; transketolase-related protein; Transketolase 2; Transketolase-like protein ......
Chromosomal LocationXq28
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TKTL1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolTKTL1
Nametransketolase-like 1
Aliases TKR; TKT2; TK 2; transketolase-2; transketolase-related protein; Transketolase 2; Transketolase-like protein ......
Chromosomal LocationXq28
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of TKTL1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolTKTL1
Nametransketolase-like 1
Aliases TKR; TKT2; TK 2; transketolase-2; transketolase-related protein; Transketolase 2; Transketolase-like protein ......
Chromosomal LocationXq28
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between TKTL1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolTKTL1
Nametransketolase-like 1
Aliases TKR; TKT2; TK 2; transketolase-2; transketolase-related protein; Transketolase 2; Transketolase-like protein ......
Chromosomal LocationXq28
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting TKTL1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.