Browse TOMM7

Summary
SymbolTOMM7
Nametranslocase of outer mitochondrial membrane 7 homolog (yeast)
Aliases TOM7; 6.2 kd protein; translocase of outer membrane 7 kDa subunit homolog; Mitochondrial import receptor sub ......
Chromosomal Location7p15.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Mitochondrion outer membrane Single-pass membrane protein
Domain PF08038 TOM7 family
Function

Required for assembly and stability of the TOM complex. Positive regulator of PRKN translocation to damaged mitochondria. Acts probably by stabilizing PINK1 on the outer membrane of depolarized mitochondria.

> Gene Ontology
 
Biological Process GO:0000422 mitophagy
GO:0000423 macromitophagy
GO:0006626 protein targeting to mitochondrion
GO:0006839 mitochondrial transport
GO:0006914 autophagy
GO:0007006 mitochondrial membrane organization
GO:0007008 outer mitochondrial membrane organization
GO:0010821 regulation of mitochondrion organization
GO:0010822 positive regulation of mitochondrion organization
GO:0016236 macroautophagy
GO:0017038 protein import
GO:0030150 protein import into mitochondrial matrix
GO:0031647 regulation of protein stability
GO:0032386 regulation of intracellular transport
GO:0032388 positive regulation of intracellular transport
GO:0033157 regulation of intracellular protein transport
GO:0044743 intracellular protein transmembrane import
GO:0045040 protein import into mitochondrial outer membrane
GO:0051222 positive regulation of protein transport
GO:0061726 mitochondrion disassembly
GO:0065002 intracellular protein transmembrane transport
GO:0070585 protein localization to mitochondrion
GO:0071806 protein transmembrane transport
GO:0072655 establishment of protein localization to mitochondrion
GO:0072657 protein localization to membrane
GO:0090150 establishment of protein localization to membrane
GO:0090151 establishment of protein localization to mitochondrial membrane
GO:0090316 positive regulation of intracellular protein transport
GO:0098779 mitophagy in response to mitochondrial depolarization
GO:0098780 response to mitochondrial depolarisation
GO:1903008 organelle disassembly
GO:1903214 regulation of protein targeting to mitochondrion
GO:1903533 regulation of protein targeting
GO:1903747 regulation of establishment of protein localization to mitochondrion
GO:1903749 positive regulation of establishment of protein localization to mitochondrion
GO:1903829 positive regulation of cellular protein localization
GO:1903955 positive regulation of protein targeting to mitochondrion
GO:1904951 positive regulation of establishment of protein localization
GO:1990542 mitochondrial transmembrane transport
Molecular Function GO:0008320 protein transmembrane transporter activity
GO:0008565 protein transporter activity
GO:0015266 protein channel activity
GO:0015267 channel activity
GO:0022803 passive transmembrane transporter activity
GO:0022884 macromolecule transmembrane transporter activity
Cellular Component GO:0005741 mitochondrial outer membrane
GO:0005742 mitochondrial outer membrane translocase complex
GO:0019867 outer membrane
GO:0031300 intrinsic component of organelle membrane
GO:0031301 integral component of organelle membrane
GO:0031306 intrinsic component of mitochondrial outer membrane
GO:0031307 integral component of mitochondrial outer membrane
GO:0031968 organelle outer membrane
GO:0032592 integral component of mitochondrial membrane
GO:0044455 mitochondrial membrane part
GO:0098573 intrinsic component of mitochondrial membrane
GO:0098798 mitochondrial protein complex
GO:0098799 outer mitochondrial membrane protein complex
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-392499: Metabolism of proteins
R-HSA-1268020: Mitochondrial protein import
R-HSA-5205647: Mitophagy
R-HSA-5205685: Pink/Parkin Mediated Mitophagy
Summary
SymbolTOMM7
Nametranslocase of outer mitochondrial membrane 7 homolog (yeast)
Aliases TOM7; 6.2 kd protein; translocase of outer membrane 7 kDa subunit homolog; Mitochondrial import receptor sub ......
Chromosomal Location7p15.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between TOMM7 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolTOMM7
Nametranslocase of outer mitochondrial membrane 7 homolog (yeast)
Aliases TOM7; 6.2 kd protein; translocase of outer membrane 7 kDa subunit homolog; Mitochondrial import receptor sub ......
Chromosomal Location7p15.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of TOMM7 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolTOMM7
Nametranslocase of outer mitochondrial membrane 7 homolog (yeast)
Aliases TOM7; 6.2 kd protein; translocase of outer membrane 7 kDa subunit homolog; Mitochondrial import receptor sub ......
Chromosomal Location7p15.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of TOMM7 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.7960.0203
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.9010.83
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.720.815
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.1360.719
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.1780.908
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.5350.786
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0880.851
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.2090.923
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.0220.993
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.1920.944
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.4580.915
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0440.507
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolTOMM7
Nametranslocase of outer mitochondrial membrane 7 homolog (yeast)
Aliases TOM7; 6.2 kd protein; translocase of outer membrane 7 kDa subunit homolog; Mitochondrial import receptor sub ......
Chromosomal Location7p15.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TOMM7. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolTOMM7
Nametranslocase of outer mitochondrial membrane 7 homolog (yeast)
Aliases TOM7; 6.2 kd protein; translocase of outer membrane 7 kDa subunit homolog; Mitochondrial import receptor sub ......
Chromosomal Location7p15.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TOMM7. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TOMM7.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolTOMM7
Nametranslocase of outer mitochondrial membrane 7 homolog (yeast)
Aliases TOM7; 6.2 kd protein; translocase of outer membrane 7 kDa subunit homolog; Mitochondrial import receptor sub ......
Chromosomal Location7p15.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TOMM7. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolTOMM7
Nametranslocase of outer mitochondrial membrane 7 homolog (yeast)
Aliases TOM7; 6.2 kd protein; translocase of outer membrane 7 kDa subunit homolog; Mitochondrial import receptor sub ......
Chromosomal Location7p15.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of TOMM7 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolTOMM7
Nametranslocase of outer mitochondrial membrane 7 homolog (yeast)
Aliases TOM7; 6.2 kd protein; translocase of outer membrane 7 kDa subunit homolog; Mitochondrial import receptor sub ......
Chromosomal Location7p15.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between TOMM7 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolTOMM7
Nametranslocase of outer mitochondrial membrane 7 homolog (yeast)
Aliases TOM7; 6.2 kd protein; translocase of outer membrane 7 kDa subunit homolog; Mitochondrial import receptor sub ......
Chromosomal Location7p15.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting TOMM7 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.