Browse VAMP2

Summary
SymbolVAMP2
Namevesicle-associated membrane protein 2 (synaptobrevin 2)
Aliases VAMP-2; SYB2; synaptobrevin 2; synaptobrevin-2; vesicle associated membrane protein 2; Vesicle-associated me ......
Chromosomal Location17p13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type IV membrane protein. Cell junction, synapse, synaptosome. Cell membrane Note=Neuronal synaptic vesicles. Colocalizes with PRKCZ and WDFY2 in intracellular vesicles (PubMed:17313651).
Domain PF00957 Synaptobrevin
Function

Involved in the targeting and/or fusion of transport vesicles to their target membrane. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1.

> Gene Ontology
 
Biological Process GO:0001505 regulation of neurotransmitter levels
GO:0002263 cell activation involved in immune response
GO:0002274 myeloid leukocyte activation
GO:0002275 myeloid cell activation involved in immune response
GO:0002278 eosinophil activation involved in immune response
GO:0002366 leukocyte activation involved in immune response
GO:0002443 leukocyte mediated immunity
GO:0002444 myeloid leukocyte mediated immunity
GO:0002447 eosinophil mediated immunity
GO:0006813 potassium ion transport
GO:0006820 anion transport
GO:0006835 dicarboxylic acid transport
GO:0006836 neurotransmitter transport
GO:0006887 exocytosis
GO:0006892 post-Golgi vesicle-mediated transport
GO:0006906 vesicle fusion
GO:0007009 plasma membrane organization
GO:0007269 neurotransmitter secretion
GO:0009743 response to carbohydrate
GO:0009746 response to hexose
GO:0009749 response to glucose
GO:0010959 regulation of metal ion transport
GO:0014047 glutamate secretion
GO:0015672 monovalent inorganic cation transport
GO:0015711 organic anion transport
GO:0016050 vesicle organization
GO:0016079 synaptic vesicle exocytosis
GO:0017156 calcium ion regulated exocytosis
GO:0017157 regulation of exocytosis
GO:0022898 regulation of transmembrane transporter activity
GO:0023061 signal release
GO:0032386 regulation of intracellular transport
GO:0032388 positive regulation of intracellular transport
GO:0032409 regulation of transporter activity
GO:0032412 regulation of ion transmembrane transporter activity
GO:0032868 response to insulin
GO:0032869 cellular response to insulin stimulus
GO:0033157 regulation of intracellular protein transport
GO:0034284 response to monosaccharide
GO:0034762 regulation of transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0036230 granulocyte activation
GO:0043001 Golgi to plasma membrane protein transport
GO:0043266 regulation of potassium ion transport
GO:0043299 leukocyte degranulation
GO:0043307 eosinophil activation
GO:0043308 eosinophil degranulation
GO:0043434 response to peptide hormone
GO:0044801 single-organism membrane fusion
GO:0045055 regulated exocytosis
GO:0046942 carboxylic acid transport
GO:0048167 regulation of synaptic plasticity
GO:0048193 Golgi vesicle transport
GO:0048284 organelle fusion
GO:0048489 synaptic vesicle transport
GO:0050804 modulation of synaptic transmission
GO:0050806 positive regulation of synaptic transmission
GO:0051222 positive regulation of protein transport
GO:0051640 organelle localization
GO:0051648 vesicle localization
GO:0051650 establishment of vesicle localization
GO:0051656 establishment of organelle localization
GO:0060291 long-term synaptic potentiation
GO:0060627 regulation of vesicle-mediated transport
GO:0061025 membrane fusion
GO:0071375 cellular response to peptide hormone stimulus
GO:0071417 cellular response to organonitrogen compound
GO:0071804 cellular potassium ion transport
GO:0071805 potassium ion transmembrane transport
GO:0072657 protein localization to membrane
GO:0072659 protein localization to plasma membrane
GO:0090002 establishment of protein localization to plasma membrane
GO:0090150 establishment of protein localization to membrane
GO:0090174 organelle membrane fusion
GO:0090316 positive regulation of intracellular protein transport
GO:0097479 synaptic vesicle localization
GO:0097480 establishment of synaptic vesicle localization
GO:0099003 vesicle-mediated transport in synapse
GO:0099504 synaptic vesicle cycle
GO:0099531 presynaptic process involved in chemical synaptic transmission
GO:0099643 signal release from synapse
GO:1901016 regulation of potassium ion transmembrane transporter activity
GO:1901379 regulation of potassium ion transmembrane transport
GO:1901652 response to peptide
GO:1901653 cellular response to peptide
GO:1902259 regulation of delayed rectifier potassium channel activity
GO:1903829 positive regulation of cellular protein localization
GO:1904062 regulation of cation transmembrane transport
GO:1904951 positive regulation of establishment of protein localization
GO:1990778 protein localization to cell periphery
GO:2001257 regulation of cation channel activity
Molecular Function GO:0000149 SNARE binding
GO:0005484 SNAP receptor activity
GO:0005516 calmodulin binding
GO:0005543 phospholipid binding
GO:0017075 syntaxin-1 binding
GO:0019905 syntaxin binding
GO:0043621 protein self-association
GO:0048306 calcium-dependent protein binding
Cellular Component GO:0005802 trans-Golgi network
GO:0008021 synaptic vesicle
GO:0008076 voltage-gated potassium channel complex
GO:0030133 transport vesicle
GO:0030135 coated vesicle
GO:0030136 clathrin-coated vesicle
GO:0030141 secretory granule
GO:0030658 transport vesicle membrane
GO:0030659 cytoplasmic vesicle membrane
GO:0030662 coated vesicle membrane
GO:0030665 clathrin-coated vesicle membrane
GO:0030667 secretory granule membrane
GO:0030672 synaptic vesicle membrane
GO:0031201 SNARE complex
GO:0031984 organelle subcompartment
GO:0034702 ion channel complex
GO:0034703 cation channel complex
GO:0034705 potassium channel complex
GO:0042588 zymogen granule
GO:0042589 zymogen granule membrane
GO:0044306 neuron projection terminus
GO:0060198 clathrin-sculpted vesicle
GO:0060199 clathrin-sculpted glutamate transport vesicle
GO:0060203 clathrin-sculpted glutamate transport vesicle membrane
GO:0061200 clathrin-sculpted gamma-aminobutyric acid transport vesicle
GO:0061202 clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex
GO:0070033 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex
GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex
GO:0070081 clathrin-sculpted monoamine transport vesicle
GO:0070083 clathrin-sculpted monoamine transport vesicle membrane
GO:0070382 exocytic vesicle
GO:0098791 Golgi subcompartment
GO:0098793 presynapse
GO:0099501 exocytic vesicle membrane
GO:0099503 secretory vesicle
GO:1902495 transmembrane transporter complex
GO:1990351 transporter complex
> KEGG and Reactome Pathway
 
KEGG hsa04130 SNARE interactions in vesicular transport
hsa04721 Synaptic vesicle cycle
hsa04911 Insulin secretion
hsa04962 Vasopressin-regulated water reabsorption
hsa04970 Salivary secretion
Reactome R-HSA-264642: Acetylcholine Neurotransmitter Release Cycle
R-HSA-8856825: Cargo recognition for clathrin-mediated endocytosis
R-HSA-421837: Clathrin derived vesicle budding
R-HSA-8856828: Clathrin-mediated endocytosis
R-HSA-1643685: Disease
R-HSA-212676: Dopamine Neurotransmitter Release Cycle
R-HSA-888590: GABA synthesis, release, reuptake and degradation
R-HSA-210500: Glutamate Neurotransmitter Release Cycle
R-HSA-432722: Golgi Associated Vesicle Biogenesis
R-HSA-5663205: Infectious disease
R-HSA-264876: Insulin processing
R-HSA-163685: Integration of energy metabolism
R-HSA-432720: Lysosome Vesicle Biogenesis
R-HSA-199991: Membrane Trafficking
R-HSA-1430728: Metabolism
R-HSA-392499: Metabolism of proteins
R-HSA-112316: Neuronal System
R-HSA-168799: Neurotoxicity of clostridium toxins
R-HSA-112310: Neurotransmitter Release Cycle
R-HSA-181430: Norepinephrine Neurotransmitter Release Cycle
R-HSA-2980736: Peptide hormone metabolism
R-HSA-422356: Regulation of insulin secretion
R-HSA-181429: Serotonin Neurotransmitter Release Cycle
R-HSA-5250958: Toxicity of botulinum toxin type B (BoNT/B)
R-HSA-5250955: Toxicity of botulinum toxin type D (BoNT/D)
R-HSA-5250981: Toxicity of botulinum toxin type F (BoNT/F)
R-HSA-5250989: Toxicity of botulinum toxin type G (BoNT/G)
R-HSA-5250982: Toxicity of tetanus toxin (TeNT)
R-HSA-1445148: Translocation of GLUT4 to the plasma membrane
R-HSA-112315: Transmission across Chemical Synapses
R-HSA-5339562: Uptake and actions of bacterial toxins
R-HSA-5653656: Vesicle-mediated transport
R-HSA-199992: trans-Golgi Network Vesicle Budding
Summary
SymbolVAMP2
Namevesicle-associated membrane protein 2 (synaptobrevin 2)
Aliases VAMP-2; SYB2; synaptobrevin 2; synaptobrevin-2; vesicle associated membrane protein 2; Vesicle-associated me ......
Chromosomal Location17p13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between VAMP2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolVAMP2
Namevesicle-associated membrane protein 2 (synaptobrevin 2)
Aliases VAMP-2; SYB2; synaptobrevin 2; synaptobrevin-2; vesicle associated membrane protein 2; Vesicle-associated me ......
Chromosomal Location17p13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of VAMP2 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolVAMP2
Namevesicle-associated membrane protein 2 (synaptobrevin 2)
Aliases VAMP-2; SYB2; synaptobrevin 2; synaptobrevin-2; vesicle associated membrane protein 2; Vesicle-associated me ......
Chromosomal Location17p13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of VAMP2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.1860.489
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.2030.934
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.4690.794
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.6910.0296
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 591.1730.464
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.0890.967
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0590.87
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.2150.891
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.4380.812
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.4040.828
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.8060.761
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0490.54
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of VAMP2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolVAMP2
Namevesicle-associated membrane protein 2 (synaptobrevin 2)
Aliases VAMP-2; SYB2; synaptobrevin 2; synaptobrevin-2; vesicle associated membrane protein 2; Vesicle-associated me ......
Chromosomal Location17p13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of VAMP2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolVAMP2
Namevesicle-associated membrane protein 2 (synaptobrevin 2)
Aliases VAMP-2; SYB2; synaptobrevin 2; synaptobrevin-2; vesicle associated membrane protein 2; Vesicle-associated me ......
Chromosomal Location17p13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of VAMP2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by VAMP2.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolVAMP2
Namevesicle-associated membrane protein 2 (synaptobrevin 2)
Aliases VAMP-2; SYB2; synaptobrevin 2; synaptobrevin-2; vesicle associated membrane protein 2; Vesicle-associated me ......
Chromosomal Location17p13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of VAMP2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolVAMP2
Namevesicle-associated membrane protein 2 (synaptobrevin 2)
Aliases VAMP-2; SYB2; synaptobrevin 2; synaptobrevin-2; vesicle associated membrane protein 2; Vesicle-associated me ......
Chromosomal Location17p13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of VAMP2 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolVAMP2
Namevesicle-associated membrane protein 2 (synaptobrevin 2)
Aliases VAMP-2; SYB2; synaptobrevin 2; synaptobrevin-2; vesicle associated membrane protein 2; Vesicle-associated me ......
Chromosomal Location17p13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between VAMP2 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolVAMP2
Namevesicle-associated membrane protein 2 (synaptobrevin 2)
Aliases VAMP-2; SYB2; synaptobrevin 2; synaptobrevin-2; vesicle associated membrane protein 2; Vesicle-associated me ......
Chromosomal Location17p13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting VAMP2 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting VAMP2.
ID Name Drug Type Targets #Targets
DB00042Botulinum Toxin Type BBiotechSYT2, VAMP1, VAMP23