Browse XK

Summary
SymbolXK
NameX-linked Kx blood group
Aliases XKR1; Kx; X1k; Kx antigen; McLeod syndrome; NA; Kell blood group precursor (McLeod phenotype); XK, Kell bloo ......
Chromosomal LocationXp21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Membrane Multi-pass membrane protein
Domain PF09815 XK-related protein
Function

May be involved in sodium-dependent transport of neutral amino acids or oligopeptides.

> Gene Ontology
 
Biological Process GO:0006865 amino acid transport
GO:0006874 cellular calcium ion homeostasis
GO:0006875 cellular metal ion homeostasis
GO:0007272 ensheathment of neurons
GO:0007409 axonogenesis
GO:0007517 muscle organ development
GO:0007519 skeletal muscle tissue development
GO:0008361 regulation of cell size
GO:0008366 axon ensheathment
GO:0010769 regulation of cell morphogenesis involved in differentiation
GO:0010960 magnesium ion homeostasis
GO:0010961 cellular magnesium ion homeostasis
GO:0010975 regulation of neuron projection development
GO:0014706 striated muscle tissue development
GO:0014902 myotube differentiation
GO:0014904 myotube cell development
GO:0015849 organic acid transport
GO:0022604 regulation of cell morphogenesis
GO:0031133 regulation of axon diameter
GO:0032535 regulation of cellular component size
GO:0032536 regulation of cell projection size
GO:0042552 myelination
GO:0042692 muscle cell differentiation
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0048741 skeletal muscle fiber development
GO:0048747 muscle fiber development
GO:0050770 regulation of axonogenesis
GO:0051146 striated muscle cell differentiation
GO:0055001 muscle cell development
GO:0055002 striated muscle cell development
GO:0055074 calcium ion homeostasis
GO:0060537 muscle tissue development
GO:0060538 skeletal muscle organ development
GO:0061564 axon development
GO:0072503 cellular divalent inorganic cation homeostasis
GO:0072507 divalent inorganic cation homeostasis
GO:0090066 regulation of anatomical structure size
Molecular Function -
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-373076: Class A/1 (Rhodopsin-like receptors)
R-HSA-500792: GPCR ligand binding
R-HSA-375276: Peptide ligand-binding receptors
R-HSA-162582: Signal Transduction
R-HSA-372790: Signaling by GPCR
Summary
SymbolXK
NameX-linked Kx blood group
Aliases XKR1; Kx; X1k; Kx antigen; McLeod syndrome; NA; Kell blood group precursor (McLeod phenotype); XK, Kell bloo ......
Chromosomal LocationXp21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between XK and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolXK
NameX-linked Kx blood group
Aliases XKR1; Kx; X1k; Kx antigen; McLeod syndrome; NA; Kell blood group precursor (McLeod phenotype); XK, Kell bloo ......
Chromosomal LocationXp21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of XK in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolXK
NameX-linked Kx blood group
Aliases XKR1; Kx; X1k; Kx antigen; McLeod syndrome; NA; Kell blood group precursor (McLeod phenotype); XK, Kell bloo ......
Chromosomal LocationXp21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of XK in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.1040.666
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.250.606
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.0040.993
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.4350.468
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.210.829
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 471.2620.293
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.1610.834
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.8130.46
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.4560.701
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.2970.562
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.9280.155
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.6020.0209
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of XK in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277301.4-1.41
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275901.7-1.71
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 382703.7-3.70.415
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161407.1-7.10.467
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolXK
NameX-linked Kx blood group
Aliases XKR1; Kx; X1k; Kx antigen; McLeod syndrome; NA; Kell blood group precursor (McLeod phenotype); XK, Kell bloo ......
Chromosomal LocationXp21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of XK. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolXK
NameX-linked Kx blood group
Aliases XKR1; Kx; X1k; Kx antigen; McLeod syndrome; NA; Kell blood group precursor (McLeod phenotype); XK, Kell bloo ......
Chromosomal LocationXp21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of XK. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by XK.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolXK
NameX-linked Kx blood group
Aliases XKR1; Kx; X1k; Kx antigen; McLeod syndrome; NA; Kell blood group precursor (McLeod phenotype); XK, Kell bloo ......
Chromosomal LocationXp21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of XK. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolXK
NameX-linked Kx blood group
Aliases XKR1; Kx; X1k; Kx antigen; McLeod syndrome; NA; Kell blood group precursor (McLeod phenotype); XK, Kell bloo ......
Chromosomal LocationXp21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of XK expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolXK
NameX-linked Kx blood group
Aliases XKR1; Kx; X1k; Kx antigen; McLeod syndrome; NA; Kell blood group precursor (McLeod phenotype); XK, Kell bloo ......
Chromosomal LocationXp21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between XK and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolXK
NameX-linked Kx blood group
Aliases XKR1; Kx; X1k; Kx antigen; McLeod syndrome; NA; Kell blood group precursor (McLeod phenotype); XK, Kell bloo ......
Chromosomal LocationXp21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting XK collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.