Symbol Name mut_rate expr_median NCOA3 nuclear receptor coactivator 3 42.86 7.8 TAF1L TATA-box binding protein associated factor 1 like 14.29 4.3 CREBBP CREB binding protein 14.29 6.6 DAXX death domain associated protein 14.29 7.8 DNMT3B DNA methyltransferase 3 beta 14.29 8 IDH1 isocitrate dehydrogenase (NADP(+)) 1, cytosolic 14.29 12.5 EP400 E1A binding protein p400 14.29 7.7 BRD2 bromodomain containing 2 14.29 9.8 NSD1 nuclear receptor binding SET domain protein 1 14.29 5.7 SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 14.29 9.1 NSD2 nuclear receptor binding SET domain protein 2 14.29 7.6 ZMYM2 zinc finger MYM-type containing 2 14.29 5.6 ARID1A AT-rich interaction domain 1A 14.29 8.4 TRRAP transformation/transcription domain associated protein 14.29 8.3 KDM6A lysine demethylase 6A 14.29 NA HDAC5 histone deacetylase 5 0 5.7 TRIM28 tripartite motif containing 28 0 10.8 PRMT3 protein arginine methyltransferase 3 0 9.9 SMNDC1 survival motor neuron domain containing 1 0 10.3 IKZF1 IKAROS family zinc finger 1 0 3.9 SMYD5 SMYD family member 5 0 7.2 PRMT5 protein arginine methyltransferase 5 0 10.9 CARM1 coactivator associated arginine methyltransferase 1 0 8.7 NCOA2 nuclear receptor coactivator 2 0 5.4 KAT5 lysine acetyltransferase 5 0 8.1 CTCF CCCTC-binding factor 0 10 RAI1 retinoic acid induced 1 0 7.3 KDM5B lysine demethylase 5B 0 9 ZMYND11 zinc finger MYND-type containing 11 0 8 SRCAP Snf2 related CREBBP activator protein 0 5.4 RUVBL2 RuvB like AAA ATPase 2 0 11.6 BRD8 bromodomain containing 8 0 7.7 EHMT2 euchromatic histone lysine methyltransferase 2 0 6.9 MORF4L1 mortality factor 4 like 1 0 12.8 TDRKH tudor and KH domain containing 0 5.1 CHD1 chromodomain helicase DNA binding protein 1 0 9.2 CHD2 chromodomain helicase DNA binding protein 2 0 7.6 CHD3 chromodomain helicase DNA binding protein 3 0 6.8 DIDO1 death inducer-obliterator 1 0 7.2 CHD4 chromodomain helicase DNA binding protein 4 0 9.7 WDR5 WD repeat domain 5 0 8.2 PRDM7 PR/SET domain 7 0 4.2 PRDM5 PR/SET domain 5 0 4.1 PRDM4 PR/SET domain 4 0 8.2 PSIP1 PC4 and SFRS1 interacting protein 1 0 9.4 BAZ2A bromodomain adjacent to zinc finger domain 2A 0 6.5 BAZ1A bromodomain adjacent to zinc finger domain 1A 0 9.6 SP140 SP140 nuclear body protein 0 4 SGF29 SAGA complex associated factor 29 0 8.4 PHF21B PHD finger protein 21B 0 3.8 CBX3 chromobox 3 0 12.3 MBD6 methyl-CpG binding domain protein 6 0 7.3 SMYD4 SET and MYND domain containing 4 0 7.5 UHRF2 ubiquitin like with PHD and ring finger domains 2 0 9.8 AEBP2 AE binding protein 2 0 6.6 TDRD9 tudor domain containing 9 0 4 CDYL2 chromodomain Y like 2 0 5.3 INO80C INO80 complex subunit C 0 10 TDRD10 tudor domain containing 10 0 4.5 SETD9 SET domain containing 9 0 8.1 NCOA7 nuclear receptor coactivator 7 0 10.2 ATF2 activating transcription factor 2 0 6.1 PHF13 PHD finger protein 13 0 9.2 SMYD1 SET and MYND domain containing 1 0 3.9 ZCWPW2 zinc finger CW-type and PWWP domain containing 2 0 3.6 KIAA2026 KIAA2026 0 7.1 TDRD5 tudor domain containing 5 0 4.2 PWWP2B PWWP domain containing 2B 0 5.6 ASXL1 additional sex combs like 1, transcriptional regulator 0 8.6 DNMT1 DNA methyltransferase 1 0 11.3 TRDMT1 tRNA aspartic acid methyltransferase 1 0 6 DNMT3A DNA methyltransferase 3 alpha 0 5.8 DUSP1 dual specificity phosphatase 1 0 7.2 PHC2 polyhomeotic homolog 2 0 9.9 ARID2 AT-rich interaction domain 2 0 8.1 TET3 tet methylcytosine dioxygenase 3 0 7 EP300 E1A binding protein p300 0 7.7 EYA4 EYA transcriptional coactivator and phosphatase 4 0 4 ERCC6 ERCC excision repair 6, chromatin remodeling factor 0 5.4 MECOM MDS1 and EVI1 complex locus 0 9.2 EYA1 EYA transcriptional coactivator and phosphatase 1 0 4 EYA2 EYA transcriptional coactivator and phosphatase 2 0 4.6 EYA3 EYA transcriptional coactivator and phosphatase 3 0 6.9 EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit 0 7 EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0 9.8 BPTF bromodomain PHD finger transcription factor 0 8.1 JMJD1C jumonji domain containing 1C 0 7.5 ALKBH3 alkB homolog 3, alpha-ketoglutaratedependent dioxygenase 0 8.9 TDRD6 tudor domain containing 6 0 3.9 KDM1B lysine demethylase 1B 0 5.7 MTF2 metal response element binding transcription factor 2 0 7.9 BAHD1 bromo adjacent homology domain containing 1 0 5.6 DHX30 DExH-box helicase 30 0 9.1 SIRT2 sirtuin 2 0 7.5 SCMH1 sex comb on midleg homolog 1 (Drosophila) 0 7 KDM2A lysine demethylase 2A 0 7.9 KDM1A lysine demethylase 1A 0 9 KDM4B lysine demethylase 4B 0 7 NCOA6 nuclear receptor coactivator 6 0 9.7 SETD1B SET domain containing 1B 0 9.1 KDM4C lysine demethylase 4C 0 5.7 POGZ pogo transposable element derived with ZNF domain 0 9.1 KDM6B lysine demethylase 6B 0 5.7 RTF1 RTF1 homolog, Paf1/RNA polymerase II complex component 0 7.2 JMJD6 arginine demethylase and lysine hydroxylase 0 6.2 MGA MGA, MAX dimerization protein 0 8.2 JADE2 jade family PHD finger 2 0 8 SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0 8.2 PHF24 PHD finger protein 24 0 4 ADNP activity dependent neuroprotector homeobox 0 10.3 SIRT5 sirtuin 5 0 6.3 SIRT4 sirtuin 4 0 4 SIRT3 sirtuin 3 0 6.8 SIRT1 sirtuin 1 0 8.6 TDRD7 tudor domain containing 7 0 8.1 CBX6 chromobox 6 0 9 CBX5 chromobox 5 0 8.2 PHF3 PHD finger protein 3 0 8.1 BRD4 bromodomain containing 4 0 8.3 CBX7 chromobox 7 0 6.4 SUZ12 SUZ12 polycomb repressive complex 2 subunit 0 10.6 ZMYND8 zinc finger MYND-type containing 8 0 9.5 BRD1 bromodomain containing 1 0 7.3 ZBTB38 zinc finger and BTB domain containing 38 0 8.4 GABRG1 gamma-aminobutyric acid type A receptor gamma1 subunit 0 3.7 SHPRH SNF2 histone linker PHD RING helicase 0 7.9 NIPBL NIPBL, cohesin loading factor 0 8.1 CHD5 chromodomain helicase DNA binding protein 5 0 4.1 SETBP1 SET binding protein 1 0 4.7 EPC2 enhancer of polycomb homolog 2 0 7.6 PHF19 PHD finger protein 19 0 9.7 KAT2A lysine acetyltransferase 2A 0 8.6 SND1 staphylococcal nuclease and tudor domain containing 1 0 10 BRPF3 bromodomain and PHD finger containing 3 0 6.2 CECR2 CECR2, histone acetyl-lysine reader 0 4 ATAD2 ATPase family, AAA domain containing 2 0 9.2 SETD2 SET domain containing 2 0 7.7 BRD7 bromodomain containing 7 0 9.1 MSH6 mutS homolog 6 0 10 GTF3C1 general transcription factor IIIC subunit 1 0 8.1 TFPT TCF3 fusion partner 0 7.4 HCFC2 host cell factor C2 0 5.8 DNMT3L DNA methyltransferase 3 like 0 4.7 BAZ2B bromodomain adjacent to zinc finger domain 2B 0 8.4 HDAC1 histone deacetylase 1 0 10.2 HDAC2 histone deacetylase 2 0 6.9 HDGF heparin binding growth factor 0 11.7 HELLS helicase, lymphoid-specific 0 9.1 CXXC1 CXXC finger protein 1 0 8.3 AIRE autoimmune regulator 0 4.9 PRMT2 protein arginine methyltransferase 2 0 6.9 PRMT1 protein arginine methyltransferase 1 0 12.7 APOBEC1 apolipoprotein B mRNA editing enzyme catalytic subunit 1 0 4 IDH2 isocitrate dehydrogenase (NADP(+)) 2, mitochondrial 0 9.5 SP110 SP110 nuclear body protein 0 6.8 ING1 inhibitor of growth family member 1 0 7.9 ING2 inhibitor of growth family member 2 0 8.8 JARID2 jumonji and AT-rich interaction domain containing 2 0 7.4 KMT5A lysine methyltransferase 5A 0 7.7 LBR lamin B receptor 0 11.2 LMNA lamin A/C 0 9.8 LMNB1 lamin B1 0 9.7 MBD1 methyl-CpG binding domain protein 1 0 6.7 MEN1 menin 1 0 8.2 MGMT O-6-methylguanine-DNA methyltransferase 0 8.5 KMT2A lysine methyltransferase 2A 0 7.4 MLLT6 MLLT6, PHD finger domain containing 0 8.2 RERE arginine-glutamic acid dipeptide repeats 0 5.2 PHF20L1 PHD finger protein 20-like 1 0 7.1 KMT5B lysine methyltransferase 5B 0 9.1 PCNA proliferating cell nuclear antigen 0 12.6 PHF11 PHD finger protein 11 0 8.8 ING4 inhibitor of growth family member 4 0 7 PHF20 PHD finger protein 20 0 8.3 PHF21A PHD finger protein 21A 0 6.2 ACTL6B actin like 6B 0 4.2 SFMBT1 Scm-like with four mbt domains 1 0 6.6 PHF7 PHD finger protein 7 0 4.9 SIRT7 sirtuin 7 0 9 SIRT6 sirtuin 6 0 6.2 HDAC7 histone deacetylase 7 0 6.7 TRIM33 tripartite motif containing 33 0 9 ARID4B AT-rich interaction domain 4B 0 8.1 RSF1 remodeling and spacing factor 1 0 7.6 KDM3B lysine demethylase 3B 0 9.5 PHF1 PHD finger protein 1 0 7.8 PHF2 PHD finger protein 2 0 7.9 MBD3 methyl-CpG binding domain protein 3 0 8.2 BRWD1 bromodomain and WD repeat domain containing 1 0 5.7 SETD4 SET domain containing 4 0 7.3 POLE3 DNA polymerase epsilon 3, accessory subunit 0 10.6 CHRAC1 chromatin accessibility complex 1 0 7.7 ATAD2B ATPase family, AAA domain containing 2B 0 6.1 PRMT7 protein arginine methyltransferase 7 0 6.8 ING3 inhibitor of growth family member 3 0 7.3 INO80 INO80 complex subunit 0 8.3 MPHOSPH8 M-phase phosphoprotein 8 0 7.7 TET2 tet methylcytosine dioxygenase 2 0 6 MBTD1 mbt domain containing 1 0 7.5 GATAD2A GATA zinc finger domain containing 2A 0 8.2 NSD3 nuclear receptor binding SET domain protein 3 0 7 PHIP pleckstrin homology domain interacting protein 0 9.1 ZCWPW1 zinc finger CW-type and PWWP domain containing 1 0 5.8 ELP3 elongator acetyltransferase complex subunit 3 0 8.4 UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 0 9.7 PRMT6 protein arginine methyltransferase 6 0 7.4 PBRM1 polybromo 1 0 7.4 SETD5 SET domain containing 5 0 7.5 ASXL2 additional sex combs like 2, transcriptional regulator 0 6.4 MRGBP MRG domain binding protein 0 8.9 PHF10 PHD finger protein 10 0 9.5 CHD7 chromodomain helicase DNA binding protein 7 0 8 PPP4R3A protein phosphatase 4 regulatory subunit 3A 0 8.6 KDM4D lysine demethylase 4D 0 4.5 ATF7IP activating transcription factor 7 interacting protein 0 9 MBD5 methyl-CpG binding domain protein 5 0 4.5 KDM3A lysine demethylase 3A 0 9.1 ASH1L ASH1 like histone lysine methyltransferase 0 9.2 KMT2E lysine methyltransferase 2E 0 8.8 DMAP1 DNA methyltransferase 1 associated protein 1 0 7.3 RNF17 ring finger protein 17 0 4 STK31 serine/threonine kinase 31 0 4.3 TDRD1 tudor domain containing 1 0 4 PRMT8 protein arginine methyltransferase 8 0 4.4 SMYD2 SET and MYND domain containing 2 0 10.5 PRDM8 PR/SET domain 8 0 3.9 PRDM9 PR/SET domain 9 0 3.7 PRDM10 PR/SET domain 10 0 6.4 PRDM11 PR/SET domain 11 0 4.3 INTS12 integrator complex subunit 12 0 8.8 PPP4R3B protein phosphatase 4 regulatory subunit 3B 0 9 CBX8 chromobox 8 0 5.9 AICDA activation induced cytidine deaminase 0 3.9 GATAD2B GATA zinc finger domain containing 2B 0 6.5 ARID1B AT-rich interaction domain 1B 0 6.9 MTA3 metastasis associated 1 family member 3 0 8.2 BAHCC1 BAH domain and coiled-coil containing 1 0 5.1 PHF12 PHD finger protein 12 0 5.8 ZBTB4 zinc finger and BTB domain containing 4 0 8.7 PHRF1 PHD and ring finger domains 1 0 6.7 CHD8 chromodomain helicase DNA binding protein 8 0 8.3 SFMBT2 Scm-like with four mbt domains 2 0 4.8 NCOA5 nuclear receptor coactivator 5 0 6.7 KMT2C lysine methyltransferase 2C 0 7.9 RAG2 recombination activating 2 0 3.7 ACTA1 actin, alpha 1, skeletal muscle 0 4 ARID4A AT-rich interaction domain 4A 0 6.5 KDM5A lysine demethylase 5A 0 6.8 RBBP4 RB binding protein 4, chromatin remodeling factor 0 7.5 RBBP5 RB binding protein 5, histone lysine methyltransferase complex subunit 0 7.4 PRDM12 PR/SET domain 12 0 4.2 PRDM13 PR/SET domain 13 0 4.4 DPF2 double PHD fingers 2 0 9.1 RING1 ring finger protein 1 0 9 RNF2 ring finger protein 2 0 6.7 ACTB actin beta 0 13.3 ATXN7 ataxin 7 0 6.4 PRDM16 PR/SET domain 16 0 3.7 PRDM15 PR/SET domain 15 0 4.8 PRDM14 PR/SET domain 14 0 5.4 PRDM1 PR/SET domain 1 0 6.1 SET SET nuclear proto-oncogene 0 12.2 SETMAR SET domain and mariner transposase fusion gene 0 7.9 ACTR6 ARP6 actin related protein 6 homolog 0 9.2 SMYD3 SET and MYND domain containing 3 0 8.4 MEAF6 MYST/Esa1 associated factor 6 0 6.7 SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 0 6.7 SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0 9.2 BRD9 bromodomain containing 9 0 7.8 SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1 0 9.3 SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2 0 8.2 SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 0 6.4 SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 0 8.2 SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 0 6.5 SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 0 10.6 SP100 SP100 nuclear antigen 0 7 BRDT bromodomain testis associated 0 3.8 HNF1A HNF1 homeobox A 0 4.6 TCF19 transcription factor 19 0 7 TCF20 transcription factor 20 0 8.7 VPS72 vacuolar protein sorting 72 homolog 0 10.2 TP53BP1 tumor protein p53 binding protein 1 0 6.4 YY1 YY1 transcription factor 0 11.9 PCGF2 polycomb group ring finger 2 0 7.1 PRDM2 PR/SET domain 2 0 6.2 BRPF1 bromodomain and PHD finger containing 1 0 8.2 FTO FTO, alpha-ketoglutarate dependent dioxygenase 0 8.1 PHF23 PHD finger protein 23 0 8.1 RIOX1 ribosomal oxygenase 1 0 8.8 TBL1XR1 transducin beta like 1 X-linked receptor 1 0 9.6 SUV39H2 suppressor of variegation 3-9 homolog 2 0 6.9 EHMT1 euchromatic histone lysine methyltransferase 1 0 6.8 ZMYM1 zinc finger MYM-type containing 1 0 7.7 KDM8 lysine demethylase 8 0 4.3 HDAC11 histone deacetylase 11 0 6.2 ACTR5 ARP5 actin related protein 5 homolog 0 7.1 SETD6 SET domain containing 6 0 8.1 JADE1 jade family PHD finger 1 0 8.1 PHC3 polyhomeotic homolog 3 0 7.3 BRD3 bromodomain containing 3 0 8.9 CHD9 chromodomain helicase DNA binding protein 9 0 7.7 MLLT10 myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10 0 7.2 TET1 tet methylcytosine dioxygenase 1 0 5.7 EPC1 enhancer of polycomb homolog 1 0 5.3 NCOA4 nuclear receptor coactivator 4 0 12.2 ASXL3 additional sex combs like 3, transcriptional regulator 0 4 KDM7A lysine demethylase 7A 0 5.4 SETD7 SET domain containing lysine methyltransferase 7 0 9.9 KMT2D lysine methyltransferase 2D 0 6.9 FXR1 FMR1 autosomal homolog 1 0 6.8 YEATS4 YEATS domain containing 4 0 7.3 TDRD3 tudor domain containing 3 0 6.8 AKAP1 A-kinase anchoring protein 1 0 9.4 DPF1 double PHD fingers 1 0 5.8 BAP1 BRCA1 associated protein 1 0 7.4 L3MBTL2 L3MBTL2 polycomb repressive complex 1 subunit 0 7.2 SETDB2 SET domain bifurcated 2 0 5.1 TAF3 TATA-box binding protein associated factor 3 0 6.4 HDAC10 histone deacetylase 10 0 4.9 CHD6 chromodomain helicase DNA binding protein 6 0 4.5 SETD3 SET domain containing 3 0 8.1 ING5 inhibitor of growth family member 5 0 6.4 RAD54L RAD54 like (S. cerevisiae) 0 7.8 DOT1L DOT1 like histone lysine methyltransferase 0 6.2 L3MBTL3 l(3)mbt-like 3 (Drosophila) 0 5.5 TTF2 transcription termination factor 2 0 8.4 ZGPAT zinc finger CCCH-type and G-patch domain containing 0 7.9 TNRC18 trinucleotide repeat containing 18 0 6.3 GLYR1 glyoxylate reductase 1 homolog 0 6.2 KDM2B lysine demethylase 2B 0 8.5 SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 0 9.2 CBX2 chromobox 2 0 5.4 PCGF1 polycomb group ring finger 1 0 8.5 KMT5C lysine methyltransferase 5C 0 5.6 LMNB2 lamin B2 0 7.9 RIOX2 ribosomal oxygenase 2 0 8.6 MUM1 melanoma associated antigen (mutated) 1 0 6.5 HAT1 histone acetyltransferase 1 0 10.9 CBX4 chromobox 4 0 8.6 RUVBL1 RuvB like AAA ATPase 1 0 10.5 NCOA1 nuclear receptor coactivator 1 0 7.4 ACTL6A actin like 6A 0 10.3 EED embryonic ectoderm development 0 6.7 TRIM24 tripartite motif containing 24 0 9.4 HDAC3 histone deacetylase 3 0 9 ALKBH1 alkB homolog 1, histone H2A dioxygenase 0 7.3 KAT2B lysine acetyltransferase 2B 0 6.6 MBD4 methyl-CpG binding domain 4, DNA glycosylase 0 9.2 MBD2 methyl-CpG binding domain protein 2 0 4.4 BAZ1B bromodomain adjacent to zinc finger domain 1B 0 8 BTAF1 B-TFIID TATA-box binding protein associated factor 1 0 9.2 ASH2L ASH2 like histone lysine methyltransferase complex subunit 0 10.1 PYGO2 pygopus family PHD finger 2 0 7.2 PRMT9 protein arginine methyltransferase 9 0 7.8 MTA1 metastasis associated 1 0 7.6 L3MBTL4 l(3)mbt-like 4 (Drosophila) 0 4.1 ZMYM4 zinc finger MYM-type containing 4 0 8.7 ZMYM6 zinc finger MYM-type containing 6 0 5.9 ZMYM5 zinc finger MYM-type containing 5 0 5.6 MTA2 metastasis associated 1 family member 2 0 5.7 GLYATL1 glycine-N-acyltransferase like 1 0 3.9 PRDM6 PR/SET domain 6 0 4.7 GTF3C4 general transcription factor IIIC subunit 4 0 8.7 SP140L SP140 nuclear body protein like 0 8 ACTR8 ARP8 actin related protein 8 homolog 0 6.8 CDYL chromodomain Y like 0 8.8 FXR2 FMR1 autosomal homolog 2 0 7.4 CLOCK clock circadian regulator 0 8.9 NCOR1 nuclear receptor corepressor 1 0 8 PHF14 PHD finger protein 14 0 6.8 KDM4A lysine demethylase 4A 0 7 HDAC9 histone deacetylase 9 0 4.7 SETD1A SET domain containing 1A 0 5.6 KMT2B lysine methyltransferase 2B 0 5.5 HDAC4 histone deacetylase 4 0 6 TRIM66 tripartite motif containing 66 0 5.7 SETDB1 SET domain bifurcated 1 0 6.7