Symbol Name mut_rate expr_median NCOA3 nuclear receptor coactivator 3 23.03 8.3 CREBBP CREB binding protein 11.8 6.8 CHD9 chromodomain helicase DNA binding protein 9 11.8 9.1 KMT2A lysine methyltransferase 2A 11.24 8.1 KMT2C lysine methyltransferase 2C 11.24 8.5 EP300 E1A binding protein p300 10.67 8.3 TRRAP transformation/transcription domain associated protein 10.67 8.8 TAF1L TATA-box binding protein associated factor 1 like 8.43 4.5 ARID1A AT-rich interaction domain 1A 8.43 9.2 NSD2 nuclear receptor binding SET domain protein 2 7.87 8.5 KAT6A lysine acetyltransferase 6A 7.3 NA EP400 E1A binding protein p400 6.74 7.9 MGA MGA, MAX dimerization protein 6.18 8.6 MSH6 mutS homolog 6 6.18 10.4 KAT6B lysine acetyltransferase 6B 5.62 NA TRIM28 tripartite motif containing 28 5.06 10.7 PHF3 PHD finger protein 3 5.06 8.9 CHD8 chromodomain helicase DNA binding protein 8 5.06 8.35 KDM5A lysine demethylase 5A 5.06 7.7 NSD1 nuclear receptor binding SET domain protein 1 5.06 5.9 TP53BP1 tumor protein p53 binding protein 1 5.06 6.6 KDM6A lysine demethylase 6A 4.49 NA ERCC6 ERCC excision repair 6, chromatin remodeling factor 3.93 5.5 NIPBL NIPBL, cohesin loading factor 3.93 8.8 HDAC2 histone deacetylase 2 3.93 7.2 TET2 tet methylcytosine dioxygenase 2 3.93 6.3 PHIP pleckstrin homology domain interacting protein 3.93 10 PRDM16 PR/SET domain 16 3.93 3.7 SETDB1 SET domain bifurcated 1 3.93 7.5 NCOA2 nuclear receptor coactivator 2 3.37 6.15 RAI1 retinoic acid induced 1 3.37 7 CHD5 chromodomain helicase DNA binding protein 5 3.37 4.2 BRD2 bromodomain containing 2 3.37 10.1 SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 3.37 10 TET1 tet methylcytosine dioxygenase 1 3.37 7.15 ATRX ATRX, chromatin remodeler 3.37 NA DNMT3B DNA methyltransferase 3 beta 2.81 7.95 JARID2 jumonji and AT-rich interaction domain containing 2 2.81 8.5 NSD3 nuclear receptor binding SET domain protein 3 2.81 7.6 ZMYM2 zinc finger MYM-type containing 2 2.81 5.8 TAF1 TATA-box binding protein associated factor 1 2.81 NA DNMT1 DNA methyltransferase 1 2.25 12.2 SIRT1 sirtuin 1 2.25 9.1 TFPT TCF3 fusion partner 2.25 8.1 MLLT6 MLLT6, PHD finger domain containing 2.25 8.1 BRDT bromodomain testis associated 2.25 3.8 BRD3 bromodomain containing 3 2.25 9.3 MLLT10 myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10 2.25 8 HDAC4 histone deacetylase 4 2.25 6 HDAC6 histone deacetylase 6 2.25 NA BMI1 BMI1 proto-oncogene, polycomb ring finger 2.25 NA CHD1 chromodomain helicase DNA binding protein 1 1.69 9.7 SP140 SP140 nuclear body protein 1.69 4.85 HDAC1 histone deacetylase 1 1.69 10.7 ING1 inhibitor of growth family member 1 1.69 7.9 LMNB1 lamin B1 1.69 10.5 MEN1 menin 1 1.69 8.8 STK31 serine/threonine kinase 31 1.69 3.9 HNF1A HNF1 homeobox A 1.69 4.3 NCOA4 nuclear receptor coactivator 4 1.69 12.3 BAP1 BRCA1 associated protein 1 1.69 7.9 NCOA1 nuclear receptor coactivator 1 1.69 8.2 IKZF1 IKAROS family zinc finger 1 1.12 7.1 DAXX death domain associated protein 1.12 8.5 SP110 SP110 nuclear body protein 1.12 8.3 LMNA lamin A/C 1.12 6.25 TRIM33 tripartite motif containing 33 1.12 9.3 ASH2L ASH2 like histone lysine methyltransferase complex subunit 1.12 10.6 BAG6 BCL2 associated athanogene 6 1.12 NA PSIP1 PC4 and SFRS1 interacting protein 1 0.56 10.8 NCOA6 nuclear receptor coactivator 6 0.56 9.7 SUZ12 SUZ12 polycomb repressive complex 2 subunit 0.56 11.1 IDH1 isocitrate dehydrogenase (NADP(+)) 1, cytosolic 0.56 11.3 IDH2 isocitrate dehydrogenase (NADP(+)) 2, mitochondrial 0.56 10.7 ARID1B AT-rich interaction domain 1B 0.56 7.55 SET SET nuclear proto-oncogene 0.56 12.5 SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 0.56 8.7 KMT2D lysine methyltransferase 2D 0.56 7.35 TNRC18 trinucleotide repeat containing 18 0.56 6.1 TRIM24 tripartite motif containing 24 0.56 9.8 HDAC3 histone deacetylase 3 0.56 9.1 HDAC8 histone deacetylase 8 0.56 NA KAT7 lysine acetyltransferase 7 0.56 NA HDAC5 histone deacetylase 5 0 6 PRMT3 protein arginine methyltransferase 3 0 9.8 SMNDC1 survival motor neuron domain containing 1 0 10.8 SMYD5 SMYD family member 5 0 6.9 PRMT5 protein arginine methyltransferase 5 0 10.4 CARM1 coactivator associated arginine methyltransferase 1 0 9 KAT5 lysine acetyltransferase 5 0 8.3 CTCF CCCTC-binding factor 0 10.45 KDM5B lysine demethylase 5B 0 8.45 ZMYND11 zinc finger MYND-type containing 11 0 7.4 SRCAP Snf2 related CREBBP activator protein 0 5.6 RUVBL2 RuvB like AAA ATPase 2 0 11.5 BRD8 bromodomain containing 8 0 7.85 EHMT2 euchromatic histone lysine methyltransferase 2 0 7.3 MORF4L1 mortality factor 4 like 1 0 12.9 TDRKH tudor and KH domain containing 0 5.2 CHD2 chromodomain helicase DNA binding protein 2 0 8.3 CHD3 chromodomain helicase DNA binding protein 3 0 7.2 DIDO1 death inducer-obliterator 1 0 7.5 CHD4 chromodomain helicase DNA binding protein 4 0 10 WDR5 WD repeat domain 5 0 8.3 PRDM7 PR/SET domain 7 0 4.1 PRDM5 PR/SET domain 5 0 4 PRDM4 PR/SET domain 4 0 8 BAZ2A bromodomain adjacent to zinc finger domain 2A 0 6.6 BAZ1A bromodomain adjacent to zinc finger domain 1A 0 10.2 SGF29 SAGA complex associated factor 29 0 8.6 PHF21B PHD finger protein 21B 0 3.8 CBX3 chromobox 3 0 12.4 MBD6 methyl-CpG binding domain protein 6 0 7.8 SMYD4 SET and MYND domain containing 4 0 7.6 UHRF2 ubiquitin like with PHD and ring finger domains 2 0 10.8 AEBP2 AE binding protein 2 0 6.8 TDRD9 tudor domain containing 9 0 4 CDYL2 chromodomain Y like 2 0 5.3 INO80C INO80 complex subunit C 0 9.75 TDRD10 tudor domain containing 10 0 4.4 SETD9 SET domain containing 9 0 7.55 NCOA7 nuclear receptor coactivator 7 0 10 ATF2 activating transcription factor 2 0 7 PHF13 PHD finger protein 13 0 9.6 SMYD1 SET and MYND domain containing 1 0 3.8 ZCWPW2 zinc finger CW-type and PWWP domain containing 2 0 3.6 KIAA2026 KIAA2026 0 7.9 TDRD5 tudor domain containing 5 0 4.2 PWWP2B PWWP domain containing 2B 0 5.3 ASXL1 additional sex combs like 1, transcriptional regulator 0 8.7 TRDMT1 tRNA aspartic acid methyltransferase 1 0 6.8 DNMT3A DNA methyltransferase 3 alpha 0 5.85 DUSP1 dual specificity phosphatase 1 0 5.55 PHC2 polyhomeotic homolog 2 0 9.5 ARID2 AT-rich interaction domain 2 0 8.9 TET3 tet methylcytosine dioxygenase 3 0 7.4 EYA4 EYA transcriptional coactivator and phosphatase 4 0 4 MECOM MDS1 and EVI1 complex locus 0 4.15 EYA1 EYA transcriptional coactivator and phosphatase 1 0 4.1 EYA2 EYA transcriptional coactivator and phosphatase 2 0 4.2 EYA3 EYA transcriptional coactivator and phosphatase 3 0 7.4 EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit 0 7.7 EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0 10.6 BPTF bromodomain PHD finger transcription factor 0 8.9 JMJD1C jumonji domain containing 1C 0 8.1 ALKBH3 alkB homolog 3, alpha-ketoglutaratedependent dioxygenase 0 9 TDRD6 tudor domain containing 6 0 3.8 KDM1B lysine demethylase 1B 0 6.5 MTF2 metal response element binding transcription factor 2 0 9.15 BAHD1 bromo adjacent homology domain containing 1 0 6.2 DHX30 DExH-box helicase 30 0 9.4 SIRT2 sirtuin 2 0 7.7 SCMH1 sex comb on midleg homolog 1 (Drosophila) 0 8 KDM2A lysine demethylase 2A 0 8.1 KDM1A lysine demethylase 1A 0 9.5 KDM4B lysine demethylase 4B 0 7.9 SETD1B SET domain containing 1B 0 9.5 KDM4C lysine demethylase 4C 0 6.6 POGZ pogo transposable element derived with ZNF domain 0 9.6 KDM6B lysine demethylase 6B 0 5.9 RTF1 RTF1 homolog, Paf1/RNA polymerase II complex component 0 7.8 JMJD6 arginine demethylase and lysine hydroxylase 0 6.3 JADE2 jade family PHD finger 2 0 7.55 SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0 9.35 PHF24 PHD finger protein 24 0 4 ADNP activity dependent neuroprotector homeobox 0 10.6 SIRT5 sirtuin 5 0 6.4 SIRT4 sirtuin 4 0 4.6 SIRT3 sirtuin 3 0 6.8 TDRD7 tudor domain containing 7 0 8.1 CBX6 chromobox 6 0 9 CBX5 chromobox 5 0 9.3 BRD4 bromodomain containing 4 0 8.4 CBX7 chromobox 7 0 6.5 ZMYND8 zinc finger MYND-type containing 8 0 9.5 BRD1 bromodomain containing 1 0 8.2 ZBTB38 zinc finger and BTB domain containing 38 0 7.2 GABRG1 gamma-aminobutyric acid type A receptor gamma1 subunit 0 3.7 SHPRH SNF2 histone linker PHD RING helicase 0 9.1 SETBP1 SET binding protein 1 0 5.6 EPC2 enhancer of polycomb homolog 2 0 8.2 PHF19 PHD finger protein 19 0 9.4 KAT2A lysine acetyltransferase 2A 0 8.4 SND1 staphylococcal nuclease and tudor domain containing 1 0 10.3 BRPF3 bromodomain and PHD finger containing 3 0 6.2 CECR2 CECR2, histone acetyl-lysine reader 0 4.2 ATAD2 ATPase family, AAA domain containing 2 0 10.1 SETD2 SET domain containing 2 0 8.1 BRD7 bromodomain containing 7 0 9.5 GTF3C1 general transcription factor IIIC subunit 1 0 8.3 HCFC2 host cell factor C2 0 6.4 DNMT3L DNA methyltransferase 3 like 0 4.5 BAZ2B bromodomain adjacent to zinc finger domain 2B 0 7.9 HDGF heparin binding growth factor 0 11.15 HELLS helicase, lymphoid-specific 0 9.3 CXXC1 CXXC finger protein 1 0 9.2 AIRE autoimmune regulator 0 4.8 PRMT2 protein arginine methyltransferase 2 0 7.4 PRMT1 protein arginine methyltransferase 1 0 12.5 APOBEC1 apolipoprotein B mRNA editing enzyme catalytic subunit 1 0 4 ING2 inhibitor of growth family member 2 0 9.3 KMT5A lysine methyltransferase 5A 0 8.5 LBR lamin B receptor 0 12 MBD1 methyl-CpG binding domain protein 1 0 7.4 MGMT O-6-methylguanine-DNA methyltransferase 0 8 RERE arginine-glutamic acid dipeptide repeats 0 5.4 PHF20L1 PHD finger protein 20-like 1 0 7.9 KMT5B lysine methyltransferase 5B 0 8.9 PCNA proliferating cell nuclear antigen 0 12.95 PHF11 PHD finger protein 11 0 10.1 ING4 inhibitor of growth family member 4 0 7.7 PHF20 PHD finger protein 20 0 8.55 PHF21A PHD finger protein 21A 0 7.3 ACTL6B actin like 6B 0 4.2 SFMBT1 Scm-like with four mbt domains 1 0 6 PHF7 PHD finger protein 7 0 5.1 SIRT7 sirtuin 7 0 8.5 SIRT6 sirtuin 6 0 6.4 HDAC7 histone deacetylase 7 0 6.8 ARID4B AT-rich interaction domain 4B 0 8.9 RSF1 remodeling and spacing factor 1 0 7.9 KDM3B lysine demethylase 3B 0 9.5 PHF1 PHD finger protein 1 0 7.9 PHF2 PHD finger protein 2 0 8.4 MBD3 methyl-CpG binding domain protein 3 0 8.6 BRWD1 bromodomain and WD repeat domain containing 1 0 6.7 SETD4 SET domain containing 4 0 7.35 POLE3 DNA polymerase epsilon 3, accessory subunit 0 11 CHRAC1 chromatin accessibility complex 1 0 8.2 ATAD2B ATPase family, AAA domain containing 2B 0 7.3 PRMT7 protein arginine methyltransferase 7 0 7.2 ING3 inhibitor of growth family member 3 0 8.3 INO80 INO80 complex subunit 0 8.2 MPHOSPH8 M-phase phosphoprotein 8 0 8.8 MBTD1 mbt domain containing 1 0 8.5 GATAD2A GATA zinc finger domain containing 2A 0 8.3 ZCWPW1 zinc finger CW-type and PWWP domain containing 1 0 5.8 ELP3 elongator acetyltransferase complex subunit 3 0 9.4 UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 0 10 PRMT6 protein arginine methyltransferase 6 0 8 PBRM1 polybromo 1 0 8.2 SETD5 SET domain containing 5 0 8 ASXL2 additional sex combs like 2, transcriptional regulator 0 6.6 MRGBP MRG domain binding protein 0 9 PHF10 PHD finger protein 10 0 10.1 CHD7 chromodomain helicase DNA binding protein 7 0 8.4 PPP4R3A protein phosphatase 4 regulatory subunit 3A 0 8.85 KDM4D lysine demethylase 4D 0 4.6 ATF7IP activating transcription factor 7 interacting protein 0 9.2 MBD5 methyl-CpG binding domain protein 5 0 5.2 KDM3A lysine demethylase 3A 0 9.8 ASH1L ASH1 like histone lysine methyltransferase 0 9.2 KMT2E lysine methyltransferase 2E 0 9.9 DMAP1 DNA methyltransferase 1 associated protein 1 0 8.2 RNF17 ring finger protein 17 0 4 TDRD1 tudor domain containing 1 0 3.6 PRMT8 protein arginine methyltransferase 8 0 4.4 SMYD2 SET and MYND domain containing 2 0 10.1 PRDM8 PR/SET domain 8 0 4 PRDM9 PR/SET domain 9 0 3.7 PRDM10 PR/SET domain 10 0 6.8 PRDM11 PR/SET domain 11 0 4.3 INTS12 integrator complex subunit 12 0 9.6 PPP4R3B protein phosphatase 4 regulatory subunit 3B 0 9.25 CBX8 chromobox 8 0 5.8 AICDA activation induced cytidine deaminase 0 3.9 GATAD2B GATA zinc finger domain containing 2B 0 7.7 MTA3 metastasis associated 1 family member 3 0 7.95 BAHCC1 BAH domain and coiled-coil containing 1 0 4.8 PHF12 PHD finger protein 12 0 6 ZBTB4 zinc finger and BTB domain containing 4 0 7.8 PHRF1 PHD and ring finger domains 1 0 7.1 SFMBT2 Scm-like with four mbt domains 2 0 6.8 NCOA5 nuclear receptor coactivator 5 0 7.3 RAG2 recombination activating 2 0 3.6 ACTA1 actin, alpha 1, skeletal muscle 0 4.1 ARID4A AT-rich interaction domain 4A 0 7.4 RBBP4 RB binding protein 4, chromatin remodeling factor 0 8.6 RBBP5 RB binding protein 5, histone lysine methyltransferase complex subunit 0 7.9 PRDM12 PR/SET domain 12 0 4.1 PRDM13 PR/SET domain 13 0 4.35 DPF2 double PHD fingers 2 0 9.4 RING1 ring finger protein 1 0 9.15 RNF2 ring finger protein 2 0 7.4 ACTB actin beta 0 13.25 ATXN7 ataxin 7 0 7.3 PRDM15 PR/SET domain 15 0 5.3 PRDM14 PR/SET domain 14 0 5.1 PRDM1 PR/SET domain 1 0 5.9 SETMAR SET domain and mariner transposase fusion gene 0 8.5 ACTR6 ARP6 actin related protein 6 homolog 0 10.1 SMYD3 SET and MYND domain containing 3 0 9.3 MEAF6 MYST/Esa1 associated factor 6 0 7.2 BRD9 bromodomain containing 9 0 7.9 SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 0 9.5 SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1 0 9.6 SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2 0 8.6 SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 0 6.8 SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 0 8.5 SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 0 5.1 SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 0 11.2 SP100 SP100 nuclear antigen 0 7.25 TCF19 transcription factor 19 0 8 TCF20 transcription factor 20 0 8.6 VPS72 vacuolar protein sorting 72 homolog 0 10.2 YY1 YY1 transcription factor 0 11.95 PCGF2 polycomb group ring finger 2 0 5.8 PRDM2 PR/SET domain 2 0 7 BRPF1 bromodomain and PHD finger containing 1 0 8.5 FTO FTO, alpha-ketoglutarate dependent dioxygenase 0 9.1 PHF23 PHD finger protein 23 0 8.5 RIOX1 ribosomal oxygenase 1 0 8.8 TBL1XR1 transducin beta like 1 X-linked receptor 1 0 9.8 SUV39H2 suppressor of variegation 3-9 homolog 2 0 7.55 EHMT1 euchromatic histone lysine methyltransferase 1 0 7.3 ZMYM1 zinc finger MYM-type containing 1 0 7.1 KDM8 lysine demethylase 8 0 4.7 HDAC11 histone deacetylase 11 0 5.6 ACTR5 ARP5 actin related protein 5 homolog 0 7.2 SETD6 SET domain containing 6 0 7.85 JADE1 jade family PHD finger 1 0 8.7 PHC3 polyhomeotic homolog 3 0 7.7 EPC1 enhancer of polycomb homolog 1 0 5.4 ASXL3 additional sex combs like 3, transcriptional regulator 0 4.1 KDM7A lysine demethylase 7A 0 5.7 SETD7 SET domain containing lysine methyltransferase 7 0 9.9 FXR1 FMR1 autosomal homolog 1 0 7.1 YEATS4 YEATS domain containing 4 0 8.8 TDRD3 tudor domain containing 3 0 7.7 AKAP1 A-kinase anchoring protein 1 0 9.2 DPF1 double PHD fingers 1 0 5.8 L3MBTL2 L3MBTL2 polycomb repressive complex 1 subunit 0 7.8 SETDB2 SET domain bifurcated 2 0 6.5 TAF3 TATA-box binding protein associated factor 3 0 7.1 HDAC10 histone deacetylase 10 0 4.9 CHD6 chromodomain helicase DNA binding protein 6 0 4.8 SETD3 SET domain containing 3 0 7.7 ING5 inhibitor of growth family member 5 0 7.1 RAD54L RAD54 like (S. cerevisiae) 0 8.6 DOT1L DOT1 like histone lysine methyltransferase 0 6.8 L3MBTL3 l(3)mbt-like 3 (Drosophila) 0 6.7 TTF2 transcription termination factor 2 0 9.4 ZGPAT zinc finger CCCH-type and G-patch domain containing 0 7.9 GLYR1 glyoxylate reductase 1 homolog 0 6.8 KDM2B lysine demethylase 2B 0 10.1 SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 0 10.3 CBX2 chromobox 2 0 5.6 PCGF1 polycomb group ring finger 1 0 8.6 KMT5C lysine methyltransferase 5C 0 5.6 LMNB2 lamin B2 0 7.6 RIOX2 ribosomal oxygenase 2 0 8.9 MUM1 melanoma associated antigen (mutated) 1 0 7.1 HAT1 histone acetyltransferase 1 0 11.3 CBX4 chromobox 4 0 9 RUVBL1 RuvB like AAA ATPase 1 0 10.5 ACTL6A actin like 6A 0 10.5 EED embryonic ectoderm development 0 6.4 ALKBH1 alkB homolog 1, histone H2A dioxygenase 0 7.5 KAT2B lysine acetyltransferase 2B 0 8.2 MBD4 methyl-CpG binding domain 4, DNA glycosylase 0 10.25 MBD2 methyl-CpG binding domain protein 2 0 4.4 BAZ1B bromodomain adjacent to zinc finger domain 1B 0 8.6 BTAF1 B-TFIID TATA-box binding protein associated factor 1 0 9.9 PYGO2 pygopus family PHD finger 2 0 7.4 PRMT9 protein arginine methyltransferase 9 0 8.5 MTA1 metastasis associated 1 0 7.8 L3MBTL4 l(3)mbt-like 4 (Drosophila) 0 4.4 ZMYM4 zinc finger MYM-type containing 4 0 9.1 ZMYM6 zinc finger MYM-type containing 6 0 7.3 ZMYM5 zinc finger MYM-type containing 5 0 6.6 MTA2 metastasis associated 1 family member 2 0 5.75 GLYATL1 glycine-N-acyltransferase like 1 0 3.9 PRDM6 PR/SET domain 6 0 4.7 GTF3C4 general transcription factor IIIC subunit 4 0 8.6 SP140L SP140 nuclear body protein like 0 8.5 ACTR8 ARP8 actin related protein 8 homolog 0 7.4 CDYL chromodomain Y like 0 9 FXR2 FMR1 autosomal homolog 2 0 7.2 CLOCK clock circadian regulator 0 8 NCOR1 nuclear receptor corepressor 1 0 8.2 PHF14 PHD finger protein 14 0 7.2 KDM4A lysine demethylase 4A 0 7.8 HDAC9 histone deacetylase 9 0 4.65 SETD1A SET domain containing 1A 0 5.8 KMT2B lysine methyltransferase 2B 0 5.4 TRIM66 tripartite motif containing 66 0 6.15