Symbol Name mut_rate expr_median KMT2C lysine methyltransferase 2C 16.67 7.9 KAT6B lysine acetyltransferase 6B 13.33 NA TAF1L TATA-box binding protein associated factor 1 like 11.67 4.3 NIPBL NIPBL, cohesin loading factor 11.67 7.9 CHD5 chromodomain helicase DNA binding protein 5 10 4 NCOA3 nuclear receptor coactivator 3 10 7.5 MEN1 menin 1 8.33 8.35 STK31 serine/threonine kinase 31 8.33 3.8 KAT6A lysine acetyltransferase 6A 8.33 NA MGA MGA, MAX dimerization protein 6.67 7.7 MSH6 mutS homolog 6 6.67 9.8 CHD8 chromodomain helicase DNA binding protein 8 6.67 7.9 PRDM16 PR/SET domain 16 6.67 3.6 CHD9 chromodomain helicase DNA binding protein 9 6.67 9.1 NCOA2 nuclear receptor coactivator 2 5 5 CREBBP CREB binding protein 5 6.5 DNMT1 DNA methyltransferase 1 5 11.5 EP300 E1A binding protein p300 5 8 ERCC6 ERCC excision repair 6, chromatin remodeling factor 5 5.5 PHF3 PHD finger protein 3 5 8.15 BRD4 bromodomain containing 4 5 8.1 KDM5A lysine demethylase 5A 5 6.9 BRD2 bromodomain containing 2 5 9.7 NSD2 nuclear receptor binding SET domain protein 2 5 7.4 BRD3 bromodomain containing 3 5 8.4 TET1 tet methylcytosine dioxygenase 1 5 6.4 ARID1A AT-rich interaction domain 1A 5 8.3 TRRAP transformation/transcription domain associated protein 5 8.2 HDAC4 histone deacetylase 4 5 6.5 TAF1 TATA-box binding protein associated factor 1 5 NA ATRX ATRX, chromatin remodeler 5 NA CHD1 chromodomain helicase DNA binding protein 1 3.33 9.3 DAXX death domain associated protein 3.33 7.9 DNMT3B DNA methyltransferase 3 beta 3.33 6.7 TRIM33 tripartite motif containing 33 3.33 9 TET2 tet methylcytosine dioxygenase 2 3.33 5.8 NSD3 nuclear receptor binding SET domain protein 3 3.33 7 PHIP pleckstrin homology domain interacting protein 3.33 9.1 SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 3.33 7.2 SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 3.33 9.2 TP53BP1 tumor protein p53 binding protein 1 3.33 6.6 ZMYM2 zinc finger MYM-type containing 2 3.33 5.3 TNRC18 trinucleotide repeat containing 18 3.33 6 TRIM24 tripartite motif containing 24 3.33 9.2 KAT7 lysine acetyltransferase 7 3.33 NA PSIP1 PC4 and SFRS1 interacting protein 1 1.67 9.4 SP140 SP140 nuclear body protein 1.67 4 TFPT TCF3 fusion partner 1.67 8.9 HDAC1 histone deacetylase 1 1.67 10.1 HDAC2 histone deacetylase 2 1.67 6.9 ING1 inhibitor of growth family member 1 1.67 7.4 JARID2 jumonji and AT-rich interaction domain containing 2 1.67 8.3 LMNB1 lamin B1 1.67 9.4 KMT2A lysine methyltransferase 2A 1.67 7.2 MLLT6 MLLT6, PHD finger domain containing 1.67 7 PCNA proliferating cell nuclear antigen 1.67 12.55 ASH1L ASH1 like histone lysine methyltransferase 1.67 9 ARID1B AT-rich interaction domain 1B 1.67 6.7 SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 1.67 9.15 NCOA1 nuclear receptor coactivator 1 1.67 7.8 HDAC6 histone deacetylase 6 1.67 NA BAG6 BCL2 associated athanogene 6 1.67 NA HDAC5 histone deacetylase 5 0 5.6 TRIM28 tripartite motif containing 28 0 10.1 PRMT3 protein arginine methyltransferase 3 0 9.6 SMNDC1 survival motor neuron domain containing 1 0 10.1 IKZF1 IKAROS family zinc finger 1 0 3.9 SMYD5 SMYD family member 5 0 6.8 PRMT5 protein arginine methyltransferase 5 0 10.1 CARM1 coactivator associated arginine methyltransferase 1 0 8.6 KAT5 lysine acetyltransferase 5 0 7.8 CTCF CCCTC-binding factor 0 9.5 RAI1 retinoic acid induced 1 0 7.5 KDM5B lysine demethylase 5B 0 8.7 ZMYND11 zinc finger MYND-type containing 11 0 7.5 SRCAP Snf2 related CREBBP activator protein 0 5.1 RUVBL2 RuvB like AAA ATPase 2 0 11.2 BRD8 bromodomain containing 8 0 7.4 EHMT2 euchromatic histone lysine methyltransferase 2 0 6.8 MORF4L1 mortality factor 4 like 1 0 13 TDRKH tudor and KH domain containing 0 4.7 CHD2 chromodomain helicase DNA binding protein 2 0 7.55 CHD3 chromodomain helicase DNA binding protein 3 0 6.75 DIDO1 death inducer-obliterator 1 0 7 CHD4 chromodomain helicase DNA binding protein 4 0 9.6 WDR5 WD repeat domain 5 0 7.75 PRDM7 PR/SET domain 7 0 4.1 PRDM5 PR/SET domain 5 0 4.1 PRDM4 PR/SET domain 4 0 7.85 BAZ2A bromodomain adjacent to zinc finger domain 2A 0 6.2 BAZ1A bromodomain adjacent to zinc finger domain 1A 0 9.1 SGF29 SAGA complex associated factor 29 0 7.25 PHF21B PHD finger protein 21B 0 3.8 CBX3 chromobox 3 0 12.4 MBD6 methyl-CpG binding domain protein 6 0 7.9 SMYD4 SET and MYND domain containing 4 0 7.55 UHRF2 ubiquitin like with PHD and ring finger domains 2 0 9.85 AEBP2 AE binding protein 2 0 6.35 TDRD9 tudor domain containing 9 0 3.95 CDYL2 chromodomain Y like 2 0 5.15 INO80C INO80 complex subunit C 0 8.95 TDRD10 tudor domain containing 10 0 4.3 SETD9 SET domain containing 9 0 8.2 NCOA7 nuclear receptor coactivator 7 0 9.75 ATF2 activating transcription factor 2 0 6.2 PHF13 PHD finger protein 13 0 9.6 SMYD1 SET and MYND domain containing 1 0 3.9 ZCWPW2 zinc finger CW-type and PWWP domain containing 2 0 3.6 KIAA2026 KIAA2026 0 7.1 TDRD5 tudor domain containing 5 0 4 PWWP2B PWWP domain containing 2B 0 5 ASXL1 additional sex combs like 1, transcriptional regulator 0 8.3 TRDMT1 tRNA aspartic acid methyltransferase 1 0 6.35 DNMT3A DNA methyltransferase 3 alpha 0 5.6 DUSP1 dual specificity phosphatase 1 0 6.15 PHC2 polyhomeotic homolog 2 0 10.5 ARID2 AT-rich interaction domain 2 0 7.8 TET3 tet methylcytosine dioxygenase 3 0 6.2 EYA4 EYA transcriptional coactivator and phosphatase 4 0 6.45 MECOM MDS1 and EVI1 complex locus 0 4.7 EYA1 EYA transcriptional coactivator and phosphatase 1 0 5.85 EYA2 EYA transcriptional coactivator and phosphatase 2 0 4.1 EYA3 EYA transcriptional coactivator and phosphatase 3 0 6.9 EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit 0 6.9 EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0 9.7 BPTF bromodomain PHD finger transcription factor 0 8.2 JMJD1C jumonji domain containing 1C 0 7.4 ALKBH3 alkB homolog 3, alpha-ketoglutaratedependent dioxygenase 0 9 TDRD6 tudor domain containing 6 0 3.8 KDM1B lysine demethylase 1B 0 6.1 MTF2 metal response element binding transcription factor 2 0 7.8 BAHD1 bromo adjacent homology domain containing 1 0 5.7 DHX30 DExH-box helicase 30 0 9.2 SIRT2 sirtuin 2 0 7.9 SCMH1 sex comb on midleg homolog 1 (Drosophila) 0 7.2 KDM2A lysine demethylase 2A 0 7.3 KDM1A lysine demethylase 1A 0 8.7 KDM4B lysine demethylase 4B 0 7.3 NCOA6 nuclear receptor coactivator 6 0 9.6 SETD1B SET domain containing 1B 0 8.9 KDM4C lysine demethylase 4C 0 5.7 POGZ pogo transposable element derived with ZNF domain 0 8.6 KDM6B lysine demethylase 6B 0 5.5 RTF1 RTF1 homolog, Paf1/RNA polymerase II complex component 0 7.2 JMJD6 arginine demethylase and lysine hydroxylase 0 6.5 JADE2 jade family PHD finger 2 0 7.1 SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0 8.3 PHF24 PHD finger protein 24 0 3.9 ADNP activity dependent neuroprotector homeobox 0 10.4 SIRT5 sirtuin 5 0 6.05 SIRT4 sirtuin 4 0 4.3 SIRT3 sirtuin 3 0 6.5 SIRT1 sirtuin 1 0 8 TDRD7 tudor domain containing 7 0 9.15 CBX6 chromobox 6 0 9.4 CBX5 chromobox 5 0 8.1 CBX7 chromobox 7 0 6.4 SUZ12 SUZ12 polycomb repressive complex 2 subunit 0 10.1 ZMYND8 zinc finger MYND-type containing 8 0 9.95 BRD1 bromodomain containing 1 0 7.6 ZBTB38 zinc finger and BTB domain containing 38 0 9.2 GABRG1 gamma-aminobutyric acid type A receptor gamma1 subunit 0 3.6 SHPRH SNF2 histone linker PHD RING helicase 0 7.9 SETBP1 SET binding protein 1 0 6.05 EPC2 enhancer of polycomb homolog 2 0 7.85 PHF19 PHD finger protein 19 0 9.5 KAT2A lysine acetyltransferase 2A 0 8 SND1 staphylococcal nuclease and tudor domain containing 1 0 10.6 BRPF3 bromodomain and PHD finger containing 3 0 6.2 CECR2 CECR2, histone acetyl-lysine reader 0 4.1 ATAD2 ATPase family, AAA domain containing 2 0 9.3 SETD2 SET domain containing 2 0 7.2 BRD7 bromodomain containing 7 0 8.8 GTF3C1 general transcription factor IIIC subunit 1 0 8.5 HCFC2 host cell factor C2 0 6.6 DNMT3L DNA methyltransferase 3 like 0 4.3 BAZ2B bromodomain adjacent to zinc finger domain 2B 0 7.7 HDGF heparin binding growth factor 0 10.6 HELLS helicase, lymphoid-specific 0 8.4 CXXC1 CXXC finger protein 1 0 8.15 AIRE autoimmune regulator 0 4.6 PRMT2 protein arginine methyltransferase 2 0 8.1 PRMT1 protein arginine methyltransferase 1 0 12 APOBEC1 apolipoprotein B mRNA editing enzyme catalytic subunit 1 0 3.9 IDH1 isocitrate dehydrogenase (NADP(+)) 1, cytosolic 0 12.2 IDH2 isocitrate dehydrogenase (NADP(+)) 2, mitochondrial 0 8.95 SP110 SP110 nuclear body protein 0 7.4 ING2 inhibitor of growth family member 2 0 8.7 KMT5A lysine methyltransferase 5A 0 7.55 LBR lamin B receptor 0 10 LMNA lamin A/C 0 10.4 MBD1 methyl-CpG binding domain protein 1 0 6.9 MGMT O-6-methylguanine-DNA methyltransferase 0 6.9 RERE arginine-glutamic acid dipeptide repeats 0 5.3 PHF20L1 PHD finger protein 20-like 1 0 7.55 KMT5B lysine methyltransferase 5B 0 8.6 PHF11 PHD finger protein 11 0 8.5 ING4 inhibitor of growth family member 4 0 7.1 PHF20 PHD finger protein 20 0 8.5 PHF21A PHD finger protein 21A 0 6.3 ACTL6B actin like 6B 0 4.15 SFMBT1 Scm-like with four mbt domains 1 0 6 PHF7 PHD finger protein 7 0 4.8 SIRT7 sirtuin 7 0 7.95 SIRT6 sirtuin 6 0 6 HDAC7 histone deacetylase 7 0 5.8 ARID4B AT-rich interaction domain 4B 0 8.15 RSF1 remodeling and spacing factor 1 0 7.6 KDM3B lysine demethylase 3B 0 8.45 PHF1 PHD finger protein 1 0 8.05 PHF2 PHD finger protein 2 0 7.9 MBD3 methyl-CpG binding domain protein 3 0 8.45 BRWD1 bromodomain and WD repeat domain containing 1 0 5.9 SETD4 SET domain containing 4 0 7.1 POLE3 DNA polymerase epsilon 3, accessory subunit 0 10 CHRAC1 chromatin accessibility complex 1 0 7.5 ATAD2B ATPase family, AAA domain containing 2B 0 5.8 PRMT7 protein arginine methyltransferase 7 0 7 ING3 inhibitor of growth family member 3 0 7.7 INO80 INO80 complex subunit 0 7.9 MPHOSPH8 M-phase phosphoprotein 8 0 8.3 MBTD1 mbt domain containing 1 0 6.85 GATAD2A GATA zinc finger domain containing 2A 0 8.25 ZCWPW1 zinc finger CW-type and PWWP domain containing 1 0 5.4 ELP3 elongator acetyltransferase complex subunit 3 0 8.75 UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 0 9.3 PRMT6 protein arginine methyltransferase 6 0 7.2 PBRM1 polybromo 1 0 7.5 SETD5 SET domain containing 5 0 7.3 ASXL2 additional sex combs like 2, transcriptional regulator 0 6.4 MRGBP MRG domain binding protein 0 9.3 PHF10 PHD finger protein 10 0 8.85 CHD7 chromodomain helicase DNA binding protein 7 0 8 PPP4R3A protein phosphatase 4 regulatory subunit 3A 0 7.7 KDM4D lysine demethylase 4D 0 4.6 ATF7IP activating transcription factor 7 interacting protein 0 9 MBD5 methyl-CpG binding domain protein 5 0 4.9 KDM3A lysine demethylase 3A 0 9.75 KMT2E lysine methyltransferase 2E 0 9.4 DMAP1 DNA methyltransferase 1 associated protein 1 0 7.7 RNF17 ring finger protein 17 0 3.8 TDRD1 tudor domain containing 1 0 3.6 PRMT8 protein arginine methyltransferase 8 0 4.2 SMYD2 SET and MYND domain containing 2 0 10.3 PRDM8 PR/SET domain 8 0 3.8 PRDM9 PR/SET domain 9 0 3.6 PRDM10 PR/SET domain 10 0 6.4 PRDM11 PR/SET domain 11 0 4.1 INTS12 integrator complex subunit 12 0 9.2 PPP4R3B protein phosphatase 4 regulatory subunit 3B 0 8.5 CBX8 chromobox 8 0 6 AICDA activation induced cytidine deaminase 0 3.7 GATAD2B GATA zinc finger domain containing 2B 0 7 MTA3 metastasis associated 1 family member 3 0 8.1 BAHCC1 BAH domain and coiled-coil containing 1 0 5 EP400 E1A binding protein p400 0 7.4 PHF12 PHD finger protein 12 0 5.8 ZBTB4 zinc finger and BTB domain containing 4 0 8.6 PHRF1 PHD and ring finger domains 1 0 6.8 SFMBT2 Scm-like with four mbt domains 2 0 4.2 NCOA5 nuclear receptor coactivator 5 0 6.7 RAG2 recombination activating 2 0 3.5 ACTA1 actin, alpha 1, skeletal muscle 0 4 ARID4A AT-rich interaction domain 4A 0 6.1 RBBP4 RB binding protein 4, chromatin remodeling factor 0 7.45 RBBP5 RB binding protein 5, histone lysine methyltransferase complex subunit 0 7.2 PRDM12 PR/SET domain 12 0 4 PRDM13 PR/SET domain 13 0 4.8 DPF2 double PHD fingers 2 0 8.7 RING1 ring finger protein 1 0 9.15 RNF2 ring finger protein 2 0 7.1 ACTB actin beta 0 13.05 ATXN7 ataxin 7 0 6.7 PRDM15 PR/SET domain 15 0 4.85 PRDM14 PR/SET domain 14 0 4.8 PRDM1 PR/SET domain 1 0 5 SET SET nuclear proto-oncogene 0 11.9 SETMAR SET domain and mariner transposase fusion gene 0 8.2 NSD1 nuclear receptor binding SET domain protein 1 0 5.65 ACTR6 ARP6 actin related protein 6 homolog 0 9.6 SMYD3 SET and MYND domain containing 3 0 8.8 MEAF6 MYST/Esa1 associated factor 6 0 6.6 BRD9 bromodomain containing 9 0 7.7 SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1 0 8.65 SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2 0 7.8 SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 0 6.6 SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 0 7.8 SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 0 7.1 SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 0 10.6 SP100 SP100 nuclear antigen 0 7.4 BRDT bromodomain testis associated 0 3.7 HNF1A HNF1 homeobox A 0 4.2 TCF19 transcription factor 19 0 7.8 TCF20 transcription factor 20 0 8.2 VPS72 vacuolar protein sorting 72 homolog 0 9.7 YY1 YY1 transcription factor 0 11.3 PCGF2 polycomb group ring finger 2 0 6.6 PRDM2 PR/SET domain 2 0 6.4 BRPF1 bromodomain and PHD finger containing 1 0 7.85 FTO FTO, alpha-ketoglutarate dependent dioxygenase 0 9.2 PHF23 PHD finger protein 23 0 8.9 RIOX1 ribosomal oxygenase 1 0 8.4 TBL1XR1 transducin beta like 1 X-linked receptor 1 0 9.3 SUV39H2 suppressor of variegation 3-9 homolog 2 0 7 EHMT1 euchromatic histone lysine methyltransferase 1 0 6.7 ZMYM1 zinc finger MYM-type containing 1 0 7.5 KDM8 lysine demethylase 8 0 4.2 HDAC11 histone deacetylase 11 0 6 ACTR5 ARP5 actin related protein 5 homolog 0 6.8 SETD6 SET domain containing 6 0 7.6 JADE1 jade family PHD finger 1 0 7.4 PHC3 polyhomeotic homolog 3 0 7.4 MLLT10 myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10 0 7.2 EPC1 enhancer of polycomb homolog 1 0 4.5 NCOA4 nuclear receptor coactivator 4 0 11.8 ASXL3 additional sex combs like 3, transcriptional regulator 0 4 KDM7A lysine demethylase 7A 0 5.3 SETD7 SET domain containing lysine methyltransferase 7 0 10 KMT2D lysine methyltransferase 2D 0 6.7 FXR1 FMR1 autosomal homolog 1 0 7.4 YEATS4 YEATS domain containing 4 0 7.85 TDRD3 tudor domain containing 3 0 7.6 AKAP1 A-kinase anchoring protein 1 0 8.65 DPF1 double PHD fingers 1 0 5.75 BAP1 BRCA1 associated protein 1 0 7.65 L3MBTL2 L3MBTL2 polycomb repressive complex 1 subunit 0 7.5 SETDB2 SET domain bifurcated 2 0 6.15 TAF3 TATA-box binding protein associated factor 3 0 6.5 HDAC10 histone deacetylase 10 0 4.7 CHD6 chromodomain helicase DNA binding protein 6 0 4.7 SETD3 SET domain containing 3 0 7.2 ING5 inhibitor of growth family member 5 0 6.3 RAD54L RAD54 like (S. cerevisiae) 0 7.9 DOT1L DOT1 like histone lysine methyltransferase 0 6.2 L3MBTL3 l(3)mbt-like 3 (Drosophila) 0 5.9 TTF2 transcription termination factor 2 0 8.7 ZGPAT zinc finger CCCH-type and G-patch domain containing 0 7.7 GLYR1 glyoxylate reductase 1 homolog 0 6.3 KDM2B lysine demethylase 2B 0 8.6 SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 0 9.4 CBX2 chromobox 2 0 5.3 PCGF1 polycomb group ring finger 1 0 9 KMT5C lysine methyltransferase 5C 0 5.2 LMNB2 lamin B2 0 7.4 RIOX2 ribosomal oxygenase 2 0 8.8 MUM1 melanoma associated antigen (mutated) 1 0 6.85 HAT1 histone acetyltransferase 1 0 11.2 CBX4 chromobox 4 0 9.1 RUVBL1 RuvB like AAA ATPase 1 0 10.1 ACTL6A actin like 6A 0 10.25 EED embryonic ectoderm development 0 5.7 HDAC3 histone deacetylase 3 0 8.75 ALKBH1 alkB homolog 1, histone H2A dioxygenase 0 7 KAT2B lysine acetyltransferase 2B 0 10.2 MBD4 methyl-CpG binding domain 4, DNA glycosylase 0 9.5 MBD2 methyl-CpG binding domain protein 2 0 4.2 BAZ1B bromodomain adjacent to zinc finger domain 1B 0 8.3 BTAF1 B-TFIID TATA-box binding protein associated factor 1 0 8.8 ASH2L ASH2 like histone lysine methyltransferase complex subunit 0 10.5 PYGO2 pygopus family PHD finger 2 0 6.9 PRMT9 protein arginine methyltransferase 9 0 8.2 MTA1 metastasis associated 1 0 6.75 L3MBTL4 l(3)mbt-like 4 (Drosophila) 0 4.75 ZMYM4 zinc finger MYM-type containing 4 0 8.9 ZMYM6 zinc finger MYM-type containing 6 0 6.5 ZMYM5 zinc finger MYM-type containing 5 0 6.3 MTA2 metastasis associated 1 family member 2 0 4.7 GLYATL1 glycine-N-acyltransferase like 1 0 3.8 PRDM6 PR/SET domain 6 0 4.7 GTF3C4 general transcription factor IIIC subunit 4 0 8.55 SP140L SP140 nuclear body protein like 0 8.4 ACTR8 ARP8 actin related protein 8 homolog 0 7.1 CDYL chromodomain Y like 0 8.75 FXR2 FMR1 autosomal homolog 2 0 7.6 CLOCK clock circadian regulator 0 8.95 NCOR1 nuclear receptor corepressor 1 0 7.5 PHF14 PHD finger protein 14 0 6.9 KDM4A lysine demethylase 4A 0 7.4 HDAC9 histone deacetylase 9 0 4.8 SETD1A SET domain containing 1A 0 5.3 KMT2B lysine methyltransferase 2B 0 5.1 TRIM66 tripartite motif containing 66 0 5.3 SETDB1 SET domain bifurcated 1 0 6.45