Symbol Name mut_rate expr_median KDM6A lysine demethylase 6A 41.67 NA EP300 E1A binding protein p300 20.83 8.15 KMT2C lysine methyltransferase 2C 20.83 7.8 TRRAP transformation/transcription domain associated protein 20.83 8.05 NIPBL NIPBL, cohesin loading factor 16.67 8.5 CHD9 chromodomain helicase DNA binding protein 9 16.67 8.7 NCOA3 nuclear receptor coactivator 3 16.67 8.5 ARID1A AT-rich interaction domain 1A 16.67 8.6 KAT6B lysine acetyltransferase 6B 16.67 NA CREBBP CREB binding protein 12.5 6.4 EP400 E1A binding protein p400 12.5 7.85 BRD2 bromodomain containing 2 12.5 9.7 NSD2 nuclear receptor binding SET domain protein 2 12.5 7.95 ATRX ATRX, chromatin remodeler 12.5 NA CHD1 chromodomain helicase DNA binding protein 1 8.33 9.05 ATF2 activating transcription factor 2 8.33 6.3 DNMT3B DNA methyltransferase 3 beta 8.33 7.8 ERCC6 ERCC excision repair 6, chromatin remodeling factor 8.33 5.5 MGA MGA, MAX dimerization protein 8.33 8 SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 8.33 9.1 BAP1 BRCA1 associated protein 1 8.33 7.3 LMNB2 lamin B2 8.33 8.1 HDAC4 histone deacetylase 4 8.33 5.6 BAG6 BCL2 associated athanogene 6 8.33 NA TRIM28 tripartite motif containing 28 4.17 10.45 IKZF1 IKAROS family zinc finger 1 4.17 3.9 TAF1L TATA-box binding protein associated factor 1 like 4.17 4.3 PHF3 PHD finger protein 3 4.17 8.25 BRD4 bromodomain containing 4 4.17 8.1 CHD5 chromodomain helicase DNA binding protein 5 4.17 4.1 MSH6 mutS homolog 6 4.17 9.95 HDAC2 histone deacetylase 2 4.17 7.1 SP110 SP110 nuclear body protein 4.17 7.1 JARID2 jumonji and AT-rich interaction domain containing 2 4.17 7.6 TET2 tet methylcytosine dioxygenase 2 4.17 5.95 NSD3 nuclear receptor binding SET domain protein 3 4.17 7.2 KDM5A lysine demethylase 5A 4.17 7.1 PRDM16 PR/SET domain 16 4.17 3.6 NSD1 nuclear receptor binding SET domain protein 1 4.17 5.9 SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 4.17 7.5 SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 4.17 9.1 NCOA1 nuclear receptor coactivator 1 4.17 7.6 TDG thymine DNA glycosylase 4.17 NA ZBTB33 zinc finger and BTB domain containing 33 4.17 NA KAT6A lysine acetyltransferase 6A 4.17 NA HDAC8 histone deacetylase 8 4.17 NA HDAC5 histone deacetylase 5 0 5.5 PRMT3 protein arginine methyltransferase 3 0 9.65 SMNDC1 survival motor neuron domain containing 1 0 10.5 SMYD5 SMYD family member 5 0 6.9 PRMT5 protein arginine methyltransferase 5 0 10.4 CARM1 coactivator associated arginine methyltransferase 1 0 8.6 NCOA2 nuclear receptor coactivator 2 0 5.35 KAT5 lysine acetyltransferase 5 0 8.15 CTCF CCCTC-binding factor 0 9.9 RAI1 retinoic acid induced 1 0 7.15 KDM5B lysine demethylase 5B 0 9.4 ZMYND11 zinc finger MYND-type containing 11 0 7.85 SRCAP Snf2 related CREBBP activator protein 0 5.25 RUVBL2 RuvB like AAA ATPase 2 0 11.45 BRD8 bromodomain containing 8 0 7.65 EHMT2 euchromatic histone lysine methyltransferase 2 0 6.9 MORF4L1 mortality factor 4 like 1 0 12.9 TDRKH tudor and KH domain containing 0 5 CHD2 chromodomain helicase DNA binding protein 2 0 7.9 CHD3 chromodomain helicase DNA binding protein 3 0 6.9 DIDO1 death inducer-obliterator 1 0 7.45 CHD4 chromodomain helicase DNA binding protein 4 0 9.45 WDR5 WD repeat domain 5 0 8.2 PRDM7 PR/SET domain 7 0 4 PRDM5 PR/SET domain 5 0 4 PRDM4 PR/SET domain 4 0 8.2 PSIP1 PC4 and SFRS1 interacting protein 1 0 9.95 BAZ2A bromodomain adjacent to zinc finger domain 2A 0 6.4 BAZ1A bromodomain adjacent to zinc finger domain 1A 0 9.65 SP140 SP140 nuclear body protein 0 4 SGF29 SAGA complex associated factor 29 0 8.05 PHF21B PHD finger protein 21B 0 3.7 CBX3 chromobox 3 0 11.9 MBD6 methyl-CpG binding domain protein 6 0 7.55 SMYD4 SET and MYND domain containing 4 0 7.35 UHRF2 ubiquitin like with PHD and ring finger domains 2 0 10.1 AEBP2 AE binding protein 2 0 6.65 TDRD9 tudor domain containing 9 0 3.85 CDYL2 chromodomain Y like 2 0 5.4 INO80C INO80 complex subunit C 0 10.2 TDRD10 tudor domain containing 10 0 4.3 SETD9 SET domain containing 9 0 8.05 NCOA7 nuclear receptor coactivator 7 0 10.55 PHF13 PHD finger protein 13 0 9.6 SMYD1 SET and MYND domain containing 1 0 3.8 ZCWPW2 zinc finger CW-type and PWWP domain containing 2 0 3.6 KIAA2026 KIAA2026 0 7.55 DAXX death domain associated protein 0 7.9 TDRD5 tudor domain containing 5 0 4 PWWP2B PWWP domain containing 2B 0 5.5 ASXL1 additional sex combs like 1, transcriptional regulator 0 8.55 DNMT1 DNA methyltransferase 1 0 11.4 TRDMT1 tRNA aspartic acid methyltransferase 1 0 6.5 DNMT3A DNA methyltransferase 3 alpha 0 5.4 DUSP1 dual specificity phosphatase 1 0 7.75 PHC2 polyhomeotic homolog 2 0 9.85 ARID2 AT-rich interaction domain 2 0 8.25 TET3 tet methylcytosine dioxygenase 3 0 7 EYA4 EYA transcriptional coactivator and phosphatase 4 0 4.05 MECOM MDS1 and EVI1 complex locus 0 8.5 EYA1 EYA transcriptional coactivator and phosphatase 1 0 4 EYA2 EYA transcriptional coactivator and phosphatase 2 0 4.15 EYA3 EYA transcriptional coactivator and phosphatase 3 0 7.05 EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit 0 6.9 EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0 9.35 BPTF bromodomain PHD finger transcription factor 0 8.15 JMJD1C jumonji domain containing 1C 0 7.7 ALKBH3 alkB homolog 3, alpha-ketoglutaratedependent dioxygenase 0 8.75 TDRD6 tudor domain containing 6 0 3.75 KDM1B lysine demethylase 1B 0 5.7 MTF2 metal response element binding transcription factor 2 0 8.3 BAHD1 bromo adjacent homology domain containing 1 0 5.75 DHX30 DExH-box helicase 30 0 8.7 SIRT2 sirtuin 2 0 7.75 SCMH1 sex comb on midleg homolog 1 (Drosophila) 0 7.3 KDM2A lysine demethylase 2A 0 8.05 KDM1A lysine demethylase 1A 0 9.8 KDM4B lysine demethylase 4B 0 7.3 NCOA6 nuclear receptor coactivator 6 0 10.1 SETD1B SET domain containing 1B 0 9.15 KDM4C lysine demethylase 4C 0 5.9 POGZ pogo transposable element derived with ZNF domain 0 8.7 KDM6B lysine demethylase 6B 0 5.6 RTF1 RTF1 homolog, Paf1/RNA polymerase II complex component 0 7.6 JMJD6 arginine demethylase and lysine hydroxylase 0 6 JADE2 jade family PHD finger 2 0 7.4 SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0 8.75 PHF24 PHD finger protein 24 0 3.9 ADNP activity dependent neuroprotector homeobox 0 10.5 SIRT5 sirtuin 5 0 6.35 SIRT4 sirtuin 4 0 4.2 SIRT3 sirtuin 3 0 6.6 SIRT1 sirtuin 1 0 8.5 TDRD7 tudor domain containing 7 0 8.8 CBX6 chromobox 6 0 9.25 CBX5 chromobox 5 0 8.4 CBX7 chromobox 7 0 6.4 SUZ12 SUZ12 polycomb repressive complex 2 subunit 0 10.4 ZMYND8 zinc finger MYND-type containing 8 0 9.35 BRD1 bromodomain containing 1 0 7.75 ZBTB38 zinc finger and BTB domain containing 38 0 8.3 GABRG1 gamma-aminobutyric acid type A receptor gamma1 subunit 0 3.7 SHPRH SNF2 histone linker PHD RING helicase 0 7.95 SETBP1 SET binding protein 1 0 6.25 EPC2 enhancer of polycomb homolog 2 0 7.8 PHF19 PHD finger protein 19 0 9.1 KAT2A lysine acetyltransferase 2A 0 8.2 SND1 staphylococcal nuclease and tudor domain containing 1 0 9.85 BRPF3 bromodomain and PHD finger containing 3 0 6.1 CECR2 CECR2, histone acetyl-lysine reader 0 3.95 ATAD2 ATPase family, AAA domain containing 2 0 9.8 SETD2 SET domain containing 2 0 7.4 BRD7 bromodomain containing 7 0 9.3 GTF3C1 general transcription factor IIIC subunit 1 0 8.35 TFPT TCF3 fusion partner 0 7.8 HCFC2 host cell factor C2 0 6.2 DNMT3L DNA methyltransferase 3 like 0 4.2 BAZ2B bromodomain adjacent to zinc finger domain 2B 0 8 HDAC1 histone deacetylase 1 0 10.45 HDGF heparin binding growth factor 0 11.2 HELLS helicase, lymphoid-specific 0 9.05 CXXC1 CXXC finger protein 1 0 8.05 AIRE autoimmune regulator 0 4.7 PRMT2 protein arginine methyltransferase 2 0 7.4 PRMT1 protein arginine methyltransferase 1 0 12.05 APOBEC1 apolipoprotein B mRNA editing enzyme catalytic subunit 1 0 3.9 IDH1 isocitrate dehydrogenase (NADP(+)) 1, cytosolic 0 12.45 IDH2 isocitrate dehydrogenase (NADP(+)) 2, mitochondrial 0 9.2 ING1 inhibitor of growth family member 1 0 7.5 ING2 inhibitor of growth family member 2 0 8.9 KMT5A lysine methyltransferase 5A 0 8.15 LBR lamin B receptor 0 10.8 LMNA lamin A/C 0 9.8 LMNB1 lamin B1 0 9.95 MBD1 methyl-CpG binding domain protein 1 0 6.85 MEN1 menin 1 0 8.7 MGMT O-6-methylguanine-DNA methyltransferase 0 8.3 KMT2A lysine methyltransferase 2A 0 7.65 MLLT6 MLLT6, PHD finger domain containing 0 7.75 RERE arginine-glutamic acid dipeptide repeats 0 5.2 PHF20L1 PHD finger protein 20-like 1 0 7.4 KMT5B lysine methyltransferase 5B 0 9 PCNA proliferating cell nuclear antigen 0 12.85 PHF11 PHD finger protein 11 0 8.9 ING4 inhibitor of growth family member 4 0 7.1 PHF20 PHD finger protein 20 0 8.6 PHF21A PHD finger protein 21A 0 6.2 ACTL6B actin like 6B 0 4.2 SFMBT1 Scm-like with four mbt domains 1 0 6 PHF7 PHD finger protein 7 0 4.8 SIRT7 sirtuin 7 0 8.65 SIRT6 sirtuin 6 0 6 HDAC7 histone deacetylase 7 0 6.55 TRIM33 tripartite motif containing 33 0 8.95 ARID4B AT-rich interaction domain 4B 0 8.2 RSF1 remodeling and spacing factor 1 0 7.8 KDM3B lysine demethylase 3B 0 9.2 PHF1 PHD finger protein 1 0 7.8 PHF2 PHD finger protein 2 0 8.65 MBD3 methyl-CpG binding domain protein 3 0 8.55 BRWD1 bromodomain and WD repeat domain containing 1 0 6.25 SETD4 SET domain containing 4 0 7.1 POLE3 DNA polymerase epsilon 3, accessory subunit 0 10.45 CHRAC1 chromatin accessibility complex 1 0 7.85 ATAD2B ATPase family, AAA domain containing 2B 0 6.4 PRMT7 protein arginine methyltransferase 7 0 7 ING3 inhibitor of growth family member 3 0 7.3 INO80 INO80 complex subunit 0 7.9 MPHOSPH8 M-phase phosphoprotein 8 0 8.2 MBTD1 mbt domain containing 1 0 7.3 GATAD2A GATA zinc finger domain containing 2A 0 8.15 PHIP pleckstrin homology domain interacting protein 0 9.4 ZCWPW1 zinc finger CW-type and PWWP domain containing 1 0 5.5 ELP3 elongator acetyltransferase complex subunit 3 0 8.5 UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 0 9.5 PRMT6 protein arginine methyltransferase 6 0 7.85 PBRM1 polybromo 1 0 7.25 SETD5 SET domain containing 5 0 7.7 ASXL2 additional sex combs like 2, transcriptional regulator 0 6.25 MRGBP MRG domain binding protein 0 9.5 PHF10 PHD finger protein 10 0 9.4 CHD7 chromodomain helicase DNA binding protein 7 0 7.95 PPP4R3A protein phosphatase 4 regulatory subunit 3A 0 8.4 KDM4D lysine demethylase 4D 0 4.75 ATF7IP activating transcription factor 7 interacting protein 0 9.4 MBD5 methyl-CpG binding domain protein 5 0 4.35 KDM3A lysine demethylase 3A 0 9.25 ASH1L ASH1 like histone lysine methyltransferase 0 9.1 KMT2E lysine methyltransferase 2E 0 8.95 DMAP1 DNA methyltransferase 1 associated protein 1 0 7.85 RNF17 ring finger protein 17 0 3.9 STK31 serine/threonine kinase 31 0 3.9 TDRD1 tudor domain containing 1 0 3.7 PRMT8 protein arginine methyltransferase 8 0 4.3 SMYD2 SET and MYND domain containing 2 0 10.6 PRDM8 PR/SET domain 8 0 3.9 PRDM9 PR/SET domain 9 0 3.7 PRDM10 PR/SET domain 10 0 6.5 PRDM11 PR/SET domain 11 0 4.2 INTS12 integrator complex subunit 12 0 8.75 PPP4R3B protein phosphatase 4 regulatory subunit 3B 0 8.8 CBX8 chromobox 8 0 5.65 AICDA activation induced cytidine deaminase 0 3.75 GATAD2B GATA zinc finger domain containing 2B 0 6.75 ARID1B AT-rich interaction domain 1B 0 6.75 MTA3 metastasis associated 1 family member 3 0 8.25 BAHCC1 BAH domain and coiled-coil containing 1 0 4.8 PHF12 PHD finger protein 12 0 5.9 ZBTB4 zinc finger and BTB domain containing 4 0 8.7 PHRF1 PHD and ring finger domains 1 0 6.6 CHD8 chromodomain helicase DNA binding protein 8 0 8.25 SFMBT2 Scm-like with four mbt domains 2 0 4.2 NCOA5 nuclear receptor coactivator 5 0 7.05 RAG2 recombination activating 2 0 3.5 ACTA1 actin, alpha 1, skeletal muscle 0 4 ARID4A AT-rich interaction domain 4A 0 6.45 RBBP4 RB binding protein 4, chromatin remodeling factor 0 7.7 RBBP5 RB binding protein 5, histone lysine methyltransferase complex subunit 0 7.15 PRDM12 PR/SET domain 12 0 3.9 PRDM13 PR/SET domain 13 0 4.2 DPF2 double PHD fingers 2 0 8.9 RING1 ring finger protein 1 0 8.9 RNF2 ring finger protein 2 0 7.15 ACTB actin beta 0 13.25 ATXN7 ataxin 7 0 6.25 PRDM15 PR/SET domain 15 0 4.8 PRDM14 PR/SET domain 14 0 4.95 PRDM1 PR/SET domain 1 0 5.6 SET SET nuclear proto-oncogene 0 12.35 SETMAR SET domain and mariner transposase fusion gene 0 8.05 ACTR6 ARP6 actin related protein 6 homolog 0 9.65 SMYD3 SET and MYND domain containing 3 0 8.5 MEAF6 MYST/Esa1 associated factor 6 0 6.9 BRD9 bromodomain containing 9 0 8.05 SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1 0 8.75 SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2 0 8.1 SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 0 6.6 SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 0 7.65 SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 0 5.3 SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 0 10.9 SP100 SP100 nuclear antigen 0 7.15 BRDT bromodomain testis associated 0 3.8 HNF1A HNF1 homeobox A 0 4.2 TCF19 transcription factor 19 0 8 TCF20 transcription factor 20 0 8.6 VPS72 vacuolar protein sorting 72 homolog 0 9.9 TP53BP1 tumor protein p53 binding protein 1 0 6.75 YY1 YY1 transcription factor 0 11.75 PCGF2 polycomb group ring finger 2 0 6.8 ZMYM2 zinc finger MYM-type containing 2 0 5.5 PRDM2 PR/SET domain 2 0 6.3 BRPF1 bromodomain and PHD finger containing 1 0 7.7 FTO FTO, alpha-ketoglutarate dependent dioxygenase 0 9.2 PHF23 PHD finger protein 23 0 8.35 RIOX1 ribosomal oxygenase 1 0 8.5 TBL1XR1 transducin beta like 1 X-linked receptor 1 0 9.6 SUV39H2 suppressor of variegation 3-9 homolog 2 0 7 EHMT1 euchromatic histone lysine methyltransferase 1 0 7.1 ZMYM1 zinc finger MYM-type containing 1 0 7.65 KDM8 lysine demethylase 8 0 4.35 HDAC11 histone deacetylase 11 0 6.2 ACTR5 ARP5 actin related protein 5 homolog 0 7.2 SETD6 SET domain containing 6 0 7.95 JADE1 jade family PHD finger 1 0 7.2 PHC3 polyhomeotic homolog 3 0 7.5 BRD3 bromodomain containing 3 0 9.1 MLLT10 myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10 0 7.35 TET1 tet methylcytosine dioxygenase 1 0 5.85 EPC1 enhancer of polycomb homolog 1 0 4.9 NCOA4 nuclear receptor coactivator 4 0 12.1 ASXL3 additional sex combs like 3, transcriptional regulator 0 3.9 KDM7A lysine demethylase 7A 0 5.05 SETD7 SET domain containing lysine methyltransferase 7 0 9.7 KMT2D lysine methyltransferase 2D 0 6.95 FXR1 FMR1 autosomal homolog 1 0 7.25 YEATS4 YEATS domain containing 4 0 7.85 TDRD3 tudor domain containing 3 0 7.05 AKAP1 A-kinase anchoring protein 1 0 8.9 DPF1 double PHD fingers 1 0 5.7 L3MBTL2 L3MBTL2 polycomb repressive complex 1 subunit 0 7.4 SETDB2 SET domain bifurcated 2 0 5.05 TAF3 TATA-box binding protein associated factor 3 0 6.6 HDAC10 histone deacetylase 10 0 4.7 CHD6 chromodomain helicase DNA binding protein 6 0 4.8 SETD3 SET domain containing 3 0 7.6 ING5 inhibitor of growth family member 5 0 6.4 RAD54L RAD54 like (S. cerevisiae) 0 8.1 DOT1L DOT1 like histone lysine methyltransferase 0 6.15 L3MBTL3 l(3)mbt-like 3 (Drosophila) 0 6.2 TTF2 transcription termination factor 2 0 8.8 ZGPAT zinc finger CCCH-type and G-patch domain containing 0 7.7 TNRC18 trinucleotide repeat containing 18 0 6.1 GLYR1 glyoxylate reductase 1 homolog 0 6.3 KDM2B lysine demethylase 2B 0 9.25 SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 0 9.45 CBX2 chromobox 2 0 5.3 PCGF1 polycomb group ring finger 1 0 8.55 KMT5C lysine methyltransferase 5C 0 5.4 RIOX2 ribosomal oxygenase 2 0 8.8 MUM1 melanoma associated antigen (mutated) 1 0 6.85 HAT1 histone acetyltransferase 1 0 11.25 CBX4 chromobox 4 0 7.95 RUVBL1 RuvB like AAA ATPase 1 0 10.55 ACTL6A actin like 6A 0 10.5 EED embryonic ectoderm development 0 6.25 TRIM24 tripartite motif containing 24 0 9 HDAC3 histone deacetylase 3 0 9 ALKBH1 alkB homolog 1, histone H2A dioxygenase 0 7.2 KAT2B lysine acetyltransferase 2B 0 7.7 MBD4 methyl-CpG binding domain 4, DNA glycosylase 0 9.75 MBD2 methyl-CpG binding domain protein 2 0 4.3 BAZ1B bromodomain adjacent to zinc finger domain 1B 0 8.1 BTAF1 B-TFIID TATA-box binding protein associated factor 1 0 9.25 ASH2L ASH2 like histone lysine methyltransferase complex subunit 0 10 PYGO2 pygopus family PHD finger 2 0 7.1 PRMT9 protein arginine methyltransferase 9 0 7.85 MTA1 metastasis associated 1 0 7.35 L3MBTL4 l(3)mbt-like 4 (Drosophila) 0 4.2 ZMYM4 zinc finger MYM-type containing 4 0 8.8 ZMYM6 zinc finger MYM-type containing 6 0 6.3 ZMYM5 zinc finger MYM-type containing 5 0 5.8 MTA2 metastasis associated 1 family member 2 0 5.55 GLYATL1 glycine-N-acyltransferase like 1 0 3.8 PRDM6 PR/SET domain 6 0 4.75 GTF3C4 general transcription factor IIIC subunit 4 0 8.85 SP140L SP140 nuclear body protein like 0 8.3 ACTR8 ARP8 actin related protein 8 homolog 0 6.65 CDYL chromodomain Y like 0 8.8 FXR2 FMR1 autosomal homolog 2 0 7.25 CLOCK clock circadian regulator 0 8.5 NCOR1 nuclear receptor corepressor 1 0 7.75 PHF14 PHD finger protein 14 0 6.65 KDM4A lysine demethylase 4A 0 7.5 HDAC9 histone deacetylase 9 0 4.4 SETD1A SET domain containing 1A 0 5.6 KMT2B lysine methyltransferase 2B 0 5.2 TRIM66 tripartite motif containing 66 0 5.4 SETDB1 SET domain bifurcated 1 0 6.5