*The size of the node in the network represents the mutation rate of the cancer type selected in the above box. Mouse over on the node would show its mutation rate and first neighbors. For edge color, blue means co-occurrence while red for mutual exclusive (p value < 0.05, Fisher's exact test).

Node 1	% Mutation Rate (Node 1)	Node 2	% Mutation Rate (Node 2)	P Value (co-occurrence)	P Value (mutual exclusive)
ATM	13.5	BARD1	2.5	0.768	0.601
ATM	13.5	BLM	4.1	0.0497	0.988
ATM	13.5	BRCA1	5.1	0.0386	0.99
ATM	13.5	EXO1	1.8	0.0543	0.992
ATM	13.5	MLH1	2.3	0.107	0.978
ATM	13.5	MRE11A	1.8	0.639	0.76
ATM	13.5	MSH2	2.8	0.173	0.953
ATM	13.5	MSH6	2.5	1	0.232
ATM	13.5	NBN	2.8	0.173	0.953
ATM	13.5	RAD50	2.8	0.8	0.551
ATM	13.5	RAD51	1.8	0.00755	0.999
ATM	13.5	RFC1	2	0.293	0.921
ATM	13.5	RFC2	1.3	0.516	0.864
ATM	13.5	RFC4	2.3	0.347	0.893
ATM	13.5	TOPBP1	3.3	0.852	0.458
BACH1	0.5	BARD1	2.5	1	0.95
BACH1	0.5	BRCA1	5.1	1	0.901
BACH1	0.5	MLH1	2.3	1	0.955
BACH1	0.5	MRE11A	1.8	1	0.965
BACH1	0.5	MSH6	2.5	1	0.95
BACH1	0.5	NBN	2.8	1	0.945
BACH1	0.5	RAD50	2.8	1	0.945
BACH1	0.5	TOPBP1	3.3	1	0.935
BARD1	2.5	BLM	4.1	1	0.657
BARD1	2.5	BRCA1	5.1	0.41	0.914
BARD1	2.5	EXO1	1.8	1	0.834
BARD1	2.5	MLH1	2.3	0.019	0.999
BARD1	2.5	MRE11A	1.8	1	0.834
BARD1	2.5	MSH6	2.5	1	0.771
BARD1	2.5	NBN	2.8	0.249	0.972
BARD1	2.5	PCNA	1	1	0.902
BARD1	2.5	RAD50	2.8	0.249	0.972
BARD1	2.5	RAD51	1.8	1	0.834
BARD1	2.5	RFC2	1.3	1	0.879
BARD1	2.5	RFC4	2.3	1	0.792
BARD1	2.5	TOPBP1	3.3	1	0.712
BARD1	2.5	TP53	49.7	0.369	0.835
BLM	4.1	BRCA1	5.1	0.192	0.959
BLM	4.1	EXO1	1.8	0.254	0.971
BLM	4.1	MLH1	2.3	0.314	0.953
BLM	4.1	MRE11A	1.8	1	0.746
BLM	4.1	MSH2	2.8	0.37	0.931
BLM	4.1	MSH6	2.5	0.343	0.942
BLM	4.1	NBN	2.8	0.00746	0.999
BLM	4.1	RAD50	2.8	0.37	0.931
BLM	4.1	RAD51	1.8	0.254	0.971
BLM	4.1	RFC1	2	1	0.716
BLM	4.1	RFC2	1.3	0.188	0.986
BLM	4.1	RFC4	2.3	1	0.686
BLM	4.1	TOPBP1	3.3	1	0.578
BLM	4.1	TP53	49.7	0.592	0.608
BRCA1	5.1	EXO1	1.8	1	0.692
BRCA1	5.1	KAT2A	2.3	0.377	0.929
BRCA1	5.1	MLH1	2.3	1	0.623
BRCA1	5.1	MRE11A	1.8	1	0.692
BRCA1	5.1	MSH2	2.8	0.44	0.898
BRCA1	5.1	MSH6	2.5	0.41	0.914
BRCA1	5.1	NBN	2.8	0.44	0.898
BRCA1	5.1	PCNA	1	0.189	0.986
BRCA1	5.1	RAD50	2.8	1	0.56
BRCA1	5.1	RAD51	1.8	0.308	0.956
BRCA1	5.1	RFC1	2	1	0.657
BRCA1	5.1	RFC2	1.3	0.23	0.978
BRCA1	5.1	RFC4	2.3	1	0.623
BRCA1	5.1	SUPT3H	1.5	1	0.73
BRCA1	5.1	TADA3	0.3	1	0.949
BRCA1	5.1	TAF10	0.5	1	0.901
BRCA1	5.1	TAF5L	0.8	0.145	0.993
BRCA1	5.1	TAF9	1	1	0.811
BRCA1	5.1	TOPBP1	3.3	1	0.503
BRCA1	5.1	TP53	49.7	0.239	0.879
BRCA1	5.1	TRRAP	8.6	0.53	0.757
EXO1	1.8	MLH1	2.3	0.15	0.991
EXO1	1.8	MRE11A	1.8	0.119	0.995
EXO1	1.8	MSH2	2.8	0.181	0.986
EXO1	1.8	MSH6	2.5	0.166	0.989
EXO1	1.8	NBN	2.8	0.181	0.986
EXO1	1.8	PCNA	1	0.0695	0.998
EXO1	1.8	PMS2	2.5	0.166	0.989
EXO1	1.8	RAD50	2.8	0.181	0.986
EXO1	1.8	RAD51	1.8	1	0.881
EXO1	1.8	RFC2	1.3	1	0.914
EXO1	1.8	RFC4	2.3	1	0.85
EXO1	1.8	TOPBP1	3.3	1	0.789
KAT2A	2.3	MSH2	2.8	0.227	0.977
KAT2A	2.3	MSH6	2.5	0.208	0.981
KAT2A	2.3	SUPT3H	1.5	1	0.87
KAT2A	2.3	TADA3	0.3	1	0.977
KAT2A	2.3	TAF10	0.5	1	0.955
KAT2A	2.3	TAF5L	0.8	1	0.933
KAT2A	2.3	TAF9	1	0.0886	0.997
KAT2A	2.3	TRRAP	8.6	1	0.44
MLH1	2.3	MRE11A	1.8	1	0.85
MLH1	2.3	MSH2	2.8	0.227	0.977
MLH1	2.3	MSH6	2.5	1	0.792
MLH1	2.3	NBN	2.8	0.227	0.977
MLH1	2.3	PCNA	1	0.0886	0.997
MLH1	2.3	PMS1	1.8	1	0.85
MLH1	2.3	PMS2	2.5	0.208	0.981
MLH1	2.3	RAD50	2.8	0.227	0.977
MLH1	2.3	RFC1	2	1	0.83
MLH1	2.3	RFC2	1.3	1	0.89
MLH1	2.3	RFC4	2.3	1	0.81
MLH1	2.3	TOPBP1	3.3	0.263	0.968
MLH1	2.3	TP53	49.7	0.91	0.256
MRE11A	1.8	MSH2	2.8	0.181	0.986
MRE11A	1.8	MSH6	2.5	1	0.834
MRE11A	1.8	NBN	2.8	0.181	0.986
MRE11A	1.8	RAD50	2.8	1	0.819
MRE11A	1.8	RAD51	1.8	1	0.881
MRE11A	1.8	RFC1	2	1	0.865
MRE11A	1.8	RFC2	1.3	1	0.914
MRE11A	1.8	RFC4	2.3	1	0.85
MRE11A	1.8	TOPBP1	3.3	1	0.789
MRE11A	1.8	TRRAP	8.6	0.471	0.885
MSH2	2.8	MSH6	2.5	0.249	0.972
MSH2	2.8	NBN	2.8	0.034	0.998
MSH2	2.8	PCNA	1	1	0.893
MSH2	2.8	PMS1	1.8	1	0.819
MSH2	2.8	PMS2	2.5	1	0.751
MSH2	2.8	PRKCZ	1	1	0.893
MSH2	2.8	RAD50	2.8	1	0.729
MSH2	2.8	RAD51	1.8	1	0.819
MSH2	2.8	RFC1	2	0.204	0.982
MSH2	2.8	RFC2	1.3	1	0.867
MSH2	2.8	RFC4	2.3	1	0.773
MSH2	2.8	SUPT3H	1.5	1	0.843
MSH2	2.8	TADA3	0.3	1	0.972
MSH2	2.8	TAF10	0.5	1	0.945
MSH2	2.8	TAF5L	0.8	1	0.918
MSH2	2.8	TAF9	1	1	0.893
MSH2	2.8	TP53	49.7	0.0297	0.995
MSH2	2.8	TRRAP	8.6	0.06	0.99
MSH6	2.5	NBN	2.8	1	0.751
MSH6	2.5	PCNA	1	1	0.902
MSH6	2.5	PMS1	1.8	0.166	0.989
MSH6	2.5	PMS2	2.5	1	0.771
MSH6	2.5	PRKCZ	1	1	0.902
MSH6	2.5	RAD50	2.8	1	0.751
MSH6	2.5	RAD51	1.8	1	0.834
MSH6	2.5	RFC1	2	0.187	0.985
MSH6	2.5	RFC2	1.3	1	0.879
MSH6	2.5	RFC4	2.3	1	0.792
MSH6	2.5	SUPT3H	1.5	1	0.856
MSH6	2.5	TADA3	0.3	1	0.975
MSH6	2.5	TAF10	0.5	1	0.95
MSH6	2.5	TAF5L	0.8	1	0.926
MSH6	2.5	TAF9	1	0.0981	0.997
MSH6	2.5	TOPBP1	3.3	0.288	0.961
MSH6	2.5	TP53	49.7	0.369	0.835
MSH6	2.5	TRRAP	8.6	1	0.401
NBN	2.8	RAD50	2.8	0.271	0.966
NBN	2.8	RAD51	1.8	1	0.819
NBN	2.8	RFC1	2	1	0.796
NBN	2.8	RFC2	1.3	1	0.867
NBN	2.8	RFC4	2.3	1	0.773
NBN	2.8	TOPBP1	3.3	1	0.688
NBN	2.8	TRRAP	8.6	0.634	0.756
PCNA	1	PMS1	1.8	1	0.931
PCNA	1	PMS2	2.5	0.0981	0.997
PCNA	1	RAD51	1.8	0.0695	0.998
PCNA	1	RFC1	2	1	0.921
PCNA	1	RFC2	1.3	1	0.95
PCNA	1	RFC4	2.3	1	0.911
PMS2	2.5	TP53	49.7	0.165	0.949
RAD50	2.8	RAD51	1.8	1	0.819
RAD50	2.8	RFC1	2	1	0.796
RAD50	2.8	RFC2	1.3	1	0.867
RAD50	2.8	RFC4	2.3	0.023	0.999
RAD50	2.8	TOPBP1	3.3	0.312	0.953
RAD50	2.8	TRRAP	8.6	0.244	0.94
RAD51	1.8	RFC2	1.3	1	0.914
RAD51	1.8	RFC4	2.3	1	0.85
RAD51	1.8	TOPBP1	3.3	0.211	0.981
RAD51	1.8	TP53	49.7	0.22	0.941
RFC1	2	RFC2	1.3	1	0.902
RFC1	2	RFC4	2.3	1	0.83
RFC2	1.3	RFC4	2.3	1	0.89
RFC2	1.3	TOPBP1	3.3	1	0.845
RFC4	2.3	TOPBP1	3.3	0.263	0.968
SUPT3H	1.5	TADA3	0.3	1	0.985
SUPT3H	1.5	TAF10	0.5	1	0.97
SUPT3H	1.5	TAF5L	0.8	1	0.955
SUPT3H	1.5	TAF9	1	1	0.94
SUPT3H	1.5	TRRAP	8.6	1	0.58
TADA3	0.3	TAF10	0.5	1	0.995
TADA3	0.3	TAF5L	0.8	1	0.992
TADA3	0.3	TAF9	1	1	0.99
TADA3	0.3	TRRAP	8.6	0.0863	1
TAF10	0.5	TAF5L	0.8	1	0.985
TAF10	0.5	TAF9	1	1	0.98
TAF10	0.5	TRRAP	8.6	0.165	0.993
TAF5L	0.8	TAF9	1	1	0.97
TAF5L	0.8	TRRAP	8.6	1	0.762
TAF9	1	TRRAP	8.6	1	0.696