*The size of the node in the network represents the mutation rate of the cancer type selected in the above box. Mouse over on the node would show its mutation rate and first neighbors. For edge color, blue means co-occurrence while red for mutual exclusive (p value < 0.05, Fisher's exact test).

Node 1	% Mutation Rate (Node 1)	Node 2	% Mutation Rate (Node 2)	P Value (co-occurrence)	P Value (mutual exclusive)
ARID1A	24.6	BCL9	3.8	0.759	0.473
ARID1A	24.6	CREBBP	12.2	0.395	0.731
ARID1A	24.6	CTNNB1	3.6	0.101	0.967
ARID1A	24.6	EP300	15.5	0.683	0.441
ARID1A	24.6	LEF1	0.8	0.573	0.849
ARID1A	24.6	PYGO2	1.5	1	0.181
ARID1A	24.6	SMAD1	1.3	0.759	0.641
ARID1A	24.6	SMAD4	2	0.311	0.894
ARID1A	24.6	SMAD5	0	1	1
ARID1A	24.6	SMARCA2	5.8	0.0825	0.967
ARID1A	24.6	SMARCA4	5.6	0.467	0.718
ARID1A	24.6	SMARCB1	1.3	1	0.241
ARID1A	24.6	SMARCC1	2.5	0.751	0.536
ARID1A	24.6	SMARCC2	4.1	0.355	0.825
ARID1A	24.6	SMARCD1	1	1	0.321
ARID1A	24.6	SMARCD2	0.3	1	0.754
ARID1A	24.6	SMARCD3	1	0.679	0.745
ARID1A	24.6	SMARCE1	1.3	1	0.241
ARID1A	24.6	TCF7L1	0	1	1
ARID1A	24.6	TCF7L2	0.3	1	0.754
ASH2L	0.3	BCL9L	2.5	0.0254	1
ASH2L	0.3	BCL9	3.8	1	0.962
ASH2L	0.3	CREBBP	12.2	1	0.878
ASH2L	0.3	CTNNB1	3.6	0.0355	1
ASH2L	0.3	EP300	15.5	1	0.845
ASH2L	0.3	KMT2D	28.9	0.289	1
ASH2L	0.3	LEF1	0.8	1	0.992
ASH2L	0.3	MEN1	0.8	1	0.992
ASH2L	0.3	PYGO2	1.5	1	0.985
ASH2L	0.3	RBBP5	1	1	0.99
ASH2L	0.3	TCF7L1	0	1	1
ASH2L	0.3	TCF7L2	0.3	1	0.997
ASH2L	0.3	TCF7	0.3	1	0.997
BCL9	3.8	CREBBP	12.2	0.565	0.728
BCL9	3.8	CTNNB1	3.6	1	0.575
BCL9	3.8	EP300	15.5	0.189	0.935
BCL9	3.8	EP400	5.6	1	0.416
BCL9	3.8	HLTF	1	1	0.856
BCL9	3.8	INO80	5.8	0.216	0.95
BCL9	3.8	KMT2D	28.9	0.0105	0.998
BCL9L	2.5	CTNNB1	3.6	0.0449	0.996
BCL9	3.8	LEF1	0.8	1	0.89
BCL9L	2.5	KMT2D	28.9	0.837	0.41
BCL9L	2.5	LEF1	0.8	1	0.926
BCL9L	2.5	MEN1	0.8	1	0.926
BCL9L	2.5	PYGO2	1.5	1	0.856
BCL9L	2.5	RBBP5	1	1	0.902
BCL9L	2.5	TCF7L1	0	1	1
BCL9L	2.5	TCF7L2	0.3	1	0.975
BCL9L	2.5	TCF7	0.3	1	0.975
BCL9	3.8	MEN1	0.8	1	0.89
BCL9	3.8	PYGO2	1.5	1	0.791
BCL9	3.8	RBBP5	1	0.144	0.992
BCL9	3.8	SMAD1	1.3	0.177	0.987
BCL9	3.8	SMAD4	2	0.0332	0.998
BCL9	3.8	SMAD5	0	1	1
BCL9	3.8	SMARCA2	5.8	0.216	0.95
BCL9	3.8	SMARCA4	5.6	0.201	0.956
BCL9	3.8	SMARCAL1	1	1	0.856
BCL9	3.8	SMARCB1	1.3	1	0.823
BCL9	3.8	SMARCC1	2.5	0.325	0.949
BCL9	3.8	SMARCC2	4.1	1	0.531
BCL9	3.8	SMARCD1	1	1	0.856
BCL9	3.8	SMARCD2	0.3	1	0.962
BCL9	3.8	SMARCD3	1	1	0.856
BCL9	3.8	SMARCE1	1.3	1	0.823
BCL9	3.8	SRCAP	8.6	0.0057	0.999
BCL9	3.8	TCF7L1	0	1	1
BCL9	3.8	TCF7L2	0.3	1	0.962
BCL9	3.8	TCF7	0.3	1	0.962
CREBBP	12.2	CTNNB1	3.6	0.526	0.764
CREBBP	12.2	EP300	15.5	0.642	0.527
CREBBP	12.2	EP400	5.6	0.517	0.727
CREBBP	12.2	HLTF	1	1	0.593
CREBBP	12.2	INO80	5.8	0.549	0.697
CREBBP	12.2	KMT2D	28.9	0.0611	0.969
CREBBP	12.2	LEF1	0.8	0.323	0.96
CREBBP	12.2	PYGO2	1.5	1	0.456
CREBBP	12.2	RBBP5	1	1	0.593
CREBBP	12.2	SMAD1	1.3	0.48	0.886
CREBBP	12.2	SMAD4	2	0.65	0.747
CREBBP	12.2	SMAD5	0	1	1
CREBBP	12.2	SMARCA2	5.8	0.798	0.451
CREBBP	12.2	SMARCA4	5.6	0.517	0.727
CREBBP	12.2	SMARCAL1	1	0.407	0.926
CREBBP	12.2	SMARCB1	1.3	1	0.52
CREBBP	12.2	SMARCC1	2.5	1	0.268
CREBBP	12.2	SMARCC2	4.1	0.117	0.966
CREBBP	12.2	SMARCD1	1	1	0.593
CREBBP	12.2	SMARCD2	0.3	1	0.878
CREBBP	12.2	SMARCD3	1	1	0.593
CREBBP	12.2	SMARCE1	1.3	1	0.52
CREBBP	12.2	SRCAP	8.6	0.99	0.0608
CREBBP	12.2	TCF7L1	0	1	1
CREBBP	12.2	TCF7L2	0.3	1	0.878
CREBBP	12.2	TCF7	0.3	1	0.878
CTNNB1	3.6	EP300	15.5	0.909	0.333
CTNNB1	3.6	EP400	5.6	1	0.441
CTNNB1	3.6	HLTF	1	1	0.865
CTNNB1	3.6	INO80	5.8	0.575	0.806
CTNNB1	3.6	KMT2D	28.9	0.075	0.977
CTNNB1	3.6	LEF1	0.8	1	0.897
CTNNB1	3.6	MEN1	0.8	1	0.897
CTNNB1	3.6	PYGO2	1.5	1	0.804
CTNNB1	3.6	RBBP5	1	1	0.865
CTNNB1	3.6	SMAD1	1.3	1	0.834
CTNNB1	3.6	SMAD4	2	1	0.747
CTNNB1	3.6	SMAD5	0	1	1
CTNNB1	3.6	SMARCA2	5.8	0.194	0.958
CTNNB1	3.6	SMARCA4	5.6	0.559	0.82
CTNNB1	3.6	SMARCAL1	1	1	0.865
CTNNB1	3.6	SMARCB1	1.3	0.166	0.989
CTNNB1	3.6	SMARCC1	2.5	0.307	0.955
CTNNB1	3.6	SMARCC2	4.1	0.446	0.894
CTNNB1	3.6	SMARCD1	1	0.135	0.993
CTNNB1	3.6	SMARCD2	0.3	1	0.964
CTNNB1	3.6	SMARCD3	1	1	0.865
CTNNB1	3.6	SMARCE1	1.3	1	0.834
CTNNB1	3.6	SRCAP	8.6	0.724	0.656
CTNNB1	3.6	TCF7L1	0	1	1
CTNNB1	3.6	TCF7L2	0.3	1	0.964
CTNNB1	3.6	TCF7	0.3	1	0.964
EP300	15.5	EP400	5.6	0.106	0.962
EP300	15.5	HLTF	1	0.115	0.987
EP300	15.5	INO80	5.8	0.127	0.952
EP300	15.5	KMT2D	28.9	0.0195	0.991
EP300	15.5	LEF1	0.8	0.397	0.936
EP300	15.5	PYGO2	1.5	0.638	0.766
EP300	15.5	RBBP5	1	0.491	0.885
EP300	15.5	SMAD1	1.3	0.173	0.972
EP300	15.5	SMAD4	2	1	0.257
EP300	15.5	SMAD5	0	1	1
EP300	15.5	SMARCA2	5.8	0.275	0.873
EP300	15.5	SMARCA4	5.6	0.242	0.894
EP300	15.5	SMARCAL1	1	1	0.509
EP300	15.5	SMARCB1	1.3	1	0.429
EP300	15.5	SMARCC1	2.5	0.475	0.81
EP300	15.5	SMARCC2	4.1	0.462	0.776
EP300	15.5	SMARCD1	1	0.491	0.885
EP300	15.5	SMARCD2	0.3	1	0.845
EP300	15.5	SMARCD3	1	1	0.509
EP300	15.5	SMARCE1	1.3	1	0.429
EP300	15.5	SRCAP	8.6	0.806	0.369
EP300	15.5	TCF7L1	0	1	1
EP300	15.5	TCF7L2	0.3	1	0.845
EP300	15.5	TCF7	0.3	1	0.845
EP400	5.6	LEF1	0.8	0.159	0.991
EP400	5.6	PYGO2	1.5	1	0.707
EP400	5.6	SMAD1	1.3	0.251	0.973
EP400	5.6	SMAD4	2	1	0.629
EP400	5.6	SMAD5	0	1	1
EP400	5.6	SRCAP	8.6	0.584	0.707
EP400	5.6	TCF7L1	0	1	1
EP400	5.6	TCF7L2	0.3	1	0.944
HLTF	1	LEF1	0.8	1	0.97
HLTF	1	PYGO2	1.5	1	0.94
HLTF	1	SMAD1	1.3	1	0.95
HLTF	1	SMAD4	2	1	0.921
HLTF	1	SMAD5	0	1	1
HLTF	1	TCF7L1	0	1	1
HLTF	1	TCF7L2	0.3	0.0102	1
INO80	5.8	LEF1	0.8	1	0.835
INO80	5.8	PYGO2	1.5	0.305	0.958
INO80	5.8	SMAD1	1.3	1	0.739
INO80	5.8	SMAD4	2	0.385	0.926
INO80	5.8	SMAD5	0	1	1
INO80	5.8	TCF7L1	0	1	1
INO80	5.8	TCF7L2	0.3	1	0.942
KMT2D	28.9	LEF1	0.8	0.642	0.798
KMT2D	28.9	MEN1	0.8	0.202	0.976
KMT2D	28.9	PYGO2	1.5	0.873	0.442
KMT2D	28.9	RBBP5	1	0.747	0.671
KMT2D	28.9	TCF7L1	0	1	1
KMT2D	28.9	TCF7L2	0.3	0.289	1
KMT2D	28.9	TCF7	0.3	0.289	1
LEF1	0.8	MEN1	0.8	1	0.977
LEF1	0.8	PYGO2	1.5	1	0.955
LEF1	0.8	RBBP5	1	1	0.97
LEF1	0.8	SMAD1	1.3	0.0377	1
LEF1	0.8	SMAD4	2	1	0.94
LEF1	0.8	SMAD5	0	1	1
LEF1	0.8	SMARCA2	5.8	0.165	0.991
LEF1	0.8	SMARCA4	5.6	1	0.841
LEF1	0.8	SMARCAL1	1	1	0.97
LEF1	0.8	SMARCB1	1.3	1	0.962
LEF1	0.8	SMARCC1	2.5	1	0.926
LEF1	0.8	SMARCC2	4.1	0.117	0.995
LEF1	0.8	SMARCD1	1	1	0.97
LEF1	0.8	SMARCD2	0.3	1	0.992
LEF1	0.8	SMARCD3	1	1	0.97
LEF1	0.8	SMARCE1	1.3	1	0.962
LEF1	0.8	SRCAP	8.6	1	0.762
MEN1	0.8	PYGO2	1.5	1	0.955
MEN1	0.8	RBBP5	1	1	0.97
MEN1	0.8	SMAD4	2	1	0.94
MEN1	0.8	TCF7L1	0	1	1
MEN1	0.8	TCF7L2	0.3	1	0.992
MEN1	0.8	TCF7	0.3	1	0.992
PYGO2	1.5	RBBP5	1	1	0.94
PYGO2	1.5	SMAD1	1.3	1	0.926
PYGO2	1.5	SMAD4	2	1	0.883
PYGO2	1.5	SMAD5	0	1	1
PYGO2	1.5	SMARCA2	5.8	0.305	0.958
PYGO2	1.5	SMARCA4	5.6	1	0.707
PYGO2	1.5	SMARCAL1	1	0.0598	0.999
PYGO2	1.5	SMARCB1	1.3	1	0.926
PYGO2	1.5	SMARCC1	2.5	1	0.856
PYGO2	1.5	SMARCC2	4.1	1	0.779
PYGO2	1.5	SMARCD1	1	1	0.94
PYGO2	1.5	SMARCD2	0.3	1	0.985
PYGO2	1.5	SMARCD3	1	0.0598	0.999
PYGO2	1.5	SMARCE1	1.3	1	0.926
PYGO2	1.5	SRCAP	8.6	1	0.58
PYGO2	1.5	TCF7L1	0	1	1
PYGO2	1.5	TCF7L2	0.3	1	0.985
PYGO2	1.5	TCF7	0.3	1	0.985
RBBP5	1	SMARCA2	5.8	0.0182	0.999
RBBP5	1	SMARCB1	1.3	0.05	0.999
RBBP5	1	SMARCC1	2.5	1	0.902
RBBP5	1	SMARCC2	4.1	1	0.847
RBBP5	1	TCF7L1	0	1	1
RBBP5	1	TCF7L2	0.3	1	0.99
RBBP5	1	TCF7	0.3	1	0.99
SMAD1	1.3	SMAD4	2	1	0.902
SMAD1	1.3	SMARCA2	5.8	1	0.739
SMAD1	1.3	SMARCA4	5.6	0.251	0.973
SMAD1	1.3	SMARCAL1	1	1	0.95
SMAD1	1.3	SMARCB1	1.3	1	0.938
SMAD1	1.3	SMARCC1	2.5	1	0.879
SMAD1	1.3	SMARCC2	4.1	0.188	0.986
SMAD1	1.3	SMARCD1	1	1	0.95
SMAD1	1.3	SMARCD2	0.3	1	0.987
SMAD1	1.3	SMARCD3	1	1	0.95
SMAD1	1.3	SMARCE1	1.3	1	0.938
SMAD1	1.3	SRCAP	8.6	1	0.635
SMAD1	1.3	TCF7L1	0	1	1
SMAD1	1.3	TCF7L2	0.3	1	0.987
SMAD4	2	SMAD5	0	1	1
SMAD4	2	SMARCA2	5.8	0.385	0.926
SMAD4	2	SMARCA4	5.6	1	0.629
SMAD4	2	SMARCAL1	1	1	0.921
SMAD4	2	SMARCB1	1.3	1	0.902
SMAD4	2	SMARCC1	2.5	1	0.813
SMAD4	2	SMARCC2	4.1	1	0.716
SMAD4	2	SMARCD1	1	1	0.921
SMAD4	2	SMARCD2	0.3	1	0.98
SMAD4	2	SMARCD3	1	1	0.921
SMAD4	2	SMARCE1	1.3	1	0.902
SMAD4	2	SRCAP	8.6	0.146	0.976
SMAD4	2	TCF7L1	0	1	1
SMAD4	2	TCF7L2	0.3	1	0.98
SMAD4	2	TCF7	0.3	1	0.98
SMAD5	0	SMARCA2	5.8	1	1
SMAD5	0	SMARCA4	5.6	1	1
SMAD5	0	SMARCAL1	1	1	1
SMAD5	0	SMARCB1	1.3	1	1
SMAD5	0	SMARCC1	2.5	1	1
SMAD5	0	SMARCC2	4.1	1	1
SMAD5	0	SMARCD1	1	1	1
SMAD5	0	SMARCD2	0.3	1	1
SMAD5	0	SMARCD3	1	1	1
SMAD5	0	SMARCE1	1.3	1	1
SMAD5	0	SRCAP	8.6	1	1
SMAD5	0	TCF7L1	0	1	1
SMAD5	0	TCF7L2	0.3	1	1
SMARCA2	5.8	SMARCA4	5.6	0.373	0.871
SMARCA2	5.8	SMARCB1	1.3	0.0293	0.998
SMARCA2	5.8	SMARCC1	2.5	0.11	0.984
SMARCA2	5.8	SMARCC2	4.1	1	0.375
SMARCA2	5.8	SMARCD1	1	1	0.785
SMARCA2	5.8	SMARCD2	0.3	1	0.942
SMARCA2	5.8	SMARCD3	1	0.215	0.982
SMARCA2	5.8	SMARCE1	1.3	0.261	0.971
SMARCA2	5.8	TCF7L1	0	1	1
SMARCA2	5.8	TCF7L2	0.3	1	0.942
SMARCA4	5.6	SMARCB1	1.3	1	0.749
SMARCA4	5.6	SMARCC1	2.5	1	0.559
SMARCA4	5.6	SMARCC2	4.1	0.609	0.777
SMARCA4	5.6	SMARCD1	1	0.206	0.983
SMARCA4	5.6	SMARCD2	0.3	1	0.944
SMARCA4	5.6	SMARCD3	1	1	0.794
SMARCA4	5.6	SMARCE1	1.3	1	0.749
SMARCA4	5.6	SRCAP	8.6	0.293	0.89
SMARCA4	5.6	TCF7L1	0	1	1
SMARCA4	5.6	TCF7L2	0.3	1	0.944
SMARCA4	5.6	TCF7	0.3	1	0.944
SMARCAL1	1	TCF7L1	0	1	1
SMARCAL1	1	TCF7L2	0.3	1	0.99
SMARCB1	1.3	SMARCC1	2.5	0.00558	1
SMARCB1	1.3	SMARCC2	4.1	1	0.812
SMARCB1	1.3	SMARCD1	1	1	0.95
SMARCB1	1.3	SMARCD2	0.3	1	0.987
SMARCB1	1.3	SMARCD3	1	1	0.95
SMARCB1	1.3	SMARCE1	1.3	1	0.938
SMARCB1	1.3	SRCAP	8.6	1	0.635
SMARCB1	1.3	TCF7L1	0	1	1
SMARCB1	1.3	TCF7L2	0.3	0.0127	1
SMARCC1	2.5	SMARCC2	4.1	1	0.657
SMARCC1	2.5	SMARCD1	1	1	0.902
SMARCC1	2.5	SMARCD2	0.3	1	0.975
SMARCC1	2.5	SMARCD3	1	1	0.902
SMARCC1	2.5	SMARCE1	1.3	1	0.879
SMARCC1	2.5	SRCAP	8.6	1	0.401
SMARCC1	2.5	TCF7L1	0	1	1
SMARCC1	2.5	TCF7L2	0.3	1	0.975
SMARCC2	4.1	SMARCD1	1	0.153	0.991
SMARCC2	4.1	SMARCD2	0.3	1	0.959
SMARCC2	4.1	SMARCD3	1	1	0.847
SMARCC2	4.1	SMARCE1	1.3	1	0.812
SMARCC2	4.1	SRCAP	8.6	0.771	0.59
SMARCC2	4.1	TCF7L1	0	1	1
SMARCC2	4.1	TCF7L2	0.3	1	0.959
SMARCD1	1	SMARCD2	0.3	1	0.99
SMARCD1	1	SMARCD3	1	1	0.96
SMARCD1	1	SMARCE1	1.3	1	0.95
SMARCD1	1	TCF7L1	0	1	1
SMARCD1	1	TCF7L2	0.3	1	0.99
SMARCD2	0.3	SMARCD3	1	1	0.99
SMARCD2	0.3	SMARCE1	1.3	1	0.987
SMARCD2	0.3	TCF7L1	0	1	1
SMARCD2	0.3	TCF7L2	0.3	1	0.997
SMARCD3	1	SMARCE1	1.3	1	0.95
SMARCD3	1	TCF7L1	0	1	1
SMARCD3	1	TCF7L2	0.3	1	0.99
SMARCE1	1.3	TCF7L1	0	1	1
SMARCE1	1.3	TCF7L2	0.3	1	0.987
SRCAP	8.6	TCF7L1	0	1	1
SRCAP	8.6	TCF7L2	0.3	1	0.914