*The size of the node in the network represents the mutation rate of the cancer type selected in the above box. Mouse over on the node would show its mutation rate and first neighbors. For edge color, blue means co-occurrence while red for mutual exclusive (p value < 0.05, Fisher's exact test).

Node 1	% Mutation Rate (Node 1)	Node 2	% Mutation Rate (Node 2)	P Value (co-occurrence)	P Value (mutual exclusive)
ACTL6A	1.5	ACTR6	0.5	0.0303	1
ACTL6A	1.5	BRD8	2.5	1	0.856
ACTL6A	1.5	DMAP1	0.3	1	0.985
ACTL6A	1.5	EAF2	1.3	1	0.926
ACTL6A	1.5	EP400	5.6	0.039	0.997
ACTL6A	1.5	EPC1	2.8	0.157	0.99
ACTL6A	1.5	H2AFZ	0.3	1	0.985
ACTL6A	1.5	RUVBL1	1.5	0.0885	0.997
ACTL6A	1.5	RUVBL2	0.5	1	0.97
ACTL6A	1.5	SMARCA4	5.6	1	0.707
ACTL6A	1.5	SMARCB1	1.3	1	0.926
ACTL6A	1.5	SMARCC1	2.5	1	0.856
ACTL6A	1.5	SMARCC2	4.1	0.221	0.979
ACTL6A	1.5	SRCAP	8.6	0.42	0.913
ACTL6A	1.5	TRRAP	8.6	0.0871	0.99
ACTL6A	1.5	VPS72	1.3	1	0.926
ACTL6A	1.5	YEATS4	0.3	1	0.985
ACTL6A	1.5	ZNHIT1	1.3	0.0742	0.998
ACTR6	0.5	EAF2	1.3	1	0.975
ACTR6	0.5	H2AFZ	0.3	1	0.995
ACTR6	0.5	RUVBL1	1.5	1	0.97
ACTR6	0.5	RUVBL2	0.5	1	0.99
ACTR6	0.5	SRCAP	8.6	0.00725	1
ACTR6	0.5	VPS72	1.3	1	0.975
ACTR6	0.5	YEATS4	0.3	1	0.995
ACTR6	0.5	ZNHIT1	1.3	1	0.975
BCL9	3.8	CREBBP	12.2	0.565	0.728
BCL9	3.8	CTNNB1	3.6	1	0.575
BCL9	3.8	EP300	15.5	0.189	0.935
BCL9	3.8	EP400	5.6	1	0.416
BCL9	3.8	LEF1	0.8	1	0.89
BCL9	3.8	PYGO1	1.8	1	0.76
BCL9	3.8	PYGO2	1.5	1	0.791
BCL9	3.8	SMAD1	1.3	0.177	0.987
BCL9	3.8	SMAD4	2	0.0332	0.998
BCL9	3.8	SMAD5	0	1	1
BCL9	3.8	SMARCA4	5.6	0.201	0.956
BCL9	3.8	SMARCB1	1.3	1	0.823
BCL9	3.8	SMARCC1	2.5	0.325	0.949
BCL9	3.8	SMARCC2	4.1	1	0.531
BCL9	3.8	SRCAP	8.6	0.0057	0.999
BCL9	3.8	TCF7L1	0	1	1
BCL9	3.8	TCF7L2	0.3	1	0.962
BRD8	2.5	DMAP1	0.3	1	0.975
BRD8	2.5	EP400	5.6	0.102	0.986
BRD8	2.5	EPC1	2.8	0.249	0.972
BRD8	2.5	RUVBL1	1.5	1	0.856
BRD8	2.5	RUVBL2	0.5	1	0.95
BRD8	2.5	SRCAP	8.6	0.599	0.79
BRD8	2.5	TRRAP	8.6	0.599	0.79
BRD8	2.5	VPS72	1.3	0.121	0.994
BRD8	2.5	YEATS4	0.3	1	0.975
CREBBP	12.2	CTNNB1	3.6	0.526	0.764
CREBBP	12.2	EP300	15.5	0.642	0.527
CREBBP	12.2	EP400	5.6	0.517	0.727
CREBBP	12.2	H2AFZ	0.3	1	0.878
CREBBP	12.2	LEF1	0.8	0.323	0.96
CREBBP	12.2	PYGO1	1.8	1	0.4
CREBBP	12.2	PYGO2	1.5	1	0.456
CREBBP	12.2	SMAD1	1.3	0.48	0.886
CREBBP	12.2	SMAD4	2	0.65	0.747
CREBBP	12.2	SMAD5	0	1	1
CREBBP	12.2	SMARCA4	5.6	0.517	0.727
CREBBP	12.2	SMARCB1	1.3	1	0.52
CREBBP	12.2	SMARCC1	2.5	1	0.268
CREBBP	12.2	SMARCC2	4.1	0.117	0.966
CREBBP	12.2	SRCAP	8.6	0.99	0.0608
CREBBP	12.2	TCF7L1	0	1	1
CREBBP	12.2	TCF7L2	0.3	1	0.878
CTNNB1	3.6	EP300	15.5	0.909	0.333
CTNNB1	3.6	EP400	5.6	1	0.441
CTNNB1	3.6	LEF1	0.8	1	0.897
CTNNB1	3.6	PYGO1	1.8	1	0.775
CTNNB1	3.6	PYGO2	1.5	1	0.804
CTNNB1	3.6	RUVBL1	1.5	0.196	0.984
CTNNB1	3.6	RUVBL2	0.5	1	0.93
CTNNB1	3.6	SMAD1	1.3	1	0.834
CTNNB1	3.6	SMAD4	2	1	0.747
CTNNB1	3.6	SMAD5	0	1	1
CTNNB1	3.6	SMARCA4	5.6	0.559	0.82
CTNNB1	3.6	SMARCB1	1.3	0.166	0.989
CTNNB1	3.6	SMARCC1	2.5	0.307	0.955
CTNNB1	3.6	SMARCC2	4.1	0.446	0.894
CTNNB1	3.6	SRCAP	8.6	0.724	0.656
CTNNB1	3.6	TCF7L1	0	1	1
CTNNB1	3.6	TCF7L2	0.3	1	0.964
CTNNB1	3.6	TRRAP	8.6	0.344	0.889
DMAP1	0.3	EP400	5.6	0.0558	1
DMAP1	0.3	EPC1	2.8	1	0.972
DMAP1	0.3	RUVBL1	1.5	1	0.985
DMAP1	0.3	RUVBL2	0.5	1	0.995
DMAP1	0.3	SRCAP	8.6	1	0.914
DMAP1	0.3	TRRAP	8.6	1	0.914
DMAP1	0.3	VPS72	1.3	0.0127	1
DMAP1	0.3	YEATS4	0.3	1	0.997
EAF2	1.3	H2AFZ	0.3	1	0.987
EAF2	1.3	RUVBL1	1.5	1	0.926
EAF2	1.3	RUVBL2	0.5	1	0.975
EAF2	1.3	SRCAP	8.6	0.365	0.939
EAF2	1.3	VPS72	1.3	0.0622	0.999
EAF2	1.3	YEATS4	0.3	1	0.987
EAF2	1.3	ZNHIT1	1.3	1	0.938
EP300	15.5	EP400	5.6	0.106	0.962
EP300	15.5	H2AFZ	0.3	1	0.845
EP300	15.5	LEF1	0.8	0.397	0.936
EP300	15.5	PYGO1	1.8	1	0.305
EP300	15.5	PYGO2	1.5	0.638	0.766
EP300	15.5	SMAD1	1.3	0.173	0.972
EP300	15.5	SMAD4	2	1	0.257
EP300	15.5	SMAD5	0	1	1
EP300	15.5	SMARCA4	5.6	0.242	0.894
EP300	15.5	SMARCB1	1.3	1	0.429
EP300	15.5	SMARCC1	2.5	0.475	0.81
EP300	15.5	SMARCC2	4.1	0.462	0.776
EP300	15.5	SRCAP	8.6	0.806	0.369
EP300	15.5	TCF7L1	0	1	1
EP300	15.5	TCF7L2	0.3	1	0.845
EP400	5.6	EPC1	2.8	1	0.527
EP400	5.6	LEF1	0.8	0.159	0.991
EP400	5.6	PYGO1	1.8	1	0.667
EP400	5.6	PYGO2	1.5	1	0.707
EP400	5.6	RUVBL1	1.5	0.293	0.961
EP400	5.6	RUVBL2	0.5	1	0.891
EP400	5.6	SMAD1	1.3	0.251	0.973
EP400	5.6	SMAD4	2	1	0.629
EP400	5.6	SMAD5	0	1	1
EP400	5.6	SRCAP	8.6	0.584	0.707
EP400	5.6	TCF7L1	0	1	1
EP400	5.6	TCF7L2	0.3	1	0.944
EP400	5.6	TRRAP	8.6	0.11	0.968
EP400	5.6	VPS72	1.3	0.0269	0.999
EP400	5.6	YEATS4	0.3	1	0.944
EPC1	2.8	RUVBL1	1.5	1	0.843
EPC1	2.8	RUVBL2	0.5	1	0.945
EPC1	2.8	SRCAP	8.6	0.634	0.756
EPC1	2.8	TRRAP	8.6	0.06	0.99
EPC1	2.8	VPS72	1.3	0.133	0.993
EPC1	2.8	YEATS4	0.3	1	0.972
H2AFZ	0.3	HDAC3	0.3	1	0.997
H2AFZ	0.3	NCOR1	8.6	1	0.914
H2AFZ	0.3	RUVBL1	1.5	1	0.985
H2AFZ	0.3	RUVBL2	0.5	1	0.995
H2AFZ	0.3	SRCAP	8.6	1	0.914
H2AFZ	0.3	VPS72	1.3	1	0.987
H2AFZ	0.3	YEATS4	0.3	1	0.997
H2AFZ	0.3	ZNHIT1	1.3	1	0.987
HDAC3	0.3	NCOR1	8.6	0.0863	1
HDAC3	0.3	SF3A1	1.5	1	0.985
HDAC3	0.3	SF3B3	5.6	1	0.944
HDAC3	0.3	SMAD1	1.3	1	0.987
HDAC3	0.3	SMAD4	2	1	0.98
HDAC3	0.3	SMAD5	0	1	1
HDAC3	0.3	SMARCA4	5.6	1	0.944
HDAC3	0.3	SMARCB1	1.3	1	0.987
HDAC3	0.3	SMARCC1	2.5	1	0.975
HDAC3	0.3	SMARCC2	4.1	1	0.959
HDAC3	0.3	SRCAP	8.6	1	0.914
HDAC3	0.3	TRIM28	1.3	1	0.987
LEF1	0.8	PYGO1	1.8	1	0.948
LEF1	0.8	PYGO2	1.5	1	0.955
LEF1	0.8	RUVBL1	1.5	0.0451	0.999
LEF1	0.8	SMAD1	1.3	0.0377	1
LEF1	0.8	SMAD4	2	1	0.94
LEF1	0.8	SMAD5	0	1	1
LEF1	0.8	SMARCA4	5.6	1	0.841
LEF1	0.8	SMARCB1	1.3	1	0.962
LEF1	0.8	SMARCC1	2.5	1	0.926
LEF1	0.8	SMARCC2	4.1	0.117	0.995
LEF1	0.8	SRCAP	8.6	1	0.762
LEF1	0.8	TRRAP	8.6	1	0.762
NCOR1	8.6	SF3A1	1.5	0.0871	0.99
NCOR1	8.6	SF3B3	5.6	0.584	0.707
NCOR1	8.6	SMAD4	2	0.146	0.976
NCOR1	8.6	SMARCA4	5.6	0.87	0.416
NCOR1	8.6	SMARCB1	1.3	0.365	0.939
NCOR1	8.6	SMARCC1	2.5	0.21	0.954
NCOR1	8.6	SMARCC2	4.1	0.151	0.96
NCOR1	8.6	SRCAP	8.6	0.00479	0.999
NCOR1	8.6	TRIM28	1.3	0.365	0.939
PYGO1	1.8	SMAD1	1.3	1	0.914
PYGO1	1.8	SMAD4	2	1	0.865
PYGO1	1.8	SMAD5	0	1	1
PYGO1	1.8	SMARCA4	5.6	1	0.667
PYGO1	1.8	SMARCB1	1.3	1	0.914
PYGO1	1.8	SMARCC1	2.5	0.166	0.989
PYGO1	1.8	SMARCC2	4.1	0.254	0.971
PYGO1	1.8	SRCAP	8.6	1	0.529
PYGO1	1.8	TCF7L1	0	1	1
PYGO1	1.8	TCF7L2	0.3	1	0.982
PYGO2	1.5	SMAD1	1.3	1	0.926
PYGO2	1.5	SMAD4	2	1	0.883
PYGO2	1.5	SMAD5	0	1	1
PYGO2	1.5	SMARCA4	5.6	1	0.707
PYGO2	1.5	SMARCB1	1.3	1	0.926
PYGO2	1.5	SMARCC1	2.5	1	0.856
PYGO2	1.5	SMARCC2	4.1	1	0.779
PYGO2	1.5	SRCAP	8.6	1	0.58
PYGO2	1.5	TCF7L1	0	1	1
PYGO2	1.5	TCF7L2	0.3	1	0.985
RUVBL1	1.5	RUVBL2	0.5	1	0.97
RUVBL1	1.5	SRCAP	8.6	0.0871	0.99
RUVBL1	1.5	TCF7L1	0	1	1
RUVBL1	1.5	TCF7L2	0.3	1	0.985
RUVBL1	1.5	TRRAP	8.6	1	0.58
RUVBL1	1.5	VPS72	1.3	1	0.926
RUVBL1	1.5	YEATS4	0.3	1	0.985
RUVBL1	1.5	ZNHIT1	1.3	0.0742	0.998
RUVBL2	0.5	SRCAP	8.6	0.165	0.993
RUVBL2	0.5	TCF7L2	0.3	1	0.995
RUVBL2	0.5	TRRAP	8.6	1	0.835
RUVBL2	0.5	VPS72	1.3	1	0.975
RUVBL2	0.5	YEATS4	0.3	1	0.995
RUVBL2	0.5	ZNHIT1	1.3	1	0.975
SF3A1	1.5	SF3B3	5.6	1	0.707
SF3A1	1.5	SMARCA4	5.6	1	0.707
SF3A1	1.5	SMARCB1	1.3	0.0742	0.998
SF3A1	1.5	SMARCC1	2.5	1	0.856
SF3A1	1.5	SMARCC2	4.1	1	0.779
SF3A1	1.5	SRCAP	8.6	0.42	0.913
SF3A1	1.5	TRIM28	1.3	1	0.926
SF3B3	5.6	SMARCA4	5.6	0.352	0.884
SF3B3	5.6	SMARCB1	1.3	1	0.749
SF3B3	5.6	SMARCC1	2.5	0.102	0.986
SF3B3	5.6	SMARCC2	4.1	0.00856	0.999
SF3B3	5.6	SRCAP	8.6	0.584	0.707
SF3B3	5.6	TRIM28	1.3	1	0.749
SF3B3	5.6	TRRAP	8.6	0.87	0.416
SMAD1	1.3	SMAD4	2	1	0.902
SMAD1	1.3	SMARCA4	5.6	0.251	0.973
SMAD1	1.3	SMARCB1	1.3	1	0.938
SMAD1	1.3	SMARCC1	2.5	1	0.879
SMAD1	1.3	SMARCC2	4.1	0.188	0.986
SMAD1	1.3	SRCAP	8.6	1	0.635
SMAD1	1.3	TCF7L1	0	1	1
SMAD1	1.3	TCF7L2	0.3	1	0.987
SMAD4	2	SMAD5	0	1	1
SMAD4	2	SMARCA4	5.6	1	0.629
SMAD4	2	SMARCB1	1.3	1	0.902
SMAD4	2	SMARCC1	2.5	1	0.813
SMAD4	2	SMARCC2	4.1	1	0.716
SMAD4	2	SRCAP	8.6	0.146	0.976
SMAD4	2	TCF7L1	0	1	1
SMAD4	2	TCF7L2	0.3	1	0.98
SMAD5	0	SMARCA4	5.6	1	1
SMAD5	0	SMARCB1	1.3	1	1
SMAD5	0	SMARCC1	2.5	1	1
SMAD5	0	SMARCC2	4.1	1	1
SMAD5	0	SRCAP	8.6	1	1
SMAD5	0	TCF7L1	0	1	1
SMAD5	0	TCF7L2	0.3	1	1
SMARCA4	5.6	SMARCB1	1.3	1	0.749
SMARCA4	5.6	SMARCC1	2.5	1	0.559
SMARCA4	5.6	SMARCC2	4.1	0.609	0.777
SMARCA4	5.6	SRCAP	8.6	0.293	0.89
SMARCA4	5.6	TCF7L1	0	1	1
SMARCA4	5.6	TCF7L2	0.3	1	0.944
SMARCA4	5.6	TRIM28	1.3	1	0.749
SMARCB1	1.3	SMARCC1	2.5	0.00558	1
SMARCB1	1.3	SMARCC2	4.1	1	0.812
SMARCB1	1.3	SRCAP	8.6	1	0.635
SMARCB1	1.3	TCF7L1	0	1	1
SMARCB1	1.3	TCF7L2	0.3	0.0127	1
SMARCB1	1.3	TRIM28	1.3	1	0.938
SMARCC1	2.5	SMARCC2	4.1	1	0.657
SMARCC1	2.5	SRCAP	8.6	1	0.401
SMARCC1	2.5	TCF7L1	0	1	1
SMARCC1	2.5	TCF7L2	0.3	1	0.975
SMARCC1	2.5	TRIM28	1.3	1	0.879
SMARCC2	4.1	SRCAP	8.6	0.771	0.59
SMARCC2	4.1	TCF7L1	0	1	1
SMARCC2	4.1	TCF7L2	0.3	1	0.959
SMARCC2	4.1	TRIM28	1.3	1	0.812
SRCAP	8.6	TCF7L1	0	1	1
SRCAP	8.6	TCF7L2	0.3	1	0.914
SRCAP	8.6	TRIM28	1.3	0.0613	0.995
SRCAP	8.6	TRRAP	8.6	0.335	0.843
SRCAP	8.6	VPS72	1.3	0.365	0.939
SRCAP	8.6	YEATS4	0.3	1	0.914
SRCAP	8.6	ZNHIT1	1.3	1	0.635
TCF7L1	0	TRRAP	8.6	1	1
TCF7L2	0.3	TRRAP	8.6	0.0863	1
TRRAP	8.6	VPS72	1.3	0.365	0.939
TRRAP	8.6	YEATS4	0.3	0.0863	1
VPS72	1.3	YEATS4	0.3	1	0.987
VPS72	1.3	ZNHIT1	1.3	1	0.938
YEATS4	0.3	ZNHIT1	1.3	1	0.987