Silent
Missense
Nonsense
Frequency of SNVs in pancancer level
| Cancer Type | Mutation | Mutation Type | # Sample |
|---|---|---|---|
| Autonomic ganglia | G1254G | Silent | 2 |
| Endometrium | G1761C | Missense | 2 |
| Endometrium | Q1835* | Nonsense | 2 |
| Endometrium | Q2115* | Nonsense | 2 |
| Biliary tract | M759V | Missense | 1 |
| Breast | N2130S | Missense | 1 |
| Breast | Q1212* | Nonsense | 1 |
| Breast | Q944* | Nonsense | 1 |
| Breast | R1276* | Nonsense | 1 |
| Breast | V1058G | Missense | 1 |
| Central nervous system | P1144T | Missense | 1 |
| Endometrium | D2277G | Missense | 1 |
| Endometrium | G2193D | Missense | 1 |
| Endometrium | M1224V | Missense | 1 |
| Endometrium | P1307S | Missense | 1 |
| Endometrium | P1576L | Missense | 1 |
| Endometrium | Q1499Q | Silent | 1 |
| Endometrium | Q404H | Missense | 1 |
| Endometrium | Q428* | Nonsense | 1 |
| Endometrium | R1323R | Silent | 1 |
| Endometrium | R1446* | Nonsense | 1 |
| Endometrium | R1989* | Nonsense | 1 |
| Endometrium | R2232W | Missense | 1 |
| Endometrium | R693* | Nonsense | 1 |
| Endometrium | R774C | Missense | 1 |
| Endometrium | S1123S | Silent | 1 |
| Endometrium | S1261S | Silent | 1 |
| Endometrium | S2272* | Nonsense | 1 |
| Endometrium | V2111I | Missense | 1 |
| Endometrium | Y1572Y | Silent | 1 |
| Endometrium | Y212H | Missense | 1 |
| Haematopoietic and lymphoid tissue | D2072H | Missense | 1 |
| Haematopoietic and lymphoid tissue | G276* | Nonsense | 1 |
| Haematopoietic and lymphoid tissue | G285* | Nonsense | 1 |
| Haematopoietic and lymphoid tissue | H1624H | Silent | 1 |
| Haematopoietic and lymphoid tissue | Q177H | Missense | 1 |
| Haematopoietic and lymphoid tissue | Q474* | Nonsense | 1 |
| Haematopoietic and lymphoid tissue | Q501* | Nonsense | 1 |
| Haematopoietic and lymphoid tissue | Q553E | Missense | 1 |
| Haematopoietic and lymphoid tissue | R1109Q | Missense | 1 |
| Haematopoietic and lymphoid tissue | R1658Q | Missense | 1 |
| Haematopoietic and lymphoid tissue | R1845Q | Missense | 1 |
| Haematopoietic and lymphoid tissue | R635K | Missense | 1 |
| Haematopoietic and lymphoid tissue | S614A | Missense | 1 |
| Large intestine | A1272A | Silent | 1 |
| Large intestine | A2065T | Missense | 1 |
| Large intestine | G701A | Missense | 1 |
| Large intestine | H1854Y | Missense | 1 |
| Large intestine | K1862R | Missense | 1 |
| Large intestine | N1597N | Silent | 1 |
| Large intestine | Q1277Q | Silent | 1 |
| Large intestine | Q561H | Missense | 1 |
| Large intestine | R774C | Missense | 1 |
| Large intestine | S1248S | Silent | 1 |
| Large intestine | S1390S | Silent | 1 |
| Liver | G623* | Nonsense | 1 |
| Liver | N1183S | Missense | 1 |
| Lung | C884* | Nonsense | 1 |
| Lung | D1957E | Missense | 1 |
| Lung | E966K | Missense | 1 |
| Lung | G1740G | Silent | 1 |
| Lung | G927* | Nonsense | 1 |
| Lung | H684D | Missense | 1 |
| Lung | M863I | Missense | 1 |
| Lung | P253S | Missense | 1 |
| Lung | P533A | Missense | 1 |
| Lung | P697L | Missense | 1 |
| Lung | P916L | Missense | 1 |
| Lung | Q1411* | Nonsense | 1 |
| Lung | R1833C | Missense | 1 |
| Lung | Y1435C | Missense | 1 |
| Oesophagus | R1989* | Nonsense | 1 |
| Ovary | G1255E | Missense | 1 |
| Ovary | P1280P | Silent | 1 |
| Ovary | Q1332* | Nonsense | 1 |
| Ovary | Q1430* | Nonsense | 1 |
| Ovary | Q1947* | Nonsense | 1 |
| Ovary | Q586* | Nonsense | 1 |
| Ovary | R1276* | Nonsense | 1 |
| Ovary | R1722* | Nonsense | 1 |
| Ovary | S2264* | Nonsense | 1 |
| Pancreas | L2239P | Missense | 1 |
| Pancreas | N957S | Missense | 1 |
| Pancreas | P1940L | Missense | 1 |
| Pancreas | Q538* | Nonsense | 1 |
| Pancreas | T572M | Missense | 1 |
| Skin | P1456L | Missense | 1 |
| Skin | Q1212* | Nonsense | 1 |
| Skin | S764F | Missense | 1 |
| Stomach | Q1458* | Nonsense | 1 |
| Thyroid | Q425R | Missense | 1 |
| Upper aerodigestive tract | F1457S | Missense | 1 |
| Upper aerodigestive tract | G1482G | Silent | 1 |
| Upper aerodigestive tract | G1483G | Silent | 1 |
| Upper aerodigestive tract | L2216F | Missense | 1 |
| Upper aerodigestive tract | N2044D | Missense | 1 |
| Upper aerodigestive tract | P1569P | Silent | 1 |
| Upper aerodigestive tract | Q1494Q | Silent | 1 |
| Upper aerodigestive tract | Q1579P | Missense | 1 |
| Upper aerodigestive tract | Y1211Y | Silent | 1 |
| Upper aerodigestive tract | Y1506Y | Silent | 1 |
| Urinary tract | E966K | Missense | 1 |
| Urinary tract | S552* | Nonsense | 1 |
| Urinary tract | Y1052* | Nonsense | 1 |
Mutational percentage of Silent, Missense and Nonsense for various cancer cell lines
Summary of mutation in pancancer level
| Tissue Type | # Cell Line | % Silent | % Missense | % Nonsense |
|---|---|---|---|---|
| Autonomic ganglia | 17 | 9.5 | 0 | 0 |
| Biliary tract | 7 | 0 | 1.9 | 0 |
| Bone | 25 | 0 | 0 | 0 |
| Breast | 58 | 0 | 3.7 | 9.1 |
| Central nervous system | 52 | 0 | 1.9 | 0 |
| Endometrium | 27 | 23.8 | 22.2 | 27.3 |
| Haematopoietic and lymphoid tissue | 178 | 4.8 | 14.8 | 12.1 |
| Kidney | 22 | 0 | 0 | 0 |
| Large intestine | 57 | 23.8 | 11.1 | 0 |
| Liver | 27 | 0 | 1.9 | 3 |
| Lung | 174 | 4.8 | 18.5 | 9.1 |
| Oesophagus | 25 | 0 | 0 | 3 |
| Ovary | 50 | 4.8 | 1.9 | 21.2 |
| Pancreas | 44 | 0 | 7.4 | 3 |
| Pleura | 10 | 0 | 0 | 0 |
| Prostate | 7 | 0 | 0 | 0 |
| Salivary gland | 2 | 0 | 0 | 0 |
| Skin | 60 | 0 | 3.7 | 3 |
| Small intestine | 1 | 0 | 0 | 0 |
| Soft tissue | 20 | 0 | 0 | 0 |
| Stomach | 38 | 0 | 0 | 3 |
| Thyroid | 12 | 0 | 1.9 | 0 |
| Upper aerodigestive tract | 30 | 28.6 | 7.4 | 0 |
| Urinary tract | 24 | 0 | 1.9 | 6.1 |