Cancer Type	Mutation	Mutation Type	# Sample
Upper aerodigestive tract	S1761*	Nonsense	2
Biliary tract	R2190Q	Missense	1
Breast	H1297Q	Missense	1
Breast	Q935*	Nonsense	1
Central nervous system	Q2196L	Missense	1
Central nervous system	Y1167C	Missense	1
Endometrium	E1573A	Missense	1
Endometrium	I1649T	Missense	1
Endometrium	K1554T	Missense	1
Endometrium	L555M	Missense	1
Endometrium	P2371L	Missense	1
Endometrium	P248L	Missense	1
Endometrium	P795S	Missense	1
Endometrium	Q929*	Nonsense	1
Endometrium	R1428C	Missense	1
Endometrium	R1664H	Missense	1
Endometrium	R1682H	Missense	1
Endometrium	S1598G	Missense	1
Endometrium	T244M	Missense	1
Endometrium	T872K	Missense	1
Endometrium	V1405M	Missense	1
Haematopoietic and lymphoid tissue	A620V	Missense	1
Haematopoietic and lymphoid tissue	D1435E	Missense	1
Haematopoietic and lymphoid tissue	E1238*	Nonsense	1
Haematopoietic and lymphoid tissue	F1440L	Missense	1
Haematopoietic and lymphoid tissue	G221V	Missense	1
Haematopoietic and lymphoid tissue	M1625L	Missense	1
Haematopoietic and lymphoid tissue	M395T	Missense	1
Haematopoietic and lymphoid tissue	P901L	Missense	1
Haematopoietic and lymphoid tissue	P928A	Missense	1
Haematopoietic and lymphoid tissue	P975L	Missense	1
Haematopoietic and lymphoid tissue	Q1491K	Missense	1
Haematopoietic and lymphoid tissue	Q170*	Nonsense	1
Haematopoietic and lymphoid tissue	Q2045*	Nonsense	1
Haematopoietic and lymphoid tissue	Q790*	Nonsense	1
Haematopoietic and lymphoid tissue	R1360*	Nonsense	1
Haematopoietic and lymphoid tissue	R1446L	Missense	1
Haematopoietic and lymphoid tissue	S1108L	Missense	1
Haematopoietic and lymphoid tissue	S1432P	Missense	1
Haematopoietic and lymphoid tissue	S1687P	Missense	1
Haematopoietic and lymphoid tissue	T1332I	Missense	1
Haematopoietic and lymphoid tissue	V605M	Missense	1
Large intestine	A206V	Missense	1
Large intestine	H1804Y	Missense	1
Large intestine	M775I	Missense	1
Large intestine	P1150H	Missense	1
Large intestine	P1546H	Missense	1
Large intestine	P1952L	Missense	1
Large intestine	P2237T	Missense	1
Large intestine	P949L	Missense	1
Large intestine	Q1187*	Nonsense	1
Large intestine	Q482R	Missense	1
Large intestine	R1091H	Missense	1
Large intestine	R1169H	Missense	1
Large intestine	R1446H	Missense	1
Large intestine	R1664C	Missense	1
Large intestine	R2194Q	Missense	1
Large intestine	T1574A	Missense	1
Large intestine	T573A	Missense	1
Large intestine	V1405A	Missense	1
Liver	E1752*	Nonsense	1
Lung	A1824T	Missense	1
Lung	A805E	Missense	1
Lung	A921V	Missense	1
Lung	D1406H	Missense	1
Lung	H67R	Missense	1
Lung	I1600M	Missense	1
Lung	I1846M	Missense	1
Lung	K1086*	Nonsense	1
Lung	K1564E	Missense	1
Lung	L2026F	Missense	1
Lung	M1798I	Missense	1
Lung	N2175S	Missense	1
Lung	Q443*	Nonsense	1
Lung	R1446C	Missense	1
Lung	S2421F	Missense	1
Lung	W1472C	Missense	1
Oesophagus	M2053V	Missense	1
Oesophagus	Y1539C	Missense	1
Ovary	M1160V	Missense	1
Ovary	P1952L	Missense	1
Ovary	P248L	Missense	1
Ovary	P773L	Missense	1
Ovary	S893*	Nonsense	1
Prostate	A110V	Missense	1
Prostate	N192S	Missense	1
Skin	G740E	Missense	1
Skin	N1813D	Missense	1
Skin	P449L	Missense	1
Soft tissue	S1072F	Missense	1
Stomach	M493T	Missense	1
Thyroid	E1541*	Nonsense	1
Upper aerodigestive tract	Q1928E	Missense	1
Upper aerodigestive tract	Q943*	Nonsense	1
Upper aerodigestive tract	T2390N	Missense	1
Urinary tract	R1341Q	Missense	1
Urinary tract	R601Q	Missense	1

Mutational percentage of Silent,  Missense and  Nonsense for various cancer cell lines

Tissue Type	# Cell Line	% Silent	% Missense	% Nonsense
Autonomic ganglia	17	0	0	0
Biliary tract	7	0	1.2	0
Bone	25	0	0	0
Breast	58	0	1.2	6.2
Central nervous system	52	0	2.4	0
Endometrium	27	0	17.1	6.2
Haematopoietic and lymphoid tissue	178	0	19.5	31.2
Kidney	22	0	0	0
Large intestine	57	0	20.7	6.2
Liver	27	0	0	6.2
Lung	174	0	17.1	12.5
Oesophagus	25	0	2.4	0
Ovary	50	0	4.9	6.2
Pancreas	44	0	0	0
Pleura	10	0	0	0
Prostate	7	0	2.4	0
Salivary gland	2	0	0	0
Skin	60	0	3.7	0
Small intestine	1	0	0	0
Soft tissue	20	0	1.2	0
Stomach	38	0	1.2	0
Thyroid	12	0	0	6.2
Upper aerodigestive tract	30	0	2.4	18.8
Urinary tract	24	0	2.4	0