Silent
Missense
Nonsense
Frequency of SNVs in pancancer level
| Cancer Type | Mutation | Mutation Type | # Sample |
|---|---|---|---|
| Breast | V83I | Missense | 2 |
| Pancreas | R735L | Missense | 2 |
| Breast | E1119L | Missense | 1 |
| Breast | E1406K | Missense | 1 |
| Breast | G1372E | Missense | 1 |
| Breast | R1038T | Missense | 1 |
| Breast | S367C | Missense | 1 |
| Central nervous system | I332V | Missense | 1 |
| Endometrium | E1423K | Missense | 1 |
| Endometrium | R1404C | Missense | 1 |
| Endometrium | T587T | Silent | 1 |
| Endometrium | V302I | Missense | 1 |
| Haematopoietic and lymphoid tissue | F1434L | Missense | 1 |
| Haematopoietic and lymphoid tissue | H1477R | Missense | 1 |
| Haematopoietic and lymphoid tissue | L1488F | Missense | 1 |
| Haematopoietic and lymphoid tissue | N115I | Missense | 1 |
| Haematopoietic and lymphoid tissue | R557H | Missense | 1 |
| Haematopoietic and lymphoid tissue | V127I | Missense | 1 |
| Large intestine | A595S | Missense | 1 |
| Large intestine | D869G | Missense | 1 |
| Large intestine | H641R | Missense | 1 |
| Large intestine | L1225P | Missense | 1 |
| Large intestine | L1427F | Missense | 1 |
| Large intestine | P219L | Missense | 1 |
| Large intestine | P591P | Silent | 1 |
| Large intestine | Q33H | Missense | 1 |
| Large intestine | R176Q | Missense | 1 |
| Large intestine | R464Q | Missense | 1 |
| Large intestine | R612Q | Missense | 1 |
| Large intestine | R857* | Nonsense | 1 |
| Lung | A211S | Missense | 1 |
| Lung | D76V | Missense | 1 |
| Lung | F1437I | Missense | 1 |
| Lung | G108A | Missense | 1 |
| Lung | G431V | Missense | 1 |
| Lung | G514F | Missense | 1 |
| Lung | I692F | Missense | 1 |
| Lung | N999K | Missense | 1 |
| Lung | S1345L | Missense | 1 |
| Lung | S212I | Missense | 1 |
| Lung | S797C | Missense | 1 |
| Oesophagus | A1439P | Missense | 1 |
| Oesophagus | P740S | Missense | 1 |
| Ovary | E382V | Missense | 1 |
| Ovary | S864P | Missense | 1 |
| Pancreas | I422F | Missense | 1 |
| Pancreas | L799L | Silent | 1 |
| Prostate | F1437I | Missense | 1 |
| Prostate | Q794H | Missense | 1 |
| Prostate | Y776C | Missense | 1 |
| Skin | E495K | Missense | 1 |
| Skin | Q177R | Missense | 1 |
| Skin | R735L | Missense | 1 |
| Stomach | A1439P | Missense | 1 |
| Stomach | A235D | Missense | 1 |
| Stomach | D475Y | Missense | 1 |
| Stomach | L799L | Silent | 1 |
| Stomach | V99I | Missense | 1 |
| Upper aerodigestive tract | A211T | Missense | 1 |
| Upper aerodigestive tract | D532D | Silent | 1 |
| Upper aerodigestive tract | R557R | Silent | 1 |
| Upper aerodigestive tract | R735L | Missense | 1 |
| Urinary tract | L789V | Missense | 1 |
| Urinary tract | P500R | Missense | 1 |
Mutational percentage of Silent, Missense and Nonsense for various cancer cell lines
Summary of mutation in pancancer level
| Tissue Type | # Cell Line | % Silent | % Missense | % Nonsense |
|---|---|---|---|---|
| Autonomic ganglia | 17 | 0 | 0 | 0 |
| Biliary tract | 7 | 0 | 0 | 0 |
| Bone | 25 | 0 | 0 | 0 |
| Breast | 58 | 0 | 11.9 | 0 |
| Central nervous system | 52 | 0 | 1.7 | 0 |
| Endometrium | 27 | 16.7 | 5.1 | 0 |
| Haematopoietic and lymphoid tissue | 178 | 0 | 10.2 | 0 |
| Kidney | 22 | 0 | 0 | 0 |
| Large intestine | 57 | 16.7 | 16.9 | 100 |
| Liver | 27 | 0 | 0 | 0 |
| Lung | 174 | 0 | 18.6 | 0 |
| Oesophagus | 25 | 0 | 3.4 | 0 |
| Ovary | 50 | 0 | 3.4 | 0 |
| Pancreas | 44 | 16.7 | 5.1 | 0 |
| Pleura | 10 | 0 | 0 | 0 |
| Prostate | 7 | 0 | 5.1 | 0 |
| Salivary gland | 2 | 0 | 0 | 0 |
| Skin | 60 | 0 | 5.1 | 0 |
| Small intestine | 1 | 0 | 0 | 0 |
| Soft tissue | 20 | 0 | 0 | 0 |
| Stomach | 38 | 16.7 | 6.8 | 0 |
| Thyroid | 12 | 0 | 0 | 0 |
| Upper aerodigestive tract | 30 | 33.3 | 3.4 | 0 |
| Urinary tract | 24 | 0 | 3.4 | 0 |