Silent
Missense
Nonsense
Frequency of SNVs in pancancer level
| Cancer Type | Mutation | Mutation Type | # Sample |
|---|---|---|---|
| Large intestine | R361W | Missense | 2 |
| Endometrium | I380M | Missense | 1 |
| Endometrium | K464N | Missense | 1 |
| Endometrium | R172H | Missense | 1 |
| Endometrium | R174H | Missense | 1 |
| Haematopoietic and lymphoid tissue | P125L | Missense | 1 |
| Large intestine | F310F | Silent | 1 |
| Large intestine | F441V | Missense | 1 |
| Large intestine | K464N | Missense | 1 |
| Large intestine | R127Q | Missense | 1 |
| Large intestine | S21P | Missense | 1 |
| Lung | A154D | Missense | 1 |
| Lung | A224T | Missense | 1 |
| Lung | A589S | Missense | 1 |
| Lung | K373N | Missense | 1 |
| Lung | M157T | Missense | 1 |
| Lung | R316R | Silent | 1 |
| Pancreas | R400S | Missense | 1 |
| Skin | L434F | Missense | 1 |
| Skin | R361Q | Missense | 1 |
| Upper aerodigestive tract | A133A | Silent | 1 |
| Upper aerodigestive tract | H149H | Silent | 1 |
| Upper aerodigestive tract | H26H | Silent | 1 |
| Upper aerodigestive tract | L326L | Silent | 1 |
| Upper aerodigestive tract | N146N | Silent | 1 |
| Upper aerodigestive tract | P125P | Silent | 1 |
| Upper aerodigestive tract | T130T | Silent | 1 |
| Upper aerodigestive tract | V147V | Silent | 1 |
Mutational percentage of Silent, Missense and Nonsense for various cancer cell lines
Summary of mutation in pancancer level
| Tissue Type | # Cell Line | % Silent | % Missense | % Nonsense |
|---|---|---|---|---|
| Autonomic ganglia | 17 | 0 | 0 | 0 |
| Biliary tract | 7 | 0 | 0 | 0 |
| Bone | 25 | 0 | 0 | 0 |
| Breast | 58 | 0 | 0 | 0 |
| Central nervous system | 52 | 0 | 0 | 0 |
| Endometrium | 27 | 0 | 21.1 | 0 |
| Haematopoietic and lymphoid tissue | 178 | 0 | 5.3 | 0 |
| Kidney | 22 | 0 | 0 | 0 |
| Large intestine | 57 | 10 | 31.6 | 0 |
| Liver | 27 | 0 | 0 | 0 |
| Lung | 174 | 10 | 26.3 | 0 |
| Oesophagus | 25 | 0 | 0 | 0 |
| Ovary | 50 | 0 | 0 | 0 |
| Pancreas | 44 | 0 | 5.3 | 0 |
| Pleura | 10 | 0 | 0 | 0 |
| Prostate | 7 | 0 | 0 | 0 |
| Salivary gland | 2 | 0 | 0 | 0 |
| Skin | 60 | 0 | 10.5 | 0 |
| Small intestine | 1 | 0 | 0 | 0 |
| Soft tissue | 20 | 0 | 0 | 0 |
| Stomach | 38 | 0 | 0 | 0 |
| Thyroid | 12 | 0 | 0 | 0 |
| Upper aerodigestive tract | 30 | 80 | 0 | 0 |
| Urinary tract | 24 | 0 | 0 | 0 |