Silent
Missense
Nonsense
Frequency of SNVs in pancancer level
| Cancer | Full Name | Mutation | Mutation Type | Sample Number |
|---|---|---|---|---|
| BRCA | Breast invasive carcinoma | A1108A | Silent | 2 |
| PAAD | Pancreatic adenocarcinoma | V280F | Missense | 2 |
| UCEC | Uterine Corpus Endometrial Carcinoma | A369T | Missense | 2 |
| BLCA | Bladder urothelial carcinoma | C1045C | Silent | 1 |
| BLCA | Bladder urothelial carcinoma | C930C | Silent | 1 |
| BLCA | Bladder urothelial carcinoma | D512H | Missense | 1 |
| BLCA | Bladder urothelial carcinoma | E28Q | Missense | 1 |
| BLCA | Bladder urothelial carcinoma | F1254F | Silent | 1 |
| BLCA | Bladder urothelial carcinoma | I1187I | Silent | 1 |
| BLCA | Bladder urothelial carcinoma | I878I | Silent | 1 |
| BLCA | Bladder urothelial carcinoma | L143V | Missense | 1 |
| BLCA | Bladder urothelial carcinoma | L427L | Silent | 1 |
| BLCA | Bladder urothelial carcinoma | L519F | Missense | 1 |
| BLCA | Bladder urothelial carcinoma | R1054K | Missense | 1 |
| BLCA | Bladder urothelial carcinoma | R449T | Missense | 1 |
| BLCA | Bladder urothelial carcinoma | R490Q | Missense | 1 |
| BRCA | Breast invasive carcinoma | A283V | Missense | 1 |
| BRCA | Breast invasive carcinoma | C1256C | Silent | 1 |
| BRCA | Breast invasive carcinoma | D682D | Silent | 1 |
| BRCA | Breast invasive carcinoma | G1235A | Missense | 1 |
| BRCA | Breast invasive carcinoma | H257N | Missense | 1 |
| BRCA | Breast invasive carcinoma | K1262R | Missense | 1 |
| BRCA | Breast invasive carcinoma | L777R | Missense | 1 |
| BRCA | Breast invasive carcinoma | M293V | Missense | 1 |
| BRCA | Breast invasive carcinoma | S1031I | Missense | 1 |
| BRCA | Breast invasive carcinoma | S418S | Silent | 1 |
| BRCA | Breast invasive carcinoma | T699T | Silent | 1 |
| BRCA | Breast invasive carcinoma | V1046M | Missense | 1 |
| CESC | Cervical and endocervical cancers | A11A | Silent | 1 |
| CESC | Cervical and endocervical cancers | C1258C | Silent | 1 |
| CESC | Cervical and endocervical cancers | E235* | Nonsense | 1 |
| CESC | Cervical and endocervical cancers | F594L | Missense | 1 |
| CESC | Cervical and endocervical cancers | L724L | Silent | 1 |
| CESC | Cervical and endocervical cancers | S38L | Missense | 1 |
| CESC | Cervical and endocervical cancers | T974M | Missense | 1 |
| CESC | Cervical and endocervical cancers | V1140M | Missense | 1 |
| COAD | Colon adenocarcinoma | A369A | Silent | 1 |
| COAD | Colon adenocarcinoma | A43A | Silent | 1 |
| COAD | Colon adenocarcinoma | C630Y | Missense | 1 |
| COAD | Colon adenocarcinoma | D1178N | Missense | 1 |
| COAD | Colon adenocarcinoma | D1181D | Silent | 1 |
| COAD | Colon adenocarcinoma | K425N | Missense | 1 |
| COAD | Colon adenocarcinoma | L831M | Missense | 1 |
| COAD | Colon adenocarcinoma | R579W | Missense | 1 |
| COAD | Colon adenocarcinoma | R706R | Silent | 1 |
| COAD | Colon adenocarcinoma | S348L | Missense | 1 |
| COAD | Colon adenocarcinoma | S418S | Silent | 1 |
| COAD | Colon adenocarcinoma | V1063A | Missense | 1 |
| COAD | Colon adenocarcinoma | Y1173C | Missense | 1 |
| ESCA | Esophageal carcinoma | A988T | Missense | 1 |
| ESCA | Esophageal carcinoma | C1105C | Silent | 1 |
| ESCA | Esophageal carcinoma | D188Y | Missense | 1 |
| ESCA | Esophageal carcinoma | E1098D | Missense | 1 |
| ESCA | Esophageal carcinoma | F1213F | Silent | 1 |
| ESCA | Esophageal carcinoma | G341V | Missense | 1 |
| ESCA | Esophageal carcinoma | L143L | Silent | 1 |
| ESCA | Esophageal carcinoma | M541L | Missense | 1 |
| ESCA | Esophageal carcinoma | P1005L | Missense | 1 |
| ESCA | Esophageal carcinoma | P208P | Silent | 1 |
| GBM | Glioblastoma multiforme | A388A | Silent | 1 |
| HNSC | Head and Neck squamous cell carcinoma | A111A | Silent | 1 |
| HNSC | Head and Neck squamous cell carcinoma | A472A | Silent | 1 |
| HNSC | Head and Neck squamous cell carcinoma | D1188D | Silent | 1 |
| HNSC | Head and Neck squamous cell carcinoma | E1233K | Missense | 1 |
| HNSC | Head and Neck squamous cell carcinoma | E971* | Nonsense | 1 |
| HNSC | Head and Neck squamous cell carcinoma | F915L | Missense | 1 |
| HNSC | Head and Neck squamous cell carcinoma | L1078L | Silent | 1 |
| HNSC | Head and Neck squamous cell carcinoma | L519L | Silent | 1 |
| HNSC | Head and Neck squamous cell carcinoma | N950S | Missense | 1 |
| HNSC | Head and Neck squamous cell carcinoma | R523W | Missense | 1 |
| HNSC | Head and Neck squamous cell carcinoma | S242C | Missense | 1 |
| HNSC | Head and Neck squamous cell carcinoma | T171T | Silent | 1 |
| HNSC | Head and Neck squamous cell carcinoma | T206I | Missense | 1 |
| HNSC | Head and Neck squamous cell carcinoma | T295T | Silent | 1 |
| HNSC | Head and Neck squamous cell carcinoma | Y1242Y | Silent | 1 |
| KIRC | Kidney renal clear cell carcinoma | A43G | Missense | 1 |
| KIRC | Kidney renal clear cell carcinoma | A667A | Silent | 1 |
| LGG | Brain Lower Grade Glioma | D1166N | Missense | 1 |
| LGG | Brain Lower Grade Glioma | I826I | Silent | 1 |
| LGG | Brain Lower Grade Glioma | R1190W | Missense | 1 |
| LGG | Brain Lower Grade Glioma | R138M | Missense | 1 |
| LGG | Brain Lower Grade Glioma | R579W | Missense | 1 |
| LGG | Brain Lower Grade Glioma | R90Q | Missense | 1 |
| LIHC | Liver hepatocellular carcinoma | G873C | Missense | 1 |
| LIHC | Liver hepatocellular carcinoma | K161K | Silent | 1 |
| LIHC | Liver hepatocellular carcinoma | R552W | Missense | 1 |
| LIHC | Liver hepatocellular carcinoma | S1267G | Missense | 1 |
| LIHC | Liver hepatocellular carcinoma | T671M | Missense | 1 |
| LUAD | Lung adenocarcinoma | A1278S | Missense | 1 |
| LUAD | Lung adenocarcinoma | C1064C | Silent | 1 |
| LUAD | Lung adenocarcinoma | D1145Y | Missense | 1 |
| LUAD | Lung adenocarcinoma | D865V | Missense | 1 |
| LUAD | Lung adenocarcinoma | E314D | Missense | 1 |
| LUAD | Lung adenocarcinoma | G361C | Missense | 1 |
| LUAD | Lung adenocarcinoma | G676G | Silent | 1 |
| LUAD | Lung adenocarcinoma | G705R | Missense | 1 |
| LUAD | Lung adenocarcinoma | G705V | Missense | 1 |
| LUAD | Lung adenocarcinoma | H321D | Missense | 1 |
| LUAD | Lung adenocarcinoma | I126M | Missense | 1 |
| LUAD | Lung adenocarcinoma | K584E | Missense | 1 |
| LUAD | Lung adenocarcinoma | L489V | Missense | 1 |
| LUAD | Lung adenocarcinoma | Q1279P | Missense | 1 |
| LUAD | Lung adenocarcinoma | R1002S | Missense | 1 |
| LUAD | Lung adenocarcinoma | R736C | Missense | 1 |
| LUAD | Lung adenocarcinoma | S649S | Silent | 1 |
| LUAD | Lung adenocarcinoma | V119V | Silent | 1 |
| LUAD | Lung adenocarcinoma | V866I | Missense | 1 |
| LUSC | Lung squamous cell carcinoma | A193D | Missense | 1 |
| LUSC | Lung squamous cell carcinoma | H108L | Missense | 1 |
| LUSC | Lung squamous cell carcinoma | L298L | Silent | 1 |
| LUSC | Lung squamous cell carcinoma | P809L | Missense | 1 |
| LUSC | Lung squamous cell carcinoma | Q16L | Missense | 1 |
| LUSC | Lung squamous cell carcinoma | R1168* | Nonsense | 1 |
| OV | Ovarian serous cystadenocarcinoma | V1046V | Silent | 1 |
| PAAD | Pancreatic adenocarcinoma | C1153C | Silent | 1 |
| PAAD | Pancreatic adenocarcinoma | E1280E | Silent | 1 |
| PAAD | Pancreatic adenocarcinoma | N1194N | Silent | 1 |
| PAAD | Pancreatic adenocarcinoma | P655P | Silent | 1 |
| PAAD | Pancreatic adenocarcinoma | P677S | Missense | 1 |
| PAAD | Pancreatic adenocarcinoma | R138K | Missense | 1 |
| PCPG | Pheochromocytoma and Paraganglioma | G850R | Missense | 1 |
| READ | Rectum adenocarcinoma | A92V | Missense | 1 |
| READ | Rectum adenocarcinoma | V1029M | Missense | 1 |
| SKCM | Skin Cutaneous Melanoma | A1278A | Silent | 1 |
| SKCM | Skin Cutaneous Melanoma | A334V | Missense | 1 |
| SKCM | Skin Cutaneous Melanoma | A746A | Silent | 1 |
| SKCM | Skin Cutaneous Melanoma | A746V | Missense | 1 |
| SKCM | Skin Cutaneous Melanoma | E1283E | Silent | 1 |
| SKCM | Skin Cutaneous Melanoma | E384E | Silent | 1 |
| SKCM | Skin Cutaneous Melanoma | F1198F | Silent | 1 |
| SKCM | Skin Cutaneous Melanoma | F1227F | Silent | 1 |
| SKCM | Skin Cutaneous Melanoma | P1100P | Silent | 1 |
| SKCM | Skin Cutaneous Melanoma | P221S | Missense | 1 |
| SKCM | Skin Cutaneous Melanoma | P436L | Missense | 1 |
| SKCM | Skin Cutaneous Melanoma | P709S | Missense | 1 |
| SKCM | Skin Cutaneous Melanoma | S1069C | Missense | 1 |
| SKCM | Skin Cutaneous Melanoma | S1069S | Silent | 1 |
| SKCM | Skin Cutaneous Melanoma | S336S | Silent | 1 |
| SKCM | Skin Cutaneous Melanoma | S745F | Missense | 1 |
| SKCM | Skin Cutaneous Melanoma | S745S | Silent | 1 |
| SKCM | Skin Cutaneous Melanoma | T1150I | Missense | 1 |
| SKCM | Skin Cutaneous Melanoma | T1150S | Missense | 1 |
| SKCM | Skin Cutaneous Melanoma | T295I | Missense | 1 |
| SKCM | Skin Cutaneous Melanoma | V1152V | Silent | 1 |
| SKCM | Skin Cutaneous Melanoma | V211I | Missense | 1 |
| STAD | Stomach adenocarcinoma | A50A | Silent | 1 |
| STAD | Stomach adenocarcinoma | A675T | Missense | 1 |
| STAD | Stomach adenocarcinoma | A726T | Missense | 1 |
| STAD | Stomach adenocarcinoma | A780T | Missense | 1 |
| STAD | Stomach adenocarcinoma | A92T | Missense | 1 |
| STAD | Stomach adenocarcinoma | D359D | Silent | 1 |
| STAD | Stomach adenocarcinoma | D392D | Silent | 1 |
| STAD | Stomach adenocarcinoma | D668N | Missense | 1 |
| STAD | Stomach adenocarcinoma | D871D | Silent | 1 |
| STAD | Stomach adenocarcinoma | E413K | Missense | 1 |
| STAD | Stomach adenocarcinoma | G710S | Missense | 1 |
| STAD | Stomach adenocarcinoma | H1265Y | Missense | 1 |
| STAD | Stomach adenocarcinoma | H778H | Silent | 1 |
| STAD | Stomach adenocarcinoma | L356L | Silent | 1 |
| STAD | Stomach adenocarcinoma | N1027N | Silent | 1 |
| STAD | Stomach adenocarcinoma | Q135Q | Silent | 1 |
| STAD | Stomach adenocarcinoma | Q748Q | Silent | 1 |
| STAD | Stomach adenocarcinoma | R1230C | Missense | 1 |
| STAD | Stomach adenocarcinoma | R446Q | Missense | 1 |
| STAD | Stomach adenocarcinoma | R581H | Missense | 1 |
| STAD | Stomach adenocarcinoma | S1042P | Missense | 1 |
| STAD | Stomach adenocarcinoma | S625S | Silent | 1 |
| STAD | Stomach adenocarcinoma | T801I | Missense | 1 |
| STAD | Stomach adenocarcinoma | V1140M | Missense | 1 |
| STAD | Stomach adenocarcinoma | V1195A | Missense | 1 |
| STAD | Stomach adenocarcinoma | Y1185H | Missense | 1 |
| TGCT | Testicular Germ Cell Tumors | C1258C | Silent | 1 |
| TGCT | Testicular Germ Cell Tumors | V280F | Missense | 1 |
| UCEC | Uterine Corpus Endometrial Carcinoma | A624T | Missense | 1 |
| UCEC | Uterine Corpus Endometrial Carcinoma | A69A | Silent | 1 |
| UCEC | Uterine Corpus Endometrial Carcinoma | A69T | Missense | 1 |
| UCEC | Uterine Corpus Endometrial Carcinoma | A797T | Missense | 1 |
| UCEC | Uterine Corpus Endometrial Carcinoma | A837T | Missense | 1 |
| UCEC | Uterine Corpus Endometrial Carcinoma | A914V | Missense | 1 |
| UCEC | Uterine Corpus Endometrial Carcinoma | A934T | Missense | 1 |
| UCEC | Uterine Corpus Endometrial Carcinoma | D1066N | Missense | 1 |
| UCEC | Uterine Corpus Endometrial Carcinoma | D112N | Missense | 1 |
| UCEC | Uterine Corpus Endometrial Carcinoma | D113N | Missense | 1 |
| UCEC | Uterine Corpus Endometrial Carcinoma | E1032D | Missense | 1 |
| UCEC | Uterine Corpus Endometrial Carcinoma | E1170D | Missense | 1 |
| UCEC | Uterine Corpus Endometrial Carcinoma | E459D | Missense | 1 |
| UCEC | Uterine Corpus Endometrial Carcinoma | E481K | Missense | 1 |
| UCEC | Uterine Corpus Endometrial Carcinoma | K327E | Missense | 1 |
| UCEC | Uterine Corpus Endometrial Carcinoma | P208P | Silent | 1 |
| UCEC | Uterine Corpus Endometrial Carcinoma | R1081H | Missense | 1 |
| UCEC | Uterine Corpus Endometrial Carcinoma | R225Q | Missense | 1 |
| UCEC | Uterine Corpus Endometrial Carcinoma | R387H | Missense | 1 |
| UCEC | Uterine Corpus Endometrial Carcinoma | R90Q | Missense | 1 |
| UCEC | Uterine Corpus Endometrial Carcinoma | R951H | Missense | 1 |
| UCEC | Uterine Corpus Endometrial Carcinoma | S729S | Silent | 1 |
| UCEC | Uterine Corpus Endometrial Carcinoma | V285A | Missense | 1 |
Mutational percentage of Silent, Missense and Nonsense for various cancers
Summary of mutation in pancancer level
| Cancer | Full Name | # Sample | % Silent | % Missense | % Nonsense |
|---|---|---|---|---|---|
| BLCA | Bladder urothelial carcinoma | 394 | 8.5 | 5.6 | 0 |
| BRCA | Breast invasive carcinoma | 976 | 8.5 | 6.4 | 0 |
| CESC | Cervical and endocervical cancers | 194 | 4.2 | 3.2 | 33.3 |
| COAD | Colon adenocarcinoma | 367 | 7 | 6.4 | 0 |
| ESCA | Esophageal carcinoma | 185 | 5.6 | 4.8 | 0 |
| GBM | Glioblastoma multiforme | 283 | 1.4 | 0 | 0 |
| HNSC | Head and Neck squamous cell carcinoma | 511 | 11.3 | 4.8 | 33.3 |
| KIRC | Kidney renal clear cell carcinoma | 476 | 1.4 | 0.8 | 0 |
| KIRP | Kidney renal papillary cell carcinoma | 282 | 0 | 0 | 0 |
| LAML | Acute Myeloid Leukemia | 192 | 0 | 0 | 0 |
| LGG | Brain Lower Grade Glioma | 516 | 1.4 | 4 | 0 |
| LIHC | Liver hepatocellular carcinoma | 373 | 1.4 | 3.2 | 0 |
| LUAD | Lung adenocarcinoma | 533 | 5.6 | 12 | 0 |
| LUSC | Lung squamous cell carcinoma | 177 | 1.4 | 3.2 | 33.3 |
| OV | Ovarian serous cystadenocarcinoma | 465 | 1.4 | 0 | 0 |
| PAAD | Pancreatic adenocarcinoma | 126 | 5.6 | 3.2 | 0 |
| PCPG | Pheochromocytoma and Paraganglioma | 179 | 0 | 0.8 | 0 |
| PRAD | Prostate adenocarcinoma | 498 | 0 | 0 | 0 |
| READ | Rectum adenocarcinoma | 122 | 0 | 1.6 | 0 |
| SARC | Sarcoma | 247 | 0 | 0 | 0 |
| SKCM | Skin Cutaneous Melanoma | 290 | 15.5 | 8.8 | 0 |
| STAD | Stomach adenocarcinoma | 393 | 14.1 | 12.8 | 0 |
| TGCT | Testicular Germ Cell Tumors | 147 | 1.4 | 0.8 | 0 |
| THCA | Thyroid carcinoma | 495 | 0 | 0 | 0 |
| THYM | Thymoma | 119 | 0 | 0 | 0 |
| UCEC | Uterine Corpus Endometrial Carcinoma | 248 | 4.2 | 17.6 | 0 |