Silent
Missense
Nonsense
Frequency of SNVs in pancancer level
| Cancer | Full Name | Mutation | Mutation Type | Sample Number |
|---|---|---|---|---|
| COAD | Colon adenocarcinoma | R1365C | Missense | 3 |
| BLCA | Bladder urothelial carcinoma | E187Q | Missense | 2 |
| BLCA | Bladder urothelial carcinoma | *1684* | Silent | 1 |
| BLCA | Bladder urothelial carcinoma | D963N | Missense | 1 |
| BLCA | Bladder urothelial carcinoma | E1274K | Missense | 1 |
| BLCA | Bladder urothelial carcinoma | H278D | Missense | 1 |
| BLCA | Bladder urothelial carcinoma | K886N | Missense | 1 |
| BLCA | Bladder urothelial carcinoma | L1519L | Silent | 1 |
| BLCA | Bladder urothelial carcinoma | M185V | Missense | 1 |
| BLCA | Bladder urothelial carcinoma | Q1204Q | Silent | 1 |
| BLCA | Bladder urothelial carcinoma | R336* | Nonsense | 1 |
| BLCA | Bladder urothelial carcinoma | R571K | Missense | 1 |
| BLCA | Bladder urothelial carcinoma | R658L | Missense | 1 |
| BLCA | Bladder urothelial carcinoma | S1493L | Missense | 1 |
| BLCA | Bladder urothelial carcinoma | V395V | Silent | 1 |
| BRCA | Breast invasive carcinoma | A8V | Missense | 1 |
| BRCA | Breast invasive carcinoma | D14N | Missense | 1 |
| BRCA | Breast invasive carcinoma | D667N | Missense | 1 |
| BRCA | Breast invasive carcinoma | E1298Q | Missense | 1 |
| BRCA | Breast invasive carcinoma | K887K | Silent | 1 |
| BRCA | Breast invasive carcinoma | K951K | Silent | 1 |
| BRCA | Breast invasive carcinoma | L176L | Silent | 1 |
| BRCA | Breast invasive carcinoma | R1091C | Missense | 1 |
| BRCA | Breast invasive carcinoma | R1361* | Nonsense | 1 |
| BRCA | Breast invasive carcinoma | R392Q | Missense | 1 |
| BRCA | Breast invasive carcinoma | R7G | Missense | 1 |
| BRCA | Breast invasive carcinoma | V76L | Missense | 1 |
| CESC | Cervical and endocervical cancers | D172N | Missense | 1 |
| CESC | Cervical and endocervical cancers | P973S | Missense | 1 |
| CESC | Cervical and endocervical cancers | S556F | Missense | 1 |
| COAD | Colon adenocarcinoma | C1229Y | Missense | 1 |
| COAD | Colon adenocarcinoma | D558D | Silent | 1 |
| COAD | Colon adenocarcinoma | E1151* | Nonsense | 1 |
| COAD | Colon adenocarcinoma | E118* | Nonsense | 1 |
| COAD | Colon adenocarcinoma | K199Q | Missense | 1 |
| COAD | Colon adenocarcinoma | P82P | Silent | 1 |
| COAD | Colon adenocarcinoma | Q1438R | Missense | 1 |
| COAD | Colon adenocarcinoma | R1052C | Missense | 1 |
| COAD | Colon adenocarcinoma | R1103* | Nonsense | 1 |
| COAD | Colon adenocarcinoma | R1479C | Missense | 1 |
| COAD | Colon adenocarcinoma | R573C | Missense | 1 |
| COAD | Colon adenocarcinoma | R658H | Missense | 1 |
| COAD | Colon adenocarcinoma | R794R | Silent | 1 |
| COAD | Colon adenocarcinoma | S1657T | Missense | 1 |
| COAD | Colon adenocarcinoma | Y564H | Missense | 1 |
| ESCA | Esophageal carcinoma | E27K | Missense | 1 |
| ESCA | Esophageal carcinoma | E404K | Missense | 1 |
| ESCA | Esophageal carcinoma | G458* | Nonsense | 1 |
| ESCA | Esophageal carcinoma | P1218P | Silent | 1 |
| ESCA | Esophageal carcinoma | Q729L | Missense | 1 |
| GBM | Glioblastoma multiforme | E342K | Missense | 1 |
| GBM | Glioblastoma multiforme | I1543T | Missense | 1 |
| HNSC | Head and Neck squamous cell carcinoma | D294Y | Missense | 1 |
| HNSC | Head and Neck squamous cell carcinoma | D640N | Missense | 1 |
| HNSC | Head and Neck squamous cell carcinoma | F623V | Missense | 1 |
| HNSC | Head and Neck squamous cell carcinoma | I1080M | Missense | 1 |
| HNSC | Head and Neck squamous cell carcinoma | I253T | Missense | 1 |
| HNSC | Head and Neck squamous cell carcinoma | K423N | Missense | 1 |
| HNSC | Head and Neck squamous cell carcinoma | K71K | Silent | 1 |
| HNSC | Head and Neck squamous cell carcinoma | L1078L | Silent | 1 |
| HNSC | Head and Neck squamous cell carcinoma | L304F | Missense | 1 |
| HNSC | Head and Neck squamous cell carcinoma | L386P | Missense | 1 |
| HNSC | Head and Neck squamous cell carcinoma | P413P | Silent | 1 |
| HNSC | Head and Neck squamous cell carcinoma | Q749H | Missense | 1 |
| HNSC | Head and Neck squamous cell carcinoma | R776L | Missense | 1 |
| HNSC | Head and Neck squamous cell carcinoma | R793C | Missense | 1 |
| HNSC | Head and Neck squamous cell carcinoma | R7H | Missense | 1 |
| HNSC | Head and Neck squamous cell carcinoma | S1168C | Missense | 1 |
| HNSC | Head and Neck squamous cell carcinoma | V293V | Silent | 1 |
| HNSC | Head and Neck squamous cell carcinoma | Y1106F | Missense | 1 |
| KIRC | Kidney renal clear cell carcinoma | N250K | Missense | 1 |
| KIRP | Kidney renal papillary cell carcinoma | A821A | Silent | 1 |
| KIRP | Kidney renal papillary cell carcinoma | R1437P | Missense | 1 |
| LGG | Brain Lower Grade Glioma | Q1557Q | Silent | 1 |
| LGG | Brain Lower Grade Glioma | Q286* | Nonsense | 1 |
| LGG | Brain Lower Grade Glioma | R443C | Missense | 1 |
| LIHC | Liver hepatocellular carcinoma | E178V | Missense | 1 |
| LIHC | Liver hepatocellular carcinoma | F1191S | Missense | 1 |
| LIHC | Liver hepatocellular carcinoma | H1230N | Missense | 1 |
| LIHC | Liver hepatocellular carcinoma | H891R | Missense | 1 |
| LIHC | Liver hepatocellular carcinoma | K697R | Missense | 1 |
| LIHC | Liver hepatocellular carcinoma | L129F | Missense | 1 |
| LIHC | Liver hepatocellular carcinoma | P45P | Silent | 1 |
| LIHC | Liver hepatocellular carcinoma | S1054P | Missense | 1 |
| LUAD | Lung adenocarcinoma | D656H | Missense | 1 |
| LUAD | Lung adenocarcinoma | D766H | Missense | 1 |
| LUAD | Lung adenocarcinoma | F701L | Missense | 1 |
| LUAD | Lung adenocarcinoma | G1425E | Missense | 1 |
| LUAD | Lung adenocarcinoma | G1440E | Missense | 1 |
| LUAD | Lung adenocarcinoma | G183D | Missense | 1 |
| LUAD | Lung adenocarcinoma | G458* | Nonsense | 1 |
| LUAD | Lung adenocarcinoma | H208L | Missense | 1 |
| LUAD | Lung adenocarcinoma | I1086I | Silent | 1 |
| LUAD | Lung adenocarcinoma | I370S | Missense | 1 |
| LUAD | Lung adenocarcinoma | K568N | Missense | 1 |
| LUAD | Lung adenocarcinoma | L1079F | Missense | 1 |
| LUAD | Lung adenocarcinoma | M168V | Missense | 1 |
| LUAD | Lung adenocarcinoma | P125P | Silent | 1 |
| LUAD | Lung adenocarcinoma | P45Q | Missense | 1 |
| LUAD | Lung adenocarcinoma | Q286P | Missense | 1 |
| LUAD | Lung adenocarcinoma | Q979H | Missense | 1 |
| LUAD | Lung adenocarcinoma | R1560H | Missense | 1 |
| LUAD | Lung adenocarcinoma | R793P | Missense | 1 |
| LUAD | Lung adenocarcinoma | S2I | Missense | 1 |
| LUAD | Lung adenocarcinoma | S460F | Missense | 1 |
| LUAD | Lung adenocarcinoma | S725Y | Missense | 1 |
| LUAD | Lung adenocarcinoma | S927F | Missense | 1 |
| LUAD | Lung adenocarcinoma | T352T | Silent | 1 |
| LUAD | Lung adenocarcinoma | T507S | Missense | 1 |
| LUAD | Lung adenocarcinoma | V774V | Silent | 1 |
| LUSC | Lung squamous cell carcinoma | A1043T | Missense | 1 |
| LUSC | Lung squamous cell carcinoma | E764* | Nonsense | 1 |
| LUSC | Lung squamous cell carcinoma | K173N | Missense | 1 |
| LUSC | Lung squamous cell carcinoma | L1532V | Missense | 1 |
| LUSC | Lung squamous cell carcinoma | P984T | Missense | 1 |
| LUSC | Lung squamous cell carcinoma | Q1160Q | Silent | 1 |
| LUSC | Lung squamous cell carcinoma | Q122H | Missense | 1 |
| LUSC | Lung squamous cell carcinoma | R1235K | Missense | 1 |
| LUSC | Lung squamous cell carcinoma | R658S | Missense | 1 |
| LUSC | Lung squamous cell carcinoma | S742T | Missense | 1 |
| OV | Ovarian serous cystadenocarcinoma | A717T | Missense | 1 |
| PAAD | Pancreatic adenocarcinoma | A1614T | Missense | 1 |
| PAAD | Pancreatic adenocarcinoma | E1681E | Silent | 1 |
| PAAD | Pancreatic adenocarcinoma | G190W | Missense | 1 |
| PAAD | Pancreatic adenocarcinoma | K586Q | Missense | 1 |
| PAAD | Pancreatic adenocarcinoma | T1597T | Silent | 1 |
| PCPG | Pheochromocytoma and Paraganglioma | L795I | Missense | 1 |
| PRAD | Prostate adenocarcinoma | A1226P | Missense | 1 |
| PRAD | Prostate adenocarcinoma | E1329K | Missense | 1 |
| PRAD | Prostate adenocarcinoma | R658R | Silent | 1 |
| PRAD | Prostate adenocarcinoma | Y474Y | Silent | 1 |
| READ | Rectum adenocarcinoma | C632S | Missense | 1 |
| READ | Rectum adenocarcinoma | E430K | Missense | 1 |
| READ | Rectum adenocarcinoma | E537* | Nonsense | 1 |
| READ | Rectum adenocarcinoma | R5W | Missense | 1 |
| READ | Rectum adenocarcinoma | R671C | Missense | 1 |
| READ | Rectum adenocarcinoma | R776H | Missense | 1 |
| READ | Rectum adenocarcinoma | S142I | Missense | 1 |
| SARC | Sarcoma | E358G | Missense | 1 |
| SARC | Sarcoma | F701S | Missense | 1 |
| SARC | Sarcoma | R936G | Missense | 1 |
| SKCM | Skin Cutaneous Melanoma | A299S | Missense | 1 |
| SKCM | Skin Cutaneous Melanoma | E1215K | Missense | 1 |
| SKCM | Skin Cutaneous Melanoma | I769I | Silent | 1 |
| SKCM | Skin Cutaneous Melanoma | K113E | Missense | 1 |
| SKCM | Skin Cutaneous Melanoma | K951E | Missense | 1 |
| SKCM | Skin Cutaneous Melanoma | L462F | Missense | 1 |
| SKCM | Skin Cutaneous Melanoma | L636L | Silent | 1 |
| SKCM | Skin Cutaneous Melanoma | P1583P | Silent | 1 |
| SKCM | Skin Cutaneous Melanoma | P595S | Missense | 1 |
| SKCM | Skin Cutaneous Melanoma | P889S | Missense | 1 |
| SKCM | Skin Cutaneous Melanoma | R882G | Missense | 1 |
| SKCM | Skin Cutaneous Melanoma | S1488L | Missense | 1 |
| SKCM | Skin Cutaneous Melanoma | S93S | Silent | 1 |
| STAD | Stomach adenocarcinoma | C1244C | Silent | 1 |
| STAD | Stomach adenocarcinoma | D545D | Silent | 1 |
| STAD | Stomach adenocarcinoma | E919K | Missense | 1 |
| STAD | Stomach adenocarcinoma | G1093G | Silent | 1 |
| STAD | Stomach adenocarcinoma | G587E | Missense | 1 |
| STAD | Stomach adenocarcinoma | H1070R | Missense | 1 |
| STAD | Stomach adenocarcinoma | H1598R | Missense | 1 |
| STAD | Stomach adenocarcinoma | K1010T | Missense | 1 |
| STAD | Stomach adenocarcinoma | L696L | Silent | 1 |
| STAD | Stomach adenocarcinoma | P413P | Silent | 1 |
| STAD | Stomach adenocarcinoma | R1163* | Nonsense | 1 |
| STAD | Stomach adenocarcinoma | R1184H | Missense | 1 |
| STAD | Stomach adenocarcinoma | R1348C | Missense | 1 |
| STAD | Stomach adenocarcinoma | R1363T | Missense | 1 |
| STAD | Stomach adenocarcinoma | R793C | Missense | 1 |
| STAD | Stomach adenocarcinoma | R976M | Missense | 1 |
| STAD | Stomach adenocarcinoma | S134S | Silent | 1 |
| STAD | Stomach adenocarcinoma | V1145V | Silent | 1 |
| STAD | Stomach adenocarcinoma | V774A | Missense | 1 |
| STAD | Stomach adenocarcinoma | Y474Y | Silent | 1 |
| TGCT | Testicular Germ Cell Tumors | L1066I | Missense | 1 |
| TGCT | Testicular Germ Cell Tumors | Q911K | Missense | 1 |
| UCEC | Uterine Corpus Endometrial Carcinoma | C826R | Missense | 1 |
| UCEC | Uterine Corpus Endometrial Carcinoma | D69E | Missense | 1 |
| UCEC | Uterine Corpus Endometrial Carcinoma | E1181D | Missense | 1 |
| UCEC | Uterine Corpus Endometrial Carcinoma | E622* | Nonsense | 1 |
| UCEC | Uterine Corpus Endometrial Carcinoma | F411C | Missense | 1 |
| UCEC | Uterine Corpus Endometrial Carcinoma | H1383R | Missense | 1 |
| UCEC | Uterine Corpus Endometrial Carcinoma | I91M | Missense | 1 |
| UCEC | Uterine Corpus Endometrial Carcinoma | K1659R | Missense | 1 |
| UCEC | Uterine Corpus Endometrial Carcinoma | L487L | Silent | 1 |
| UCEC | Uterine Corpus Endometrial Carcinoma | L719L | Silent | 1 |
| UCEC | Uterine Corpus Endometrial Carcinoma | L762L | Silent | 1 |
| UCEC | Uterine Corpus Endometrial Carcinoma | L858I | Missense | 1 |
| UCEC | Uterine Corpus Endometrial Carcinoma | P1431H | Missense | 1 |
| UCEC | Uterine Corpus Endometrial Carcinoma | P1604L | Missense | 1 |
| UCEC | Uterine Corpus Endometrial Carcinoma | P413Q | Missense | 1 |
| UCEC | Uterine Corpus Endometrial Carcinoma | R1163* | Nonsense | 1 |
| UCEC | Uterine Corpus Endometrial Carcinoma | R1283* | Nonsense | 1 |
| UCEC | Uterine Corpus Endometrial Carcinoma | R1560P | Missense | 1 |
| UCEC | Uterine Corpus Endometrial Carcinoma | R573C | Missense | 1 |
| UCEC | Uterine Corpus Endometrial Carcinoma | R776H | Missense | 1 |
| UCEC | Uterine Corpus Endometrial Carcinoma | S251Y | Missense | 1 |
| UCEC | Uterine Corpus Endometrial Carcinoma | T1195P | Missense | 1 |
| UCEC | Uterine Corpus Endometrial Carcinoma | V65M | Missense | 1 |
| UCEC | Uterine Corpus Endometrial Carcinoma | Y514D | Missense | 1 |
Mutational percentage of Silent, Missense and Nonsense for various cancers
Summary of mutation in pancancer level
| Cancer | Full Name | # Sample | % Silent | % Missense | % Nonsense |
|---|---|---|---|---|---|
| BLCA | Bladder urothelial carcinoma | 394 | 9.5 | 6.8 | 7.1 |
| BRCA | Breast invasive carcinoma | 976 | 7.1 | 5.4 | 7.1 |
| CESC | Cervical and endocervical cancers | 194 | 0 | 2 | 0 |
| COAD | Colon adenocarcinoma | 367 | 7.1 | 8.2 | 21.4 |
| ESCA | Esophageal carcinoma | 185 | 2.4 | 2 | 7.1 |
| GBM | Glioblastoma multiforme | 283 | 0 | 1.4 | 0 |
| HNSC | Head and Neck squamous cell carcinoma | 511 | 9.5 | 9.5 | 0 |
| KIRC | Kidney renal clear cell carcinoma | 476 | 0 | 0.7 | 0 |
| KIRP | Kidney renal papillary cell carcinoma | 282 | 2.4 | 0.7 | 0 |
| LAML | Acute Myeloid Leukemia | 192 | 0 | 0 | 0 |
| LGG | Brain Lower Grade Glioma | 516 | 2.4 | 0.7 | 7.1 |
| LIHC | Liver hepatocellular carcinoma | 373 | 2.4 | 4.8 | 0 |
| LUAD | Lung adenocarcinoma | 533 | 9.5 | 14.3 | 7.1 |
| LUSC | Lung squamous cell carcinoma | 177 | 2.4 | 5.4 | 7.1 |
| OV | Ovarian serous cystadenocarcinoma | 465 | 0 | 0.7 | 0 |
| PAAD | Pancreatic adenocarcinoma | 126 | 4.8 | 2 | 0 |
| PCPG | Pheochromocytoma and Paraganglioma | 179 | 0 | 0.7 | 0 |
| PRAD | Prostate adenocarcinoma | 498 | 4.8 | 1.4 | 0 |
| READ | Rectum adenocarcinoma | 122 | 0 | 4.1 | 7.1 |
| SARC | Sarcoma | 247 | 0 | 2 | 0 |
| SKCM | Skin Cutaneous Melanoma | 290 | 9.5 | 6.1 | 0 |
| STAD | Stomach adenocarcinoma | 393 | 19 | 7.5 | 7.1 |
| TGCT | Testicular Germ Cell Tumors | 147 | 0 | 1.4 | 0 |
| THCA | Thyroid carcinoma | 495 | 0 | 0 | 0 |
| THYM | Thymoma | 119 | 0 | 0 | 0 |
| UCEC | Uterine Corpus Endometrial Carcinoma | 248 | 7.1 | 12.2 | 21.4 |