microRNA information: hsa-let-7b-3p

SectionIDlink
Mature name: hsa-let-7b-3pmiRbase
Accession: MIMAT0004482miRbase
Precursor name: hsa-let-7b miRbase
Precursor accession: MI0000063miRbase
Symbol: MIRLET7BHGNC
RefSeq ID: NR_029479GenBank
Sequence: CUAUACAACCUACUGCCUUCCC



Reported expression in cancers: hsa-let-7b-3p

miRNAcancerregulationreportingPUBMEDmethod
hsa-let-7b-3p

acute myeloid leukemiadownregulation"Among them miR-128a and -128b are significantly ov ......"18056805qPCR
hsa-let-7b-3p

breast cancerdownregulation"Previously we found that let-7 miRNAs were downreg ......"21826373
hsa-let-7b-3p

breast cancerdownregulation"The heterochronic microRNA let 7 inhibits cell mot ......"23339187
hsa-let-7b-3p

breast cancerdownregulation"Breast cancer specific TRAIL expression mediated b ......"25150312qPCR
hsa-let-7b-3p

colon cancerdownregulation"Recently let-7 miRNAs were found to regulate human ......"16651716
hsa-let-7b-3p

colorectal cancerupregulation"Of the 99 mCRC patients we studied differential mi ......"23098991Microarray
hsa-let-7b-3p

colorectal cancerupregulation"High expression of let-7 g was associated with a g ......"23932154
hsa-let-7b-3p

head and neck cancerderegulation"Significance was determined using significance ana ......"18798260Microarray
hsa-let-7b-3p

liver cancerdownregulation"In present study we found that the tumor suppresso ......"21814544
hsa-let-7b-3p

liver cancerdownregulation"Downregulation of let-7 miRNA in many human cancer ......"22289550
hsa-let-7b-3p

liver cancerdownregulation"Let-7 family microRNAs have been reported to be do ......"24724096
hsa-let-7b-3p

lung cancerdownregulation"Reduced expression of the let 7 microRNAs in human ......"15172979
hsa-let-7b-3p

lung cancerdownregulation"Suppression of non small cell lung tumor developme ......"18308936
hsa-let-7b-3p

lung cancerdownregulation"Indeed some transcripts of the let-7 family that a ......"19275611
hsa-let-7b-3p

lung cancerdownregulation"Down-regulation of let-7 microRNA miRNA plays an i ......"20033209
hsa-let-7b-3p

lung cancerdownregulation"Most miRs including all members of the let-7 famil ......"20068076qPCR
hsa-let-7b-3p

lung cancerdownregulation"let 7b and miR 126 are down regulated in tumor tis ......"23029111qPCR
hsa-let-7b-3p

melanomadownregulation"A microRNA expression screen was performed analyzi ......"18379589qPCR
hsa-let-7b-3p

ovarian cancerdownregulation"Using microRNA microarrays we identify several miR ......"18560586Microarray
hsa-let-7b-3p

ovarian cancerdownregulation"The aim of this study was to find specific profile ......"23542579Microarray; qPCR
hsa-let-7b-3p

pancreatic cancerupregulation"The rapamycin effects centered on decreased mTOR-r ......"25576058
hsa-let-7b-3p

prostate cancerdownregulation"Previous work has shown reduced expression levels ......"20418948
hsa-let-7b-3p

prostate cancerdownregulation"Multiple tumor-suppressive miRNAs were downregulat ......"22719071
hsa-let-7b-3p

sarcomadownregulation"We detected decreased expression levels of some le ......"21412931



Reported cancer pathway affected by hsa-let-7b-3p

miRNAcancerpathwayreportingPUBMEDfunctional study
hsa-let-7b-3p

breast cancerWnt signaling pathway; Apoptosis pathway; Notch signaling pathway"The miRNAs and their clusters such as the miR-200 ......"26712794
hsa-let-7b-3p

breast cancerApoptosis pathway"The tumor-suppressive let-7 family of microRNAs mi ......"27574028Western blot; Luciferase
hsa-let-7b-3p

esophageal cancerEpithelial mesenchymal transition pathway"HMGA2 is down regulated by microRNA let 7 and asso ......"24612219
hsa-let-7b-3p

head and neck cancerEpithelial mesenchymal transition pathway"The tumour suppressor roles of the let-7 family th ......"23340306
hsa-let-7b-3p

liver cancerApoptosis pathway"The let 7 family of microRNAs inhibits Bcl xL expr ......"20347499Western blot
hsa-let-7b-3p

lung cancercell cycle pathway"Reduced miR 31 and let 7 maintain the balance betw ......"22301433
hsa-let-7b-3p

lung cancerEpithelial mesenchymal transition pathway"Specifically let-7 and miR-9 are deregulated in bo ......"23365639
hsa-let-7b-3p

lung cancerApoptosis pathway"Specifically following HDAC inhibition MYC which n ......"26915294
hsa-let-7b-3p

lung squamous cell cancercell cycle pathway"Flow cytometry analysis revealed these miRNAs indu ......"19688090Flow cytometry
hsa-let-7b-3p

melanomacell cycle pathway"MicroRNA let 7b targets important cell cycle molec ......"18379589
hsa-let-7b-3p

melanomaEpithelial mesenchymal transition pathway"An exploratory miRNA analysis of 666 miRs by low d ......"20302635
hsa-let-7b-3p

melanomaApoptosis pathway"Let 7b and microRNA 199a inhibit the proliferation ......"23162627
hsa-let-7b-3p

pancreatic cancercell cycle pathway"The rapamycin effects centered on decreased mTOR-r ......"25576058
hsa-let-7b-3p

pancreatic cancercell cycle pathway"LIN28B suppresses microRNA let 7b expression to pr ......"26609473Flow cytometry; RNAi
hsa-let-7b-3p

prostate cancercell cycle pathway"Distinct microRNA expression profiles in prostate ......"22719071
hsa-let-7b-3p

retinoblastomacell cycle pathway"In addition hsa-miR-25 hsa-miR-18a and hsa-miR-20a ......"26730174
hsa-let-7b-3p

sarcomaEpithelial mesenchymal transition pathway"Using miRNA microarrays capable of detecting a kno ......"24457375Cell proliferation assay; Cell Proliferation Assay



Reported cancer prognosis affected by hsa-let-7b-3p

miRNAcancerprognosisreportingPUBMEDfunctional study
hsa-let-7b-3p

acute myeloid leukemiadifferentiation"We studied miRNA expression of leukemic blasts of ......"20425795
hsa-let-7b-3p

bladder cancerpoor survival"A let 7 microRNA binding site polymorphism in the ......"27620744
hsa-let-7b-3p

breast cancertumorigenesis; staging; malignant trasformation"Let 7 family miRNAs regulate estrogen receptor alp ......"20535543Luciferase
hsa-let-7b-3p

breast cancermetastasis"To identify microRNAs miRNA involved in metastasis ......"21057539
hsa-let-7b-3p

breast cancerdrug resistance"let 7 microRNAs induce tamoxifen sensitivity by do ......"21826373Luciferase
hsa-let-7b-3p

breast cancertumorigenesis"LIN28: a regulator of tumor suppressing activity o ......"22081076
hsa-let-7b-3p

breast cancermotility; metastasis; cell migration"The heterochronic microRNA let 7 inhibits cell mot ......"23339187
hsa-let-7b-3p

breast cancermalignant trasformation"Here we identified 33 miRNAs with similar deregula ......"24104550
hsa-let-7b-3p

breast cancerdrug resistance"Breast cancer specific TRAIL expression mediated b ......"25150312Luciferase
hsa-let-7b-3p

breast cancermetastasis; motility"Among these we identified miRNAs previously associ ......"25277099
hsa-let-7b-3p

breast cancerrecurrence"Multiple Let-7 family members were negatively corr ......"26717565
hsa-let-7b-3p

breast cancerdrug resistance"Specifically we will discuss key miRNAs involved i ......"27721895
hsa-let-7b-3p

colon cancerstaging"Association study of the let 7 miRNA complementary ......"24727325
hsa-let-7b-3p

colon cancermetastasis"Nine dysregulated miRNA pairs fell into three miRN ......"25287248
hsa-let-7b-3p

colorectal cancerpoor survival"Genetic modulation of the Let 7 microRNA binding t ......"20177422
hsa-let-7b-3p

colorectal cancerdrug resistance; poor survival"A let 7 microRNA binding site polymorphism in 3' u ......"20603437
hsa-let-7b-3p

colorectal cancerdrug resistance"We investigated this issue by profiling the expres ......"20881268
hsa-let-7b-3p

colorectal cancerstaging; poor survival"A let 7 microRNA SNP in the KRAS 3'UTR is prognost ......"21994416
hsa-let-7b-3p

colorectal cancermetastasis"We investigated expression of the reported metasta ......"22120473
hsa-let-7b-3p

colorectal cancerdrug resistance"The LCS6 polymorphism in the binding site of let 7 ......"23324806
hsa-let-7b-3p

colorectal cancerworse prognosis"High expression of let-7 g was associated with a g ......"23932154
hsa-let-7b-3p

colorectal cancermetastasis"We investigated the expression of metastasis-assoc ......"24653631
hsa-let-7b-3p

colorectal cancerdrug resistance"We identified a miRNA profile that was analysed by ......"25197016
hsa-let-7b-3p

colorectal cancerstaging"We performed miRNA profiling of 1547 human miRNAs ......"26045793
hsa-let-7b-3p

colorectal cancerprogression"rs712 polymorphism within let 7 microRNA binding s ......"26543374
hsa-let-7b-3p

colorectal cancerprogression"Of these 3 upregulated let-7b miR-1290 and miR-126 ......"27698796
hsa-let-7b-3p

colorectal cancerpoor survival; immune evasion; immune resistance; worse prognosis"MicroRNA let 7 T cells and patient survival in col ......"27737877
hsa-let-7b-3p

esophageal cancermetastasis; tumorigenesis"Role of microRNA let 7 and effect to HMGA2 in esop ......"21598109Western blot
hsa-let-7b-3p

gastric cancermetastasis; tumorigenesis"Let 7 microRNA family is selectively secreted into ......"20949044Western blot
hsa-let-7b-3p

gastric cancermetastasis; tumorigenesis"MicroRNA let 7b suppresses human gastric cancer ma ......"25613480Luciferase; Western blot
hsa-let-7b-3p

head and neck cancermetastasis; poor survival"Let-7 has been shown to function as a tumour suppr ......"21292542
hsa-let-7b-3p

liver cancermotility; drug resistance"We evaluated the expression of microRNA in human H ......"21352471
hsa-let-7b-3p

liver cancertumorigenesis"In the present study we analyzed mCRP expression i ......"24297460Western blot
hsa-let-7b-3p

lung cancerpoor survival"Reduced expression of the let 7 microRNAs in human ......"15172979
hsa-let-7b-3p

lung cancerdifferentiation"Reduced miR 31 and let 7 maintain the balance betw ......"22301433
hsa-let-7b-3p

lung cancerpoor survival"let 7b and miR 126 are down regulated in tumor tis ......"23029111
hsa-let-7b-3p

lung cancerdrug resistance"For better understanding of the cellular response ......"25451482
hsa-let-7b-3p

lung cancerpoor survival"Specifically following HDAC inhibition MYC which n ......"26915294
hsa-let-7b-3p

lung squamous cell cancerprogression"Flow cytometry analysis revealed these miRNAs indu ......"19688090Flow cytometry
hsa-let-7b-3p

lung squamous cell cancermetastasis; staging; poor survival"Different members of let-7 family have been report ......"23981581
hsa-let-7b-3p

lung squamous cell cancerpoor survival"Systemic nanodelivery of miR-34 and let-7 suppress ......"25174400
hsa-let-7b-3p

lung squamous cell cancerdrug resistance"Combinatorial Action of MicroRNAs let 7 and miR 34 ......"25714397
hsa-let-7b-3p

melanomamalignant trasformation; progression"MicroRNA let 7b targets important cell cycle molec ......"18379589
hsa-let-7b-3p

melanomametastasis; differentiation"An exploratory miRNA analysis of 666 miRs by low d ......"20302635
hsa-let-7b-3p

melanomaprogression"In situ analysis of melanoma samples using progres ......"23728176
hsa-let-7b-3p

melanomadifferentiation"Let-7 microRNAs miRNAs are highly conserved well-e ......"25669981
hsa-let-7b-3p

ovarian cancerworse prognosis"The microRNA expression profiles were examined usi ......"18451233
hsa-let-7b-3p

ovarian cancerworse prognosis"We highlight the role of the let-7 and miR-200 fam ......"20083225
hsa-let-7b-3p

ovarian cancerdrug resistance"Luciferase assays and real-time PCRs showed that t ......"21109987Luciferase
hsa-let-7b-3p

ovarian cancerdrug resistance"Let-7 is a family of small non-coding RNAs regulat ......"21571355
hsa-let-7b-3p

ovarian cancerworse prognosis; staging"Two families of miRNAs miR-200 and let-7 are frequ ......"23237306
hsa-let-7b-3p

ovarian cancerdifferentiation"These overwhelmingly observed oncogenic genes were ......"24129674
hsa-let-7b-3p

ovarian cancertumorigenesis"To explore miRNAs involved in the tumorigenesis in ......"25273528
hsa-let-7b-3p

ovarian cancermotility"LncRNA HOST2 regulates cell biological behaviors i ......"25292198
hsa-let-7b-3p

pancreatic cancerprogression"let 7 MicroRNA transfer in pancreatic cancer deriv ......"19323605
hsa-let-7b-3p

pancreatic cancerpoor survival"The expression of miR-21 was significantly higher ......"21139804
hsa-let-7b-3p

pancreatic cancertumorigenesis"miR-122 let-7 family and miR-101 are down-regulate ......"22303361
hsa-let-7b-3p

pancreatic cancermetastasis"We therefore established a screening strategy to f ......"23733161Western blot
hsa-let-7b-3p

pancreatic cancerpoor survival"The rapamycin effects centered on decreased mTOR-r ......"25576058
hsa-let-7b-3p

pancreatic cancerstaging"In addition from 10 to 50 weeks of age stage-speci ......"26516699
hsa-let-7b-3p

pancreatic cancerdrug resistance"In particular modulations of let-7 miR-29a miR-17- ......"27539232
hsa-let-7b-3p

prostate cancerprogression; poor survival"Distinct microRNA expression profile in prostate c ......"23798998
hsa-let-7b-3p

prostate cancerdrug resistance; metastasis"Loss of let 7 microRNA upregulates IL 6 in bone ma ......"23977098Luciferase
hsa-let-7b-3p

prostate cancermalignant trasformation"Role of miRNA let 7 and its major targets in prost ......"25276782
hsa-let-7b-3p

prostate cancerworse prognosis"miRNA let 7b modulates macrophage polarization and ......"27157642
hsa-let-7b-3p

retinoblastomametastasis"In addition hsa-miR-25 hsa-miR-18a and hsa-miR-20a ......"26730174
hsa-let-7b-3p

sarcomamalignant trasformation"Let 7 microRNA and HMGA2 levels of expression are ......"21412931
hsa-let-7b-3p

thyroid cancerdifferentiation"Effects of let 7 microRNA on Cell Growth and Diffe ......"19956384



Reported gene related to hsa-let-7b-3p

miRNAcancergenereportingPUBMED
hsa-let-7b-3p

bladder cancerKRAS"A let 7 microRNA binding site polymorphism in the ......"27620744
hsa-let-7b-3p

colon cancerKRAS"Association study of the let 7 miRNA complementary ......"24727325
hsa-let-7b-3p

colorectal cancerKRAS"A let 7 microRNA binding site polymorphism in 3' u ......"20603437
hsa-let-7b-3p

colorectal cancerKRAS"Let 7 microRNA binding site polymorphism in the 3' ......"24890702
hsa-let-7b-3p

colorectal cancerKRAS"The LCS6 polymorphism in the binding site of let 7 ......"23324806
hsa-let-7b-3p

colorectal cancerKRAS"A let 7 microRNA SNP in the KRAS 3'UTR is prognost ......"21994416
hsa-let-7b-3p

colorectal cancerKRAS"Let 7 miRNA binding site polymorphism in the KRAS ......"23167843
hsa-let-7b-3p

colorectal cancerKRAS"Genetic modulation of the Let 7 microRNA binding t ......"20177422
hsa-let-7b-3p

colorectal cancerKRAS"A let 7 microRNA binding site polymorphism in KRAS ......"25183481
hsa-let-7b-3p

colorectal cancerKRAS"Our results showed that miR-143 but not let-7b inc ......"26581910
hsa-let-7b-3p

colorectal cancerKRAS"Preclinical and experimental data in vivo indicate ......"22584434
hsa-let-7b-3p

lung squamous cell cancerKRAS"A SNP in a let 7 microRNA complementary site in th ......"18922928
hsa-let-7b-3p

pancreatic cancerKRAS"Interestingly the differential expression of miRNA ......"26516699
hsa-let-7b-3p

esophageal cancerHMGA2"Role of microRNA let 7 and effect to HMGA2 in esop ......"21598109
hsa-let-7b-3p

esophageal cancerHMGA2"HMGA2 is down regulated by microRNA let 7 and asso ......"24612219
hsa-let-7b-3p

gastric cancerHMGA2"Since let-7 miRNAs generally play a tumor-suppress ......"20949044
hsa-let-7b-3p

gastric cancerHMGA2"Recent studies report that HMGA2 is negatively reg ......"18413822
hsa-let-7b-3p

lung cancerHMGA2"MiR-98 a member in the let-7 family acts as a nega ......"23700794
hsa-let-7b-3p

ovarian cancerHMGA2"HMGA2 mRNA and let-7 family microRNA were detected ......"23073586
hsa-let-7b-3p

sarcomaHMGA2"Let 7 microRNA and HMGA2 levels of expression are ......"21412931
hsa-let-7b-3p

colorectal cancerHRAS"On the basis of these data we suggest that the dow ......"20881268
hsa-let-7b-3p

glioblastomaHRAS"Transfection of let-7 miRNA reduced expression of ......"20607356
hsa-let-7b-3p

lung cancerHRAS"Using an established orthotopic mouse lung cancer ......"18344688
hsa-let-7b-3p

lung cancerHRAS"k-Ras and c-Myc two key oncogenes in lung cancer h ......"20033209
hsa-let-7b-3p

pancreatic cancerHRAS"Because let-7 microRNA targets the K-ras oncogene ......"19323605
hsa-let-7b-3p

breast cancerEGFR"The tumours in the TMAs were assigned to subtypes ......"22294324
hsa-let-7b-3p

colorectal cancerEGFR"The LCS6 polymorphism in the binding site of let 7 ......"23324806
hsa-let-7b-3p

lung cancerEGFR"Our mathematical model explains the signaling link ......"23365639
hsa-let-7b-3p

lung squamous cell cancerEGFR"This effect was observed over a wide range of miRN ......"25714397
hsa-let-7b-3p

breast cancerLIN28A"Moreover further studies showed that p21 Rb and Le ......"22808086
hsa-let-7b-3p

breast cancerLIN28A"LIN28 is a RNA-binding protein that has been well ......"22081076
hsa-let-7b-3p

breast cancerLIN28A"The Wnt β catenin pathway represses let 7 microRN ......"23613467
hsa-let-7b-3p

prostate cancerLIN28A"Furthermore let-7c expression is downregulated in ......"22479342
hsa-let-7b-3p

liver cancerBCL2L1"The let 7 family of microRNAs inhibits Bcl xL expr ......"20347499
hsa-let-7b-3p

lung cancerBCL2L1"As a result transcript levels of the tumor-suppres ......"26915294
hsa-let-7b-3p

melanomaCCND1"The effect of let-7b on protein expression was due ......"18379589
hsa-let-7b-3p

melanomaCCND1"Cyclin D1 expression was significantly higher in c ......"23162627
hsa-let-7b-3p

breast cancerERBB2"The tumours in the TMAs were assigned to subtypes ......"22294324
hsa-let-7b-3p

breast cancerERBB2"For instance an abundant expression of multiple le ......"25907662
hsa-let-7b-3p

breast cancerESR1"Let 7 family miRNAs regulate estrogen receptor alp ......"20535543
hsa-let-7b-3p

breast cancerESR1"let 7 microRNAs induce tamoxifen sensitivity by do ......"21826373
hsa-let-7b-3p

liver cancerIL6"Knocking down IL-6 and Twist in HSCs significantly ......"21352471
hsa-let-7b-3p

prostate cancerIL6"Loss of let 7 microRNA upregulates IL 6 in bone ma ......"23977098
hsa-let-7b-3p

melanomaLIN28B"Mechanistically we discovered that Lin28B a well-c ......"26071398
hsa-let-7b-3p

pancreatic cancerLIN28B"LIN28B suppresses microRNA let 7b expression to pr ......"26609473
hsa-let-7b-3p

lung cancerMYC"Our mathematical model explains the signaling link ......"23365639
hsa-let-7b-3p

lung cancerMYC"k-Ras and c-Myc two key oncogenes in lung cancer h ......"20033209
hsa-let-7b-3p

melanomaPCNA"The effect of let-7b on protein expression was due ......"18379589
hsa-let-7b-3p

melanomaPCNA"Cyclin D1 expression was significantly higher in c ......"23162627
hsa-let-7b-3p

melanomaADAR"Importantly we discovered that ADAR1 fundamentally ......"23728176
hsa-let-7b-3p

liver cancerAFP"As a single marker α-fetoprotein AFP and miR-122 ......"26264553
hsa-let-7b-3p

lung cancerBCL2"As a result transcript levels of the tumor-suppres ......"26915294
hsa-let-7b-3p

esophageal cancerBRD2"Let-7 expressions were detected in esophageal canc ......"21598109
hsa-let-7b-3p

liver cancerCD46"The present study suggests that CD46 plays an impo ......"24297460
hsa-let-7b-3p

prostate cancerCFTR"Validation of the data using an independent high-r ......"23798998
hsa-let-7b-3p

breast cancerCTCFL"Circulating cell free cancer testis MAGE A RNA BOR ......"24983365
hsa-let-7b-3p

gastric cancerDDR1"Let-7 g improved the effects of X-rays on GC cells ......"25972194
hsa-let-7b-3p

melanomaDICER1"Importantly we discovered that ADAR1 fundamentally ......"23728176
hsa-let-7b-3p

B cell lymphomaGBA"Let-7 in particular let-7b is overexpressed in DLB ......"20651244
hsa-let-7b-3p

prostate cancerHMGA1"Furthermore we identified HMGA1 a non-histone prot ......"23798998
hsa-let-7b-3p

head and neck cancerHMI"Subsequently microarray analysis followed by Ingen ......"27588466
hsa-let-7b-3p

gastric cancerING1"MicroRNA let 7b suppresses human gastric cancer ma ......"25613480
hsa-let-7b-3p

breast cancerKDM5B"In MCF-7 cells with stable RNAi-mediated suppressi ......"21969366
hsa-let-7b-3p

lung squamous cell cancerLCS1"The purpose of this study was to identify single n ......"18922928
hsa-let-7b-3p

breast cancerLMNA"Twenty-five differentially expressed miRNAs P < 0. ......"20535543
hsa-let-7b-3p

pancreatic cancerMAP2K6"Restoring let-7 levels in cancer-derived cell line ......"19323605
hsa-let-7b-3p

head and neck cancerMMP8"However the role of let-7 in head and neck cancer ......"21292542
hsa-let-7b-3p

lung cancerMVD"We demonstrated significantly higher MVD and decre ......"23029111
hsa-let-7b-3p

head and neck cancerNANOG"Most importantly overexpression of let-7 or knockd ......"21292542
hsa-let-7b-3p

thyroid cancerNKX2-1"In addition let-7 enhanced transcriptional express ......"19956384
hsa-let-7b-3p

glioblastomaNRAS"Transfection of let-7 miRNA reduced expression of ......"20607356
hsa-let-7b-3p

gastric cancerPGC"This study examined the expression patterns of ser ......"25549793
hsa-let-7b-3p

ovarian cancerPGRMC1"In conclusion we propose that PGRMC1 expression is ......"21109987
hsa-let-7b-3p

B cell lymphomaPRDM1"Data obtained from expression analysis luciferase ......"20651244
hsa-let-7b-3p

breast cancerRAD52"We found that individuals with AC OR 0.684 95%CI 0 ......"27726100
hsa-let-7b-3p

lung squamous cell cancerSCLC1"Among them five downregulated miRNAs let-7 miR-20 ......"23117485
hsa-let-7b-3p

sarcomaSERPINH1"Using a quantitative shotgun proteomics approach w ......"24457375
hsa-let-7b-3p

pancreatic cancerSOCS3"MicroRNA let 7 downregulates STAT3 phosphorylation ......"24491408
hsa-let-7b-3p

colon cancerSTAB2"Nine dysregulated miRNA pairs fell into three miRN ......"25287248
hsa-let-7b-3p

pancreatic cancerSTAT3"MicroRNA let 7 downregulates STAT3 phosphorylation ......"24491408
hsa-let-7b-3p

breast cancerTAM"Transfection of let-7 mimics to Tam-resistant MCF7 ......"21826373
hsa-let-7b-3p

ovarian cancerTCF7L1"These overwhelmingly observed oncogenic genes were ......"24129674
hsa-let-7b-3p

colorectal cancerTGFBR1"rs868 is contained in a let-7 miRNA binding site i ......"27234654
hsa-let-7b-3p

liver cancerTRIM71"Lin-41 is a stem cell-specific E3 ligase and a kno ......"23097274
hsa-let-7b-3p

liver cancerTWIST1"Knocking down IL-6 and Twist in HSCs significantly ......"21352471
hsa-let-7b-3p

sarcomaVIM"Using a quantitative shotgun proteomics approach w ......"24457375



Expression profile in cancer corhorts:




Putative target regulations

miRNAGeneCancerInteractionCorrelation beta
hsa-let-7b-3p
CACNG4
11 cancers: BLCA; CESC; COAD; KIRC; LIHC; PAAD; PRAD; SARC; THCA; STAD; UCEC
MirTarget
TCGA BLCA -0.477; TCGA CESC -0.641; TCGA COAD -0.828; TCGA KIRC -0.745; TCGA LIHC -0.531; TCGA PAAD -0.639; TCGA PRAD -0.521; TCGA SARC -0.48; TCGA THCA -1.215; TCGA STAD -0.872; TCGA UCEC -0.538
hsa-let-7b-3p
NLGN1
9 cancers: BLCA; COAD; KIRP; LUSC; PAAD; PRAD; SARC; STAD; UCEC
MirTarget; miRNATAP
TCGA BLCA -0.65; TCGA COAD -0.575; TCGA KIRP -0.339; TCGA LUSC -0.358; TCGA PAAD -0.49; TCGA PRAD -0.513; TCGA SARC -0.64; TCGA STAD -1.508; TCGA UCEC -0.447
hsa-let-7b-3p
MIF4GD
9 cancers: BLCA; CESC; HNSC; KIRP; LGG; LUSC; PAAD; SARC; THCA
MirTarget
TCGA BLCA -0.091; TCGA CESC -0.101; TCGA HNSC -0.24; TCGA KIRP -0.148; TCGA LGG -0.054; TCGA LUSC -0.09; TCGA PAAD -0.217; TCGA SARC -0.148; TCGA THCA -0.239
hsa-let-7b-3p
LRRC34
11 cancers: BLCA; ESCA; HNSC; KIRC; KIRP; LUSC; OV; PAAD; PRAD; STAD; UCEC
MirTarget
TCGA BLCA -0.179; TCGA ESCA -0.579; TCGA HNSC -0.157; TCGA KIRC -0.21; TCGA KIRP -0.207; TCGA LUSC -0.331; TCGA OV -0.184; TCGA PAAD -0.265; TCGA PRAD -0.25; TCGA STAD -0.323; TCGA UCEC -0.172
hsa-let-7b-3p
ITM2C
10 cancers: BLCA; BRCA; CESC; ESCA; LIHC; LUAD; OV; PAAD; PRAD; UCEC
MirTarget
TCGA BLCA -0.328; TCGA BRCA -0.183; TCGA CESC -0.23; TCGA ESCA -0.373; TCGA LIHC -0.218; TCGA LUAD -0.127; TCGA OV -0.231; TCGA PAAD -0.278; TCGA PRAD -0.287; TCGA UCEC -0.476
hsa-let-7b-3p
MAP4K3
9 cancers: BLCA; ESCA; KIRC; LGG; LUAD; LUSC; OV; STAD; UCEC
mirMAP
TCGA BLCA -0.112; TCGA ESCA -0.223; TCGA KIRC -0.178; TCGA LGG -0.05; TCGA LUAD -0.095; TCGA LUSC -0.132; TCGA OV -0.104; TCGA STAD -0.189; TCGA UCEC -0.096
hsa-let-7b-3p
CNR1
10 cancers: BLCA; CESC; COAD; ESCA; KIRP; LIHC; PRAD; SARC; STAD; UCEC
mirMAP
TCGA BLCA -0.577; TCGA CESC -0.37; TCGA COAD -0.532; TCGA ESCA -1.301; TCGA KIRP -0.385; TCGA LIHC -0.631; TCGA PRAD -0.509; TCGA SARC -0.839; TCGA STAD -1.7; TCGA UCEC -0.288
hsa-let-7b-3p
MAP1B
9 cancers: BLCA; CESC; COAD; ESCA; LUSC; PAAD; PRAD; SARC; STAD
mirMAP
TCGA BLCA -0.481; TCGA CESC -0.287; TCGA COAD -0.339; TCGA ESCA -0.347; TCGA LUSC -0.306; TCGA PAAD -0.502; TCGA PRAD -0.578; TCGA SARC -0.242; TCGA STAD -0.984
hsa-let-7b-3p
SCN3A
9 cancers: BLCA; CESC; COAD; ESCA; KIRC; PAAD; PRAD; SARC; STAD
mirMAP
TCGA BLCA -0.454; TCGA CESC -0.464; TCGA COAD -0.414; TCGA ESCA -0.446; TCGA KIRC -0.437; TCGA PAAD -0.673; TCGA PRAD -0.201; TCGA SARC -0.729; TCGA STAD -0.784
hsa-let-7b-3p
UQCRB
11 cancers: BLCA; BRCA; HNSC; KIRC; LIHC; LUAD; LUSC; PAAD; SARC; THCA; UCEC
mirMAP
TCGA BLCA -0.106; TCGA BRCA -0.103; TCGA HNSC -0.288; TCGA KIRC -0.135; TCGA LIHC -0.218; TCGA LUAD -0.132; TCGA LUSC -0.175; TCGA PAAD -0.178; TCGA SARC -0.169; TCGA THCA -0.079; TCGA UCEC -0.179
hsa-let-7b-3p
RIC3
9 cancers: BLCA; COAD; KIRC; LUSC; OV; PAAD; SARC; STAD; UCEC
mirMAP
TCGA BLCA -0.597; TCGA COAD -0.657; TCGA KIRC -0.588; TCGA LUSC -0.373; TCGA OV -0.308; TCGA PAAD -0.603; TCGA SARC -0.499; TCGA STAD -1.371; TCGA UCEC -0.356
hsa-let-7b-3p
SLC24A5
10 cancers: BLCA; BRCA; CESC; KIRC; KIRP; LGG; OV; SARC; THCA; STAD
mirMAP
TCGA BLCA -0.516; TCGA BRCA -0.226; TCGA CESC -0.519; TCGA KIRC -0.279; TCGA KIRP -0.311; TCGA LGG -0.086; TCGA OV -0.269; TCGA SARC -0.594; TCGA THCA -0.567; TCGA STAD -1.447
hsa-let-7b-3p
ZNF84
11 cancers: BLCA; CESC; ESCA; HNSC; KIRP; LGG; LIHC; LUAD; LUSC; OV; PAAD
mirMAP
TCGA BLCA -0.107; TCGA CESC -0.086; TCGA ESCA -0.188; TCGA HNSC -0.126; TCGA KIRP -0.163; TCGA LGG -0.053; TCGA LIHC -0.092; TCGA LUAD -0.129; TCGA LUSC -0.156; TCGA OV -0.128; TCGA PAAD -0.131
hsa-let-7b-3p
ZNF248
11 cancers: BLCA; CESC; ESCA; HNSC; LIHC; LUSC; OV; PAAD; PRAD; STAD; UCEC
mirMAP
TCGA BLCA -0.171; TCGA CESC -0.121; TCGA ESCA -0.231; TCGA HNSC -0.132; TCGA LIHC -0.095; TCGA LUSC -0.148; TCGA OV -0.114; TCGA PAAD -0.135; TCGA PRAD -0.079; TCGA STAD -0.465; TCGA UCEC -0.125
hsa-let-7b-3p
NFYB
9 cancers: BLCA; ESCA; HNSC; KIRP; LUSC; PAAD; PRAD; STAD; UCEC
miRNATAP
TCGA BLCA -0.084; TCGA ESCA -0.136; TCGA HNSC -0.124; TCGA KIRP -0.086; TCGA LUSC -0.121; TCGA PAAD -0.161; TCGA PRAD -0.066; TCGA STAD -0.184; TCGA UCEC -0.105
hsa-let-7b-3p
PCSK2
9 cancers: BLCA; BRCA; CESC; COAD; HNSC; PRAD; THCA; STAD; UCEC
miRNATAP
TCGA BLCA -1.1; TCGA BRCA -0.25; TCGA CESC -0.592; TCGA COAD -0.528; TCGA HNSC -0.458; TCGA PRAD -0.826; TCGA THCA -1.1; TCGA STAD -1.813; TCGA UCEC -0.237
hsa-let-7b-3p
KIF5C
10 cancers: BLCA; CESC; COAD; ESCA; LUAD; LUSC; PAAD; SARC; STAD; UCEC
miRNATAP
TCGA BLCA -0.503; TCGA CESC -0.268; TCGA COAD -0.285; TCGA ESCA -0.608; TCGA LUAD -0.172; TCGA LUSC -0.232; TCGA PAAD -0.654; TCGA SARC -0.397; TCGA STAD -0.75; TCGA UCEC -0.181
hsa-let-7b-3p
STXBP5L
10 cancers: BLCA; CESC; ESCA; LUAD; LUSC; PAAD; PRAD; SARC; STAD; UCEC
miRNATAP
TCGA BLCA -0.801; TCGA CESC -0.353; TCGA ESCA -0.671; TCGA LUAD -0.498; TCGA LUSC -0.619; TCGA PAAD -1.121; TCGA PRAD -0.598; TCGA SARC -1.045; TCGA STAD -1.108; TCGA UCEC -0.231
hsa-let-7b-3p
NOVA1
9 cancers: BLCA; COAD; ESCA; HNSC; LUSC; PAAD; PRAD; STAD; UCEC
miRNATAP
TCGA BLCA -0.897; TCGA COAD -0.546; TCGA ESCA -0.646; TCGA HNSC -0.307; TCGA LUSC -0.314; TCGA PAAD -0.975; TCGA PRAD -0.262; TCGA STAD -1.429; TCGA UCEC -0.554
hsa-let-7b-3p
NGDN
9 cancers: BRCA; COAD; HNSC; LIHC; LUAD; LUSC; OV; PAAD; UCEC
MirTarget
TCGA BRCA -0.058; TCGA COAD -0.132; TCGA HNSC -0.107; TCGA LIHC -0.116; TCGA LUAD -0.135; TCGA LUSC -0.107; TCGA OV -0.114; TCGA PAAD -0.092; TCGA UCEC -0.18
hsa-let-7b-3p
TSFM
12 cancers: BRCA; HNSC; KIRC; KIRP; LGG; LIHC; LUAD; LUSC; OV; PAAD; THCA; UCEC
MirTarget
TCGA BRCA -0.126; TCGA HNSC -0.148; TCGA KIRC -0.161; TCGA KIRP -0.082; TCGA LGG -0.103; TCGA LIHC -0.103; TCGA LUAD -0.199; TCGA LUSC -0.166; TCGA OV -0.162; TCGA PAAD -0.169; TCGA THCA -0.081; TCGA UCEC -0.106
hsa-let-7b-3p
PDCL3
11 cancers: BRCA; HNSC; KIRP; LIHC; LUAD; LUSC; OV; PAAD; SARC; THCA; UCEC
MirTarget
TCGA BRCA -0.097; TCGA HNSC -0.173; TCGA KIRP -0.09; TCGA LIHC -0.143; TCGA LUAD -0.16; TCGA LUSC -0.115; TCGA OV -0.083; TCGA PAAD -0.094; TCGA SARC -0.08; TCGA THCA -0.056; TCGA UCEC -0.119
hsa-let-7b-3p
POLR2K
9 cancers: BRCA; COAD; HNSC; KIRC; LIHC; LUAD; LUSC; SARC; UCEC
MirTarget
TCGA BRCA -0.07; TCGA COAD -0.2; TCGA HNSC -0.104; TCGA KIRC -0.107; TCGA LIHC -0.218; TCGA LUAD -0.194; TCGA LUSC -0.115; TCGA SARC -0.158; TCGA UCEC -0.188
hsa-let-7b-3p
RNF8
9 cancers: BRCA; COAD; HNSC; LIHC; LUSC; OV; PAAD; PRAD; UCEC
mirMAP
TCGA BRCA -0.06; TCGA COAD -0.115; TCGA HNSC -0.109; TCGA LIHC -0.205; TCGA LUSC -0.089; TCGA OV -0.118; TCGA PAAD -0.097; TCGA PRAD -0.108; TCGA UCEC -0.066
hsa-let-7b-3p
ATP5E
9 cancers: BRCA; COAD; HNSC; KIRC; LIHC; LUAD; PAAD; THCA; UCEC
mirMAP
TCGA BRCA -0.149; TCGA COAD -0.125; TCGA HNSC -0.29; TCGA KIRC -0.181; TCGA LIHC -0.237; TCGA LUAD -0.128; TCGA PAAD -0.237; TCGA THCA -0.131; TCGA UCEC -0.179
hsa-let-7b-3p
TBCA
10 cancers: BRCA; HNSC; KIRP; LIHC; LUAD; LUSC; PAAD; SARC; THCA; UCEC
mirMAP
TCGA BRCA -0.086; TCGA HNSC -0.173; TCGA KIRP -0.094; TCGA LIHC -0.172; TCGA LUAD -0.144; TCGA LUSC -0.198; TCGA PAAD -0.243; TCGA SARC -0.115; TCGA THCA -0.115; TCGA UCEC -0.076
hsa-let-7b-3p
RBBP7
9 cancers: BRCA; HNSC; KIRP; LGG; LIHC; LUAD; LUSC; SARC; STAD
miRNATAP
TCGA BRCA -0.054; TCGA HNSC -0.075; TCGA KIRP -0.095; TCGA LGG -0.065; TCGA LIHC -0.096; TCGA LUAD -0.128; TCGA LUSC -0.129; TCGA SARC -0.137; TCGA STAD -0.106
hsa-let-7b-3p
GDPD1
9 cancers: CESC; ESCA; HNSC; KIRP; LIHC; LUAD; LUSC; OV; PAAD
MirTarget
TCGA CESC -0.308; TCGA ESCA -0.658; TCGA HNSC -0.159; TCGA KIRP -0.138; TCGA LIHC -0.295; TCGA LUAD -0.196; TCGA LUSC -0.211; TCGA OV -0.313; TCGA PAAD -0.287
hsa-let-7b-3p
PLAG1
10 cancers: CESC; COAD; HNSC; KIRC; LIHC; OV; PRAD; THCA; STAD; UCEC
MirTarget; miRNATAP
TCGA CESC -0.554; TCGA COAD -0.534; TCGA HNSC -0.283; TCGA KIRC -0.436; TCGA LIHC -0.45; TCGA OV -0.332; TCGA PRAD -0.548; TCGA THCA -0.299; TCGA STAD -0.269; TCGA UCEC -0.517
hsa-let-7b-3p
MRS2
10 cancers: CESC; COAD; HNSC; KIRC; KIRP; LIHC; LUAD; LUSC; OV; UCEC
mirMAP
TCGA CESC -0.093; TCGA COAD -0.1; TCGA HNSC -0.087; TCGA KIRC -0.167; TCGA KIRP -0.072; TCGA LIHC -0.07; TCGA LUAD -0.086; TCGA LUSC -0.15; TCGA OV -0.123; TCGA UCEC -0.075
hsa-let-7b-3p
PCMTD2
10 cancers: CESC; COAD; ESCA; HNSC; KIRC; LUAD; LUSC; OV; STAD; UCEC
mirMAP
TCGA CESC -0.126; TCGA COAD -0.194; TCGA ESCA -0.167; TCGA HNSC -0.098; TCGA KIRC -0.099; TCGA LUAD -0.075; TCGA LUSC -0.19; TCGA OV -0.134; TCGA STAD -0.154; TCGA UCEC -0.141
hsa-let-7b-3p
PM20D2
10 cancers: COAD; KIRC; LGG; LIHC; LUAD; LUSC; PAAD; SARC; STAD; UCEC
MirTarget
TCGA COAD -0.429; TCGA KIRC -0.139; TCGA LGG -0.072; TCGA LIHC -0.257; TCGA LUAD -0.203; TCGA LUSC -0.299; TCGA PAAD -0.184; TCGA SARC -0.216; TCGA STAD -0.254; TCGA UCEC -0.17
hsa-let-7b-3p
SYT1
9 cancers: COAD; LIHC; LUAD; LUSC; OV; PRAD; THCA; STAD; UCEC
MirTarget; mirMAP; miRNATAP
TCGA COAD -0.476; TCGA LIHC -0.471; TCGA LUAD -0.455; TCGA LUSC -0.397; TCGA OV -0.209; TCGA PRAD -0.335; TCGA THCA -0.713; TCGA STAD -0.898; TCGA UCEC -0.304
hsa-let-7b-3p
TIGD7
11 cancers: COAD; HNSC; KIRP; LGG; LIHC; LUAD; LUSC; OV; SARC; STAD; UCEC
MirTarget
TCGA COAD -0.256; TCGA HNSC -0.123; TCGA KIRP -0.124; TCGA LGG -0.065; TCGA LIHC -0.255; TCGA LUAD -0.102; TCGA LUSC -0.151; TCGA OV -0.124; TCGA SARC -0.135; TCGA STAD -0.356; TCGA UCEC -0.185
hsa-let-7b-3p
HSDL1
9 cancers: COAD; HNSC; KIRC; LGG; LIHC; LUAD; LUSC; OV; STAD
mirMAP
TCGA COAD -0.109; TCGA HNSC -0.053; TCGA KIRC -0.084; TCGA LGG -0.056; TCGA LIHC -0.178; TCGA LUAD -0.099; TCGA LUSC -0.117; TCGA OV -0.165; TCGA STAD -0.168
hsa-let-7b-3p
MYBL1
9 cancers: COAD; KIRP; LIHC; LUAD; LUSC; PRAD; SARC; STAD; UCEC
mirMAP; miRNATAP
TCGA COAD -0.224; TCGA KIRP -0.342; TCGA LIHC -0.153; TCGA LUAD -0.381; TCGA LUSC -0.283; TCGA PRAD -0.188; TCGA SARC -0.362; TCGA STAD -0.462; TCGA UCEC -0.091
hsa-let-7b-3p
GDAP1
10 cancers: ESCA; HNSC; KIRC; KIRP; LIHC; LUAD; LUSC; PAAD; STAD; UCEC
MirTarget
TCGA ESCA -0.244; TCGA HNSC -0.125; TCGA KIRC -0.123; TCGA KIRP -0.118; TCGA LIHC -0.206; TCGA LUAD -0.136; TCGA LUSC -0.26; TCGA PAAD -0.325; TCGA STAD -0.369; TCGA UCEC -0.294
hsa-let-7b-3p
LBR
11 cancers: ESCA; KIRP; LGG; LIHC; LUAD; LUSC; OV; PRAD; SARC; STAD; UCEC
mirMAP
TCGA ESCA -0.292; TCGA KIRP -0.093; TCGA LGG -0.078; TCGA LIHC -0.171; TCGA LUAD -0.1; TCGA LUSC -0.12; TCGA OV -0.115; TCGA PRAD -0.092; TCGA SARC -0.241; TCGA STAD -0.264; TCGA UCEC -0.187
hsa-let-7b-3p
RAB6B
9 cancers: ESCA; HNSC; KIRP; LIHC; LUAD; LUSC; PAAD; STAD; UCEC
miRNATAP
TCGA ESCA -0.374; TCGA HNSC -0.409; TCGA KIRP -0.318; TCGA LIHC -0.13; TCGA LUAD -0.203; TCGA LUSC -0.685; TCGA PAAD -0.416; TCGA STAD -0.574; TCGA UCEC -0.159
hsa-let-7b-3p
RIMKLB
9 cancers: HNSC; KIRC; KIRP; LGG; LUSC; OV; PRAD; STAD; UCEC
MirTarget
TCGA HNSC -0.119; TCGA KIRC -0.151; TCGA KIRP -0.139; TCGA LGG -0.07; TCGA LUSC -0.142; TCGA OV -0.118; TCGA PRAD -0.192; TCGA STAD -0.63; TCGA UCEC -0.134
hsa-let-7b-3p
TMEM117
9 cancers: KIRC; KIRP; LGG; LUAD; LUSC; PAAD; PRAD; THCA; STAD
MirTarget
TCGA KIRC -0.173; TCGA KIRP -0.195; TCGA LGG -0.074; TCGA LUAD -0.117; TCGA LUSC -0.239; TCGA PAAD -0.149; TCGA PRAD -0.173; TCGA THCA -0.309; TCGA STAD -0.143





Enriched cancer pathways of putative targets