microRNA information: hsa-miR-106b-3p

SectionIDlink
Mature name: hsa-miR-106b-3pmiRbase
Accession: MIMAT0004672miRbase
Precursor name: hsa-mir-106b miRbase
Precursor accession: MI0000734miRbase
Symbol: MIR106BHGNC
RefSeq ID: NR_029831GenBank
Sequence: CCGCACUGUGGGUACUUGCUGC



Reported expression in cancers: hsa-miR-106b-3p

miRNAcancerregulationreportingPUBMEDmethod
hsa-miR-106b-3p

bladder cancerderegulation"We screened 723 miRNAs by microarray and selected ......"23945108qPCR; Microarray
hsa-miR-106b-3p

breast cancerdownregulation"Previously it has been shown that miR-18a/b miR-25 ......"23144930qPCR
hsa-miR-106b-3p

breast cancerdownregulation"MicroRNA expression profiling showed miR-106b to b ......"24164962
hsa-miR-106b-3p

breast cancerupregulation"Prognostic value of miR 106b expression in breast ......"25619461Reverse transcription PCR; in situ hybridization
hsa-miR-106b-3p

breast cancerupregulation"MicroRNA-106b-5p miR-106b a carcinogenic miRNA is ......"27519168
hsa-miR-106b-3p

cervical and endocervical cancerupregulation"MicroRNA-106b miR-106b was recently identified as ......"26769181qPCR; in situ hybridization
hsa-miR-106b-3p

chronic myeloid leukemiaderegulation"Some onco-miRNAs were found to be downregulated mi ......"25833191
hsa-miR-106b-3p

colorectal cancerupregulation"Aberrant miR-106b expression has been reported in ......"26223867qPCR
hsa-miR-106b-3p

endometrial cancerdownregulation"In this pilot study we examined the expression of ......"25827090qPCR
hsa-miR-106b-3p

gastric cancerupregulation"The most highly expressed miRNAs in gastric cancer ......"19175831
hsa-miR-106b-3p

gastric cancerupregulation"The expression levels of miR-20a miR-21 miR-25 miR ......"22996433qPCR
hsa-miR-106b-3p

gastric cancerupregulation"MicroRNAs miRNAs such as miR-17-5p miR-21 miR-106a ......"23267156
hsa-miR-106b-3p

gastric cancerupregulation"We identified five miRNAs that were most consisten ......"24040025qPCR
hsa-miR-106b-3p

head and neck cancerderegulation"A global miRNA profiling was done on 51 formalin-f ......"20145181Reverse transcription PCR
hsa-miR-106b-3p

kidney renal cell cancerdownregulation"Conversely decreased expression of miR-106b miR-99 ......"26416448
hsa-miR-106b-3p

kidney renal cell cancerupregulation"MicroRNA 106b functions as an oncogene in renal ce ......"26648244Microarray; qPCR; RNA-Seq
hsa-miR-106b-3p

liver cancerupregulation"In this study we report that miR-106b expression i ......"23087084
hsa-miR-106b-3p

liver cancerupregulation"Over expression of miR 106b promotes cell migratio ......"23483935
hsa-miR-106b-3p

liver cancerupregulation"Over-expression of miR-106b was transfected by miR ......"25327652
hsa-miR-106b-3p

liver cancerupregulation"Upregulation of microRNA 106b is associated with p ......"25466449qPCR
hsa-miR-106b-3p

melanomaupregulation"Expression of microRNA 106b and its clinical signi ......"26662433qPCR



Reported cancer pathway affected by hsa-miR-106b-3p

miRNAcancerpathwayreportingPUBMEDfunctional study
hsa-miR-106b-3p

colorectal cancerEpithelial mesenchymal transition pathway"Down regualtion of miR 106b induces epithelial mes ......"26617763Luciferase
hsa-miR-106b-3p

endometrial cancerEpithelial mesenchymal transition pathway"MicroRNA 106b modulates epithelial mesenchymal tra ......"24002805
hsa-miR-106b-3p

esophageal cancerEpithelial mesenchymal transition pathway"MiR 106b promotes migration and invasion through e ......"27619676Transwell assay; Luciferase; Western blot
hsa-miR-106b-3p

gastric cancercell cycle pathway"To investigate the effects of miR-106b on malignan ......"23803041Flow cytometry; Transwell assay
hsa-miR-106b-3p

head and neck cancercell cycle pathway"A global miRNA profiling was done on 51 formalin-f ......"20145181Flow cytometry
hsa-miR-106b-3p

kidney renal cell cancerApoptosis pathway"MicroRNA 106b functions as an oncogene in renal ce ......"26648244Flow cytometry; MTT assay
hsa-miR-106b-3p

liver cancerApoptosis pathway"Role of the miR 106b 25 microRNA cluster in hepato ......"19486339
hsa-miR-106b-3p

liver cancerEpithelial mesenchymal transition pathway"Over expression of miR 106b promotes cell migratio ......"23483935
hsa-miR-106b-3p

liver cancercell cycle pathway"Effects of miR 106b expression on the proliferatio ......"25327652Flow cytometry
hsa-miR-106b-3p

lung cancerMAPK signaling pathway"RNA-seq data and miRNA-seq data of lung adenocarci ......"27338053
hsa-miR-106b-3p

prostate cancercell cycle pathway"Down regulation of microRNA 106b is involved in p2 ......"20878953
hsa-miR-106b-3p

thyroid cancerApoptosis pathway"microRNA 106b mediated down regulation of C1orf24 ......"26317551Luciferase



Reported cancer prognosis affected by hsa-miR-106b-3p

miRNAcancerprognosisreportingPUBMEDfunctional study
hsa-miR-106b-3p

bladder cancermalignant trasformation"We screened 723 miRNAs by microarray and selected ......"23945108
hsa-miR-106b-3p

bladder cancerstaging"Urinary cell free microRNA 106b as a novel biomark ......"25168920
hsa-miR-106b-3p

breast cancerpoor survival; metastasis"Previously it has been shown that miR-18a/b miR-25 ......"23144930
hsa-miR-106b-3p

breast cancermotility; metastasis"Downregulation of miR 106b induced breast cancer c ......"24164962RNAi
hsa-miR-106b-3p

breast cancermetastasis; staging; progression"MiR 106b expression determines the proliferation p ......"24292682
hsa-miR-106b-3p

breast cancerpoor survival; recurrence"Prognostic value of miR 106b expression in breast ......"25619461
hsa-miR-106b-3p

breast cancerdrug resistance"Cantharidin modulates the E2F1/MCM7 miR 106b 93/p2 ......"26722252MTT assay; Western blot
hsa-miR-106b-3p

breast cancercell migration; staging; worse prognosis"MicroRNA 106b targets FUT6 to promote cell migrati ......"27519168
hsa-miR-106b-3p

cervical and endocervical cancercell migration; progression; tumorigenesis"MicroRNA 106b is involved in transforming growth f ......"26769181Transwell assay; Western blot; Luciferase
hsa-miR-106b-3p

colorectal cancercell migration; staging; metastasis; poor survival"MicroRNA 106b promotes colorectal cancer cell migr ......"26223867MTT assay; Transwell assay; Wound Healing Assay; Western blot; Luciferase
hsa-miR-106b-3p

colorectal cancerdrug resistance"MiR 106b induces cell radioresistance via the PTEN ......"26238857Luciferase
hsa-miR-106b-3p

colorectal cancermetastasis"Down regualtion of miR 106b induces epithelial mes ......"26617763Luciferase
hsa-miR-106b-3p

esophageal cancermetastasis"MiR 106b promotes migration and invasion through e ......"27619676Transwell assay; Luciferase; Western blot
hsa-miR-106b-3p

gastric cancermetastasis"Differential expression of miRNAs was studied usin ......"20726036
hsa-miR-106b-3p

gastric cancermetastasis; poor survival"The expression levels of miR-20a miR-21 miR-25 miR ......"22996433
hsa-miR-106b-3p

gastric cancermalignant trasformation; progression"To investigate the effects of miR-106b on malignan ......"23803041Flow cytometry; Transwell assay
hsa-miR-106b-3p

gastric cancertumorigenesis"Deregulation of the expression of these miRNAs in ......"24643999
hsa-miR-106b-3p

gastric cancercell migration; worse prognosis"MicroRNA 106b in cancer associated fibroblasts fro ......"24842611
hsa-miR-106b-3p

gastric cancerstaging; metastasis; differentiation; progression"Downregulation of serum miR 17 and miR 106b levels ......"25561770
hsa-miR-106b-3p

kidney renal cell cancermetastasis"We examined the expression levels of selected micr ......"20609231
hsa-miR-106b-3p

kidney renal cell cancerworse prognosis"Conversely decreased expression of miR-106b miR-99 ......"26416448
hsa-miR-106b-3p

kidney renal cell cancermetastasis; cell migration"MicroRNA 106b functions as an oncogene in renal ce ......"26648244Flow cytometry; MTT assay
hsa-miR-106b-3p

liver cancermetastasis; cell migration"Over expression of miR 106b promotes cell migratio ......"23483935
hsa-miR-106b-3p

liver cancermetastasis"Effects of miR 106b expression on the proliferatio ......"25327652Flow cytometry
hsa-miR-106b-3p

liver cancerworse prognosis; tumor size; poor survival"Upregulation of microRNA 106b is associated with p ......"25466449
hsa-miR-106b-3p

liver cancerprogression; poor survival; differentiation"miR 106b promotes cancer progression in hepatitis ......"27298561
hsa-miR-106b-3p

lung squamous cell cancercell migration"MicroRNA 106b 25 cluster targets β TRCP2 increase ......"23611780Colony formation
hsa-miR-106b-3p

lymphomadifferentiation"We also used microarray analysis to identify a dif ......"21698185
hsa-miR-106b-3p

melanomametastasis; staging; poor survival; progression; worse prognosis"Expression of microRNA 106b and its clinical signi ......"26662433
hsa-miR-106b-3p

pancreatic cancerworse prognosis"We furthermore show that hsa-miR-106b which itself ......"26621835
hsa-miR-106b-3p

prostate cancerdrug resistance"Down regulation of microRNA 106b is involved in p2 ......"20878953
hsa-miR-106b-3p

prostate cancerrecurrence"MicroRNA 106b 25 cluster expression is associated ......"22986525Western blot; Colony formation
hsa-miR-106b-3p

prostate cancerdifferentiation"We demonstrate hypoxia promotes neuronal and neuro ......"24135225
hsa-miR-106b-3p

prostate cancerprogression"CIC overexpression suppressed prostate cancer cell ......"26124181RNAi
hsa-miR-106b-3p

thyroid cancermalignant trasformation"microRNA 106b mediated down regulation of C1orf24 ......"26317551Luciferase



Reported gene related to hsa-miR-106b-3p

miRNAcancergenereportingPUBMED
hsa-miR-106b-3p

breast cancerPTEN"Cantharidin modulates the E2F1/MCM7 miR 106b 93/p2 ......"26722252
hsa-miR-106b-3p

colorectal cancerPTEN"We further identified PTEN and p21 as novel direct ......"26238857
hsa-miR-106b-3p

gastric cancerPTEN"MicroRNA 106b in cancer associated fibroblasts fro ......"24842611
hsa-miR-106b-3p

breast cancerSMAD7"The miR 106b 25 cluster targets Smad7 activates TG ......"22286770
hsa-miR-106b-3p

esophageal cancerSMAD7"MiR 106b promotes migration and invasion through e ......"27619676
hsa-miR-106b-3p

gastric cancerSMAD7"Smad7 which inhibits transforming growth factor-β ......"25286029
hsa-miR-106b-3p

liver cancerAPC"miR 106b downregulates adenomatous polyposis coli ......"23087084
hsa-miR-106b-3p

esophageal cancerBRD2"The present study showed that miR-106b was pronoun ......"27619676
hsa-miR-106b-3p

breast cancerBSG"We also found that EMMPRIN could down-regulate miR ......"27325313
hsa-miR-106b-3p

prostate cancerCASP7"MicroRNA 106b 25 cluster expression is associated ......"22986525
hsa-miR-106b-3p

gastric cancerCD44"miR 106b modulates cancer stem cell characteristic ......"25286029
hsa-miR-106b-3p

bladder cancerCDKN2A"In conclusion DE-miRNAs in bladder cancer tissue s ......"25955758
hsa-miR-106b-3p

cervical and endocervical cancerDAB2"The expression of the miR-106b target gene DAB2 in ......"26769181
hsa-miR-106b-3p

breast cancerDGCR8"Based on the bioinformatics prediction rs417309 is ......"23629745
hsa-miR-106b-3p

colorectal cancerDLC1"MicroRNA 106b promotes colorectal cancer cell migr ......"26223867
hsa-miR-106b-3p

gastric cancerE2F1"In turn miR-106b and miR-93 regulate E2F1 expressi ......"18328430
hsa-miR-106b-3p

gastric cancerE2F5"Overexpression of miR-106b shortened the G0/G1 pha ......"23803041
hsa-miR-106b-3p

breast cancerERBB2"High expression of miR-18a/b are strongly associat ......"23144930
hsa-miR-106b-3p

thyroid cancerFAM129A"microRNA 106b mediated down regulation of C1orf24 ......"26317551
hsa-miR-106b-3p

breast cancerFUT6"MicroRNA 106b targets FUT6 to promote cell migrati ......"27519168
hsa-miR-106b-3p

colorectal cancerINSR"We found overexpression of miR-106b could induce r ......"26238857
hsa-miR-106b-3p

pancreatic cancerITCH"We furthermore show that hsa-miR-106b which itself ......"26621835
hsa-miR-106b-3p

breast cancerJUN"TGF-β1 enhances the transcription of miR-106b via ......"24292682
hsa-miR-106b-3p

breast cancerMCM7"TGF-β1 enhances the transcription of miR-106b via ......"24292682
hsa-miR-106b-3p

breast cancerMMP2"Downregulation of miR 106b induced breast cancer c ......"24164962
hsa-miR-106b-3p

liver cancerPPFIA3"The differentially expressed hsa-miR-106b was chos ......"25916067
hsa-miR-106b-3p

colorectal cancerPRRX1"Down regualtion of miR 106b induces epithelial mes ......"26617763
hsa-miR-106b-3p

liver cancerPTPRT"The differentially expressed hsa-miR-106b was chos ......"25916067
hsa-miR-106b-3p

liver cancerRHOA"Further functional studies demonstrated that miR-1 ......"23483935
hsa-miR-106b-3p

liver cancerRHOC"Further functional studies demonstrated that miR-1 ......"23483935
hsa-miR-106b-3p

kidney renal cell cancerSETD2"miR 106b 5p targets tumor suppressor gene SETD2 to ......"25714014
hsa-miR-106b-3p

breast cancerSIX1"The miR 106b 25 cluster targets Smad7 activates TG ......"22286770
hsa-miR-106b-3p

lung squamous cell cancerSNAI1"MicroRNA 106b 25 cluster targets β TRCP2 increase ......"23611780
hsa-miR-106b-3p

breast cancerSTAT3"We also found that EMMPRIN could down-regulate miR ......"27325313
hsa-miR-106b-3p

thyroid cancerTPCN1"To demonstrate that miR-106b reduces C1orf24 expre ......"26317551
hsa-miR-106b-3p

endometrial cancerTWIST1"MicroRNA 106b modulates epithelial mesenchymal tra ......"24002805



Expression profile in cancer corhorts:




Putative target regulations

miRNAGeneCancerInteractionCorrelation beta
hsa-miR-106b-3p
FOXO1
14 cancers: BLCA; BRCA; CESC; COAD; ESCA; KIRC; KIRP; LIHC; LUAD; LUSC; PAAD; PRAD; STAD; UCEC
miRNAWalker2 validate
TCGA BLCA -0.224; TCGA BRCA -0.118; TCGA CESC -0.192; TCGA COAD -0.297; TCGA ESCA -0.317; TCGA KIRC -0.346; TCGA KIRP -0.17; TCGA LIHC -0.354; TCGA LUAD -0.119; TCGA LUSC -0.122; TCGA PAAD -0.302; TCGA PRAD -0.192; TCGA STAD -0.155; TCGA UCEC -0.429
hsa-miR-106b-3p
KIAA0232
11 cancers: BLCA; BRCA; CESC; ESCA; HNSC; KIRC; KIRP; LIHC; LUSC; STAD; UCEC
miRNAWalker2 validate
TCGA BLCA -0.14; TCGA BRCA -0.25; TCGA CESC -0.088; TCGA ESCA -0.197; TCGA HNSC -0.149; TCGA KIRC -0.303; TCGA KIRP -0.15; TCGA LIHC -0.121; TCGA LUSC -0.091; TCGA STAD -0.204; TCGA UCEC -0.141
hsa-miR-106b-3p
MECP2
9 cancers: BLCA; BRCA; ESCA; KIRC; KIRP; SARC; THCA; STAD; UCEC
mirMAP
TCGA BLCA -0.069; TCGA BRCA -0.087; TCGA ESCA -0.074; TCGA KIRC -0.139; TCGA KIRP -0.07; TCGA SARC -0.159; TCGA THCA -0.053; TCGA STAD -0.147; TCGA UCEC -0.173
hsa-miR-106b-3p
TNRC6C
9 cancers: BLCA; BRCA; CESC; ESCA; KIRC; LIHC; PAAD; STAD; UCEC
miRNATAP
TCGA BLCA -0.159; TCGA BRCA -0.252; TCGA CESC -0.149; TCGA ESCA -0.205; TCGA KIRC -0.067; TCGA LIHC -0.105; TCGA PAAD -0.25; TCGA STAD -0.234; TCGA UCEC -0.217
hsa-miR-106b-3p
UQCR11
10 cancers: BRCA; HNSC; KIRC; LUAD; OV; PAAD; PRAD; SARC; THCA; STAD
miRNAWalker2 validate
TCGA BRCA -0.127; TCGA HNSC -0.207; TCGA KIRC -0.167; TCGA LUAD -0.07; TCGA OV -0.336; TCGA PAAD -0.174; TCGA PRAD -0.128; TCGA SARC -0.118; TCGA THCA -0.136; TCGA STAD -0.095





Enriched cancer pathways of putative targets