Cancer

breast cancer

Regulation

upregulation

Reporting

MiR 190b the highest up regulated miRNA in ERα positive compared to ERα negative breast tumors a new biomarker in breast cancers?. Numerous microarray studies reported different expression patterns of miRNAs in breast cancers and found clinical interest for several miRNAs but often with contradictory results. We used the robust and reproductive tool of quantitative RT-PCR in a large cohort of well-annotated 153 breast cancers with long-term follow-up to identify miRNAs specifically differentially expressed between ER+ and ER- breast cancers. MiR-190b retained our attention as it was the miRNA the most strongly over-expressed in ER+ compared to ER- with a fold change upper to 23. Expression level of miR-190b impacts metastasis-free and event-free survival independently of ER status. This study reveals miR-190b as the highest up-regulated miRNA in hormone-dependent breast cancers. Due to its specificity and high expression level miR-190b could therefore represent a new biomarker in hormone-dependent breast cancers but its exact role carcinogenesis remains to elucidate

Pubmed

26141719

Method

Microarray; qPCR

Cancer

liver cancer

Regulation

upregulation

Reporting

Up regulation of microRNA 190b plays a role for decreased IGF 1 that induces insulin resistance in human hepatocellular carcinoma. Specific miRNA miR-190b which was significantly up-regulated in HCC tumor tissues when compared with paired non-tumor tissues was among those predicted to interact with 3'-untranslated region UTR of IGF-1. Increased expression of miR-190 may cause decreased IGF-1 in HCC development

Pubmed

24586785

Method

Cancer

pancreatic cancer

Regulation

upregulation

Reporting

Profiling of 95 microRNAs in pancreatic cancer cell lines and surgical specimens by real time PCR analysis. Differential expression of 95 miRNAs was analyzed by real time RT-PCR using the QuantiMir System. Eight miRNAs were significantly upregulated in most pancreatic cancer tissues and cell lines including miR-196a miR-190 miR-186 miR-221 miR-222 miR-200b miR-15b and miR-95

Pubmed

19030927

Method

qPCR