microRNA information: hsa-miR-204-5p

SectionIDlink
Mature name: hsa-miR-204-5pmiRbase
Accession: MIMAT0000265miRbase
Precursor name: hsa-mir-204 miRbase
Precursor accession: MI0000284miRbase
Symbol: MIR204HGNC
RefSeq ID: NR_029621GenBank
Sequence: UUCCCUUUGUCAUCCUAUGCCU



Reported expression in cancers: hsa-miR-204-5p

miRNAcancerregulationreportingPUBMEDmethod
hsa-miR-204-5p

acute myeloid leukemiadownregulation"Many of the down-regulated miRNAs including miR-20 ......"18308931
hsa-miR-204-5p

acute myeloid leukemiadownregulation"Low expression of microRNA 204 miR 204 is associat ......"26126974
hsa-miR-204-5p

bladder cancerdownregulation"We investigated the miRNA expression signature of ......"21304530
hsa-miR-204-5p

bladder cancerdownregulation"In the first - discovery - phase microarray cards ......"27468885Microarray; qPCR
hsa-miR-204-5p

breast cancerdownregulation"Studying the miRNome of locally advanced breast tu ......"27703260
hsa-miR-204-5p

colorectal cancerdownregulation"miR-204-5p was found to be downregulated in colore ......"25294901Microarray
hsa-miR-204-5p

colorectal cancerdownregulation"Screening miRNAs for early diagnosis of colorectal ......"27022275RNA-Seq
hsa-miR-204-5p

gastric cancerdownregulation"Our results suggest that down-regulation of miR-20 ......"23768087
hsa-miR-204-5p

gastric cancerdownregulation"Our and others' data revealed that miR-204-5p was ......"25429829
hsa-miR-204-5p

gastric cancerdownregulation"miR-204 was found to be downregulated in gastric c ......"26729198qPCR
hsa-miR-204-5p

glioblastomadownregulation"Till now little has been known about the role of m ......"27588402
hsa-miR-204-5p

kidney renal cell cancerdownregulation"MicroRNA-204 miR-204 has been reported to be frequ ......"26323722
hsa-miR-204-5p

lung squamous cell cancerdownregulation"Decreased expression of miR 204 in plasma is assoc ......"26497897qPCR
hsa-miR-204-5p

lung squamous cell cancerupregulation"Deregulated expression of miR-204 has been reporte ......"26935060qPCR
hsa-miR-204-5p

ovarian cancerdownregulation"In this study we aimed to find out the influence o ......"25962115
hsa-miR-204-5p

retinoblastomadownregulation"Aberrant expression of miR-204 had been frequently ......"25647033
hsa-miR-204-5p

thyroid cancerdownregulation"It was recently shown that miR-204-5p is downregul ......"25603050



Reported cancer pathway affected by hsa-miR-204-5p

miRNAcancerpathwayreportingPUBMEDfunctional study
hsa-miR-204-5p

breast cancerApoptosis pathway"MicroRNA 204 targets JAK2 in breast cancer and ind ......"26191195
hsa-miR-204-5p

breast cancerEpithelial mesenchymal transition pathway"MiR 204 5p/Six1 feedback loop promotes epithelial ......"26408179
hsa-miR-204-5p

colorectal cancerApoptosis pathway"miR 204 5p expression in colorectal cancer: an aut ......"25209181
hsa-miR-204-5p

esophageal cancerEpithelial mesenchymal transition pathway"miR 204 inhibits invasion and epithelial mesenchym ......"26722467
hsa-miR-204-5p

gastric cancerEpithelial mesenchymal transition pathway"MiR 204 down regulates SIRT1 and reverts SIRT1 ind ......"23768087Luciferase; Western blot
hsa-miR-204-5p

gastric cancerEpithelial mesenchymal transition pathway"Decreased miR 204 in H pylori associated gastric c ......"24984017Luciferase
hsa-miR-204-5p

gastric cancerEpithelial mesenchymal transition pathway"miR 204 regulates the EMT by targeting snai1 to su ......"26729198Luciferase; Transwell assay
hsa-miR-204-5p

liver cancerApoptosis pathway"To investigate the level of microRNA-204 miR-204 i ......"25652855Flow cytometry; MTT assay; Western blot
hsa-miR-204-5p

liver cancerApoptosis pathway"miR 204 5p targeting SIRT1 regulates hepatocellula ......"27748572Western blot; Cell proliferation assay; Colony formation; Cell Proliferation Assay
hsa-miR-204-5p

lung squamous cell cancercell cycle pathway; Apoptosis pathway"Deregulated expression of miR-204 has been reporte ......"26935060Western blot; Colony formation; Cell migration assay
hsa-miR-204-5p

ovarian cancerApoptosis pathway; PI3K/Akt signaling pathway"Up Regulation of miR 204 Enhances Anoikis Sensitiv ......"25962115Wound Healing Assay; Western blot
hsa-miR-204-5p

prostate cancerApoptosis pathway"Human miR-204-5p potentially targeting BCL2 has be ......"27519795Luciferase; Western blot
hsa-miR-204-5p

prostate cancerApoptosis pathway"In this study we firstly investigated the regulati ......"27686228Western blot
hsa-miR-204-5p

sarcomaEpithelial mesenchymal transition pathway"MicroRNA 204 inhibits proliferation migration inva ......"25998694Luciferase
hsa-miR-204-5p

thyroid cancercell cycle pathway; Apoptosis pathway"MiR 204 5p suppresses cell proliferation by inhibi ......"25603050Luciferase



Reported cancer prognosis affected by hsa-miR-204-5p

miRNAcancerprognosisreportingPUBMEDfunctional study
hsa-miR-204-5p

acute myeloid leukemiapoor survival"Low expression of microRNA 204 miR 204 is associat ......"26126974
hsa-miR-204-5p

bladder cancerstaging"Expression levels of miRNAs were assessed by quant ......"23169479
hsa-miR-204-5p

breast cancerworse prognosis; staging; metastasis; poor survival; drug resistance"Decreased expression of miR 204 is associated with ......"25031750
hsa-miR-204-5p

breast cancerprogression"CONSORT: Sam68 Is Directly Regulated by MiR 204 an ......"26656364Flow cytometry; Western blot; Luciferase
hsa-miR-204-5p

breast cancerstaging"Dual targeting of ANGPT1 and TGFBR2 genes by miR 2 ......"27703260Luciferase
hsa-miR-204-5p

colorectal cancerpoor survival"miR 204 5p expression in colorectal cancer: an aut ......"25209181
hsa-miR-204-5p

colorectal cancerprogression; metastasis; poor survival"miR 204 5p inhibits proliferation and invasion and ......"25294901Western blot; Luciferase
hsa-miR-204-5p

colorectal cancerworse prognosis"Screening miRNAs for early diagnosis of colorectal ......"27022275
hsa-miR-204-5p

colorectal cancerdrug resistance"LncRNA UCA1 enhances cell proliferation and 5 fluo ......"27046651
hsa-miR-204-5p

colorectal cancerdrug resistance"MicroRNA 204 modulates colorectal cancer cell sens ......"27095441
hsa-miR-204-5p

endometrial cancerstaging; metastasis; poor survival; tumorigenesis"A TrkB STAT3 miR 204 5p regulatory circuitry contr ......"24321270Luciferase; MTT assay; Transwell assay
hsa-miR-204-5p

gastric cancercell migration; tumorigenesis"MiR-204 which was predicted to target ezrin was do ......"21416062Luciferase
hsa-miR-204-5p

gastric cancerdrug resistance"miR 204 targets Bcl 2 expression and enhances resp ......"23152059
hsa-miR-204-5p

gastric cancerdrug resistance; metastasis"MiR 204 down regulates SIRT1 and reverts SIRT1 ind ......"23768087Luciferase; Western blot
hsa-miR-204-5p

gastric cancerstaging"In the second stage differentially expressed miRNA ......"26172537
hsa-miR-204-5p

gastric cancerprogression; metastasis"miR 204 regulates the EMT by targeting snai1 to su ......"26729198Luciferase; Transwell assay
hsa-miR-204-5p

gastric cancerworse prognosis; staging; metastasis; differentiation; poor survival; malignant trasformation; drug resistance"Reduced expression of serum miR 204 predicts poor ......"27173244
hsa-miR-204-5p

glioblastomaprogression"miR 204 suppresses the development and progression ......"27588402
hsa-miR-204-5p

head and neck cancermetastasis; progression"Network modeling identifies molecular functions ta ......"20369013
hsa-miR-204-5p

kidney renal cell cancercell migration; metastasis"Upregulation of microRNA 204 inhibits cell prolife ......"26323722Western blot; Luciferase; Cell migration assay; MTT assay
hsa-miR-204-5p

liver cancerstaging; tumor size"To investigate the level of microRNA-204 miR-204 i ......"25652855Flow cytometry; MTT assay; Western blot
hsa-miR-204-5p

liver cancerprogression; poor survival"miR 204 5p targeting SIRT1 regulates hepatocellula ......"27748572Western blot; Cell proliferation assay; Colony formation; Cell Proliferation Assay
hsa-miR-204-5p

lung squamous cell cancerworse prognosis; staging; metastasis; poor survival"Decreased expression of miR 204 in plasma is assoc ......"26497897
hsa-miR-204-5p

lung squamous cell cancercell migration"Deregulated expression of miR-204 has been reporte ......"26935060Western blot; Colony formation; Cell migration assay
hsa-miR-204-5p

pancreatic cancerpoor survival"Two gemcitabine-resistant pancreatic cancer cell l ......"21347785
hsa-miR-204-5p

pancreatic cancerstaging"Using Affymetrix microarrays we established a glob ......"26807325
hsa-miR-204-5p

prostate cancerprogression; metastasis; differentiation; staging"miR 204 is dysregulated in metastatic prostate can ......"25630658Luciferase
hsa-miR-204-5p

retinoblastomaprogression"MiR 204 down regulated in retinoblastoma regulates ......"25647033



Reported gene related to hsa-miR-204-5p

miRNAcancergenereportingPUBMED
hsa-miR-204-5p

breast cancerBCL2"Moreover the level of miR-204 is negatively correl ......"26191195
hsa-miR-204-5p

colorectal cancerBCL2"This may be explained by the fact that miR-204-5p ......"25209181
hsa-miR-204-5p

gastric cancerBCL2"miR 204 targets Bcl 2 expression and enhances resp ......"23152059
hsa-miR-204-5p

liver cancerBCL2"The expressions of Bcl-2 and Sirt1 in the lower mi ......"25652855
hsa-miR-204-5p

prostate cancerBCL2"Human miR-204-5p potentially targeting BCL2 has be ......"27519795
hsa-miR-204-5p

gastric cancerSIRT1"MiR 204 down regulates SIRT1 and reverts SIRT1 ind ......"23768087
hsa-miR-204-5p

liver cancerSIRT1"miR 204 5p targeting SIRT1 regulates hepatocellula ......"27748572
hsa-miR-204-5p

liver cancerSIRT1"The expressions of Bcl-2 and Sirt1 in the lower mi ......"25652855
hsa-miR-204-5p

prostate cancerSIRT1"In this study we firstly investigated the regulati ......"27686228
hsa-miR-204-5p

sarcomaSIRT1"MicroRNA 204 inhibits proliferation migration inva ......"25998694
hsa-miR-204-5p

glioblastomaATF2"miR 204 suppresses the development and progression ......"27588402
hsa-miR-204-5p

lung squamous cell cancerATF2"Additionally activating transcription factor 2 ATF ......"26935060
hsa-miR-204-5p

colorectal cancerHMGA2"We identified high mobility group protein A2 HMGA2 ......"27095441
hsa-miR-204-5p

thyroid cancerHMGA2"MiR 204 regulates HMGA2 expression and inhibits ce ......"26406941
hsa-miR-204-5p

colorectal cancerRAB22A"miR 204 5p inhibits proliferation and invasion and ......"25294901
hsa-miR-204-5p

gastric cancerRAB22A"MicroRNA 204 5p inhibits gastric cancer cell proli ......"25429829
hsa-miR-204-5p

gastric cancerSOX4"Decreased miR 204 in H pylori associated gastric c ......"24984017
hsa-miR-204-5p

kidney renal cell cancerSOX4"Upregulation of microRNA 204 inhibits cell prolife ......"26323722
hsa-miR-204-5p

endometrial cancerTRPM3"Moreover ChIP assays showed that phospho-STAT3 cou ......"24321270
hsa-miR-204-5p

kidney renal cell cancerTRPM3"TRPM3 and miR 204 establish a regulatory circuit t ......"25517751
hsa-miR-204-5p

colorectal cancerUCA1"LncRNA UCA1 enhances cell proliferation and 5 fluo ......"27046651
hsa-miR-204-5p

prostate cancerUCA1"Then we examined whether miR-204 downregulation in ......"27686228
hsa-miR-204-5p

liver cancerAGO2"In the current study we identified miR-192 and miR ......"26710269
hsa-miR-204-5p

breast cancerANGPT1"Dual targeting of ANGPT1 and TGFBR2 genes by miR 2 ......"27703260
hsa-miR-204-5p

prostate cancerAR"Importantly overexpression of miR-204 and knockdow ......"25797256
hsa-miR-204-5p

ovarian cancerBDNF"Restored expression level of miR-204 enables cells ......"25962115
hsa-miR-204-5p

thyroid cancerCCND1"MiR-204 overexpression decreased cyclin D1 and Ki6 ......"26406941
hsa-miR-204-5p

gastric cancerCDH1"Up-regulation of miR-204 influenced the levels of ......"23768087
hsa-miR-204-5p

lung squamous cell cancerCEACAM5"The value of the area under the receiver operating ......"26497897
hsa-miR-204-5p

colorectal cancerCREB1"We also identified CREB1 as a new target of miR-20 ......"27046651
hsa-miR-204-5p

prostate cancerERG"We aimed to investigate miR-204 in the context of ......"25630658
hsa-miR-204-5p

prostate cancerETS1"We found dualistic miR-204 effects either acting a ......"25630658
hsa-miR-204-5p

gastric cancerEZR"MiR-204 which was predicted to target ezrin was do ......"21416062
hsa-miR-204-5p

endometrial cancerFOXC1"Dysregulation of microRNA 204 mediates migration a ......"21400511
hsa-miR-204-5p

esophageal cancerFOXM1"miR 204 inhibits invasion and epithelial mesenchym ......"26722467
hsa-miR-204-5p

lung squamous cell cancerHNF1B"Additionally activating transcription factor 2 ATF ......"26935060
hsa-miR-204-5p

liver cancerHOTTIP"In the current study we identified miR-192 and miR ......"26710269
hsa-miR-204-5p

acute myeloid leukemiaHOXA10"Indeed we confirmed that miR-204 targets HOXA10 an ......"18308931
hsa-miR-204-5p

thyroid cancerIGFBP5"MiR 204 5p suppresses cell proliferation by inhibi ......"25603050
hsa-miR-204-5p

breast cancerJAK2"MicroRNA 204 targets JAK2 in breast cancer and ind ......"26191195
hsa-miR-204-5p

breast cancerKHDRBS1"CONSORT: Sam68 Is Directly Regulated by MiR 204 an ......"26656364
hsa-miR-204-5p

lung cancerMALAT1"LncRNA MALAT1 exerts oncogenic functions in lung a ......"27294002
hsa-miR-204-5p

pancreatic cancerMCL1"Using pancreatic cancer cell lines we have shown t ......"24025188
hsa-miR-204-5p

acute myeloid leukemiaMEIS1"Indeed we confirmed that miR-204 targets HOXA10 an ......"18308931
hsa-miR-204-5p

retinoblastomaMMP9"MiR 204 down regulated in retinoblastoma regulates ......"25647033
hsa-miR-204-5p

prostate cancerMYB"We found dualistic miR-204 effects either acting a ......"25630658
hsa-miR-204-5p

ovarian cancerNTF3"Up Regulation of miR 204 Enhances Anoikis Sensitiv ......"25962115
hsa-miR-204-5p

endometrial cancerNTRK2"A TrkB STAT3 miR 204 5p regulatory circuitry contr ......"24321270
hsa-miR-204-5p

thyroid cancerPCNA"MiR-204 overexpression decreased cyclin D1 and Ki6 ......"26406941
hsa-miR-204-5p

breast cancerPRDX2"Here we show that Trichostatin A TSA could increas ......"26436206
hsa-miR-204-5p

breast cancerPTGS2"Gene expression analysis of miR-204 and miR-379-tr ......"22629385
hsa-miR-204-5p

breast cancerSIX1"We also identified that upregulation of Six1 could ......"26408179
hsa-miR-204-5p

gastric cancerSNAI1"miR 204 regulates the EMT by targeting snai1 to su ......"26729198
hsa-miR-204-5p

lung cancerSNAI2"In particular MALAT1 upregulated the expression of ......"27294002
hsa-miR-204-5p

endometrial cancerSTAT3"A TrkB STAT3 miR 204 5p regulatory circuitry contr ......"24321270
hsa-miR-204-5p

gastric cancerSTK11"We demonstrated that the regulation of EMT by miR- ......"23768087
hsa-miR-204-5p

breast cancerTAM"When miR-204 is down regulated the inhibition of T ......"26436206
hsa-miR-204-5p

colon cancerTFAM"Dual luciferase reporter assays was performed to e ......"26499153
hsa-miR-204-5p

breast cancerTGFBR2"Dual targeting of ANGPT1 and TGFBR2 genes by miR 2 ......"27703260
hsa-miR-204-5p

gastric cancerUSP47"MicroRNA 204 5p inhibits gastric cancer cell proli ......"25429829
hsa-miR-204-5p

gastric cancerVIM"Up-regulation of miR-204 influenced the levels of ......"23768087
hsa-miR-204-5p

prostate cancerXRN1"A dual yet opposite growth regulating function of ......"25797256



Expression profile in cancer corhorts:




Putative target regulations

miRNAGeneCancerInteractionCorrelation beta
hsa-miR-204-5p
IL1RAP
9 cancers: KIRC; KIRP; LIHC; LUAD; LUSC; PAAD; PRAD; THCA; UCEC
miRNAWalker2 validate
TCGA KIRC -0.172; TCGA KIRP -0.352; TCGA LIHC -0.102; TCGA LUAD -0.109; TCGA LUSC -0.066; TCGA PAAD -0.168; TCGA PRAD -0.088; TCGA THCA -0.432; TCGA UCEC -0.057
hsa-miR-204-5p
PLAUR
9 cancers: KIRC; KIRP; LIHC; LUAD; LUSC; PAAD; SARC; THCA; UCEC
miRNAWalker2 validate
TCGA KIRC -0.273; TCGA KIRP -0.148; TCGA LIHC -0.213; TCGA LUAD -0.14; TCGA LUSC -0.136; TCGA PAAD -0.26; TCGA SARC -0.154; TCGA THCA -0.412; TCGA UCEC -0.074
hsa-miR-204-5p
ESCO2
10 cancers: KIRC; KIRP; LGG; LIHC; LUAD; PAAD; PRAD; SARC; THCA; UCEC
MirTarget
TCGA KIRC -0.21; TCGA KIRP -0.416; TCGA LGG -0.172; TCGA LIHC -0.19; TCGA LUAD -0.167; TCGA PAAD -0.13; TCGA PRAD -0.391; TCGA SARC -0.064; TCGA THCA -0.143; TCGA UCEC -0.203
hsa-miR-204-5p
PAQR4
9 cancers: KIRC; KIRP; LIHC; LUAD; PAAD; PRAD; SARC; THCA; UCEC
MirTarget
TCGA KIRC -0.181; TCGA KIRP -0.134; TCGA LIHC -0.21; TCGA LUAD -0.065; TCGA PAAD -0.197; TCGA PRAD -0.143; TCGA SARC -0.078; TCGA THCA -0.155; TCGA UCEC -0.089
hsa-miR-204-5p
WDR76
10 cancers: KIRC; KIRP; LGG; LIHC; LUAD; LUSC; PRAD; SARC; THCA; UCEC
MirTarget
TCGA KIRC -0.076; TCGA KIRP -0.218; TCGA LGG -0.07; TCGA LIHC -0.16; TCGA LUAD -0.134; TCGA LUSC -0.083; TCGA PRAD -0.137; TCGA SARC -0.079; TCGA THCA -0.099; TCGA UCEC -0.091
hsa-miR-204-5p
E2F2
10 cancers: KIRC; KIRP; LGG; LIHC; LUAD; PAAD; PRAD; SARC; THCA; UCEC
mirMAP
TCGA KIRC -0.198; TCGA KIRP -0.294; TCGA LGG -0.168; TCGA LIHC -0.269; TCGA LUAD -0.093; TCGA PAAD -0.13; TCGA PRAD -0.446; TCGA SARC -0.065; TCGA THCA -0.059; TCGA UCEC -0.223





Enriched cancer pathways of putative targets