microRNA information: hsa-miR-223-5p

SectionIDlink
Mature name: hsa-miR-223-5pmiRbase
Accession: MIMAT0004570miRbase
Precursor name: hsa-mir-223 miRbase
Precursor accession: MI0000300miRbase
Symbol: MIR223HGNC
RefSeq ID: NR_029637GenBank
Sequence: CGUGUAUUUGACAAGCUGAGUU



Reported expression in cancers: hsa-miR-223-5p

miRNAcancerregulationreportingPUBMEDmethod
hsa-miR-223-5p

B cell lymphomaderegulation"Expression of microRNA 223 and its clinicopatholog ......"22932402Microarray; Reverse transcription PCR; qPCR
hsa-miR-223-5p

T cell leukemiaderegulation"Specifically miR-150 and miR-223 were up-regulated ......"19246560
hsa-miR-223-5p

acute myeloid leukemiadownregulation"Among them miR-128a and -128b are significantly ov ......"18056805qPCR
hsa-miR-223-5p

acute myeloid leukemiadownregulation"Recent studies show microRNA-223 miR-223 a transcr ......"20029046
hsa-miR-223-5p

acute myeloid leukemiadownregulation"We identified a single case with a hemizygous dele ......"24009227
hsa-miR-223-5p

breast cancerdownregulation"RNA was extracted reverse transcribed and subjecte ......"24498016Microarray
hsa-miR-223-5p

breast cancerdownregulation"MiR-223 reportedly acts as a tumor suppressor in a ......"27618431
hsa-miR-223-5p

cervical and endocervical cancerdownregulation"MiR 223 inhibited cell metastasis of human cervica ......"26617846
hsa-miR-223-5p

colon cancerdownregulation"Microarray analyses of miRNAs in exosome-enriched ......"24705249Microarray; qPCR
hsa-miR-223-5p

colorectal cancerupregulation"Deregulated level of microRNA-223 miR-223 was scre ......"24819398qPCR; Microarray
hsa-miR-223-5p

colorectal cancerupregulation"Overexpression of miR 223 correlates with tumor me ......"25270282qPCR
hsa-miR-223-5p

colorectal cancerupregulation"The functional effects of miR-223 and the effects ......"25867276
hsa-miR-223-5p

colorectal cancerupregulation"Serum miRNAs were extracted from all subjects to a ......"27135244
hsa-miR-223-5p

esophageal cancerdownregulation"We found that miR-223 expression was significantly ......"22108521
hsa-miR-223-5p

esophageal cancerderegulation"Among these miRNAs that displayed unique miRNA exp ......"23516093
hsa-miR-223-5p

esophageal cancerderegulation"The expression profiles of miRNAs in paired EC and ......"23761828Microarray; qPCR
hsa-miR-223-5p

esophageal cancerupregulation"Importantly the high ESCC marked-ZD esophagus had ......"26918602
hsa-miR-223-5p

gastric cancerupregulation"MicroRNA 223 functions as an oncogene in human gas ......"22270966qPCR
hsa-miR-223-5p

gastric cancerupregulation"In the group of consistently reported microRNAs mi ......"24902858
hsa-miR-223-5p

gastric cancerupregulation"Increased microRNA 223 in Helicobacter pylori asso ......"25036956
hsa-miR-223-5p

head and neck cancerupregulation"To explore circulating miRNAs as cancer therapy bi ......"25950115qPCR; Microarray
hsa-miR-223-5p

kidney renal cell cancerupregulation"Expression of miR 223 in clear cell renal cell car ......"25818776qPCR
hsa-miR-223-5p

liver cancerdownregulation"MicroRNA 223 is commonly repressed in hepatocellul ......"18555017Microarray
hsa-miR-223-5p

liver cancerdownregulation"This study was divided into four phases: I Ten can ......"22174818qPCR
hsa-miR-223-5p

liver cancerdownregulation"Expression of microRNAs miR 21 miR 31 miR 122 miR ......"22213236qPCR
hsa-miR-223-5p

lymphomadownregulation"miR 223 regulates cell growth and targets proto on ......"24304814
hsa-miR-223-5p

melanomaderegulation"Comparative microarray analysis of microRNA expres ......"23111773Microarray; RNA-Seq; qPCR
hsa-miR-223-5p

pancreatic cancerdownregulation"The miR-223 inhibitor was used to determine its ro ......"25638153
hsa-miR-223-5p

prostate cancerupregulation"The altered expression of miR-223 has been reporte ......"25519054
hsa-miR-223-5p

prostate cancerdownregulation"Tumor suppressive microRNA 223 inhibits cancer cel ......"26509963
hsa-miR-223-5p

sarcomadownregulation"Similar analysis in mouse metastatic sarcomas reve ......"26044957



Reported cancer pathway affected by hsa-miR-223-5p

miRNAcancerpathwayreportingPUBMEDfunctional study
hsa-miR-223-5p

acute myeloid leukemiacell cycle pathway"Cell cycle regulator E2F1 and microRNA 223 compris ......"20029046
hsa-miR-223-5p

breast cancerApoptosis pathway"MicroRNA 223 Increases the Sensitivity of Triple N ......"27618431
hsa-miR-223-5p

cervical and endocervical cancerEpithelial mesenchymal transition pathway"MiR 223 inhibited cell metastasis of human cervica ......"26617846Cell migration assay
hsa-miR-223-5p

gastric cancerApoptosis pathway"MicroRNA 223 functions as an oncogene in human gas ......"22270966Western blot; Flow cytometry; Colony formation; Transwell assay; Luciferase
hsa-miR-223-5p

gastric cancerApoptosis pathway"We also identified miR-223 which can regulate FBXW ......"25159729
hsa-miR-223-5p

gastric cancercell cycle pathway"MiR 223 promotes the cisplatin resistance of human ......"25888377
hsa-miR-223-5p

glioblastomacell cycle pathway"microRNA 223 promotes the growth and invasion of g ......"23970099Luciferase
hsa-miR-223-5p

kidney renal cell cancercell cycle pathway"Expression of miR 223 in clear cell renal cell car ......"25818776Flow cytometry
hsa-miR-223-5p

lymphomaApoptosis pathway"According to the literature and miRNA database the ......"22177245
hsa-miR-223-5p

lymphomaApoptosis pathway"Aberrant expression of oncogenic miRNAs including ......"24479800
hsa-miR-223-5p

pancreatic cancerApoptosis pathway"Genistein down regulates miR 223 expression in pan ......"23834147
hsa-miR-223-5p

pancreatic cancerEpithelial mesenchymal transition pathway"Down regulation of miR 223 reverses epithelial mes ......"25638153Western blot
hsa-miR-223-5p

sarcomacell cycle pathway; Apoptosis pathway"Heat shock protein 90B1 plays an oncogenic role an ......"23208072Luciferase; Western blot; MTT assay; Flow cytometry
hsa-miR-223-5p

sarcomacell cycle pathway"Cell cycle analysis by flow cytometry showed the a ......"23601845Flow cytometry
hsa-miR-223-5p

sarcomacell cycle pathway"MicroRNA-223 miR-223 has been demonstrated to be i ......"24784921



Reported cancer prognosis affected by hsa-miR-223-5p

miRNAcancerprognosisreportingPUBMEDfunctional study
hsa-miR-223-5p

B cell lymphomaworse prognosis; poor survival"Expression of microRNA 223 and its clinicopatholog ......"22932402
hsa-miR-223-5p

acute myeloid leukemiaprogression; differentiation"Cell cycle regulator E2F1 and microRNA 223 compris ......"20029046
hsa-miR-223-5p

acute myeloid leukemiadifferentiation"The integrated information gathered from the two m ......"25612891
hsa-miR-223-5p

acute myeloid leukemiadifferentiation; poor survival"De Novo Acute Myeloid Leukemia in Adults: Suppress ......"25710580
hsa-miR-223-5p

acute myeloid leukemiadifferentiation; worse prognosis; staging"MicroRNA 223 dose levels fine tune proliferation a ......"26163797
hsa-miR-223-5p

bladder cancertumorigenesis"miR 223 increases gallbladder cancer cell sensitiv ......"27577078Flow cytometry; Western blot
hsa-miR-223-5p

bladder cancercell migration"Ginkgolide B Inhibits Human Bladder Cancer Cell Mi ......"27744452
hsa-miR-223-5p

breast cancermalignant trasformation"Caprin 1 is a novel microRNA 223 target for regula ......"23953883
hsa-miR-223-5p

breast cancerprogression; tumorigenesis; poor survival; drug resistance"miR 223 is a coordinator of breast cancer progress ......"24400121
hsa-miR-223-5p

breast cancerstaging"Global miRNA analysis was performed on prospective ......"25004125
hsa-miR-223-5p

breast cancerdrug resistance; recurrence"Radiotherapy induced miR 223 prevents relapse of b ......"26876200
hsa-miR-223-5p

cervical and endocervical cancermetastasis; cell migration"MiR 223 inhibited cell metastasis of human cervica ......"26617846Cell migration assay
hsa-miR-223-5p

colon cancerstaging"Microarray analyses of miRNAs in exosome-enriched ......"24705249
hsa-miR-223-5p

colorectal cancercell migration; staging"MicroRNA 223 functions as an oncogene in human col ......"24819398Colony formation; Transwell assay
hsa-miR-223-5p

colorectal cancermetastasis; worse prognosis; tumorigenesis; staging; poor survival; differentiation; tumor size; progression"Overexpression of miR 223 correlates with tumor me ......"25270282
hsa-miR-223-5p

esophageal cancercell migration; metastasis"miR 223 regulates migration and invasion by target ......"21453483Western blot; Wound Healing Assay; Luciferase
hsa-miR-223-5p

esophageal cancerworse prognosis; poor survival"Overexpression of microRNA 223 regulates the ubiqu ......"22108521
hsa-miR-223-5p

esophageal cancerpoor survival"Clinical significance of serum miR 223 miR 25 and ......"24390317
hsa-miR-223-5p

gastric cancerpoor survival"Several microarray studies have reported microRNA ......"19951901
hsa-miR-223-5p

gastric cancermetastasis; poor survival"In this study we evaluated the miRNA expression pa ......"21628394
hsa-miR-223-5p

gastric cancermotility; staging; metastasis"MicroRNA 223 functions as an oncogene in human gas ......"22270966Western blot; Flow cytometry; Colony formation; Transwell assay; Luciferase
hsa-miR-223-5p

gastric cancermetastasis; tumorigenesis; staging"Plasma microRNAs miR 223 miR 21 and miR 218 as nov ......"22860003
hsa-miR-223-5p

gastric cancerworse prognosis"Increased microRNA 223 in Helicobacter pylori asso ......"25036956Colony formation
hsa-miR-223-5p

gastric cancerdrug resistance"We also identified miR-223 which can regulate FBXW ......"25159729
hsa-miR-223-5p

gastric cancerdrug resistance"MiR 223 promotes the cisplatin resistance of human ......"25888377
hsa-miR-223-5p

kidney renal cell cancertumor size; cell migration"Expression of miR 223 in clear cell renal cell car ......"25818776Flow cytometry
hsa-miR-223-5p

liver cancertumorigenesis"Role of microRNA 223 and its target gene oncogene ......"21492514Western blot
hsa-miR-223-5p

liver cancerrecurrence"18 miRNAs including 6 up-regulated and 12 down-reg ......"22552153
hsa-miR-223-5p

liver cancerdrug resistance"MiR 223 modulates multidrug resistance via downreg ......"23925649Western blot
hsa-miR-223-5p

liver cancermetastasis; cell migration"Sulfatide epigenetically regulates miR 223 and pro ......"24333181
hsa-miR-223-5p

lung squamous cell cancerpoor survival"Five selected miRNAs let-7f miR-20b miR-30e-3p miR ......"20595154
hsa-miR-223-5p

lung squamous cell cancerstaging"In order to find novel noninvasive biomarkers with ......"25421010
hsa-miR-223-5p

lung squamous cell cancerdrug resistance"miR 223 enhances the sensitivity of non small cell ......"27177336Western blot
hsa-miR-223-5p

lymphomastaging; progression"miR 223 regulates cell growth and targets proto on ......"24304814
hsa-miR-223-5p

lymphomadifferentiation"Aberrant expression of oncogenic miRNAs including ......"24479800
hsa-miR-223-5p

lymphomapoor survival"Studies using miRNA arrays and subsequent real-tim ......"24745613
hsa-miR-223-5p

lymphomaworse prognosis; drug resistance"Presence of certain miRs miRNA-16 -21 -24 -29b -12 ......"25388103
hsa-miR-223-5p

melanomametastasis; malignant trasformation"Comparative microarray analysis of microRNA expres ......"23111773
hsa-miR-223-5p

pancreatic cancerstaging"In addition from 10 to 50 weeks of age stage-speci ......"26516699
hsa-miR-223-5p

pancreatic cancerstaging"Using Affymetrix microarrays we established a glob ......"26807325
hsa-miR-223-5p

pancreatic cancermotility"Synergistic reversal effect of epithelial to mesen ......"27429851
hsa-miR-223-5p

prostate cancercell migration"Tumor suppressive microRNA 223 inhibits cancer cel ......"26509963
hsa-miR-223-5p

sarcomadifferentiation"In order to investigate the involvement of miRNAs ......"23133552
hsa-miR-223-5p

sarcomaprogression"Cell cycle analysis by flow cytometry showed the a ......"23601845Flow cytometry
hsa-miR-223-5p

sarcomaprogression; metastasis; recurrence; drug resistance; worse prognosis"MicroRNA-223 miR-223 has been demonstrated to be i ......"24784921
hsa-miR-223-5p

sarcomapoor survival; cell migration; staging; metastasis"MicroRNA-223 miR-223 has been shown to be a potent ......"27335775



Reported gene related to hsa-miR-223-5p

miRNAcancergenereportingPUBMED
hsa-miR-223-5p

esophageal cancerFBXW7"Overexpression of microRNA 223 regulates the ubiqu ......"22108521
hsa-miR-223-5p

gastric cancerFBXW7"MiR 223 promotes the cisplatin resistance of human ......"25888377
hsa-miR-223-5p

gastric cancerFBXW7"We also identified miR-223 which can regulate FBXW ......"25159729
hsa-miR-223-5p

gastric cancerFBXW7"FBXW7/hCdc4 protein FBW7 levels in gastric cancer ......"22270966
hsa-miR-223-5p

lung squamous cell cancerFBXW7"In addition FBW7 was identified as a functional ta ......"27398136
hsa-miR-223-5p

pancreatic cancerFBXW7"We found that genistein treatment significantly in ......"23834147
hsa-miR-223-5p

pancreatic cancerFBXW7"More importantly miR-223 governs GR-induced EMT in ......"25638153
hsa-miR-223-5p

bladder cancerSTMN1"miR 223 increases gallbladder cancer cell sensitiv ......"27577078
hsa-miR-223-5p

gastric cancerSTMN1"We also explored the regulation of STMN1 expressio ......"22470493
hsa-miR-223-5p

liver cancerSTMN1"A strong inverse relationship between STMN1 mRNA a ......"18555017
hsa-miR-223-5p

sarcomaECT2"MicroRNA-223 miR-223 has been demonstrated to be i ......"24784921
hsa-miR-223-5p

sarcomaECT2"Further mechanistic study indicated that Ect2 was ......"23601845
hsa-miR-223-5p

gastric cancerEPB41L3"Mechanistically miR-223 induced by the transcripti ......"21628394
hsa-miR-223-5p

lung cancerEPB41L3"MicroRNA 223 delivered by platelet derived microve ......"25881295
hsa-miR-223-5p

B cell lymphomaLMO2"We provide experimental evidence that these change ......"19047678
hsa-miR-223-5p

acute myeloid leukemiaLMO2"De Novo Acute Myeloid Leukemia in Adults: Suppress ......"25710580
hsa-miR-223-5p

liver cancerABCB1"MiR 223 modulates multidrug resistance via downreg ......"23925649
hsa-miR-223-5p

esophageal cancerARTN"miR 223 regulates migration and invasion by target ......"21453483
hsa-miR-223-5p

breast cancerCAPRIN1"Caprin 1 is a novel microRNA 223 target for regula ......"23953883
hsa-miR-223-5p

lung cancerCASP3"miR-223 transfection in the LLC cells was observed ......"24137330
hsa-miR-223-5p

breast cancerCASZ1"The analysis of miR-223 predicted targets revealed ......"24400121
hsa-miR-223-5p

cervical and endocervical cancerCDH1"In terms of mechanism miR-223 influenced the expre ......"26617846
hsa-miR-223-5p

lung cancerCDK2"Using a luciferase activity assay and western blot ......"24137330
hsa-miR-223-5p

acute myeloid leukemiaCORD1"MicroRNA 223 dose levels fine tune proliferation a ......"26163797
hsa-miR-223-5p

acute myeloid leukemiaE2F1"Cell cycle regulator E2F1 and microRNA 223 compris ......"20029046
hsa-miR-223-5p

breast cancerEGF"Radiotherapy induced miR 223 prevents relapse of b ......"26876200
hsa-miR-223-5p

breast cancerEGFR"Accordingly both RT-induced miR-223 and peri-opera ......"26876200
hsa-miR-223-5p

acute myeloid leukemiaFANCB"In AML not otherwise specified category AML with m ......"25710580
hsa-miR-223-5p

liver cancerGAL3ST1"Orthotopic growth and intrahepatic and pulmonary m ......"24333181
hsa-miR-223-5p

B cell lymphomaGBA"The expression levels of miR-223 measured by real- ......"22932402
hsa-miR-223-5p

breast cancerHAX1"MicroRNA 223 Increases the Sensitivity of Triple N ......"27618431
hsa-miR-223-5p

liver cancerHDAC10"The expression of histone deacetylases HDAC9 and H ......"24333181
hsa-miR-223-5p

liver cancerHDAC9"The expression of histone deacetylases HDAC9 and H ......"24333181
hsa-miR-223-5p

sarcomaHSP90B1"Co-transfection of miR-223 expression vector with ......"23208072
hsa-miR-223-5p

B cell lymphomaIRF4"We provide experimental evidence that these change ......"19047678
hsa-miR-223-5p

prostate cancerITGA3"In silico database and genome-wide gene expression ......"26509963
hsa-miR-223-5p

liver cancerITGA9"Our aim was to investigate miR-223 regulation in H ......"24333181
hsa-miR-223-5p

prostate cancerITGB1"In silico database and genome-wide gene expression ......"26509963
hsa-miR-223-5p

liver cancerKAT6A"Intriguingly miR-223 expression was suppressed by ......"24333181
hsa-miR-223-5p

gastric cancerMMRN1"Gastric cancer cell line SGC7901 transfected with ......"22270966
hsa-miR-223-5p

liver cancerMYC"Role of microRNA 223 and its target gene oncogene ......"21492514
hsa-miR-223-5p

pancreatic cancerNOTCH1"More importantly miR-223 governs GR-induced EMT in ......"25638153
hsa-miR-223-5p

acute myeloid leukemiaNR4A3"This also explains the complex yet minor role of m ......"26163797
hsa-miR-223-5p

glioblastomaPAX6"microRNA 223 promotes the growth and invasion of g ......"23970099
hsa-miR-223-5p

lung cancerPCNA"miR 223 functions as a potent tumor suppressor of ......"24137330
hsa-miR-223-5p

lymphomaPRDM1"Luciferase assays were performed to verify the dir ......"24438193
hsa-miR-223-5p

colorectal cancerRASA1"C/EBP β activated microRNA 223 promotes tumour gr ......"25867276
hsa-miR-223-5p

acute myeloid leukemiaRUNX1"The integrated information gathered from the two m ......"25612891
hsa-miR-223-5p

prostate cancerSEPT6"MiR 223 3p targeting SEPT6 promotes the biological ......"25519054
hsa-miR-223-5p

breast cancerSTAT5A"In addition we proved that STAT5A is a direct miR- ......"24400121
hsa-miR-223-5p

lymphomaTCF3"Taken together aberrant E2A expression is a diagno ......"20802470
hsa-miR-223-5p

gastric cancerTIMM8A"Furthermore miR-223 was found to be significantly ......"25888377
hsa-miR-223-5p

lymphomaTOX"In addition we showed that the 3'-UTR of TOX mRNA ......"24304814
hsa-miR-223-5p

lymphomaTSPYL2"CTCL peripheral blood mononuclear cells and cell l ......"24304814
hsa-miR-223-5p

gastric cancerTWIST1"Mechanistically miR-223 induced by the transcripti ......"21628394
hsa-miR-223-5p

cervical and endocervical cancerVIM"In terms of mechanism miR-223 influenced the expre ......"26617846



Expression profile in cancer corhorts: