microRNA information: hsa-miR-224-3p

SectionIDlink
Mature name: hsa-miR-224-3pmiRbase
Accession: MIMAT0009198miRbase
Precursor name: hsa-mir-224 miRbase
Precursor accession: MI0000301miRbase
Symbol: MIR224HGNC
RefSeq ID: NR_029638GenBank
Sequence: AAAAUGGUGCCCUAGUGACUACA



Reported expression in cancers: hsa-miR-224-3p

miRNAcancerregulationreportingPUBMEDmethod
hsa-miR-224-3p

B cell lymphomadownregulation"In this study we analyzed the expression of miR-22 ......"25146331
hsa-miR-224-3p

B cell lymphomadownregulation"To investigate the expression and prognostic value ......"26301883
hsa-miR-224-3p

breast cancerdownregulation"Moreover metastasis as assayed by Transwell migrat ......"22809510
hsa-miR-224-3p

cervical and endocervical cancerupregulation"Upregulation of microRNA 224 is associated with ag ......"23631806Microarray; qPCR
hsa-miR-224-3p

cervical and endocervical cancerupregulation"Vote-counting analysis showed that up-regulation w ......"25920605
hsa-miR-224-3p

cervical and endocervical cancerupregulation"In the current study we demonstrated by real-time ......"27626930qPCR
hsa-miR-224-3p

colorectal cancerupregulation"Up regulation of miR 224 promotes cancer cell prol ......"24152489qPCR
hsa-miR-224-3p

colorectal cancerupregulation"miR 224 overexpression is a strong and independent ......"25420464qPCR
hsa-miR-224-3p

colorectal cancerupregulation"In order to clarify the miRNA profile in CRC tissu ......"25421755Microarray
hsa-miR-224-3p

colorectal cancerupregulation"MicroRNA 224 sustains Wnt/β catenin signaling and ......"26822534qPCR
hsa-miR-224-3p

gastric cancerupregulation"From the set of the 29 microRNAs of interest we fo ......"27081844
hsa-miR-224-3p

liver cancerupregulation"Role of miR 224 in hepatocellular carcinoma: a too ......"22122284
hsa-miR-224-3p

liver cancerupregulation"MicroRNA 224 is up regulated in hepatocellular car ......"22459148
hsa-miR-224-3p

liver cancerupregulation"MicroRNA 224 upregulation and AKT activation syner ......"24923856in situ hybridization
hsa-miR-224-3p

liver cancerupregulation"MicroRNA 224 Induces G1/S Checkpoint Release in Li ......"26343737Microarray
hsa-miR-224-3p

lung cancerupregulation"By examining the expression of 22 HCC-related miRN ......"22392644
hsa-miR-224-3p

lung cancerupregulation"We recently reported that miR-224 was significantl ......"26307684
hsa-miR-224-3p

lung squamous cell cancerdownregulation"Decreased microRNA 224 and its clinical significan ......"25410592qPCR
hsa-miR-224-3p

lung squamous cell cancerdownregulation"Quantitative real-time PCR assay was employed to c ......"27073334qPCR
hsa-miR-224-3p

prostate cancerdownregulation"Downregulation and prognostic performance of micro ......"23136246qPCR
hsa-miR-224-3p

prostate cancerdownregulation"Our previous microarray data showed that microRNA- ......"24382668Microarray
hsa-miR-224-3p

prostate cancerdownregulation"Our recent study of the microRNA expression signat ......"24768995
hsa-miR-224-3p

prostate cancerdownregulation"Our previous study revealed that microRNA miR-224 ......"25532941
hsa-miR-224-3p

thyroid cancerupregulation"We analyzed the expression of nine miRNAs miR-21 m ......"22747440qPCR



Reported cancer pathway affected by hsa-miR-224-3p

miRNAcancerpathwayreportingPUBMEDfunctional study
hsa-miR-224-3p

breast cancerApoptosis pathway"Epigenetic changes and nuclear factor κB activati ......"26788213Western blot; Flow cytometry
hsa-miR-224-3p

colorectal cancerPI3K/Akt signaling pathway"microRNA 224 promotes cell proliferation and tumor ......"23846336Luciferase
hsa-miR-224-3p

colorectal cancerEpithelial mesenchymal transition pathway"MicroRNA 224 is associated with colorectal cancer ......"25919696
hsa-miR-224-3p

esophageal cancerApoptosis pathway"Aberrant expression of miR-224 is associated with ......"26245343Western blot; Colony formation; Luciferase
hsa-miR-224-3p

gastric cancerApoptosis pathway"Effect of antisense miR 224 on gastric cancer cell ......"24796455Flow cytometry; MTT assay
hsa-miR-224-3p

gastric cancerApoptosis pathway"RKIP suppresses gastric cancer cell proliferation ......"25017365Western blot; MTT assay; Flow cytometry; Cell migration assay; Luciferase
hsa-miR-224-3p

gastric cancerApoptosis pathway"MicroRNA 224 aggrevates tumor growth and progressi ......"27315344Luciferase
hsa-miR-224-3p

liver cancerApoptosis pathway"Profiling microRNA expression in hepatocellular ca ......"18319255
hsa-miR-224-3p

liver cancerApoptosis pathway"MicroRNA 224 is up regulated in hepatocellular car ......"22459148
hsa-miR-224-3p

liver cancerApoptosis pathway"Involvement of microRNA 224 in cell proliferation ......"22989374Western blot
hsa-miR-224-3p

liver cancerPI3K/Akt signaling pathway"miR 224 functions as an onco miRNA in hepatocellul ......"23741247Western blot; Luciferase
hsa-miR-224-3p

liver cancerPI3K/Akt signaling pathway"MicroRNA 224 upregulation and AKT activation syner ......"24923856
hsa-miR-224-3p

liver cancercell cycle pathway"MicroRNA 224 Induces G1/S Checkpoint Release in Li ......"26343737
hsa-miR-224-3p

lung cancerApoptosis pathway; cell cycle pathway"MiR 224 promotes the chemoresistance of human lung ......"24921914
hsa-miR-224-3p

lung cancerApoptosis pathway"MicroRNA 224 is implicated in lung cancer pathogen ......"26307684
hsa-miR-224-3p

lung squamous cell cancerApoptosis pathway"Decreased microRNA 224 and its clinical significan ......"25410592Cell migration assay
hsa-miR-224-3p

lung squamous cell cancerApoptosis pathway"Quantitative real-time PCR assay was employed to c ......"27073334Flow cytometry; Wound Healing Assay
hsa-miR-224-3p

ovarian cancerApoptosis pathway"Upregulated microRNA 224 promotes ovarian cancer c ......"27663866
hsa-miR-224-3p

prostate cancerApoptosis pathway"MicroRNA 224 inhibits progression of human prostat ......"24382668
hsa-miR-224-3p

prostate cancercell cycle pathway"GABRE∼miR-452∼miR-224 promoter methylation was ......"24737792
hsa-miR-224-3p

prostate cancercell cycle pathway"MicroRNA 224 and its target CAMKK2 synergistically ......"25394900



Reported cancer prognosis affected by hsa-miR-224-3p

miRNAcancerprognosisreportingPUBMEDfunctional study
hsa-miR-224-3p

B cell lymphomastaging; drug resistance"In the discovery phase real-time polymerase chain ......"24858372
hsa-miR-224-3p

B cell lymphomaworse prognosis; staging; progression"Expression of miR 224 in diffuse large B cell lymp ......"25052605
hsa-miR-224-3p

B cell lymphomaprogression; poor survival; drug resistance"Deregulated expression of miR 224 and its target g ......"25146331Luciferase
hsa-miR-224-3p

bladder cancerpoor survival"Uncovering the clinical utility of miR 143 miR 145 ......"25804644
hsa-miR-224-3p

breast cancermetastasis; drug resistance"MicroRNA 224 targets RKIP to control cell invasion ......"22809510
hsa-miR-224-3p

breast cancerdrug resistance"Increased fucosylation has a pivotal role in multi ......"26701615Luciferase
hsa-miR-224-3p

cervical and endocervical cancerprogression; worse prognosis; metastasis; poor survival"Upregulation of microRNA 224 is associated with ag ......"23631806
hsa-miR-224-3p

cervical and endocervical cancerprogression; staging; metastasis; tumor size"Over Expressed miR 224 Promotes the Progression of ......"27626930Western blot; Luciferase; RNAi
hsa-miR-224-3p

colon cancerdrug resistance"Underexpression of miR 224 in methotrexate resista ......"21864507
hsa-miR-224-3p

colorectal cancerprogression"Furthermore several of these miRNAs were associate ......"19843336
hsa-miR-224-3p

colorectal cancerstaging"Genome-wide microarray analysis of miRNA expressio ......"23673725
hsa-miR-224-3p

colorectal cancermetastasis; staging; poor survival; motility; progression"Decreased levels of miR 224 and the passenger stra ......"23770133
hsa-miR-224-3p

colorectal cancerpoor survival; worse prognosis"microRNA 224 promotes cell proliferation and tumor ......"23846336Luciferase
hsa-miR-224-3p

colorectal cancerpoor survival"Up regulation of miR 224 promotes cancer cell prol ......"24152489Western blot; Luciferase
hsa-miR-224-3p

colorectal cancercell migration; progression"MicroRNA 224 suppresses colorectal cancer cell mig ......"24817781
hsa-miR-224-3p

colorectal cancerpoor survival; malignant trasformation"miR 224 overexpression is a strong and independent ......"25420464
hsa-miR-224-3p

colorectal cancermetastasis; poor survival"The clinical and biological significance of MIR 22 ......"25804630Western blot; Luciferase
hsa-miR-224-3p

colorectal cancerprogression; drug resistance"MicroRNA 224 is associated with colorectal cancer ......"25919696
hsa-miR-224-3p

colorectal cancermetastasis"MicroRNA 224 sustains Wnt/β catenin signaling and ......"26822534Luciferase; Western blot
hsa-miR-224-3p

esophageal cancerprogression; staging"Aberrant expression of miR-224 is associated with ......"26245343Western blot; Colony formation; Luciferase
hsa-miR-224-3p

gastric cancerpoor survival"Effect of antisense miR 224 on gastric cancer cell ......"24796455Flow cytometry; MTT assay
hsa-miR-224-3p

gastric cancerprogression; metastasis"MicroRNA 224 aggrevates tumor growth and progressi ......"27315344Luciferase
hsa-miR-224-3p

glioblastomapoor survival"MiR 224 expression increases radiation sensitivity ......"24785373
hsa-miR-224-3p

kidney renal cell cancermetastasis; malignant trasformation"miR-122 miR-141 miR-155 miR-184 miR-200c miR-210 m ......"23178446
hsa-miR-224-3p

liver cancertumorigenesis"Profiling microRNA expression in hepatocellular ca ......"18319255
hsa-miR-224-3p

liver cancermalignant trasformation"Our study identified and validated miR-224 overexp ......"18433021
hsa-miR-224-3p

liver cancertumorigenesis; progression"Involvement of microRNA 224 in cell proliferation ......"22989374Western blot
hsa-miR-224-3p

liver cancertumorigenesis; progression; cell migration"Autophagy suppresses tumorigenesis of hepatitis B ......"23913306
hsa-miR-224-3p

liver cancercell migration"miR 224 promotion of cell migration and invasion b ......"24219032Luciferase; Western blot
hsa-miR-224-3p

liver cancerworse prognosis; staging; poor survival; progression"MicroRNA 224 upregulation and AKT activation syner ......"24923856
hsa-miR-224-3p

liver cancerstaging; poor survival; metastasis"Serum miR 224 reflects stage of hepatocellular car ......"25688365
hsa-miR-224-3p

liver cancerprogression"MicroRNA 224 Induces G1/S Checkpoint Release in Li ......"26343737
hsa-miR-224-3p

liver cancermalignant trasformation"Using gene expression microarrays and high-through ......"26646011
hsa-miR-224-3p

lung cancerstaging"By examining the expression of 22 HCC-related miRN ......"22392644
hsa-miR-224-3p

lung cancerdrug resistance; poor survival"MiR 224 promotes the chemoresistance of human lung ......"24921914
hsa-miR-224-3p

lung cancermetastasis; progression"MicroRNA 224 is implicated in lung cancer pathogen ......"26307684
hsa-miR-224-3p

lung squamous cell cancerprogression; tumorigenesis; worse prognosis; staging; metastasis; poor survival"Decreased microRNA 224 and its clinical significan ......"25410592Cell migration assay
hsa-miR-224-3p

lung squamous cell cancerprogression; metastasis; cell migration"MicroRNA 224 promotes tumor progression in nonsmal ......"26187928
hsa-miR-224-3p

ovarian cancermetastasis; poor survival"Upregulated microRNA 224 promotes ovarian cancer c ......"27663866
hsa-miR-224-3p

prostate cancermalignant trasformation; staging; progression; poor survival; worse prognosis"Downregulation and prognostic performance of micro ......"23136246
hsa-miR-224-3p

prostate cancerprogression; staging; metastasis; poor survival; recurrence; worse prognosis"MicroRNA 224 inhibits progression of human prostat ......"24382668
hsa-miR-224-3p

prostate cancermalignant trasformation; motility"GABRE∼miR-452∼miR-224 promoter methylation was ......"24737792
hsa-miR-224-3p

prostate cancercell migration"Tumour suppressive microRNA 224 inhibits cancer ce ......"24768995
hsa-miR-224-3p

prostate cancerprogression; worse prognosis; staging; malignant trasformation"MicroRNA 224 and its target CAMKK2 synergistically ......"25394900
hsa-miR-224-3p

prostate cancerprogression; poor survival; recurrence; staging; metastasis"Our previous study revealed that microRNA miR-224 ......"25532941
hsa-miR-224-3p

sarcomaprogression; poor survival"MicroRNA 224 promotes the sensitivity of osteosarc ......"27222381
hsa-miR-224-3p

thyroid cancerstaging; metastasis"We analyzed the expression of nine miRNAs miR-21 m ......"22747440
hsa-miR-224-3p

thyroid cancermalignant trasformation"A limited set of miRNA have been assessed as part ......"22771635



Reported gene related to hsa-miR-224-3p

miRNAcancergenereportingPUBMED
hsa-miR-224-3p

colorectal cancerSMAD4"Increased miR-224 diminished Cdc42 and SMAD4 expre ......"24817781
hsa-miR-224-3p

colorectal cancerSMAD4"In addition the regulation of SMAD4 by miR-224 was ......"24152489
hsa-miR-224-3p

colorectal cancerSMAD4"We identified SMAD4 as a miR-224 target and observ ......"25804630
hsa-miR-224-3p

liver cancerSMAD4"Our in vitro study demonstrated that miR-224 playe ......"23913306
hsa-miR-224-3p

lung cancerSMAD4"We further demonstrated that miR-224 functions as ......"26307684
hsa-miR-224-3p

lung squamous cell cancerSMAD4"Increased miR-224 expression promotes cell migrati ......"26187928
hsa-miR-224-3p

breast cancerPEBP1"MicroRNA 224 targets RKIP to control cell invasion ......"22809510
hsa-miR-224-3p

breast cancerPEBP1"Bisulphite modification methylation specific-polym ......"26788213
hsa-miR-224-3p

gastric cancerPEBP1"RKIP suppresses gastric cancer cell proliferation ......"25017365
hsa-miR-224-3p

liver cancerAFP"In addition the combined upregulation of miR-224 a ......"24923856
hsa-miR-224-3p

liver cancerAFP"Serum levels of miR-224 showed significant relatio ......"25688365
hsa-miR-224-3p

glioblastomaAPI5"MiR-224 expression in glioblastoma cells resulted ......"24785373
hsa-miR-224-3p

liver cancerAPI5"Profiling microRNA expression in hepatocellular ca ......"18319255
hsa-miR-224-3p

liver cancerMMP9"We also performed real-time PCR to measure miR-224 ......"23988648
hsa-miR-224-3p

liver cancerMMP9"iii miR-224 promoted expression of the tumor invas ......"24219032
hsa-miR-224-3p

colorectal cancerPHLPP1"microRNA 224 promotes cell proliferation and tumor ......"23846336
hsa-miR-224-3p

esophageal cancerPHLPP1"miR-224 expression was associated with advanced cl ......"26245343
hsa-miR-224-3p

colorectal cancerPHLPP2"microRNA 224 promotes cell proliferation and tumor ......"23846336
hsa-miR-224-3p

esophageal cancerPHLPP2"miR-224 expression was associated with advanced cl ......"26245343
hsa-miR-224-3p

lung cancerTNFAIP1"We further demonstrated that miR-224 functions as ......"26307684
hsa-miR-224-3p

lung squamous cell cancerTNFAIP1"Increased miR-224 expression promotes cell migrati ......"26187928
hsa-miR-224-3p

prostate cancerTPD52"miR-224 functions as a tumour suppressor by target ......"27070713
hsa-miR-224-3p

prostate cancerTPD52"Tumour suppressive microRNA 224 inhibits cancer ce ......"24768995
hsa-miR-224-3p

prostate cancerAPLN"In the current study apelin APLN was identified as ......"25532941
hsa-miR-224-3p

gastric cancerBCL2"In addition the expressions of Bcl2 mRNA and prote ......"24796455
hsa-miR-224-3p

colorectal cancerBRAF"5-FU chemosensitivity was significantly increased ......"25919696
hsa-miR-224-3p

prostate cancerCAMKK2"MicroRNA 224 and its target CAMKK2 synergistically ......"25394900
hsa-miR-224-3p

lung cancerCASP3"MicroRNA 224 is implicated in lung cancer pathogen ......"26307684
hsa-miR-224-3p

lung cancerCASP7"MicroRNA 224 is implicated in lung cancer pathogen ......"26307684
hsa-miR-224-3p

liver cancerCCNE1"We next identified p21 p15 and CCNE1 as downstream ......"26343737
hsa-miR-224-3p

B cell lymphomaCD59"Deregulated expression of miR 224 and its target g ......"25146331
hsa-miR-224-3p

colorectal cancerCDC42"MicroRNA 224 suppresses colorectal cancer cell mig ......"24817781
hsa-miR-224-3p

colorectal cancerCDKN1A"Interestingly cell-unique downregulation of miR-22 ......"26634414
hsa-miR-224-3p

lung cancerCDKN3"p21WAF1/CIP1 a potent cyclin-dependent kinase inhi ......"24921914
hsa-miR-224-3p

liver cancerCHRFAM7A"miR 224 promotion of cell migration and invasion b ......"24219032
hsa-miR-224-3p

B cell lymphomaDDIT3"Deregulated expression of miR 224 and its target g ......"25146331
hsa-miR-224-3p

liver cancerDLL1"2-Delta Delta CT method was used for quantitative ......"19403413
hsa-miR-224-3p

liver cancerEP300"Notably in HCC tumors that significantly overexpre ......"22459148
hsa-miR-224-3p

breast cancerFUT4"Increased fucosylation has a pivotal role in multi ......"26701615
hsa-miR-224-3p

breast cancerFZD1"Collectively these data indicated that miR-224 dow ......"27323393
hsa-miR-224-3p

breast cancerFZD5"Collectively these data indicated that miR-224 dow ......"27323393
hsa-miR-224-3p

liver cancerHOXD10"A luciferase reporter assay was used to confirm th ......"24219032
hsa-miR-224-3p

kidney renal cell cancerKLK1"Transfection of miR-224 into HEK-293 cells resulte ......"20180642
hsa-miR-224-3p

ovarian cancerKLK10"When we co-transfected cells with pMIR-KLK10 and e ......"20354523
hsa-miR-224-3p

ovarian cancerKLLN"Upregulated microRNA 224 promotes ovarian cancer c ......"27663866
hsa-miR-224-3p

colorectal cancerKRAS"MicroRNA 224 is associated with colorectal cancer ......"25919696
hsa-miR-224-3p

colorectal cancerMBD2"Decreased levels of miR 224 and the passenger stra ......"23770133
hsa-miR-224-3p

liver cancerMMP2"We also performed real-time PCR to measure miR-224 ......"23988648
hsa-miR-224-3p

gastric cancerMTOR"MicroRNA 224 aggrevates tumor growth and progressi ......"27315344
hsa-miR-224-3p

colon cancerMTX1"The underexpression of miR-224 was also observed i ......"21864507
hsa-miR-224-3p

lung cancerPARP1"In addition miR-224 attenuated TNF-α induced apop ......"26307684
hsa-miR-224-3p

liver cancerPPP2R1B"These data suggest that miR-224 plays a significan ......"23741247
hsa-miR-224-3p

cervical and endocervical cancerPTGIS"Bioinformatic analysis indicated that RASSF8 RAS-a ......"27626930
hsa-miR-224-3p

cervical and endocervical cancerPTK2"In addition we found that miR-224-3p directly inhi ......"27615604
hsa-miR-224-3p

sarcomaRAC1"MicroRNA 224 promotes the sensitivity of osteosarc ......"27222381
hsa-miR-224-3p

breast cancerRAF1"Epigenetic changes and nuclear factor κB activati ......"26788213
hsa-miR-224-3p

cervical and endocervical cancerRASSF8"Over Expressed miR 224 Promotes the Progression of ......"27626930
hsa-miR-224-3p

cervical and endocervical cancerRB1CC1"miR 224 3p inhibits autophagy in cervical cancer c ......"27615604
hsa-miR-224-3p

colorectal cancerSERPINB5"Decreased levels of miR 224 and the passenger stra ......"23770133
hsa-miR-224-3p

colorectal cancerSFRP2"Bioinformatics analysis combined with in vivo and ......"26822534
hsa-miR-224-3p

lung cancerSSB"The aim of our study was to investigate the roles ......"24921914
hsa-miR-224-3p

lung cancerTIMM8A"Here we showed that miR-224 could promote the in v ......"24921914
hsa-miR-224-3p

prostate cancerTRIB1"MicroRNA 224 inhibits progression of human prostat ......"24382668
hsa-miR-224-3p

kidney renal cell cancerVHL"Importantly both VHL and the hypoxia-inducible fac ......"22326755



Expression profile in cancer corhorts:




Putative target regulations

miRNAGeneCancerInteractionCorrelation beta
hsa-miR-224-3p
PGR
10 cancers: BLCA; CESC; COAD; ESCA; HNSC; KIRC; LIHC; LUSC; PAAD; THCA
mirMAP
TCGA BLCA -0.21; TCGA CESC -0.246; TCGA COAD -0.219; TCGA ESCA -0.262; TCGA HNSC -0.346; TCGA KIRC -0.163; TCGA LIHC -0.151; TCGA LUSC -0.24; TCGA PAAD -0.361; TCGA THCA -0.131
hsa-miR-224-3p
PDE4D
10 cancers: BLCA; CESC; COAD; ESCA; HNSC; KIRC; LIHC; LUAD; LUSC; PAAD
mirMAP
TCGA BLCA -0.115; TCGA CESC -0.228; TCGA COAD -0.218; TCGA ESCA -0.169; TCGA HNSC -0.159; TCGA KIRC -0.065; TCGA LIHC -0.103; TCGA LUAD -0.252; TCGA LUSC -0.074; TCGA PAAD -0.109
hsa-miR-224-3p
PRICKLE2
9 cancers: BLCA; CESC; COAD; ESCA; HNSC; LIHC; LUSC; PAAD; THCA
mirMAP
TCGA BLCA -0.097; TCGA CESC -0.117; TCGA COAD -0.163; TCGA ESCA -0.13; TCGA HNSC -0.168; TCGA LIHC -0.194; TCGA LUSC -0.101; TCGA PAAD -0.171; TCGA THCA -0.151
hsa-miR-224-3p
DENND5B
9 cancers: BLCA; CESC; ESCA; HNSC; LIHC; LUAD; LUSC; PAAD; THCA
mirMAP
TCGA BLCA -0.256; TCGA CESC -0.281; TCGA ESCA -0.453; TCGA HNSC -0.302; TCGA LIHC -0.072; TCGA LUAD -0.119; TCGA LUSC -0.126; TCGA PAAD -0.155; TCGA THCA -0.088
hsa-miR-224-3p
PNMA2
9 cancers: BLCA; CESC; COAD; ESCA; HNSC; LIHC; LUSC; PAAD; THCA
mirMAP
TCGA BLCA -0.311; TCGA CESC -0.364; TCGA COAD -0.367; TCGA ESCA -0.677; TCGA HNSC -0.3; TCGA LIHC -0.129; TCGA LUSC -0.352; TCGA PAAD -0.336; TCGA THCA -0.146





Enriched cancer pathways of putative targets