microRNA information: hsa-miR-27b-5p

SectionIDlink
Mature name: hsa-miR-27b-5pmiRbase
Accession: MIMAT0004588miRbase
Precursor name: hsa-mir-27b miRbase
Precursor accession: MI0000440miRbase
Symbol: MIR27BHGNC
RefSeq ID: NR_029665GenBank
Sequence: AGAGCUUAGCUGAUUGGUGAAC



Reported expression in cancers: hsa-miR-27b-5p

miRNAcancerregulationreportingPUBMEDmethod
hsa-miR-27b-5p

breast cancerdownregulation"These miRNAs include miR-21 and miR-27 that were f ......"20952761
hsa-miR-27b-5p

breast cancerupregulation"We identified miR-23b and miR-27b as miRNAs that a ......"23338610
hsa-miR-27b-5p

cervical and endocervical cancerupregulation"In the present study we report that HPV16 E7 upreg ......"26397063
hsa-miR-27b-5p

cervical and endocervical cancerupregulation"MicroRNA 27b up regulated by human papillomavirus ......"26910911
hsa-miR-27b-5p

colorectal cancerupregulation"To address this issue we profiled 742 microRNAs in ......"23506979
hsa-miR-27b-5p

colorectal cancerupregulation"High expression of miR-27b miR-148a and miR-326 we ......"24119443
hsa-miR-27b-5p

gastric cancerupregulation"In this study we found that ectopic miR-27b is suf ......"26623719
hsa-miR-27b-5p

kidney renal cell cancerdownregulation"Conversely decreased expression of miR-106b miR-99 ......"26416448
hsa-miR-27b-5p

liver cancerupregulation"Up-regulation of miR-15a miR-16 miR-27b miR-30b mi ......"24314246qPCR
hsa-miR-27b-5p

lymphomaupregulation"The up-regulation of miR-155 miR-27b miR-30c and m ......"22776000Microarray
hsa-miR-27b-5p

prostate cancerdownregulation"The expression of miR-23b and miR-27b which are en ......"23300597
hsa-miR-27b-5p

prostate cancerdownregulation"Kaplan-Meier survival curves showed that low expre ......"25115396



Reported cancer pathway affected by hsa-miR-27b-5p

miRNAcancerpathwayreportingPUBMEDfunctional study
hsa-miR-27b-5p

breast cancerEpithelial mesenchymal transition pathway"MiR 27b is epigenetically downregulated in tamoxif ......"27363334Western blot; Luciferase
hsa-miR-27b-5p

cervical and endocervical cancerApoptosis pathway"MicroRNA 27b up regulated by human papillomavirus ......"26910911Luciferase
hsa-miR-27b-5p

gastric cancerEpithelial mesenchymal transition pathway"miR 27 promotes human gastric cancer cell metastas ......"22018270Western blot; Luciferase
hsa-miR-27b-5p

gastric cancerWnt signaling pathway"MicroRNA 27b suppresses Helicobacter pylori induce ......"26780940
hsa-miR-27b-5p

gastric cancerApoptosis pathway"Long Non Coding RNA LncRNA Urothelial Carcinoma As ......"27694794Western blot
hsa-miR-27b-5p

head and neck cancerEpithelial mesenchymal transition pathway"Among several miRNAs in which the expression was a ......"21899661



Reported cancer prognosis affected by hsa-miR-27b-5p

miRNAcancerprognosisreportingPUBMEDfunctional study
hsa-miR-27b-5p

breast cancerprogression; poor survival"MiR 27 as a prognostic marker for breast cancer pr ......"23240057
hsa-miR-27b-5p

breast cancerdrug resistance"MiR 27b is epigenetically downregulated in tamoxif ......"27363334Western blot; Luciferase
hsa-miR-27b-5p

breast cancerstaging"Our results showed significant increase of miR-17 ......"27596294
hsa-miR-27b-5p

cervical and endocervical cancerprogression"Elevation of miR 27b by HPV16 E7 inhibits PPARγ e ......"26397063
hsa-miR-27b-5p

colorectal cancerdrug resistance"To address this issue we profiled 742 microRNAs in ......"23506979
hsa-miR-27b-5p

colorectal cancerprogression"A tumor suppressor role for miR-27b has recently b ......"23593282Colony formation
hsa-miR-27b-5p

colorectal cancerprogression; poor survival"High expression of miR-27b miR-148a and miR-326 we ......"24119443
hsa-miR-27b-5p

endometrial cancermalignant trasformation"Expression profiling of normal and malignant endom ......"20028871
hsa-miR-27b-5p

esophageal cancerdrug resistance"miR 27 is associated with chemoresistance in esoph ......"26026166
hsa-miR-27b-5p

gastric cancermetastasis"miR 27 promotes human gastric cancer cell metastas ......"22018270Western blot; Luciferase
hsa-miR-27b-5p

gastric cancerdrug resistance"The miR27b CCNG1 P53 miR 508 5p axis regulates mul ......"26623719
hsa-miR-27b-5p

gastric cancertumorigenesis"MicroRNA 27b suppresses Helicobacter pylori induce ......"26780940
hsa-miR-27b-5p

gastric cancerdrug resistance"Long Non Coding RNA LncRNA Urothelial Carcinoma As ......"27694794Western blot
hsa-miR-27b-5p

kidney renal cell cancerworse prognosis"Conversely decreased expression of miR-106b miR-99 ......"26416448
hsa-miR-27b-5p

liver cancerdrug resistance"The cell viability MTT assay was used to detect dr ......"23229111MTT assay
hsa-miR-27b-5p

liver cancermalignant trasformation"Using gene expression microarrays and high-through ......"26646011
hsa-miR-27b-5p

lymphomastaging"The miRNA expression profiles of skin biopsies fro ......"22776000
hsa-miR-27b-5p

pancreatic cancerstaging"Based on relevance to cancer a seven-miRNA signatu ......"25184537
hsa-miR-27b-5p

prostate cancerprogression; poor survival"The expression of miR-23b and miR-27b which are en ......"23300597Colony formation
hsa-miR-27b-5p

prostate cancerprogression; poor survival"Kaplan-Meier survival curves showed that low expre ......"25115396



Reported gene related to hsa-miR-27b-5p

miRNAcancergenereportingPUBMED
hsa-miR-27b-5p

gastric cancerAPC"Finally the APC gene was identified as the direct ......"22018270
hsa-miR-27b-5p

gastric cancerCCNG1"Moreover miR-27b directly targets the 3' untransla ......"26623719
hsa-miR-27b-5p

cervical and endocervical cancerDGCR8"Furthermore DGCR8 was found to mediate the up-regu ......"26910911
hsa-miR-27b-5p

bladder cancerDROSHA"Genetic variation in DROSHA 3'UTR regulated by hsa ......"24312312
hsa-miR-27b-5p

breast cancerEGF"Prooncogenic factors miR 23b and miR 27b are regul ......"23338610
hsa-miR-27b-5p

breast cancerENPP1"Loss of microRNA 27b contributes to breast cancer ......"26065921
hsa-miR-27b-5p

gastric cancerFZD7"Restoration of FZD7 expression significantly atten ......"26780940
hsa-miR-27b-5p

prostate cancerGOLM1"GOLM1 was directly regulated by miR-27b in PCa cel ......"25115396
hsa-miR-27b-5p

head and neck cancerHGF"Among several miRNAs in which the expression was a ......"21899661
hsa-miR-27b-5p

breast cancerHMGB3"MiR 27b is epigenetically downregulated in tamoxif ......"27363334
hsa-miR-27b-5p

breast cancerNISCH"Nischarin NISCH expression was augmented by knockd ......"23338610
hsa-miR-27b-5p

cervical and endocervical cancerPLK2"Dual-luciferase experiment confirmed miR-27b down- ......"26910911
hsa-miR-27b-5p

cervical and endocervical cancerPPIE"The results showed that PPARγ as a target of miR- ......"26397063
hsa-miR-27b-5p

melanomaPRDX2"Treatment with 125OH2D3 and/or epigenetic drugs 5- ......"22213330
hsa-miR-27b-5p

cervical and endocervical cancerSLC9A1"The results showed that PPARγ as a target of miR- ......"26397063
hsa-miR-27b-5p

breast cancerTNF"Prooncogenic factors miR 23b and miR 27b are regul ......"23338610
hsa-miR-27b-5p

gastric cancerTP53"Moreover miR-27b directly targets the 3' untransla ......"26623719
hsa-miR-27b-5p

gastric cancerUCA1"Long Non Coding RNA LncRNA Urothelial Carcinoma As ......"27694794
hsa-miR-27b-5p

melanomaVDR"The expression of VDR mRNA protein and two candida ......"22213330
hsa-miR-27b-5p

colorectal cancerVEGFC"We identified vascular endothelial growth factor C ......"23593282



Expression profile in cancer corhorts:




Putative target regulations

miRNAGeneCancerInteractionCorrelation beta
hsa-miR-27b-5p
RAB11FIP2
11 cancers: BLCA; BRCA; CESC; COAD; ESCA; HNSC; LGG; LIHC; LUAD; LUSC; OV
MirTarget
TCGA BLCA -0.102; TCGA BRCA -0.051; TCGA CESC -0.092; TCGA COAD -0.128; TCGA ESCA -0.267; TCGA HNSC -0.137; TCGA LGG -0.12; TCGA LIHC -0.096; TCGA LUAD -0.091; TCGA LUSC -0.193; TCGA OV -0.116
hsa-miR-27b-5p
ZEB2
12 cancers: BLCA; COAD; ESCA; HNSC; KIRC; LGG; LUAD; LUSC; PAAD; SARC; THCA; STAD
MirTarget; miRNATAP
TCGA BLCA -0.266; TCGA COAD -0.289; TCGA ESCA -0.353; TCGA HNSC -0.366; TCGA KIRC -0.142; TCGA LGG -0.069; TCGA LUAD -0.249; TCGA LUSC -0.494; TCGA PAAD -0.397; TCGA SARC -0.12; TCGA THCA -0.306; TCGA STAD -0.245
hsa-miR-27b-5p
FKBP5
10 cancers: BLCA; BRCA; KIRC; LIHC; LUAD; LUSC; PAAD; PRAD; THCA; STAD
mirMAP
TCGA BLCA -0.268; TCGA BRCA -0.12; TCGA KIRC -0.379; TCGA LIHC -0.22; TCGA LUAD -0.197; TCGA LUSC -0.277; TCGA PAAD -0.39; TCGA PRAD -0.225; TCGA THCA -0.174; TCGA STAD -0.276
hsa-miR-27b-5p
CRTC1
9 cancers: BLCA; BRCA; CESC; COAD; ESCA; LGG; LUSC; OV; STAD
mirMAP
TCGA BLCA -0.097; TCGA BRCA -0.108; TCGA CESC -0.16; TCGA COAD -0.105; TCGA ESCA -0.147; TCGA LGG -0.16; TCGA LUSC -0.149; TCGA OV -0.077; TCGA STAD -0.134
hsa-miR-27b-5p
MKLN1
9 cancers: BLCA; BRCA; ESCA; LGG; LIHC; OV; PRAD; THCA; UCEC
mirMAP
TCGA BLCA -0.071; TCGA BRCA -0.089; TCGA ESCA -0.083; TCGA LGG -0.185; TCGA LIHC -0.067; TCGA OV -0.063; TCGA PRAD -0.114; TCGA THCA -0.05; TCGA UCEC -0.071
hsa-miR-27b-5p
ACE
9 cancers: BLCA; BRCA; CESC; ESCA; HNSC; KIRC; LUAD; LUSC; SARC
mirMAP
TCGA BLCA -0.179; TCGA BRCA -0.13; TCGA CESC -0.395; TCGA ESCA -0.403; TCGA HNSC -0.19; TCGA KIRC -0.252; TCGA LUAD -0.309; TCGA LUSC -0.481; TCGA SARC -0.192
hsa-miR-27b-5p
FSTL1
9 cancers: BLCA; CESC; COAD; ESCA; HNSC; KIRC; LUSC; SARC; THCA
mirMAP
TCGA BLCA -0.192; TCGA CESC -0.359; TCGA COAD -0.328; TCGA ESCA -0.284; TCGA HNSC -0.476; TCGA KIRC -0.221; TCGA LUSC -0.322; TCGA SARC -0.305; TCGA THCA -0.188
hsa-miR-27b-5p
TSPAN13
11 cancers: BRCA; CESC; ESCA; HNSC; KIRC; LGG; LIHC; LUSC; OV; PRAD; UCEC
MirTarget
TCGA BRCA -0.17; TCGA CESC -0.439; TCGA ESCA -0.191; TCGA HNSC -0.115; TCGA KIRC -0.143; TCGA LGG -0.097; TCGA LIHC -0.249; TCGA LUSC -0.228; TCGA OV -0.247; TCGA PRAD -0.383; TCGA UCEC -0.277
hsa-miR-27b-5p
GLCCI1
9 cancers: BRCA; CESC; ESCA; KIRC; LGG; LUAD; LUSC; OV; STAD
MirTarget; miRNATAP
TCGA BRCA -0.092; TCGA CESC -0.117; TCGA ESCA -0.272; TCGA KIRC -0.228; TCGA LGG -0.424; TCGA LUAD -0.178; TCGA LUSC -0.325; TCGA OV -0.168; TCGA STAD -0.252
hsa-miR-27b-5p
MGAT4A
10 cancers: BRCA; CESC; ESCA; HNSC; LUSC; PRAD; SARC; THCA; STAD; UCEC
mirMAP
TCGA BRCA -0.144; TCGA CESC -0.43; TCGA ESCA -0.584; TCGA HNSC -0.16; TCGA LUSC -0.487; TCGA PRAD -0.243; TCGA SARC -0.141; TCGA THCA -0.077; TCGA STAD -0.252; TCGA UCEC -0.253
hsa-miR-27b-5p
GFRA1
9 cancers: BRCA; COAD; ESCA; HNSC; LGG; LUSC; SARC; THCA; STAD
mirMAP
TCGA BRCA -0.318; TCGA COAD -0.483; TCGA ESCA -0.637; TCGA HNSC -0.476; TCGA LGG -0.938; TCGA LUSC -0.357; TCGA SARC -0.399; TCGA THCA -0.831; TCGA STAD -0.73
hsa-miR-27b-5p
STC1
9 cancers: BRCA; CESC; COAD; HNSC; LUAD; LUSC; SARC; STAD; UCEC
miRNATAP
TCGA BRCA -0.155; TCGA CESC -0.575; TCGA COAD -0.318; TCGA HNSC -0.24; TCGA LUAD -0.202; TCGA LUSC -0.173; TCGA SARC -0.332; TCGA STAD -0.186; TCGA UCEC -0.424
hsa-miR-27b-5p
PGM3
10 cancers: CESC; HNSC; KIRC; KIRP; LGG; PAAD; PRAD; SARC; THCA; UCEC
MirTarget
TCGA CESC -0.243; TCGA HNSC -0.192; TCGA KIRC -0.162; TCGA KIRP -0.16; TCGA LGG -0.159; TCGA PAAD -0.197; TCGA PRAD -0.276; TCGA SARC -0.084; TCGA THCA -0.088; TCGA UCEC -0.13
hsa-miR-27b-5p
SEC63
10 cancers: CESC; ESCA; HNSC; KIRP; LGG; LUAD; OV; PAAD; PRAD; SARC
MirTarget
TCGA CESC -0.138; TCGA ESCA -0.156; TCGA HNSC -0.123; TCGA KIRP -0.072; TCGA LGG -0.103; TCGA LUAD -0.083; TCGA OV -0.083; TCGA PAAD -0.174; TCGA PRAD -0.159; TCGA SARC -0.108
hsa-miR-27b-5p
LHFPL2
9 cancers: CESC; ESCA; HNSC; KIRC; KIRP; LUAD; LUSC; SARC; STAD
mirMAP
TCGA CESC -0.132; TCGA ESCA -0.184; TCGA HNSC -0.252; TCGA KIRC -0.672; TCGA KIRP -0.226; TCGA LUAD -0.154; TCGA LUSC -0.309; TCGA SARC -0.107; TCGA STAD -0.165





Enriched cancer pathways of putative targets