microRNA information: hsa-miR-34c-5p
| Section | ID | link |
|---|---|---|
| Mature name: | hsa-miR-34c-5p | miRbase |
| Accession: | MIMAT0000686 | miRbase |
| Precursor name: | hsa-mir-34c | miRbase |
| Precursor accession: | MI0000743 | miRbase |
| Symbol: | MIR34C | HGNC |
| RefSeq ID: | NR_029840 | GenBank |
| Sequence: | AGGCAGUGUAGUUAGCUGAUUGC |
Reported expression in cancers: hsa-miR-34c-5p
| miRNA | cancer | regulation | reporting | PUBMED | method |
|---|---|---|---|---|---|
| hsa-miR-34c-5p | breast cancer | downregulation | "Effects on potential targets were analyzed with qP ......" | 25064703 | qPCR |
| hsa-miR-34c-5p | breast cancer | downregulation | "Here we found that microRNA-34c miR-34c was signif ......" | 27698902 | |
| hsa-miR-34c-5p | colorectal cancer | downregulation | "Silence of the tumor suppressor miR-34c is implica ......" | 26674205 | qPCR |
| hsa-miR-34c-5p | gastric cancer | downregulation | "We found that miR-34b and miR-34c are epigenetical ......" | 20924086 | |
| hsa-miR-34c-5p | gastric cancer | downregulation | "Human miR-34c has been reported to be associated w ......" | 23423488 | RNA-Seq; qPCR |
| hsa-miR-34c-5p | lung cancer | downregulation | "MiR-34a and miR-34c were downregulated in lung tum ......" | 23805317 | |
| hsa-miR-34c-5p | ovarian cancer | downregulation | "The variations in cell growth rate and cell cycle ......" | 26770455 | |
| hsa-miR-34c-5p | prostate cancer | downregulation | "miR 34c is downregulated in prostate cancer and ex ......" | 21351256 | qPCR |
| hsa-miR-34c-5p | prostate cancer | downregulation | "The microRNA miR-34c is a well-established regulat ......" | 23922103 |
Reported cancer pathway affected by hsa-miR-34c-5p
| miRNA | cancer | pathway | reporting | PUBMED | functional study |
|---|---|---|---|---|---|
| hsa-miR-34c-5p | breast cancer | Epithelial mesenchymal transition pathway | "MicroRNA 34c gene down regulation via DNA methylat ......" | 22074923 | |
| hsa-miR-34c-5p | breast cancer | cell cycle pathway | "Expression of miR 34c induces G2/M cell cycle arre ......" | 25064703 | Western blot |
| hsa-miR-34c-5p | lung cancer | Apoptosis pathway | "miR 34c may protect lung cancer cells from paclita ......" | 22370637 | |
| hsa-miR-34c-5p | melanoma | cell cycle pathway | "Subsequently uveal melanoma cell proliferation was ......" | 22419847 | Flow cytometry; Cell migration assay; Luciferase; Western blot |
| hsa-miR-34c-5p | ovarian cancer | cell cycle pathway | "miR 449b and miR 34c on inducing down regulation o ......" | 21321636 | Western blot |
| hsa-miR-34c-5p | ovarian cancer | cell cycle pathway | "The reactivation of p53 was detected by Western bl ......" | 22340095 | Western blot |
| hsa-miR-34c-5p | ovarian cancer | cell cycle pathway; Apoptosis pathway | "Functional analysis of miR 34c as a putative tumor ......" | 25273528 | |
| hsa-miR-34c-5p | ovarian cancer | cell cycle pathway | "The variations in cell growth rate and cell cycle ......" | 26770455 | Flow cytometry; Cell Proliferation Assay; Western blot |
| hsa-miR-34c-5p | prostate cancer | Apoptosis pathway | "MiR-34c expression increased 27 fold after DOX and ......" | 18497571 | |
| hsa-miR-34c-5p | prostate cancer | Apoptosis pathway | "miR 34c is downregulated in prostate cancer and ex ......" | 21351256 | |
| hsa-miR-34c-5p | prostate cancer | cell cycle pathway | "The tumour suppressor miR 34c targets MET in prost ......" | 23922103 | Luciferase |
| hsa-miR-34c-5p | retinoblastoma | cell cycle pathway | "To investigate differential expression of microRNA ......" | 21941147 |
Reported cancer prognosis affected by hsa-miR-34c-5p
| miRNA | cancer | prognosis | reporting | PUBMED | functional study |
|---|---|---|---|---|---|
| hsa-miR-34c-5p | breast cancer | poor survival | "Global miRNA expression profiling was performed on ......" | 19798417 | |
| hsa-miR-34c-5p | breast cancer | metastasis | "Here we describe the regulation and function of mi ......" | 23001043 | |
| hsa-miR-34c-5p | breast cancer | worse prognosis; progression | "Expression of miR 34c induces G2/M cell cycle arre ......" | 25064703 | Western blot |
| hsa-miR-34c-5p | breast cancer | cell migration | "MicroRNA 34c Suppresses Breast Cancer Migration an ......" | 27698902 | |
| hsa-miR-34c-5p | colorectal cancer | metastasis; tumorigenesis | "KITLG is a novel target of miR 34c that is associa ......" | 25213795 | Luciferase |
| hsa-miR-34c-5p | colorectal cancer | progression | "Resveratrol elicits anti colorectal cancer effect ......" | 26674205 | Flow cytometry; Colony formation; Western blot |
| hsa-miR-34c-5p | gastric cancer | drug resistance | "Regulation of microtubule associated protein tau M ......" | 23423488 | Western blot; Luciferase; MTT assay |
| hsa-miR-34c-5p | gastric cancer | tumorigenesis; poor survival | "PABPC1 exerts carcinogenesis in gastric carcinoma ......" | 26097561 | |
| hsa-miR-34c-5p | lung cancer | drug resistance | "miR 34c may protect lung cancer cells from paclita ......" | 22370637 | |
| hsa-miR-34c-5p | lung cancer | drug resistance | "We analyzed the expression of 14 selected miRNAs b ......" | 23268837 | |
| hsa-miR-34c-5p | lung cancer | poor survival | "Some representative cases from each group were pro ......" | 26170125 | |
| hsa-miR-34c-5p | lung squamous cell cancer | drug resistance | "The miR-34 family is composed of three miRNAs miR- ......" | 19736307 | |
| hsa-miR-34c-5p | melanoma | cell migration | "Subsequently uveal melanoma cell proliferation was ......" | 22419847 | Flow cytometry; Cell migration assay; Luciferase; Western blot |
| hsa-miR-34c-5p | ovarian cancer | malignant trasformation | "miR 449b and miR 34c on inducing down regulation o ......" | 21321636 | Western blot |
| hsa-miR-34c-5p | ovarian cancer | staging | "The reactivation of p53 was detected by Western bl ......" | 22340095 | Western blot |
| hsa-miR-34c-5p | ovarian cancer | tumorigenesis | "Functional analysis of miR 34c as a putative tumor ......" | 25273528 | |
| hsa-miR-34c-5p | pancreatic cancer | staging | "In addition from 10 to 50 weeks of age stage-speci ......" | 26516699 | |
| hsa-miR-34c-5p | prostate cancer | drug resistance | "Using multiplexed quantitative real-time PCR we pe ......" | 18668526 | |
| hsa-miR-34c-5p | prostate cancer | metastasis; poor survival | "miR 34c is downregulated in prostate cancer and ex ......" | 21351256 | |
| hsa-miR-34c-5p | prostate cancer | progression | "The tumour suppressor miR 34c targets MET in prost ......" | 23922103 | Luciferase |
| hsa-miR-34c-5p | sarcoma | metastasis; drug resistance | "MiR 34c inhibits osteosarcoma metastasis and chemo ......" | 24802328 |
Reported gene related to hsa-miR-34c-5p
| miRNA | cancer | gene | reporting | PUBMED |
|---|---|---|---|---|
| hsa-miR-34c-5p | breast cancer | TP53 | "Downregulation of nuclear FOXO3a decreased the exp ......" | 25647415 |
| hsa-miR-34c-5p | colorectal cancer | TP53 | "The anti-CRC effect of Res was partially but speci ......" | 26674205 |
| hsa-miR-34c-5p | colorectal cancer | TP53 | "We found that miRNA-34b miR-34b and miR-34c two co ......" | 18519671 |
| hsa-miR-34c-5p | ovarian cancer | TP53 | "The expressions of miR-449a/b miR-34b and miR-34c ......" | 22340095 |
| hsa-miR-34c-5p | sarcoma | TP53 | "Importantly Nutlin-3-mediated stabilization of p53 ......" | 23720736 |
| hsa-miR-34c-5p | colorectal cancer | KITLG | "KITLG is a novel target of miR 34c that is associa ......" | 25213795 |
| hsa-miR-34c-5p | colorectal cancer | KITLG | "Resveratrol elicits anti colorectal cancer effect ......" | 26674205 |
| hsa-miR-34c-5p | colorectal cancer | KITLG | "Interrupted E2F1 miR 34c SCF negative feedback loo ......" | 26704889 |
| hsa-miR-34c-5p | prostate cancer | AR | "In particular analysis of clinical prostate cancer ......" | 21343391 |
| hsa-miR-34c-5p | prostate cancer | BCL2 | "In concordance to this miR-34c was found to negati ......" | 21351256 |
| hsa-miR-34c-5p | breast cancer | CDC23 | "In addition the levels of CDC23 an important media ......" | 25064703 |
| hsa-miR-34c-5p | ovarian cancer | CDC25A | "Ectopic expression of miR-449b and miR-34c resulte ......" | 21321636 |
| hsa-miR-34c-5p | ovarian cancer | CDK6 | "Ectopic expression of miR-449b and miR-34c resulte ......" | 21321636 |
| hsa-miR-34c-5p | colorectal cancer | E2F1 | "Interrupted E2F1 miR 34c SCF negative feedback loo ......" | 26704889 |
| hsa-miR-34c-5p | prostate cancer | E2F3 | "In concordance to this miR-34c was found to negati ......" | 21351256 |
| hsa-miR-34c-5p | lung cancer | EGFR | "In EGFR exon 19 mutation group miR-34c high expres ......" | 26170125 |
| hsa-miR-34c-5p | lung squamous cell cancer | EIF4E | "miR 34c 3p functions as a tumour suppressor by inh ......" | 26250586 |
| hsa-miR-34c-5p | breast cancer | FOXO3 | "Downregulation of nuclear FOXO3a decreased the exp ......" | 25647415 |
| hsa-miR-34c-5p | breast cancer | GIT1 | "MicroRNA 34c Suppresses Breast Cancer Migration an ......" | 27698902 |
| hsa-miR-34c-5p | sarcoma | LEF1 | "Taken together our data indicate that miR-34c supp ......" | 24802328 |
| hsa-miR-34c-5p | gastric cancer | MAPT | "Luciferase activity assay confirmed that the 3'-UT ......" | 23423488 |
| hsa-miR-34c-5p | liver cancer | MARCKS | "miR 34c 3p inhibits cell proliferation migration a ......" | 26722462 |
| hsa-miR-34c-5p | liver cancer | NCKAP1 | "MicroRNA 34c 3p promotes cell proliferation and in ......" | 27704267 |
| hsa-miR-34c-5p | sarcoma | NOTCH1 | "Taken together our data indicate that miR-34c supp ......" | 24802328 |
| hsa-miR-34c-5p | breast cancer | NOTCH4 | "Ectopic expression of miR-34c reduced the self-ren ......" | 22074923 |
| hsa-miR-34c-5p | gastric cancer | PABPC1 | "PABPC1 exerts carcinogenesis in gastric carcinoma ......" | 26097561 |
| hsa-miR-34c-5p | lung cancer | PCNA | "The miR-34c target cyclin E was repressed by miR-3 ......" | 19228723 |
| hsa-miR-34c-5p | ovarian cancer | PHLDA2 | "miR 449b and miR 34c on inducing down regulation o ......" | 21321636 |
| hsa-miR-34c-5p | breast cancer | PRKCA | "However protein levels of PRKCA a predicted miR-34 ......" | 25064703 |
| hsa-miR-34c-5p | sarcoma | RUNX2 | "The p53-dependent miR-34c is the most significantl ......" | 23720736 |
| hsa-miR-34c-5p | breast cancer | SP1 | "Furthermore we identified a single hypermethylated ......" | 22074923 |
| hsa-miR-34c-5p | lung cancer | TXK | "In this study we found that miR-34a and miR-34c ta ......" | 23805317 |
Expression profile in cancer corhorts:
Putative target regulations
| miRNA | Gene | Cancer | Interaction | Correlation beta |
|---|---|---|---|---|
hsa-miR-34c-5p | UNC13B | 9 cancers: BLCA; BRCA; CESC; ESCA; HNSC; LUAD; PAAD; THCA; STAD | miRanda | TCGA BLCA -0.076; TCGA BRCA -0.063; TCGA CESC -0.062; TCGA ESCA -0.216; TCGA HNSC -0.064; TCGA LUAD -0.052; TCGA PAAD -0.114; TCGA THCA -0.059; TCGA STAD -0.088 |
hsa-miR-34c-5p | KIAA1958 | 12 cancers: BRCA; CESC; COAD; ESCA; LGG; LUAD; LUSC; PAAD; PRAD; SARC; THCA; STAD | miRanda | TCGA BRCA -0.087; TCGA CESC -0.063; TCGA COAD -0.172; TCGA ESCA -0.123; TCGA LGG -0.074; TCGA LUAD -0.055; TCGA LUSC -0.053; TCGA PAAD -0.169; TCGA PRAD -0.143; TCGA SARC -0.134; TCGA THCA -0.072; TCGA STAD -0.13 |
hsa-miR-34c-5p | TUBGCP4 | 9 cancers: BRCA; COAD; LGG; LUSC; PRAD; SARC; THCA; STAD; UCEC | miRanda | TCGA BRCA -0.078; TCGA COAD -0.183; TCGA LGG -0.089; TCGA LUSC -0.068; TCGA PRAD -0.103; TCGA SARC -0.06; TCGA THCA -0.076; TCGA STAD -0.052; TCGA UCEC -0.052 |
hsa-miR-34c-5p | SLC39A14 | 9 cancers: BRCA; COAD; ESCA; LGG; LUAD; LUSC; PRAD; THCA; UCEC | miRanda | TCGA BRCA -0.054; TCGA COAD -0.146; TCGA ESCA -0.248; TCGA LGG -0.092; TCGA LUAD -0.07; TCGA LUSC -0.112; TCGA PRAD -0.084; TCGA THCA -0.071; TCGA UCEC -0.078 |
hsa-miR-34c-5p | SLC7A1 | 10 cancers: BRCA; COAD; HNSC; LGG; LUAD; LUSC; PAAD; PRAD; THCA; STAD | mirMAP | TCGA BRCA -0.121; TCGA COAD -0.156; TCGA HNSC -0.06; TCGA LGG -0.06; TCGA LUAD -0.069; TCGA LUSC -0.06; TCGA PAAD -0.165; TCGA PRAD -0.106; TCGA THCA -0.08; TCGA STAD -0.086 |
Enriched cancer pathways of putative targets