microRNA information: hsa-miR-378a-3p

SectionIDlink
Mature name: hsa-miR-378a-3pmiRbase
Accession: MIMAT0000732miRbase
Precursor name: hsa-mir-378a miRbase
Precursor accession: MI0000786miRbase
Symbol: NAHGNC
RefSeq ID: NAGenBank
Sequence: ACUGGACUUGGAGUCAGAAGGC



Reported expression in cancers: hsa-miR-378a-3p

miRNAcancerregulationreportingPUBMEDmethod
hsa-miR-378a-3p

acute myeloid leukemiaupregulation"Overexpression of miR 378 is frequent and may affe ......"23582927qPCR
hsa-miR-378a-3p

breast cancerupregulation"Association between mir 24 and mir 378 in formalin ......"25120807qPCR
hsa-miR-378a-3p

breast cancerdownregulation"We found that miR-378a-3p expression was downregul ......"26255816
hsa-miR-378a-3p

colorectal cancerdownregulation"MiR 378 is an independent prognostic factor and in ......"24555885
hsa-miR-378a-3p

gastric cancerupregulation"The most highly expressed miRNAs in non-tumorous t ......"19175831
hsa-miR-378a-3p

gastric cancerderegulation"The results from the miRNA microarray analysis wer ......"21475928qPCR; Microarray
hsa-miR-378a-3p

gastric cancerdownregulation"The low expression of miR-195 and miR-378 was clos ......"23333942
hsa-miR-378a-3p

gastric cancerupregulation"We identified five miRNAs that were most consisten ......"24040025qPCR
hsa-miR-378a-3p

gastric cancerdownregulation"Currently a large number of miRNAs have been repor ......"24139413
hsa-miR-378a-3p

liver cancerupregulation"miR-378 regulates osteoblast differentiation and p ......"25562172qPCR
hsa-miR-378a-3p

lung cancerupregulation"The effect of miR-378 upregulation on tumor growth ......"26781643
hsa-miR-378a-3p

lung squamous cell cancerderegulation"The most potently down-regulated was miR-378. Over ......"23617628
hsa-miR-378a-3p

prostate cancerdownregulation"Thereafter RNA was polyadenylated and reverse tran ......"25153390qPCR
hsa-miR-378a-3p

prostate cancerdownregulation"Here we evaluated the anti-proliferative role of m ......"26346167



Reported cancer pathway affected by hsa-miR-378a-3p

miRNAcancerpathwayreportingPUBMEDfunctional study
hsa-miR-378a-3p

acute myeloid leukemiaApoptosis pathway"Overexpression of miR 378 is frequent and may affe ......"23582927
hsa-miR-378a-3p

colorectal cancercell cycle pathway; Apoptosis pathway"Clinical and biological significance of miR 378a 3 ......"24412052Colony formation
hsa-miR-378a-3p

colorectal cancerApoptosis pathway"MiR-378 is frequently downregulated in colorectal ......"25328987Luciferase
hsa-miR-378a-3p

gastric cancerVEGF signaling pathway"We found that microRNA-195 miR-195 and microRNA-37 ......"23333942
hsa-miR-378a-3p

gastric cancercell cycle pathway; Apoptosis pathway"MiR 378 inhibits progression of human gastric canc ......"24139413
hsa-miR-378a-3p

ovarian cancercell cycle pathway; Apoptosis pathway"MiR 378 as a biomarker for response to anti angiog ......"24680769
hsa-miR-378a-3p

sarcomaApoptosis pathway; cell cycle pathway"Deep Sequencing the microRNA profile in rhabdomyos ......"25427715Western blot; Cell migration assay



Reported cancer prognosis affected by hsa-miR-378a-3p

miRNAcancerprognosisreportingPUBMEDfunctional study
hsa-miR-378a-3p

acute myeloid leukemiatumorigenesis; poor survival; cell migration; worse prognosis"Overexpression of miR 378 is frequent and may affe ......"23582927
hsa-miR-378a-3p

acute myeloid leukemiapoor survival"The 5' flanking region of miR 378 is hypomethylate ......"26191124
hsa-miR-378a-3p

breast cancerworse prognosis"miR 378a 3p modulates tamoxifen sensitivity in bre ......"26255816
hsa-miR-378a-3p

breast cancerstaging; progression; cell migration"Microarray profiling of the MMTV-PyMT model reveal ......"26749280Luciferase
hsa-miR-378a-3p

chronic myeloid leukemiastaging"Methylation of miR 378 in Chronic Myeloid Leukemia ......"26913395
hsa-miR-378a-3p

colorectal cancerstaging; differentiation; poor survival; tumorigenesis"Clinical and biological significance of miR 378a 3 ......"24412052Colony formation
hsa-miR-378a-3p

colorectal cancerpoor survival; worse prognosis"MiR 378 is an independent prognostic factor and in ......"24555885Luciferase
hsa-miR-378a-3p

colorectal cancerworse prognosis; drug resistance"MiR-378 is frequently downregulated in colorectal ......"25328987Luciferase
hsa-miR-378a-3p

colorectal cancerdrug resistance"Previous studies have connected higher expression ......"26496897
hsa-miR-378a-3p

esophageal cancerdrug resistance"An in-vitro model of acquired chemotherapy resista ......"25356050
hsa-miR-378a-3p

gastric cancerprogression; cell migration"MiR 378 inhibits progression of human gastric canc ......"24139413
hsa-miR-378a-3p

kidney renal cell cancermalignant trasformation; staging; metastasis"Analysis of serum microRNAs miR 26a 2* miR 191 miR ......"22542158
hsa-miR-378a-3p

kidney renal cell cancerstaging"Markedly dysregulated miRNAs in RCC cases were sub ......"25556603
hsa-miR-378a-3p

kidney renal cell cancerstaging; poor survival"Combination of MiR 378 and MiR 210 Serum Levels En ......"26426010
hsa-miR-378a-3p

liver cancerworse prognosis; poor survival"A genetic variant in primary miR 378 is associated ......"24751683
hsa-miR-378a-3p

liver cancerdifferentiation; drug resistance; cell migration; metastasis"MiR 378 promotes the migration of liver cancer cel ......"25562172
hsa-miR-378a-3p

lung cancerdrug resistance"The objectives of the study were to determine the ......"26781643Luciferase
hsa-miR-378a-3p

lung squamous cell cancermetastasis; cell migration"In this study using RT-PCR and further northern bl ......"22052152
hsa-miR-378a-3p

lung squamous cell cancermetastasis; progression"Interplay between heme oxygenase 1 and miR 378 aff ......"23617628
hsa-miR-378a-3p

ovarian cancerdrug resistance; progression; poor survival"MiR 378 as a biomarker for response to anti angiog ......"24680769
hsa-miR-378a-3p

prostate cancerstaging; worse prognosis; poor survival; recurrence; progression"Loss of miR 378 in prostate cancer a common regula ......"25153390
hsa-miR-378a-3p

sarcomadifferentiation; cell migration"Deep Sequencing the microRNA profile in rhabdomyos ......"25427715Western blot; Cell migration assay



Reported gene related to hsa-miR-378a-3p

miRNAcancergenereportingPUBMED
hsa-miR-378a-3p

colorectal cancerIGF1R"Furthermore miR-378a-3p over-expression or down-re ......"24412052
hsa-miR-378a-3p

liver cancerIGF1R"The insulin-like growth factor 1 receptor IGF1R wa ......"24119742
hsa-miR-378a-3p

sarcomaIGF1R"Interestingly members of the miR-378 family presen ......"25427715
hsa-miR-378a-3p

gastric cancerMAPK1"MiR 378 inhibits progression of human gastric canc ......"24139413
hsa-miR-378a-3p

prostate cancerMAPK1"MiR 378 suppresses prostate cancer cell growth thr ......"26346167
hsa-miR-378a-3p

colorectal cancerBRAF"Previous studies have connected higher expression ......"26496897
hsa-miR-378a-3p

colorectal cancerCDC40"Bioinformatics analysis further deduced that CDC40 ......"25328987
hsa-miR-378a-3p

gastric cancerCDK6"Expression of cyclin-dependent kinase 6 and vascul ......"23333942
hsa-miR-378a-3p

liver cancerFUS"MiR 378 promotes the migration of liver cancer cel ......"25562172
hsa-miR-378a-3p

breast cancerGOLT1A"miR 378a 3p modulates tamoxifen sensitivity in bre ......"26255816
hsa-miR-378a-3p

lung squamous cell cancerHMOX1"Interplay between heme oxygenase 1 and miR 378 aff ......"23617628
hsa-miR-378a-3p

acute myeloid leukemiaIBSP"Methylation status of miR-378 5'-flanking region w ......"26191124
hsa-miR-378a-3p

prostate cancerKLK2"Loss of miR 378 in prostate cancer a common regula ......"25153390
hsa-miR-378a-3p

prostate cancerKLK4"Loss of miR 378 in prostate cancer a common regula ......"25153390
hsa-miR-378a-3p

colorectal cancerKRAS"Previous studies have connected higher expression ......"26496897
hsa-miR-378a-3p

breast cancerPPARGC1B"Depletion of Runx1 in late-stage breast cancer cel ......"26749280
hsa-miR-378a-3p

breast cancerRUNX1"One of these miR-378 was inversely correlated with ......"26749280
hsa-miR-378a-3p

colorectal cancerVIM"Luciferase assay was performed to assess miR-378 b ......"24555885



Expression profile in cancer corhorts:




Putative target regulations

miRNAGeneCancerInteractionCorrelation beta
hsa-miR-378a-3p
FLNA
11 cancers: BLCA; COAD; ESCA; HNSC; KIRC; KIRP; LIHC; LUSC; SARC; STAD; UCEC
miRNAWalker2 validate
TCGA BLCA -0.491; TCGA COAD -0.68; TCGA ESCA -0.318; TCGA HNSC -0.162; TCGA KIRC -0.149; TCGA KIRP -0.094; TCGA LIHC -0.197; TCGA LUSC -0.233; TCGA SARC -0.382; TCGA STAD -0.351; TCGA UCEC -0.168
hsa-miR-378a-3p
NLGN2
13 cancers: BLCA; COAD; ESCA; HNSC; KIRC; KIRP; LIHC; LUAD; OV; SARC; THCA; STAD; UCEC
miRNAWalker2 validate
TCGA BLCA -0.21; TCGA COAD -0.489; TCGA ESCA -0.345; TCGA HNSC -0.162; TCGA KIRC -0.19; TCGA KIRP -0.292; TCGA LIHC -0.113; TCGA LUAD -0.123; TCGA OV -0.125; TCGA SARC -0.171; TCGA THCA -0.101; TCGA STAD -0.25; TCGA UCEC -0.172
hsa-miR-378a-3p
STXBP1
9 cancers: BLCA; COAD; ESCA; HNSC; KIRP; LUSC; PAAD; STAD; UCEC
miRNAWalker2 validate
TCGA BLCA -0.389; TCGA COAD -0.347; TCGA ESCA -0.285; TCGA HNSC -0.159; TCGA KIRP -0.067; TCGA LUSC -0.19; TCGA PAAD -0.275; TCGA STAD -0.399; TCGA UCEC -0.127
hsa-miR-378a-3p
SULF1
14 cancers: BLCA; BRCA; CESC; COAD; ESCA; HNSC; KIRP; LGG; LIHC; LUAD; LUSC; SARC; STAD; UCEC
MirTarget; miRNATAP
TCGA BLCA -0.866; TCGA BRCA -0.257; TCGA CESC -0.34; TCGA COAD -0.81; TCGA ESCA -0.695; TCGA HNSC -0.234; TCGA KIRP -0.459; TCGA LGG -0.398; TCGA LIHC -0.302; TCGA LUAD -0.145; TCGA LUSC -0.246; TCGA SARC -0.407; TCGA STAD -0.469; TCGA UCEC -0.261
hsa-miR-378a-3p
MPP3
9 cancers: BLCA; BRCA; HNSC; KIRP; LIHC; LUAD; SARC; THCA; STAD
MirTarget
TCGA BLCA -0.411; TCGA BRCA -0.107; TCGA HNSC -0.175; TCGA KIRP -0.291; TCGA LIHC -0.442; TCGA LUAD -0.129; TCGA SARC -0.155; TCGA THCA -0.197; TCGA STAD -0.133
hsa-miR-378a-3p
SERINC1
9 cancers: BLCA; CESC; COAD; ESCA; KIRC; LUSC; PAAD; STAD; UCEC
MirTarget
TCGA BLCA -0.08; TCGA CESC -0.054; TCGA COAD -0.159; TCGA ESCA -0.189; TCGA KIRC -0.069; TCGA LUSC -0.173; TCGA PAAD -0.124; TCGA STAD -0.078; TCGA UCEC -0.079
hsa-miR-378a-3p
FCGR1A
11 cancers: BLCA; BRCA; CESC; COAD; ESCA; HNSC; LGG; LIHC; LUSC; PRAD; STAD
MirTarget
TCGA BLCA -0.666; TCGA BRCA -0.214; TCGA CESC -0.264; TCGA COAD -0.583; TCGA ESCA -0.468; TCGA HNSC -0.178; TCGA LGG -0.261; TCGA LIHC -0.16; TCGA LUSC -0.478; TCGA PRAD -0.312; TCGA STAD -0.244
hsa-miR-378a-3p
SSPN
9 cancers: BLCA; COAD; ESCA; KIRC; KIRP; LGG; LIHC; LUSC; STAD
MirTarget
TCGA BLCA -0.137; TCGA COAD -0.518; TCGA ESCA -0.536; TCGA KIRC -0.092; TCGA KIRP -0.1; TCGA LGG -0.238; TCGA LIHC -0.245; TCGA LUSC -0.549; TCGA STAD -0.33
hsa-miR-378a-3p
PAPPA
9 cancers: BLCA; CESC; COAD; ESCA; HNSC; KIRC; LUAD; LUSC; UCEC
MirTarget
TCGA BLCA -0.423; TCGA CESC -0.535; TCGA COAD -0.474; TCGA ESCA -0.274; TCGA HNSC -0.182; TCGA KIRC -0.3; TCGA LUAD -0.223; TCGA LUSC -0.425; TCGA UCEC -0.536
hsa-miR-378a-3p
FCGR1B
10 cancers: BLCA; BRCA; CESC; COAD; ESCA; HNSC; LGG; LIHC; LUSC; PRAD
MirTarget
TCGA BLCA -0.592; TCGA BRCA -0.153; TCGA CESC -0.267; TCGA COAD -0.483; TCGA ESCA -0.402; TCGA HNSC -0.149; TCGA LGG -0.256; TCGA LIHC -0.137; TCGA LUSC -0.407; TCGA PRAD -0.265
hsa-miR-378a-3p
TMEM86A
10 cancers: BLCA; BRCA; CESC; COAD; ESCA; HNSC; LGG; LUSC; PRAD; STAD
MirTarget
TCGA BLCA -0.081; TCGA BRCA -0.065; TCGA CESC -0.123; TCGA COAD -0.198; TCGA ESCA -0.195; TCGA HNSC -0.219; TCGA LGG -0.05; TCGA LUSC -0.298; TCGA PRAD -0.126; TCGA STAD -0.157
hsa-miR-378a-3p
TMEM130
15 cancers: BLCA; BRCA; CESC; COAD; ESCA; HNSC; KIRC; KIRP; LIHC; LUSC; OV; PAAD; PRAD; STAD; UCEC
MirTarget
TCGA BLCA -0.5; TCGA BRCA -0.189; TCGA CESC -0.252; TCGA COAD -0.783; TCGA ESCA -0.722; TCGA HNSC -0.288; TCGA KIRC -0.443; TCGA KIRP -0.869; TCGA LIHC -0.551; TCGA LUSC -0.725; TCGA OV -0.226; TCGA PAAD -0.419; TCGA PRAD -0.593; TCGA STAD -0.515; TCGA UCEC -0.141
hsa-miR-378a-3p
GNAO1
9 cancers: BLCA; COAD; ESCA; LGG; LUSC; OV; SARC; STAD; UCEC
mirMAP
TCGA BLCA -0.546; TCGA COAD -0.756; TCGA ESCA -0.448; TCGA LGG -0.104; TCGA LUSC -0.204; TCGA OV -0.173; TCGA SARC -0.436; TCGA STAD -0.579; TCGA UCEC -0.178
hsa-miR-378a-3p
TSPAN11
10 cancers: BLCA; CESC; COAD; ESCA; HNSC; LGG; LUAD; LUSC; OV; UCEC
mirMAP
TCGA BLCA -0.237; TCGA CESC -0.276; TCGA COAD -0.312; TCGA ESCA -0.28; TCGA HNSC -0.127; TCGA LGG -0.08; TCGA LUAD -0.421; TCGA LUSC -0.506; TCGA OV -0.199; TCGA UCEC -0.417
hsa-miR-378a-3p
HIVEP3
9 cancers: BLCA; BRCA; COAD; ESCA; KIRC; KIRP; LUSC; STAD; UCEC
mirMAP
TCGA BLCA -0.313; TCGA BRCA -0.073; TCGA COAD -0.261; TCGA ESCA -0.393; TCGA KIRC -0.086; TCGA KIRP -0.123; TCGA LUSC -0.416; TCGA STAD -0.194; TCGA UCEC -0.21
hsa-miR-378a-3p
KIAA1614
10 cancers: BLCA; CESC; COAD; ESCA; HNSC; LIHC; LUSC; SARC; STAD; UCEC
mirMAP
TCGA BLCA -0.271; TCGA CESC -0.201; TCGA COAD -0.411; TCGA ESCA -0.351; TCGA HNSC -0.142; TCGA LIHC -0.391; TCGA LUSC -0.323; TCGA SARC -0.24; TCGA STAD -0.273; TCGA UCEC -0.288
hsa-miR-378a-3p
ABL2
12 cancers: BLCA; CESC; COAD; ESCA; HNSC; KIRP; LIHC; LUAD; LUSC; OV; STAD; UCEC
mirMAP
TCGA BLCA -0.158; TCGA CESC -0.119; TCGA COAD -0.145; TCGA ESCA -0.213; TCGA HNSC -0.194; TCGA KIRP -0.088; TCGA LIHC -0.192; TCGA LUAD -0.062; TCGA LUSC -0.148; TCGA OV -0.054; TCGA STAD -0.144; TCGA UCEC -0.109
hsa-miR-378a-3p
HHIPL1
10 cancers: BLCA; CESC; COAD; ESCA; HNSC; KIRC; LIHC; LUSC; OV; STAD
mirMAP
TCGA BLCA -0.464; TCGA CESC -0.288; TCGA COAD -0.714; TCGA ESCA -0.448; TCGA HNSC -0.305; TCGA KIRC -0.202; TCGA LIHC -0.164; TCGA LUSC -0.388; TCGA OV -0.108; TCGA STAD -0.346
hsa-miR-378a-3p
NME4
9 cancers: BRCA; CESC; HNSC; LGG; LUAD; OV; PRAD; THCA; STAD
miRNAWalker2 validate
TCGA BRCA -0.158; TCGA CESC -0.201; TCGA HNSC -0.167; TCGA LGG -0.061; TCGA LUAD -0.186; TCGA OV -0.075; TCGA PRAD -0.113; TCGA THCA -0.114; TCGA STAD -0.134
hsa-miR-378a-3p
IGF1R
12 cancers: BRCA; COAD; KIRP; LGG; LIHC; LUAD; OV; PAAD; SARC; THCA; STAD; UCEC
miRTarBase; MirTarget; miRNATAP
TCGA BRCA -0.411; TCGA COAD -0.165; TCGA KIRP -0.071; TCGA LGG -0.064; TCGA LIHC -0.309; TCGA LUAD -0.127; TCGA OV -0.207; TCGA PAAD -0.235; TCGA SARC -0.168; TCGA THCA -0.107; TCGA STAD -0.189; TCGA UCEC -0.097
hsa-miR-378a-3p
ZNF260
10 cancers: BRCA; ESCA; KIRC; KIRP; LGG; LIHC; LUAD; OV; PRAD; STAD
MirTarget
TCGA BRCA -0.096; TCGA ESCA -0.158; TCGA KIRC -0.052; TCGA KIRP -0.066; TCGA LGG -0.111; TCGA LIHC -0.115; TCGA LUAD -0.133; TCGA OV -0.065; TCGA PRAD -0.056; TCGA STAD -0.137
hsa-miR-378a-3p
QSOX1
10 cancers: BRCA; CESC; HNSC; KIRC; KIRP; LIHC; LUAD; LUSC; OV; UCEC
mirMAP
TCGA BRCA -0.177; TCGA CESC -0.175; TCGA HNSC -0.097; TCGA KIRC -0.151; TCGA KIRP -0.09; TCGA LIHC -0.518; TCGA LUAD -0.081; TCGA LUSC -0.267; TCGA OV -0.109; TCGA UCEC -0.16
hsa-miR-378a-3p
KIF6
10 cancers: BRCA; CESC; HNSC; KIRP; LGG; LIHC; LUSC; OV; STAD; UCEC
mirMAP
TCGA BRCA -0.298; TCGA CESC -0.303; TCGA HNSC -0.21; TCGA KIRP -0.226; TCGA LGG -0.293; TCGA LIHC -0.175; TCGA LUSC -0.494; TCGA OV -0.154; TCGA STAD -0.526; TCGA UCEC -0.171
hsa-miR-378a-3p
BRD3
9 cancers: BRCA; ESCA; KIRC; KIRP; LGG; LIHC; SARC; STAD; UCEC
miRNATAP
TCGA BRCA -0.105; TCGA ESCA -0.08; TCGA KIRC -0.082; TCGA KIRP -0.139; TCGA LGG -0.116; TCGA LIHC -0.082; TCGA SARC -0.082; TCGA STAD -0.112; TCGA UCEC -0.091
hsa-miR-378a-3p
GRIK2
10 cancers: BRCA; CESC; COAD; ESCA; KIRP; LUAD; LUSC; OV; PAAD; STAD
miRNATAP
TCGA BRCA -0.118; TCGA CESC -0.218; TCGA COAD -0.33; TCGA ESCA -0.579; TCGA KIRP -0.383; TCGA LUAD -0.248; TCGA LUSC -0.477; TCGA OV -0.206; TCGA PAAD -0.76; TCGA STAD -0.363
hsa-miR-378a-3p
ERRFI1
9 cancers: CESC; ESCA; HNSC; KIRP; LUAD; LUSC; PAAD; THCA; UCEC
miRNAWalker2 validate
TCGA CESC -0.117; TCGA ESCA -0.26; TCGA HNSC -0.132; TCGA KIRP -0.218; TCGA LUAD -0.185; TCGA LUSC -0.349; TCGA PAAD -0.419; TCGA THCA -0.257; TCGA UCEC -0.14
hsa-miR-378a-3p
C15orf52
10 cancers: CESC; COAD; KIRC; KIRP; LGG; LIHC; LUSC; SARC; STAD; UCEC
mirMAP
TCGA CESC -0.247; TCGA COAD -0.275; TCGA KIRC -0.142; TCGA KIRP -0.103; TCGA LGG -0.128; TCGA LIHC -0.183; TCGA LUSC -0.339; TCGA SARC -0.429; TCGA STAD -0.364; TCGA UCEC -0.118
hsa-miR-378a-3p
MAFK
10 cancers: CESC; HNSC; KIRC; KIRP; LUAD; LUSC; PRAD; THCA; STAD; UCEC
mirMAP
TCGA CESC -0.099; TCGA HNSC -0.096; TCGA KIRC -0.125; TCGA KIRP -0.181; TCGA LUAD -0.231; TCGA LUSC -0.114; TCGA PRAD -0.078; TCGA THCA -0.084; TCGA STAD -0.082; TCGA UCEC -0.09
hsa-miR-378a-3p
TIGD1
9 cancers: KIRP; LGG; LIHC; LUAD; OV; PAAD; PRAD; THCA; STAD
miRNAWalker2 validate
TCGA KIRP -0.195; TCGA LGG -0.168; TCGA LIHC -0.277; TCGA LUAD -0.202; TCGA OV -0.153; TCGA PAAD -0.149; TCGA PRAD -0.229; TCGA THCA -0.179; TCGA STAD -0.107





Enriched cancer pathways of putative targets