miRNACancerMap

microRNA information: hsa-miR-381-3p

Reported expression in cancers: hsa-miR-381-3p

miRNA	cancer	regulation	reporting	PUBMED	method
hsa-miR-381-3p	colon cancer	downregulation	"Down regulation of MicroRNA 381 promotes cell prol ......"	26320367	qPCR
hsa-miR-381-3p	colorectal cancer	downregulation	"MiR-381 has been reported to be dysregulated in se ......"	27094913	qPCR
hsa-miR-381-3p	glioblastoma	upregulation	"MicroRNA-381 miR-381 is a highly expressed onco-mi ......"	25605243
hsa-miR-381-3p	lung cancer	downregulation	"MiR-381 expression was measured in 18 human lung a ......"	22592211	Reverse transcription PCR
hsa-miR-381-3p	ovarian cancer	deregulation	"A series of recent studies suggested that miR-381 ......"	26768613
hsa-miR-381-3p	sarcoma	downregulation	"In this study we found that miR-381 is a positive ......"	27612424

Reported cancer pathway affected by hsa-miR-381-3p

miRNA	cancer	pathway	reporting	PUBMED	functional study
hsa-miR-381-3p	colorectal cancer	Epithelial mesenchymal transition pathway	"MiR 381 functions as a tumor suppressor in colorec ......"	27094913	Luciferase
hsa-miR-381-3p	liver cancer	cell cycle pathway; Wnt signaling pathway	"MicroRNA 381 suppresses cell growth and invasion b ......"	26677080	Colony formation; Western blot; Luciferase
hsa-miR-381-3p	ovarian cancer	Wnt signaling pathway	"MiR 381 inhibits epithelial ovarian cancer maligna ......"	26768613
hsa-miR-381-3p	prostate cancer	Apoptosis pathway	"MicroRNAs miR 154 miR 299 5p miR 376a miR 376c miR ......"	24166498

Reported cancer prognosis affected by hsa-miR-381-3p

miRNA	cancer	prognosis	reporting	PUBMED	functional study
hsa-miR-381-3p	colon cancer	progression	"Down regulation of MicroRNA 381 promotes cell prol ......"	26320367	Luciferase
hsa-miR-381-3p	colorectal cancer	staging; metastasis; progression	"MiR 381 functions as a tumor suppressor in colorec ......"	27094913	Luciferase
hsa-miR-381-3p	esophageal cancer	metastasis	"MicroRNA 381 increases radiosensitivity in esophag ......"	25628936	Colony formation; Transwell assay
hsa-miR-381-3p	glioblastoma	drug resistance; malignant trasformation; progression	"Targeting miR 381 NEFL axis sensitizes glioblastom ......"	25605243
hsa-miR-381-3p	liver cancer	tumorigenesis	"MicroRNA 381 suppresses cell growth and invasion b ......"	26677080	Colony formation; Western blot; Luciferase
hsa-miR-381-3p	lung cancer	cell migration; worse prognosis	"MicroRNA 381 represses ID1 and is deregulated in l ......"	22592211	Luciferase
hsa-miR-381-3p	ovarian cancer	drug resistance	"Hybridization was carried out on miRNA microarray ......"	24805828
hsa-miR-381-3p	ovarian cancer	cell migration	"MiR 381 inhibits epithelial ovarian cancer maligna ......"	26768613
hsa-miR-381-3p	sarcoma	malignant trasformation	"SMARCB1 expression in epithelioid sarcoma is regul ......"	24327545
hsa-miR-381-3p	sarcoma	worse prognosis; poor survival	"Low expression of miR 381 is a favorite prognosis ......"	27612424

Reported gene related to hsa-miR-381-3p

miRNA	cancer	gene	reporting	PUBMED
hsa-miR-381-3p	liver cancer	CDC37	"MicroRNA 381 suppresses cell growth and invasion b ......"	26677080
hsa-miR-381-3p	breast cancer	GJA1	"miR 381 suppresses C/EBPα dependent Cx43 expressi ......"	26450928
hsa-miR-381-3p	lung cancer	ID1	"MicroRNA 381 represses ID1 and is deregulated in l ......"	22592211
hsa-miR-381-3p	sarcoma	LRRC4	"Our results also showed a strong negative correlat ......"	27612424
hsa-miR-381-3p	sarcoma	MTOR	"This demonstrated that LRRC4 is a direct target ge ......"	27612424
hsa-miR-381-3p	glioblastoma	NEFL	"Targeting miR 381 NEFL axis sensitizes glioblastom ......"	25605243
hsa-miR-381-3p	liver cancer	NR5A2	"Bioinformatics analysis and dual-luciferase report ......"	26677080
hsa-miR-381-3p	colorectal cancer	TWIST1	"MiR 381 functions as a tumor suppressor in colorec ......"	27094913
hsa-miR-381-3p	sarcoma	VEGFA	"Basic fibroblast growth factor promotes VEGF C dep ......"	27229532
hsa-miR-381-3p	sarcoma	VEGFC	"Basic fibroblast growth factor promotes VEGF C dep ......"	27229532
hsa-miR-381-3p	ovarian cancer	YY1	"MiR 381 inhibits epithelial ovarian cancer maligna ......"	26768613

Expression profile in cancer corhorts:

Putative target regulations

miRNA	Gene	Cancer	Interaction	Correlation beta
hsa-miR-381-3p	ACBD5	9 cancers: BLCA; BRCA; ESCA; KIRC; LGG; LIHC; LUAD; LUSC; THCA	MirTarget	TCGA BLCA -0.078; TCGA BRCA -0.159; TCGA ESCA -0.197; TCGA KIRC -0.052; TCGA LGG -0.054; TCGA LIHC -0.056; TCGA LUAD -0.082; TCGA LUSC -0.083; TCGA THCA -0.053
hsa-miR-381-3p	NDUFA5	9 cancers: BLCA; BRCA; COAD; ESCA; KIRC; KIRP; OV; THCA; STAD	mirMAP	TCGA BLCA -0.062; TCGA BRCA -0.142; TCGA COAD -0.119; TCGA ESCA -0.127; TCGA KIRC -0.081; TCGA KIRP -0.114; TCGA OV -0.055; TCGA THCA -0.066; TCGA STAD -0.104
hsa-miR-381-3p	VSIG10	12 cancers: BLCA; BRCA; ESCA; KIRC; KIRP; LGG; LIHC; LUAD; LUSC; PAAD; PRAD; SARC	mirMAP	TCGA BLCA -0.102; TCGA BRCA -0.118; TCGA ESCA -0.233; TCGA KIRC -0.094; TCGA KIRP -0.081; TCGA LGG -0.124; TCGA LIHC -0.075; TCGA LUAD -0.086; TCGA LUSC -0.241; TCGA PAAD -0.1; TCGA PRAD -0.129; TCGA SARC -0.092
hsa-miR-381-3p	PARD6B	13 cancers: BRCA; CESC; ESCA; HNSC; KIRC; KIRP; LUAD; LUSC; PAAD; PRAD; SARC; THCA; UCEC	MirTarget	TCGA BRCA -0.434; TCGA CESC -0.109; TCGA ESCA -0.21; TCGA HNSC -0.165; TCGA KIRC -0.154; TCGA KIRP -0.065; TCGA LUAD -0.093; TCGA LUSC -0.105; TCGA PAAD -0.211; TCGA PRAD -0.1; TCGA SARC -0.229; TCGA THCA -0.05; TCGA UCEC -0.129

Enriched cancer pathways of putative targets