microRNA information: hsa-miR-449a

SectionIDlink
Mature name: hsa-miR-449amiRbase
Accession: MIMAT0001541miRbase
Precursor name: hsa-mir-449a miRbase
Precursor accession: MI0001648miRbase
Symbol: MIR449AHGNC
RefSeq ID: NR_029960GenBank
Sequence: UGGCAGUGUAUUGUUAGCUGGU



Reported expression in cancers: hsa-miR-449a

miRNAcancerregulationreportingPUBMEDmethod
hsa-miR-449a

bladder cancerdownregulation"MicroRNA 449a acts as a tumor suppressor in human ......"22266187
hsa-miR-449a

gastric cancerdownregulation"miR 449 inhibits cell proliferation and is down re ......"21418558qPCR
hsa-miR-449a

gastric cancerdownregulation"MicroRNA-449a is a tumor suppressor that is down-r ......"25871967
hsa-miR-449a

liver cancerupregulation"miR-449a expression was lower in liver cancer tiss ......"26375440
hsa-miR-449a

lung cancerdownregulation"MicroRNA-449a miR-449a was significantly downregul ......"24211326
hsa-miR-449a

lung cancerdownregulation"MicroRNA 449a inhibits cell growth in lung cancer ......"25818739
hsa-miR-449a

lung squamous cell cancerdownregulation"MicroRNA-449a is expressed at a low level in sever ......"23734217qPCR
hsa-miR-449a

melanomaderegulation"An exploratory miRNA analysis of 666 miRs by low d ......"20302635Microarray
hsa-miR-449a

prostate cancerdownregulation"Using real-time PCR we found that miR-449a is down ......"19252524qPCR
hsa-miR-449a

prostate cancerdownregulation"MicroRNAs miRNAs are a class of small non-coding R ......"20948989RNA-Seq
hsa-miR-449a

prostate cancerupregulation"In the present study cell viability was assessed b ......"26081756
hsa-miR-449a

prostate cancerupregulation"miR-449a a novel tumor suppressor is deregulated i ......"26520443
hsa-miR-449a

sarcomadownregulation"Accumulating evidence reveals that miR-449a is exp ......"26002578
hsa-miR-449a

thyroid cancerupregulation"The present study is aimed to investigate the role ......"27633255



Reported cancer pathway affected by hsa-miR-449a

miRNAcancerpathwayreportingPUBMEDfunctional study
hsa-miR-449a

colorectal cancerApoptosis pathway"miR 449a inhibits colorectal cancer progression by ......"27486765
hsa-miR-449a

endometrial cancerApoptosis pathway"MiR 449a functions as a tumor suppressor in endome ......"24993091Western blot
hsa-miR-449a

gastric cancercell cycle pathway; Apoptosis pathway"miR 449 inhibits cell proliferation and is down re ......"21418558Luciferase
hsa-miR-449a

gastric cancerApoptosis pathway"miR 449a and CDK6 in gastric carcinoma; The presen ......"25202363Western blot
hsa-miR-449a

gastric cancerApoptosis pathway"MicroRNA 449a inhibits proliferation and induces a ......"25871967Western blot; Luciferase; Colony formation
hsa-miR-449a

gastric cancerEpithelial mesenchymal transition pathway"miR 449a targets Flot2 and inhibits gastric cancer ......"26576674Western blot; Luciferase
hsa-miR-449a

glioblastomaApoptosis pathway"MiR 449a exerts tumor suppressive functions in hum ......"25487955Western blot; Luciferase
hsa-miR-449a

liver cancerApoptosis pathway"Histone deacetylases activate hepatocyte growth fa ......"22641068Luciferase
hsa-miR-449a

liver cancerApoptosis pathway"miR 449a promotes liver cancer cell apoptosis by d ......"26375440Luciferase; Western blot
hsa-miR-449a

liver cancerEpithelial mesenchymal transition pathway"MiR 449a suppresses the epithelial mesenchymal tra ......"26471185
hsa-miR-449a

lung cancercell cycle pathway; Apoptosis pathway"MicroRNA 449a enhances radiosensitivity in CL1 0 l ......"23614048
hsa-miR-449a

lung cancercell cycle pathway"Tumor suppressive microRNA 449a induces growth arr ......"24211326
hsa-miR-449a

lung cancercell cycle pathway; Apoptosis pathway"MicroRNA 449a inhibits cell growth in lung cancer ......"25818739
hsa-miR-449a

lung squamous cell cancerApoptosis pathway"MicroRNA 449a is downregulated in non small cell l ......"23734217
hsa-miR-449a

lung squamous cell cancerApoptosis pathway"microRNA 449a suppresses non small cell lung cance ......"25424357Western blot
hsa-miR-449a

ovarian cancercell cycle pathway"To investigate the effects of miR-449 and miR-34 o ......"21321636Western blot
hsa-miR-449a

ovarian cancerApoptosis pathway"MicroRNA 449a reduces cell survival and enhances c ......"25179844Luciferase
hsa-miR-449a

ovarian cancercell cycle pathway"The effect of miR-449 and miR-34 on the growth cel ......"26770455Flow cytometry; Cell Proliferation Assay
hsa-miR-449a

prostate cancercell cycle pathway; Apoptosis pathway"miR 449a targets HDAC 1 and induces growth arrest ......"19252524Luciferase
hsa-miR-449a

prostate cancercell cycle pathway"miR 449a causes Rb dependent cell cycle arrest and ......"20948989Luciferase
hsa-miR-449a

prostate cancercell cycle pathway"Capsaicin causes inactivation and degradation of t ......"26081756MTT assay; Flow cytometry; Western blot
hsa-miR-449a

prostate cancercell cycle pathway; Apoptosis pathway"miR 449a enhances radiosensitivity through modulat ......"26520443
hsa-miR-449a

prostate cancercell cycle pathway"MicroRNA 449a enhances radiosensitivity by downreg ......"27250340
hsa-miR-449a

retinoblastomaApoptosis pathway"We are the first to confirm an inhibitory effect o ......"24120948
hsa-miR-449a

sarcomaApoptosis pathway"Accumulating evidence reveals that miR-449a is exp ......"26002578
hsa-miR-449a

thyroid cancercell cycle pathway"miR 449 overexpression inhibits papillary thyroid ......"27633255



Reported cancer prognosis affected by hsa-miR-449a

miRNAcancerprognosisreportingPUBMEDfunctional study
hsa-miR-449a

breast cancerprogression; malignant trasformation; poor survival"MiR 449a promotes breast cancer progression by tar ......"26934316Western blot; Luciferase
hsa-miR-449a

colorectal cancerstaging; worse prognosis"Increased miR 449a expression in colorectal carcin ......"24396489
hsa-miR-449a

colorectal cancerprogression"miR 449a inhibits colorectal cancer progression by ......"27486765
hsa-miR-449a

endometrial cancerpoor survival"MiR 449a functions as a tumor suppressor in endome ......"24993091Western blot
hsa-miR-449a

gastric cancermetastasis"MicroRNA 449a inhibits proliferation and induces a ......"25871967Western blot; Luciferase; Colony formation
hsa-miR-449a

glioblastomapoor survival"MiR 449a exerts tumor suppressive functions in hum ......"25487955Western blot; Luciferase
hsa-miR-449a

liver cancermetastasis; motility"MiR 449a suppresses the epithelial mesenchymal tra ......"26471185
hsa-miR-449a

lung cancerpoor survival; recurrence; tumorigenesis"Tumor suppressive microRNA 449a induces growth arr ......"24211326
hsa-miR-449a

lung cancerdrug resistance"To address this issue we inserted microRNA respons ......"25132116
hsa-miR-449a

lung squamous cell cancerworse prognosis; metastasis; poor survival; cell migration; progression"MicroRNA 449a is downregulated in non small cell l ......"23734217
hsa-miR-449a

lung squamous cell cancerdifferentiation"microRNA 449a suppresses non small cell lung cance ......"25424357Western blot
hsa-miR-449a

lung squamous cell cancermetastasis"MiR 449a suppresses cell invasion by inhibiting MA ......"26609480
hsa-miR-449a

ovarian cancerpoor survival; drug resistance"MicroRNA 449a reduces cell survival and enhances c ......"25179844Luciferase
hsa-miR-449a

prostate cancerprogression"miR 449a causes Rb dependent cell cycle arrest and ......"20948989Luciferase
hsa-miR-449a

prostate cancerdrug resistance; progression"miR 449a enhances radiosensitivity through modulat ......"26520443
hsa-miR-449a

prostate cancerdrug resistance"MicroRNA 449a enhances radiosensitivity by downreg ......"27250340
hsa-miR-449a

sarcomastaging; metastasis; poor survival; progression"Accumulating evidence reveals that miR-449a is exp ......"26002578
hsa-miR-449a

thyroid cancerprogression"miR 449 overexpression inhibits papillary thyroid ......"27633255



Reported gene related to hsa-miR-449a

miRNAcancergenereportingPUBMED
hsa-miR-449a

endometrial cancerCDC25A"MiR 449a functions as a tumor suppressor in endome ......"24993091
hsa-miR-449a

prostate cancerCDC25A"Furthermore we showed that miR-449a enhanced radia ......"27250340
hsa-miR-449a

prostate cancerCDC25A"Furthermore elevated miR-449a downregulates cell c ......"26520443
hsa-miR-449a

colon cancerE2F3"The 3'UTRs of CCND1 and E2F3 contain miR-449 bindi ......"23674142
hsa-miR-449a

gastric cancerE2F3"MicroRNA 449a inhibits proliferation and induces a ......"25871967
hsa-miR-449a

lung cancerE2F3"Tumor suppressive microRNA 449a induces growth arr ......"24211326
hsa-miR-449a

liver cancerHDAC9"In cell lines inhibition of HDAC significantly inc ......"22641068
hsa-miR-449a

lung cancerHDAC9"Furthermore co-treatment with miR-449a and HDAC in ......"22078727
hsa-miR-449a

prostate cancerHDAC9"miR 449a targets HDAC 1 and induces growth arrest ......"19252524
hsa-miR-449a

gastric cancerTP53"We also show that miR-449 over-expression activate ......"21418558
hsa-miR-449a

lung squamous cell cancerTP53"Further we transfected microRNA-449a mimic and inh ......"25424357
hsa-miR-449a

ovarian cancerTP53"To investigate the effects of miR-449 and miR-34 o ......"21321636
hsa-miR-449a

lung squamous cell cancerBCL2"Further we transfected microRNA-449a mimic and inh ......"25424357
hsa-miR-449a

sarcomaBCL2"Moreover BCL2 an antiapoptotic molecule was identi ......"26002578
hsa-miR-449a

colon cancerCCND1"The 3'UTRs of CCND1 and E2F3 contain miR-449 bindi ......"23674142
hsa-miR-449a

prostate cancerCCND1"Luciferase 3'UTR reporter constructs and inhibitor ......"20948989
hsa-miR-449a

prostate cancerHDAC1"Using a luciferase 3'-UTR reporter system we estab ......"19252524
hsa-miR-449a

prostate cancerHDAC1"Furthermore elevated miR-449a downregulates cell c ......"26520443
hsa-miR-449a

liver cancerMET"Incubation of HCC cells with trichostatin A or tra ......"22641068
hsa-miR-449a

lung squamous cell cancerMET"MicroRNA 449a is downregulated in non small cell l ......"23734217
hsa-miR-449a

glioblastomaMYC"MiR 449a exerts tumor suppressive functions in hum ......"25487955
hsa-miR-449a

prostate cancerMYC"MicroRNA 449a enhances radiosensitivity by downreg ......"27250340
hsa-miR-449a

prostate cancerAR"Capsaicin causes inactivation and degradation of t ......"26081756
hsa-miR-449a

liver cancerCAPN6"miR 449a promotes liver cancer cell apoptosis by d ......"26375440
hsa-miR-449a

gastric cancerCASP3"We also show that miR-449 over-expression activate ......"21418558
hsa-miR-449a

gastric cancerCDK6"miR 449a and CDK6 in gastric carcinoma; The presen ......"25202363
hsa-miR-449a

colorectal cancerCEACAM5"Increased miR 449a expression in colorectal carcin ......"24396489
hsa-miR-449a

breast cancerCRIP2"MiR 449a promotes breast cancer progression by tar ......"26934316
hsa-miR-449a

breast cancerCSRP2"By utilizing a tri-modal in silico approach for ta ......"26934316
hsa-miR-449a

prostate cancerERG"Loss of miR 449a in ERG associated prostate cancer ......"26988912
hsa-miR-449a

gastric cancerFLOT2"miR 449a targets Flot2 and inhibits gastric cancer ......"26576674
hsa-miR-449a

liver cancerFOS"Further studies revealed that the reintroduction o ......"26471185
hsa-miR-449a

gastric cancerGAST"Invitrogen NCode miRNA microarrays identified miR- ......"21418558
hsa-miR-449a

liver cancerHGF"Histone deacetylases activate hepatocyte growth fa ......"22641068
hsa-miR-449a

prostate cancerINSR"MiR-449a was upregulated and c-Myc was downregulat ......"27250340
hsa-miR-449a

lung squamous cell cancerMAP2K1"MiR 449a suppresses cell invasion by inhibiting MA ......"26609480
hsa-miR-449a

glioblastomaMAZ"Myc-associated zinc-finger protein MAZ was identif ......"25487955
hsa-miR-449a

bladder cancerMKI67"The growth of T24 tumor xenografts was suppressed ......"22266187
hsa-miR-449a

lung cancerNEAT1"In this study we aimed to investigate the function ......"25818739
hsa-miR-449a

ovarian cancerNOTCH1"MicroRNA 449a reduces cell survival and enhances c ......"25179844
hsa-miR-449a

prostate cancerPCNA"Luciferase 3'UTR reporter constructs and inhibitor ......"20948989
hsa-miR-449a

liver cancerPOU2F1"miR 449a promotes liver cancer cell apoptosis by d ......"26375440
hsa-miR-449a

thyroid cancerRET"miR 449 overexpression inhibits papillary thyroid ......"27633255
hsa-miR-449a

colorectal cancerSATB2"miR 449a inhibits colorectal cancer progression by ......"27486765
hsa-miR-449a

prostate cancerSIRT1"Loss of miR 449a in ERG associated prostate cancer ......"26988912
hsa-miR-449a

liver cancerSNAI1"Further studies revealed that the reintroduction o ......"26471185
hsa-miR-449a

colorectal cancerSTAB2"Expression of miR-449a was increased epigeneticall ......"27486765
hsa-miR-449a

lung squamous cell cancerSUZ12"Furthermore the histone methylation mediated the d ......"26609480
hsa-miR-449a

gastric cancerTCF3"We also identified E2F3 E2F transcription factor 3 ......"25871967
hsa-miR-449a

breast cancerVEGFA"Our data revealed that overexpression of miR-449a ......"26934316