microRNA information: hsa-miR-486-5p

SectionIDlink
Mature name: hsa-miR-486-5pmiRbase
Accession: MIMAT0002177miRbase
Precursor name: hsa-mir-486-1 miRbase
Precursor accession: MI0002470miRbase
Symbol: NAHGNC
RefSeq ID: NAGenBank
Sequence: UCCUGUACUGAGCUGCCCCGAG



Reported expression in cancers: hsa-miR-486-5p

miRNAcancerregulationreportingPUBMEDmethod
hsa-miR-486-5p

breast cancerdownregulation"Recently miR-486-5p has been proved to play an imp ......"25104088
hsa-miR-486-5p

colorectal cancerdownregulation"Despite ample research revealing the dysregualtion ......"27284245qPCR
hsa-miR-486-5p

esophageal cancerderegulation"The expression profiles of miRNAs in paired EC and ......"23761828Microarray; qPCR
hsa-miR-486-5p

gastric cancerdownregulation"Using Agilent miRNA microarrays we compared miRNA ......"21415212Microarray
hsa-miR-486-5p

liver cancerdownregulation"In previous studies conducted in our laboratory th ......"25475121RNA-Seq
hsa-miR-486-5p

lung cancerdownregulation"We have previously shown that miR-486-5p is one of ......"23474761
hsa-miR-486-5p

lung cancerdownregulation"Here we conducted global profiling for miRNAs in a ......"23980150
hsa-miR-486-5p

lung squamous cell cancerdownregulation"Expression of ten miRNAs in the plasma and tumor s ......"26237047qPCR
hsa-miR-486-5p

lung squamous cell cancerdownregulation"Expression profile analysis of microRNAs and downr ......"26238736Microarray
hsa-miR-486-5p

lung squamous cell cancerdownregulation"In this study we found that miR-486-5p was signifi ......"27049724
hsa-miR-486-5p

prostate cancerderegulation"Expression profile analysis of microRNAs in prosta ......"25597612RNA-Seq; qPCR
hsa-miR-486-5p

thyroid cancerdownregulation"Previous studies have demonstrated that miR-486-5p ......"27133060



Reported cancer pathway affected by hsa-miR-486-5p

miRNAcancerpathwayreportingPUBMEDfunctional study
hsa-miR-486-5p

breast cancerApoptosis pathway"Recently miR-486-5p has been proved to play an imp ......"25104088
hsa-miR-486-5p

lung squamous cell cancercell cycle pathway"Direct repression of the oncogene CDK4 by the tumo ......"27049724
hsa-miR-486-5p

thyroid cancerApoptosis pathway"miR 486 5p inhibits cell growth of papillary thyro ......"27133060



Reported cancer prognosis affected by hsa-miR-486-5p

miRNAcancerprognosisreportingPUBMEDfunctional study
hsa-miR-486-5p

breast cancerstaging"Quantitative RT-PCR was used to determine expressi ......"23526361
hsa-miR-486-5p

breast cancermalignant trasformation"In support of these findings in vitro functional s ......"24104550
hsa-miR-486-5p

breast cancermetastasis"Differential expression of miR 139 miR 486 and miR ......"25027758
hsa-miR-486-5p

breast cancermetastasis"These included miR-141 miR-144 miR-193b miR-200a m ......"26785733
hsa-miR-486-5p

cervical and endocervical cancermetastasis"MiR 486 3p targeting ECM1 represses cell prolifera ......"27133046
hsa-miR-486-5p

colorectal cancerstaging"miR 486 5p attenuates tumor growth and lymphangiog ......"27284245Luciferase
hsa-miR-486-5p

endometrial cancermalignant trasformation"Expression profiling of normal and malignant endom ......"20028871
hsa-miR-486-5p

esophageal cancerworse prognosis"miR 486 5p expression pattern in esophageal squamo ......"26895105
hsa-miR-486-5p

gastric cancerprogression"Genomic loss of miR 486 regulates tumor progressio ......"21415212Luciferase
hsa-miR-486-5p

gastric cancerpoor survival; staging; metastasis; differentiation"Then we further investigated these GC specific miR ......"27173517
hsa-miR-486-5p

gastric cancerstaging"In our previous study a panel of five circulating ......"27605261
hsa-miR-486-5p

glioblastomadifferentiation"We examined the microRNA profiles of Glioblastoma ......"18765229
hsa-miR-486-5p

kidney renal cell cancerstaging; worse prognosis"Expression of miR 486 is a potential prognostic fa ......"24649153
hsa-miR-486-5p

liver cancerrecurrence; progression"In previous studies conducted in our laboratory th ......"25475121Western blot; Luciferase
hsa-miR-486-5p

liver cancerstaging"In the discovery stage 2 serum samples pooled from ......"25962820
hsa-miR-486-5p

liver cancerrecurrence; poor survival"In the present study TaqMan Real-time PCR microRNA ......"26176380
hsa-miR-486-5p

lung cancermalignant trasformation"In the training set miR-21 and miR-210 display hig ......"21864403
hsa-miR-486-5p

lung cancermetastasis; progression; cell migration; tumorigenesis; staging"Downregulation of miR 486 5p contributes to tumor ......"23474761Luciferase
hsa-miR-486-5p

lung cancerstaging"Here we conducted global profiling for miRNAs in a ......"23980150
hsa-miR-486-5p

lung cancertumorigenesis; drug resistance; poor survival"Pim 1 kinase is a target of miR 486 5p and eukaryo ......"25342548Western blot; Luciferase
hsa-miR-486-5p

lung squamous cell cancerstaging; poor survival"In the discovery stage Solexa sequencing followed ......"20194856
hsa-miR-486-5p

lung squamous cell cancerpoor survival; recurrence; drug resistance; staging"Expression of ten miRNAs in the plasma and tumor s ......"26237047
hsa-miR-486-5p

lung squamous cell cancerprogression"Direct repression of the oncogene CDK4 by the tumo ......"27049724
hsa-miR-486-5p

ovarian cancermalignant trasformation; progression; tumorigenesis"Estrogen receptor mediated miR 486 5p regulation o ......"26871282
hsa-miR-486-5p

sarcomametastasis; poor survival; tumorigenesis"TLS CHOP represses miR 486 expression inducing upr ......"22995304



Reported gene related to hsa-miR-486-5p

miRNAcancergenereportingPUBMED
hsa-miR-486-5p

gastric cancerOLFM4"Genomic loss of miR 486 regulates tumor progressio ......"21415212
hsa-miR-486-5p

ovarian cancerOLFM4"Estrogen receptor mediated miR 486 5p regulation o ......"26871282
hsa-miR-486-5p

liver cancerAFP"Multivariate analysis demonstrated that miR-486-5p ......"26176380
hsa-miR-486-5p

glioblastomaAMACR"Nineteen and 26 microRNAs exhibited cohort-depende ......"21737610
hsa-miR-486-5p

lung cancerARHGAP5"Downregulation of miR 486 5p contributes to tumor ......"23474761
hsa-miR-486-5p

lung squamous cell cancerCDK4"Direct repression of the oncogene CDK4 by the tumo ......"27049724
hsa-miR-486-5p

cervical and endocervical cancerECM1"MiR 486 3p targeting ECM1 represses cell prolifera ......"27133046
hsa-miR-486-5p

lung cancerEIF4E"The downregulated miR-486-5p and upregulated eIF4E ......"25342548
hsa-miR-486-5p

ovarian cancerESR1"Estrogen receptor mediated miR 486 5p regulation o ......"26871282
hsa-miR-486-5p

thyroid cancerFBN1"miR 486 5p inhibits cell growth of papillary thyro ......"27133060
hsa-miR-486-5p

lung cancerFMOD"This method exhibits ultrahigh sensitivity toward ......"24215456
hsa-miR-486-5p

liver cancerFRTS1"Multivariate analysis demonstrated that miR-486-5p ......"26176380
hsa-miR-486-5p

sarcomaHCCS"In this study we have found that miR-486 expressio ......"22995304
hsa-miR-486-5p

colorectal cancerNRP2"miR 486 5p attenuates tumor growth and lymphangiog ......"27284245
hsa-miR-486-5p

liver cancerPIK3R1"Mechanistically miR-486-5p was confirmed to direct ......"25475121
hsa-miR-486-5p

lung cancerPIM1"Pim 1 kinase is a target of miR 486 5p and eukaryo ......"25342548
hsa-miR-486-5p

sarcomaSERPINE1"Collectively these results suggest a novel essenti ......"22995304
hsa-miR-486-5p

gastric cancerTECRL"Bioinformatic analysis identified the secreted ant ......"21415212
hsa-miR-486-5p

lung cancerTP53"Our findings support the role for miR-486 loss in ......"23980150



Expression profile in cancer corhorts:




Putative target regulations

miRNAGeneCancerInteractionCorrelation beta
hsa-miR-486-5p
GPX8
10 cancers: BLCA; BRCA; COAD; ESCA; HNSC; LIHC; LUAD; LUSC; PAAD; STAD
MirTarget; miRanda
TCGA BLCA -0.126; TCGA BRCA -0.094; TCGA COAD -0.123; TCGA ESCA -0.172; TCGA HNSC -0.102; TCGA LIHC -0.094; TCGA LUAD -0.061; TCGA LUSC -0.106; TCGA PAAD -0.112; TCGA STAD -0.152
hsa-miR-486-5p
MOXD1
11 cancers: BLCA; BRCA; CESC; COAD; ESCA; KIRC; KIRP; LIHC; PRAD; STAD; UCEC
miRanda
TCGA BLCA -0.305; TCGA BRCA -0.114; TCGA CESC -0.135; TCGA COAD -0.339; TCGA ESCA -0.355; TCGA KIRC -0.335; TCGA KIRP -0.161; TCGA LIHC -0.207; TCGA PRAD -0.104; TCGA STAD -0.268; TCGA UCEC -0.198
hsa-miR-486-5p
TMOD1
9 cancers: BLCA; CESC; COAD; ESCA; KIRC; KIRP; LGG; SARC; STAD
miRanda; miRNATAP
TCGA BLCA -0.114; TCGA CESC -0.144; TCGA COAD -0.109; TCGA ESCA -0.163; TCGA KIRC -0.073; TCGA KIRP -0.098; TCGA LGG -0.054; TCGA SARC -0.315; TCGA STAD -0.139
hsa-miR-486-5p
CTSK
10 cancers: BLCA; CESC; COAD; ESCA; HNSC; LIHC; LUAD; LUSC; STAD; UCEC
miRanda
TCGA BLCA -0.299; TCGA CESC -0.08; TCGA COAD -0.14; TCGA ESCA -0.176; TCGA HNSC -0.149; TCGA LIHC -0.189; TCGA LUAD -0.077; TCGA LUSC -0.095; TCGA STAD -0.114; TCGA UCEC -0.186
hsa-miR-486-5p
CORIN
11 cancers: BLCA; BRCA; COAD; ESCA; HNSC; KIRC; KIRP; PAAD; THCA; STAD; UCEC
miRanda
TCGA BLCA -0.251; TCGA BRCA -0.361; TCGA COAD -0.318; TCGA ESCA -0.343; TCGA HNSC -0.195; TCGA KIRC -0.112; TCGA KIRP -0.082; TCGA PAAD -0.193; TCGA THCA -0.074; TCGA STAD -0.448; TCGA UCEC -0.11
hsa-miR-486-5p
COL16A1
9 cancers: BLCA; ESCA; HNSC; KIRC; KIRP; LIHC; LUSC; STAD; UCEC
miRanda
TCGA BLCA -0.28; TCGA ESCA -0.179; TCGA HNSC -0.082; TCGA KIRC -0.122; TCGA KIRP -0.092; TCGA LIHC -0.162; TCGA LUSC -0.146; TCGA STAD -0.201; TCGA UCEC -0.191
hsa-miR-486-5p
ITGBL1
9 cancers: BLCA; BRCA; CESC; COAD; ESCA; HNSC; PAAD; STAD; UCEC
miRanda
TCGA BLCA -0.43; TCGA BRCA -0.111; TCGA CESC -0.164; TCGA COAD -0.476; TCGA ESCA -0.646; TCGA HNSC -0.268; TCGA PAAD -0.157; TCGA STAD -0.663; TCGA UCEC -0.13
hsa-miR-486-5p
PMEPA1
12 cancers: BLCA; COAD; ESCA; HNSC; KIRP; LIHC; LUAD; PAAD; PRAD; THCA; STAD; UCEC
miRanda
TCGA BLCA -0.16; TCGA COAD -0.227; TCGA ESCA -0.153; TCGA HNSC -0.146; TCGA KIRP -0.156; TCGA LIHC -0.217; TCGA LUAD -0.06; TCGA PAAD -0.139; TCGA PRAD -0.157; TCGA THCA -0.156; TCGA STAD -0.254; TCGA UCEC -0.073
hsa-miR-486-5p
TNFSF4
11 cancers: BLCA; BRCA; COAD; ESCA; HNSC; LIHC; LUAD; LUSC; PRAD; THCA; STAD
miRanda
TCGA BLCA -0.277; TCGA BRCA -0.197; TCGA COAD -0.165; TCGA ESCA -0.258; TCGA HNSC -0.262; TCGA LIHC -0.155; TCGA LUAD -0.09; TCGA LUSC -0.103; TCGA PRAD -0.089; TCGA THCA -0.119; TCGA STAD -0.261
hsa-miR-486-5p
CERCAM
10 cancers: BLCA; BRCA; COAD; ESCA; HNSC; KIRP; LIHC; LUAD; LUSC; STAD
miRanda
TCGA BLCA -0.108; TCGA BRCA -0.109; TCGA COAD -0.147; TCGA ESCA -0.15; TCGA HNSC -0.162; TCGA KIRP -0.15; TCGA LIHC -0.135; TCGA LUAD -0.152; TCGA LUSC -0.169; TCGA STAD -0.123
hsa-miR-486-5p
PSD
11 cancers: BLCA; BRCA; CESC; COAD; HNSC; KIRC; KIRP; LUSC; THCA; STAD; UCEC
miRanda; miRNATAP
TCGA BLCA -0.338; TCGA BRCA -0.13; TCGA CESC -0.148; TCGA COAD -0.362; TCGA HNSC -0.129; TCGA KIRC -0.174; TCGA KIRP -0.115; TCGA LUSC -0.095; TCGA THCA -0.216; TCGA STAD -0.287; TCGA UCEC -0.277
hsa-miR-486-5p
BGN
13 cancers: BLCA; BRCA; CESC; COAD; ESCA; HNSC; KIRP; LUAD; PRAD; SARC; THCA; STAD; UCEC
miRanda
TCGA BLCA -0.253; TCGA BRCA -0.213; TCGA CESC -0.102; TCGA COAD -0.184; TCGA ESCA -0.25; TCGA HNSC -0.177; TCGA KIRP -0.146; TCGA LUAD -0.053; TCGA PRAD -0.076; TCGA SARC -0.132; TCGA THCA -0.08; TCGA STAD -0.398; TCGA UCEC -0.138
hsa-miR-486-5p
STRA6
13 cancers: BLCA; BRCA; COAD; ESCA; HNSC; KIRC; LIHC; LUAD; LUSC; PAAD; PRAD; THCA; STAD
miRanda
TCGA BLCA -0.253; TCGA BRCA -0.339; TCGA COAD -0.286; TCGA ESCA -0.372; TCGA HNSC -0.301; TCGA KIRC -0.375; TCGA LIHC -0.33; TCGA LUAD -0.326; TCGA LUSC -0.503; TCGA PAAD -0.238; TCGA PRAD -0.12; TCGA THCA -0.788; TCGA STAD -0.558
hsa-miR-486-5p
PRRX1
9 cancers: BLCA; COAD; ESCA; LGG; LIHC; LUAD; LUSC; STAD; UCEC
miRanda
TCGA BLCA -0.298; TCGA COAD -0.178; TCGA ESCA -0.253; TCGA LGG -0.073; TCGA LIHC -0.263; TCGA LUAD -0.063; TCGA LUSC -0.085; TCGA STAD -0.303; TCGA UCEC -0.119
hsa-miR-486-5p
NUDT10
9 cancers: BLCA; BRCA; CESC; COAD; HNSC; KIRC; KIRP; LUSC; UCEC
miRanda
TCGA BLCA -0.178; TCGA BRCA -0.106; TCGA CESC -0.162; TCGA COAD -0.301; TCGA HNSC -0.151; TCGA KIRC -0.342; TCGA KIRP -0.178; TCGA LUSC -0.202; TCGA UCEC -0.198
hsa-miR-486-5p
ST6GALNAC5
9 cancers: BLCA; BRCA; COAD; ESCA; HNSC; KIRC; LIHC; THCA; STAD
miRanda
TCGA BLCA -0.318; TCGA BRCA -0.117; TCGA COAD -0.253; TCGA ESCA -0.222; TCGA HNSC -0.161; TCGA KIRC -0.175; TCGA LIHC -0.137; TCGA THCA -0.648; TCGA STAD -0.311
hsa-miR-486-5p
FHL3
9 cancers: BLCA; CESC; COAD; KIRP; LIHC; LUSC; THCA; STAD; UCEC
miRNATAP
TCGA BLCA -0.089; TCGA CESC -0.067; TCGA COAD -0.1; TCGA KIRP -0.089; TCGA LIHC -0.137; TCGA LUSC -0.059; TCGA THCA -0.174; TCGA STAD -0.132; TCGA UCEC -0.08
hsa-miR-486-5p
CLIP3
9 cancers: BLCA; COAD; ESCA; HNSC; LIHC; SARC; THCA; STAD; UCEC
miRNATAP
TCGA BLCA -0.181; TCGA COAD -0.226; TCGA ESCA -0.15; TCGA HNSC -0.138; TCGA LIHC -0.079; TCGA SARC -0.212; TCGA THCA -0.281; TCGA STAD -0.213; TCGA UCEC -0.27
hsa-miR-486-5p
NRK
9 cancers: BLCA; BRCA; CESC; COAD; ESCA; KIRC; LUAD; STAD; UCEC
miRNATAP
TCGA BLCA -0.265; TCGA BRCA -0.08; TCGA CESC -0.188; TCGA COAD -0.432; TCGA ESCA -0.459; TCGA KIRC -0.519; TCGA LUAD -0.147; TCGA STAD -0.645; TCGA UCEC -0.225
hsa-miR-486-5p
LYPD1
9 cancers: BRCA; HNSC; KIRP; LGG; LIHC; LUAD; LUSC; PAAD; THCA
PITA; miRanda
TCGA BRCA -0.173; TCGA HNSC -0.163; TCGA KIRP -0.117; TCGA LGG -0.059; TCGA LIHC -0.442; TCGA LUAD -0.182; TCGA LUSC -0.303; TCGA PAAD -0.263; TCGA THCA -0.296
hsa-miR-486-5p
CLK2
10 cancers: BRCA; ESCA; HNSC; KIRP; LIHC; LUAD; LUSC; OV; THCA; STAD
miRanda
TCGA BRCA -0.073; TCGA ESCA -0.052; TCGA HNSC -0.078; TCGA KIRP -0.068; TCGA LIHC -0.123; TCGA LUAD -0.104; TCGA LUSC -0.114; TCGA OV -0.081; TCGA THCA -0.053; TCGA STAD -0.051
hsa-miR-486-5p
GAD1
9 cancers: BRCA; CESC; ESCA; HNSC; KIRC; LIHC; LUAD; LUSC; STAD
miRanda
TCGA BRCA -0.25; TCGA CESC -0.178; TCGA ESCA -0.299; TCGA HNSC -0.289; TCGA KIRC -0.296; TCGA LIHC -0.244; TCGA LUAD -0.31; TCGA LUSC -0.442; TCGA STAD -0.358
hsa-miR-486-5p
CNKSR1
9 cancers: BRCA; CESC; KIRC; KIRP; LGG; LUAD; OV; PAAD; THCA
miRanda
TCGA BRCA -0.216; TCGA CESC -0.06; TCGA KIRC -0.439; TCGA KIRP -0.212; TCGA LGG -0.104; TCGA LUAD -0.085; TCGA OV -0.086; TCGA PAAD -0.202; TCGA THCA -0.099
hsa-miR-486-5p
PLXNB3
10 cancers: BRCA; HNSC; KIRP; LGG; LIHC; LUAD; LUSC; PRAD; SARC; STAD
miRanda
TCGA BRCA -0.059; TCGA HNSC -0.109; TCGA KIRP -0.137; TCGA LGG -0.056; TCGA LIHC -0.274; TCGA LUAD -0.268; TCGA LUSC -0.41; TCGA PRAD -0.108; TCGA SARC -0.253; TCGA STAD -0.183
hsa-miR-486-5p
TCTE3
14 cancers: BRCA; CESC; ESCA; HNSC; KIRC; KIRP; LGG; LUAD; LUSC; OV; PRAD; SARC; THCA; STAD
miRanda
TCGA BRCA -0.072; TCGA CESC -0.06; TCGA ESCA -0.126; TCGA HNSC -0.139; TCGA KIRC -0.093; TCGA KIRP -0.156; TCGA LGG -0.058; TCGA LUAD -0.103; TCGA LUSC -0.172; TCGA OV -0.142; TCGA PRAD -0.09; TCGA SARC -0.123; TCGA THCA -0.053; TCGA STAD -0.118
hsa-miR-486-5p
DLG5
9 cancers: BRCA; KIRP; LGG; LIHC; LUAD; LUSC; PAAD; SARC; STAD
miRanda
TCGA BRCA -0.053; TCGA KIRP -0.071; TCGA LGG -0.07; TCGA LIHC -0.161; TCGA LUAD -0.113; TCGA LUSC -0.219; TCGA PAAD -0.081; TCGA SARC -0.077; TCGA STAD -0.098
hsa-miR-486-5p
ZGLP1
9 cancers: BRCA; HNSC; KIRP; LGG; LUAD; OV; THCA; STAD; UCEC
miRanda
TCGA BRCA -0.076; TCGA HNSC -0.17; TCGA KIRP -0.104; TCGA LGG -0.069; TCGA LUAD -0.082; TCGA OV -0.134; TCGA THCA -0.132; TCGA STAD -0.116; TCGA UCEC -0.079
hsa-miR-486-5p
DNAH14
9 cancers: BRCA; HNSC; KIRP; LIHC; LUAD; LUSC; PRAD; THCA; STAD
miRanda
TCGA BRCA -0.248; TCGA HNSC -0.178; TCGA KIRP -0.098; TCGA LIHC -0.207; TCGA LUAD -0.192; TCGA LUSC -0.233; TCGA PRAD -0.082; TCGA THCA -0.056; TCGA STAD -0.176
hsa-miR-486-5p
SOX12
9 cancers: BRCA; HNSC; LGG; LIHC; LUAD; LUSC; OV; THCA; STAD
miRNATAP
TCGA BRCA -0.224; TCGA HNSC -0.154; TCGA LGG -0.089; TCGA LIHC -0.166; TCGA LUAD -0.128; TCGA LUSC -0.211; TCGA OV -0.084; TCGA THCA -0.063; TCGA STAD -0.124
hsa-miR-486-5p
BRSK1
9 cancers: BRCA; COAD; HNSC; KIRP; LIHC; LUAD; LUSC; SARC; THCA
miRNATAP
TCGA BRCA -0.162; TCGA COAD -0.1; TCGA HNSC -0.125; TCGA KIRP -0.162; TCGA LIHC -0.319; TCGA LUAD -0.243; TCGA LUSC -0.261; TCGA SARC -0.151; TCGA THCA -0.109
hsa-miR-486-5p
RNF207
10 cancers: CESC; ESCA; KIRP; LIHC; LUAD; LUSC; OV; PAAD; THCA; STAD
miRanda
TCGA CESC -0.091; TCGA ESCA -0.171; TCGA KIRP -0.146; TCGA LIHC -0.066; TCGA LUAD -0.143; TCGA LUSC -0.088; TCGA OV -0.136; TCGA PAAD -0.145; TCGA THCA -0.079; TCGA STAD -0.177
hsa-miR-486-5p
NUDT11
10 cancers: COAD; HNSC; KIRC; KIRP; LGG; LUSC; PRAD; THCA; STAD; UCEC
miRanda
TCGA COAD -0.19; TCGA HNSC -0.214; TCGA KIRC -0.236; TCGA KIRP -0.127; TCGA LGG -0.067; TCGA LUSC -0.311; TCGA PRAD -0.197; TCGA THCA -0.219; TCGA STAD -0.168; TCGA UCEC -0.241





Enriched cancer pathways of putative targets