microRNA information: hsa-miR-503-5p

SectionIDlink
Mature name: hsa-miR-503-5pmiRbase
Accession: MIMAT0002874miRbase
Precursor name: hsa-mir-503 miRbase
Precursor accession: MI0003188miRbase
Symbol: MIR503HGNC
RefSeq ID: NR_030228GenBank
Sequence: UAGCAGCGGGAACAGUUCUGCAG



Reported expression in cancers: hsa-miR-503-5p

miRNAcancerregulationreportingPUBMEDmethod
hsa-miR-503-5p

breast cancerdownregulation"Aberrant expression of miR-503 has been reported i ......"26047605
hsa-miR-503-5p

cervical and endocervical cancerdownregulation"Reduced expression of miR 503 is associated with p ......"26592830qPCR
hsa-miR-503-5p

colorectal cancerdownregulation"MicroRNA miR-503 is downregulated in several cance ......"26999740
hsa-miR-503-5p

esophageal cancerupregulation"MicroRNA 503 promotes tumor progression and acts a ......"25750296Reverse transcription PCR
hsa-miR-503-5p

gastric cancerdownregulation"MiR-503 expression was measured by quantitative re ......"24931256qPCR
hsa-miR-503-5p

liver cancerdownregulation"Downregulation of microRNA-503 has been observed i ......"23967867
hsa-miR-503-5p

prostate cancerdownregulation"Although increasing evidence demonstrated that der ......"27267060
hsa-miR-503-5p

retinoblastomaupregulation"Identification of miRNAs associated with tumorigen ......"18818933Microarray; Northern blot; in situ hybridization
hsa-miR-503-5p

thyroid cancerdownregulation"Of these miR-296 and miR-139 were down-regulated a ......"19926710



Reported cancer pathway affected by hsa-miR-503-5p

miRNAcancerpathwayreportingPUBMEDfunctional study
hsa-miR-503-5p

breast cancercell cycle pathway"MiR 503 inhibited cell proliferation of human brea ......"26047605
hsa-miR-503-5p

colorectal cancerApoptosis pathway; cell cycle pathway"miR 503 inhibits cell proliferation and induces ap ......"26722476MTT assay; Flow cytometry; Western blot; Luciferase
hsa-miR-503-5p

endometrial cancercell cycle pathway"MicroRNA 503 suppresses proliferation and cell cyc ......"23731275
hsa-miR-503-5p

gastric cancerApoptosis pathway"MiR 503 regulates cisplatin resistance of human ga ......"24931256Luciferase; Western blot
hsa-miR-503-5p

glioblastomacell cycle pathway; Apoptosis pathway; PI3K/Akt signaling pathway"MicroRNA 503 acts as a tumor suppressor in gliobla ......"24378652Luciferase
hsa-miR-503-5p

liver cancercell cycle pathway"MicroRNA 503 inhibits the G1/S transition by downr ......"23967867Western blot; Luciferase
hsa-miR-503-5p

liver cancerEpithelial mesenchymal transition pathway"miR 503 suppresses metastasis of hepatocellular ca ......"26163260Luciferase; Western blot; Wound Healing Assay
hsa-miR-503-5p

lung squamous cell cancerApoptosis pathway"miR 503 regulates the resistance of non small cell ......"23856992
hsa-miR-503-5p

lung squamous cell cancerApoptosis pathway"Epigenetic silencing of MicroRNA 503 regulates FAN ......"24486548
hsa-miR-503-5p

prostate cancerEpithelial mesenchymal transition pathway"GATA3 driven expression of miR 503 inhibits prosta ......"27267060
hsa-miR-503-5p

sarcomaApoptosis pathway"Reverse transcription‑quantitative polymerase ch ......"26461038



Reported cancer prognosis affected by hsa-miR-503-5p

miRNAcancerprognosisreportingPUBMEDfunctional study
hsa-miR-503-5p

breast cancerstaging"Quantitative RT-PCR was used to determine expressi ......"23526361
hsa-miR-503-5p

breast cancermetastasis"Microparticles Mediate the Intercellular Regulatio ......"25177548Cell migration assay
hsa-miR-503-5p

breast cancerdrug resistance"Using miRNA profiling we identified miR-503 which ......"25860935
hsa-miR-503-5p

breast cancerprogression"MiR 503 inhibited cell proliferation of human brea ......"26047605
hsa-miR-503-5p

breast cancerdrug resistance; poor survival"An integrative transcriptomics approach identifies ......"27539783
hsa-miR-503-5p

cervical and endocervical cancerworse prognosis; poor survival; recurrence"Reduced expression of miR 503 is associated with p ......"26592830
hsa-miR-503-5p

colorectal cancertumorigenesis; metastasis; tumor size; worse prognosis; staging; recurrence"MicroRNA miR-503 is downregulated in several cance ......"26999740
hsa-miR-503-5p

endometrial cancerprogression; poor survival; tumorigenesis"MicroRNA 503 suppresses proliferation and cell cyc ......"23731275
hsa-miR-503-5p

esophageal cancerprogression; worse prognosis; tumor size; poor survival; recurrence"MicroRNA 503 promotes tumor progression and acts a ......"25750296
hsa-miR-503-5p

gastric cancerdrug resistance"MiR 503 regulates cisplatin resistance of human ga ......"24931256Luciferase; Western blot
hsa-miR-503-5p

gastric cancermetastasis; cell migration"microRNA 503 inhibits gastric cancer cell growth a ......"24944699
hsa-miR-503-5p

glioblastomacell migration; progression"MicroRNA 503 acts as a tumor suppressor in gliobla ......"24378652Luciferase
hsa-miR-503-5p

liver cancermetastasis"Analysis of microRNA expression profiling identifi ......"21495032
hsa-miR-503-5p

liver cancerstaging; malignant trasformation; worse prognosis; poor survival"MicroRNA 503 inhibits the G1/S transition by downr ......"23967867Western blot; Luciferase
hsa-miR-503-5p

liver cancermetastasis"miR 503 regulates metastatic function through Rho ......"24405610Luciferase
hsa-miR-503-5p

liver cancermetastasis; progression"miR 503 suppresses metastasis of hepatocellular ca ......"26163260Luciferase; Western blot; Wound Healing Assay
hsa-miR-503-5p

lung squamous cell cancerdrug resistance"miR 503 regulates the resistance of non small cell ......"23856992
hsa-miR-503-5p

lung squamous cell cancerdrug resistance"Epigenetic silencing of MicroRNA 503 regulates FAN ......"24486548
hsa-miR-503-5p

lung squamous cell cancerprogression; poor survival; metastasis; malignant trasformation"MiR 503 targets PI3K p85 and IKK β and suppresses ......"24550137
hsa-miR-503-5p

prostate cancermetastasis; progression"miR 503 suppresses tumor cell proliferation and me ......"26231797Western blot; Luciferase
hsa-miR-503-5p

prostate cancerprogression; tumorigenesis; staging; worse prognosis; cell migration"GATA3 driven expression of miR 503 inhibits prosta ......"27267060
hsa-miR-503-5p

retinoblastomatumorigenesis"Identification of miRNAs associated with tumorigen ......"18818933
hsa-miR-503-5p

sarcomatumorigenesis; poor survival"MicroRNA 503 acts as a tumor suppressor in osteosa ......"25536034



Reported gene related to hsa-miR-503-5p

miRNAcancergenereportingPUBMED
hsa-miR-503-5p

gastric cancerBCL2"MiR 503 regulates cisplatin resistance of human ga ......"24931256
hsa-miR-503-5p

lung squamous cell cancerBCL2"miR 503 regulates the resistance of non small cell ......"23856992
hsa-miR-503-5p

breast cancerCCND1"MiR 503 inhibited cell proliferation of human brea ......"26047605
hsa-miR-503-5p

endometrial cancerCCND1"MicroRNA 503 suppresses proliferation and cell cyc ......"23731275
hsa-miR-503-5p

breast cancerZNF217"We confirmed experimentally that miR-503 directly ......"27539783
hsa-miR-503-5p

prostate cancerZNF217"GATA3 driven expression of miR 503 inhibits prosta ......"27267060
hsa-miR-503-5p

liver cancerAFP"Low expression levels of miR-503 were associated w ......"23967867
hsa-miR-503-5p

liver cancerARHGEF19"Furthermore we demonstrated that ARHGEF19 is a dir ......"24405610
hsa-miR-503-5p

lung squamous cell cancerARHGEF7"MiR 503 targets PI3K p85 and IKK β and suppresses ......"24550137
hsa-miR-503-5p

colorectal cancerCASR"The putative target gene calcium-sensing receptor ......"26999740
hsa-miR-503-5p

breast cancerCCND2"We then identified two targets of miR-503 CCND2 an ......"25860935
hsa-miR-503-5p

breast cancerCCND3"We then identified two targets of miR-503 CCND2 an ......"25860935
hsa-miR-503-5p

colorectal cancerE2F3"miR 503 inhibits cell proliferation and induces ap ......"26722476
hsa-miR-503-5p

lung squamous cell cancerFANCA"Epigenetic silencing of MicroRNA 503 regulates FAN ......"24486548
hsa-miR-503-5p

prostate cancerGATA3"GATA3 driven expression of miR 503 inhibits prosta ......"27267060
hsa-miR-503-5p

lung squamous cell cancerIBSP"In the present study the level of miR-503 expressi ......"24486548
hsa-miR-503-5p

gastric cancerIGF1R"MiR 503 regulates cisplatin resistance of human ga ......"24931256
hsa-miR-503-5p

sarcomaL1CAM"MicroRNA 503 acts as a tumor suppressor in osteosa ......"25536034
hsa-miR-503-5p

endometrial cancerPCNA"MicroRNA 503 suppresses proliferation and cell cyc ......"23731275
hsa-miR-503-5p

liver cancerPRMT1"miR 503 suppresses metastasis of hepatocellular ca ......"26163260
hsa-miR-503-5p

prostate cancerRNF31"miR 503 suppresses tumor cell proliferation and me ......"26231797
hsa-miR-503-5p

breast cancerTXK"Microparticles Mediate the Intercellular Regulatio ......"25177548
hsa-miR-503-5p

breast cancerTYK2"Microparticles Mediate the Intercellular Regulatio ......"25177548



Expression profile in cancer corhorts:




Putative target regulations

miRNAGeneCancerInteractionCorrelation beta
hsa-miR-503-5p
FGF2
10 cancers: BLCA; BRCA; COAD; ESCA; HNSC; KIRP; LGG; LUAD; LUSC; STAD
miRNAWalker2 validate
TCGA BLCA -0.407; TCGA BRCA -0.319; TCGA COAD -0.242; TCGA ESCA -0.329; TCGA HNSC -0.222; TCGA KIRP -0.145; TCGA LGG -0.051; TCGA LUAD -0.205; TCGA LUSC -0.236; TCGA STAD -0.406
hsa-miR-503-5p
KIAA1671
10 cancers: BLCA; BRCA; ESCA; HNSC; KIRP; LGG; LIHC; LUAD; OV; SARC
miRNAWalker2 validate
TCGA BLCA -0.136; TCGA BRCA -0.054; TCGA ESCA -0.129; TCGA HNSC -0.289; TCGA KIRP -0.06; TCGA LGG -0.114; TCGA LIHC -0.142; TCGA LUAD -0.13; TCGA OV -0.075; TCGA SARC -0.084
hsa-miR-503-5p
GREM2
11 cancers: BLCA; BRCA; COAD; ESCA; HNSC; LGG; LIHC; LUSC; SARC; THCA; STAD
MirTarget
TCGA BLCA -0.454; TCGA BRCA -0.239; TCGA COAD -0.326; TCGA ESCA -0.912; TCGA HNSC -0.566; TCGA LGG -0.167; TCGA LIHC -0.398; TCGA LUSC -0.349; TCGA SARC -0.368; TCGA THCA -0.155; TCGA STAD -0.767
hsa-miR-503-5p
SCN2B
9 cancers: BLCA; BRCA; ESCA; HNSC; LGG; LUAD; LUSC; SARC; STAD
mirMAP
TCGA BLCA -0.46; TCGA BRCA -0.393; TCGA ESCA -0.582; TCGA HNSC -0.182; TCGA LGG -0.239; TCGA LUAD -0.26; TCGA LUSC -0.332; TCGA SARC -0.38; TCGA STAD -0.737
hsa-miR-503-5p
LONRF2
9 cancers: BLCA; BRCA; COAD; ESCA; HNSC; LUAD; LUSC; SARC; STAD
mirMAP
TCGA BLCA -0.5; TCGA BRCA -0.25; TCGA COAD -0.259; TCGA ESCA -0.783; TCGA HNSC -0.612; TCGA LUAD -0.195; TCGA LUSC -0.198; TCGA SARC -0.686; TCGA STAD -0.792
hsa-miR-503-5p
KCNK3
10 cancers: BLCA; BRCA; COAD; ESCA; HNSC; LGG; LUAD; LUSC; SARC; STAD
mirMAP
TCGA BLCA -0.413; TCGA BRCA -0.133; TCGA COAD -0.253; TCGA ESCA -0.46; TCGA HNSC -0.166; TCGA LGG -0.266; TCGA LUAD -0.304; TCGA LUSC -0.613; TCGA SARC -0.738; TCGA STAD -0.742
hsa-miR-503-5p
TOM1L2
11 cancers: BLCA; BRCA; COAD; ESCA; HNSC; LGG; LUAD; LUSC; PAAD; SARC; STAD
mirMAP
TCGA BLCA -0.055; TCGA BRCA -0.108; TCGA COAD -0.073; TCGA ESCA -0.278; TCGA HNSC -0.104; TCGA LGG -0.101; TCGA LUAD -0.11; TCGA LUSC -0.195; TCGA PAAD -0.095; TCGA SARC -0.141; TCGA STAD -0.235





Enriched cancer pathways of putative targets