Cancer

colorectal cancer

Regulation

deregulation

Reporting

Of the 99 mCRC patients we studied differential miRNA expression by microarrays from primary tumors of 33 patients who had wild-type KRAS/BRAF and third- to sixth-line anti-EGFRmAb treatment with/without irinotecan. Significant miR-31* up-regulation and miR-592 down-regulation appeared in progressive disease versus disease control

Pubmed

23098991

Method

Microarray

Cancer

colorectal cancer

Regulation

deregulation

Reporting

Deep Sequencing the MicroRNA Transcriptome in Colorectal Cancer. Few associations were found between clinical parameters and miRNA expression among them low expression of miR-592 and high expression of miR-10b-5p and miR-615-3p were associated with tumors located in the right colon relative to the left colon and rectum

Pubmed

23824282

Method

RNA-Seq

Cancer

colorectal cancer

Regulation

deregulation

Reporting

Up regulation of miR 592 correlates with tumor progression and poor prognosis in patients with colorectal cancer. miR-592 as a potential biomarker has been linked to several cancers. However the expression level and prognostic value of miR-592 in CRC have not been elucidated. In this study we detected the miR-592 expression in CRC serum tumor tissues adjacent non-tumor tissues NATs and four colorectal cancer cell lines by RT-PCR. Our data proved that miR-592 expression was up-regulated in clinical CRC serum and tissues P<0.05. Serum or tissue miR-592 in CRC metastatic patients also maintained a high level compared to that in non-metastatic CRC patients P<0.05. After radical surgery postoperative serum miR-592 level in CRC patients significantly decreased P<0.05. Our clinicopathological analysis revealed that high miR-592 was significant associated with the tumor size P=0.008 TNM stage P=0.026 distant metastasis P=0.004 and preoperative CEA level P=0.022 which led to a shorter overall survival rate in CRC patients P=0.032. All these results suggested that miR-592 functioned as a novel and potential carcinogen-initiated and metastasis-related biomarker in CRC and down-regulation of miR-592 might be considered as a potentially significant molecular treatment strategy for CRC patients

Pubmed

25661360

Method

Cancer

colorectal cancer

Regulation

downregulation

Reporting

Previous studies have shown that miR-592 play critical roles in cancer cell biological processes. However the function of miR-592 in CRC remains largely unknown. MiR-592 expression was markedly down-regulated in CRC tissues and CRC cells. Therefore miR-592 represents a potential anti-onco-miR and serves as a useful therapeutic agent for miRNA-based CRC therapy

Pubmed

26064240

Method

Cancer

colorectal cancer

Regulation

upregulation

Reporting

Here we interrogate the biological significance of miR-592 in colorectal cancer CRC. The expression of miR-592 in CRC tissues and cell lines was ascertained by qRT-PCR assay and the expression of its target gene was determined by immunohistochemistry staining. A striking upregulation of miR-592 was observed in CRC tissues and cell lines compared to the matched adjacent non-tumor tissues and normal colon cells

Pubmed

27167185

Method

qPCR

Cancer

liver cancer

Regulation

deregulation

Reporting

In this study we identified 10 upregulated miRNAs miR-217 miR-518b miR-517c miR-520g miR-519a miR-522 miR-518e miR-525-3p miR-512-3p and miR-518a-3p and 10 downregulated miRNAs miR-138 miR-214 miR-214 miR-27a miR-199a-5p miR-433 miR-511 miR-592 miR-483-5p and miR-483-3p by Taqman miRNAs array and quantitative real-time PCR qRT-PCR confirmation

Pubmed

22362728

Method

qPCR

Cancer

liver cancer

Regulation

deregulation

Reporting

Six hundred and sixty seven human miRNAs were quantitatively analyzed by Taqman low-density miRNA array TLDA in HBV-HCC tissues. Western blotting and luciferase assay were performed to verify the targets of these miRNAs. Ten up-regulated miRNAs miR-217 miR-518b miR-517c miR-520g miR-519a miR-522 miR-518e miR-525-3p miR-512-3p and miR-518a-3p and 11 down-regulated miRNAs miR-138 miR-214 miR-214 miR-199a-5p miR-433 miR-511 miR-592 miR-483-3p miR-483-5p miR-708 and miR-1275 were identified by Taqman miRNAs array and confirmed quantitatively by reverse transcription polymerase chain reaction in HCC and adjacent non-tumor tissues

Pubmed

23082062

Method

Microarray; Reverse transcription PCR

Cancer

lung cancer

Regulation

deregulation

Reporting

Therefore we conduct to systematically identify miRNAs related to NSCLC and their target genes expression changes using microarray data sets. We screened out five miRNAs and six genes microarray data sets that contained miRNAs and genes expression in NSCLC from Gene Expression Omnibus. Five of them were up-regulated miR-9 miR-708 miR-296-3p miR-892b miR-140-5P while nine were down-regulated miR-584 miR-218 miR-30b miR-522 miR486-5P miR-34c-3p miR-34b miR-516b miR-592

Pubmed

26870998

Method

Microarray

Cancer

prostate cancer

Regulation

upregulation

Reporting

In the present study the effect of miR-592 on the cell proliferation of PC was investigated. The results showed that miR-592 was significantly upregulated in PC cell and PC tissues. Our results demonstrated that the upregulation of miR-592promoted cell growth while miR-592 inhibitor showed the opposite effect. In sum our data indicated a novel aspect of the miR-592 in the molecular etiology of PC

Pubmed

26629010

Method