| Enriched cancer pathway | Genes under regulation | P value |
|---|
| Focal adhesion |
21 genes: COL1A1, COL1A2, COL3A1, COL5A1, COL5A2, COL11A1, HGF, IBSP, IGF1, ITGA1, ITGA3, ITGB1, LAMA4, MYLK, PDGFB, PDGFRA, PARVA, PRKCB, RAC2, ACTB, ACTN1
|
1.317e-08 |
| Phagosome |
16 genes: CTSS, CYBB, CD209, HLA-DMB, HLA-DOB, HLA-DQA1, HLA-DQA2, HLA-E, HLA-F, ITGB1, MSR1, OLR1, ACTB, CLEC7A, C1R, MARCO
|
9.746e-07 |
| Antigen processing and presentation |
11 genes: CTSS, HLA-DMB, HLA-DOB, HLA-DQA1, HLA-DQA2, HLA-E, HLA-F, KLRC2, CIITA, TAPBP, CD4
|
2.195e-06 |
| Cell adhesion molecules .CAMs. |
14 genes: VCAN, ICOSLG, HLA-DMB, HLA-DOB, HLA-DQA1, HLA-DQA2, HLA-E, HLA-F, ICAM1, ITGB1, JAM2, SPN, CD4, CD86
|
4.431e-06 |
| Calcium signaling pathway |
16 genes: ADCY2, CYSLTR1, CHRM2, ADRB3, EDNRA, HRH1, ITPR2, MYLK, P2RX7, PDE1A, PDGFRA, PLN, PRKCB, PTGFR, CACNA1C, CAMK2A
|
5.143e-06 |
| ECM.receptor interaction |
11 genes: COL1A1, COL1A2, COL3A1, COL5A1, COL5A2, COL11A1, IBSP, ITGA1, ITGA3, ITGB1, LAMA4
|
5.188e-06 |
| Vascular smooth muscle contraction |
11 genes: MRVI1, ADCY2, EDNRA, ITPR2, MYH11, MYLK, PPP1R12B, PRKCB, ACTG2, CACNA1C, CALD1
|
9.904e-05 |
| Protein digestion and absorption |
8 genes: COL1A1, COL1A2, COL3A1, COL5A1, COL5A2, COL11A1, MME, COL14A1
|
0.0006642 |
| Intestinal immune network for IgA production |
6 genes: ICOSLG, HLA-DMB, HLA-DOB, HLA-DQA1, HLA-DQA2, CD86
|
0.001013 |
| Complement and coagulation cascades |
7 genes: F13A1, SERPINE1, C1R, C1S, C2, C5AR1, C6
|
0.001221 |
| Regulation of actin cytoskeleton |
13 genes: ARPC1B, CHRM2, GSN, ITGA1, ITGA3, ITGB1, MYLK, PDGFB, PDGFRA, RAC2, ACTB, WAS, ACTN1
|
0.001855 |
| ABC transporters |
5 genes: ABCC9, ABCD1, ABCD2, ABCA6, ABCG1
|
0.003714 |
| Glycosphingolipid biosynthesis . ganglio series |
3 genes: HEXA, HEXB, ST6GALNAC5
|
0.004867 |
| Hematopoietic cell lineage |
7 genes: CSF2RA, IL7R, ITGA1, ITGA3, MME, CD3E, CD4
|
0.004899 |
| Leukocyte transendothelial migration |
8 genes: CYBB, ICAM1, ITGB1, PRKCB, JAM2, RAC2, ACTB, ACTN1
|
0.00675 |
| Other glycan degradation |
3 genes: MAN2B2, HEXA, HEXB
|
0.007023 |
| Adherens junction |
6 genes: SORBS1, PTPRJ, RAC2, ACTB, WAS, ACTN1
|
0.007667 |
| Gastric acid secretion |
6 genes: ADCY2, ITPR2, MYLK, PRKCB, ACTB, CAMK2A
|
0.008181 |
| Natural killer cell mediated cytotoxicity |
8 genes: KLRK1, HLA-E, ICAM1, KLRC2, LCP2, PRKCB, RAC2, TNFSF10
|
0.01586 |
| PPAR signaling pathway |
5 genes: SORBS1, ACSL1, ME1, OLR1, ADIPOQ
|
0.02517 |
| Lysosome |
7 genes: NPC2, CTSS, HEXA, HEXB, LIPA, NAGPA, LAPTM5
|
0.02524 |
| Amino sugar and nucleotide sugar metabolism |
4 genes: HEXA, HEXB, NAGK, NPL
|
0.02669 |
| N.Glycan biosynthesis |
4 genes: MGAT4A, FUT8, B4GALT1, MAN1A1
|
0.02853 |
| Chemokine signaling pathway |
9 genes: ADCY2, CCR1, CCR4, CCR8, PRKCB, RAC2, CCL8, STAT1, WAS
|
0.03665 |
| PI3K AKT signaling pathway |
14 genes: IGF1, PDGFB, HGF, PDGFRA, IL7R, COL1A1, COL1A2, LAMA4, IBSP, ITGA1, ITGA3, ITGB1, CHRM2, CREB3L1
|
0.04115 |
| Glycosphingolipid biosynthesis . globo series |
2 genes: HEXA, HEXB
|
0.04226 |
| Steroid hormone biosynthesis |
4 genes: COMT, CYP1B1, HSD11B1, HSD17B6
|
0.04599 |
| Biotin metabolism |
1 genes: BTD
|
0.04684 |
| Glycosaminoglycan biosynthesis . keratan sulfate |
2 genes: FUT8, B4GALT1
|
0.04801 |