| Enriched cancer pathway | Genes under regulation | P value |
|---|
| PI3K AKT signaling pathway |
35 genes: PDGFB, CSF1, EGFR, FGFR1, PDGFRA, FLT1, TLR4, OSM, IL6R, JAK1, COL1A1, COL4A1, COL4A3, THBS1, THBS2, ITGA4, ITGB8, PIK3CA, PIK3R1, CHRM2, GNB5, PDPK1, PRKAA2, AKT3, PTEN, PPP2R3A, PHLPP2, CDKN1A, CDK6, CCND2, RBL2, BCL2, CREB3L2, CREB5, MCL1
|
1.143e-06 |
| Circadian rhythm . mammal |
8 genes: CRY2, FBXW11, FBXL3, PER1, RORA, RORB, PER2, CLOCK
|
2.127e-06 |
| Focal adhesion |
23 genes: AKT3, COL1A1, COL4A1, CRK, EGFR, FLT1, FYN, RAPGEF1, ITGA4, ITGB8, ARHGAP5, PDGFB, PDGFRA, PDPK1, PIK3CA, PIK3R1, PTEN, BCL2, THBS1, THBS2, VASP, CCND2, ROCK2
|
7.792e-06 |
| TGF.beta signaling pathway |
13 genes: SMAD1, SMAD3, SMAD7, SMAD9, RBL2, BMP2, BMP7, BMPR2, TGFBR2, THBS1, THBS2, ZFYVE9, ROCK2
|
3.902e-05 |
| Gap junction |
12 genes: MAP3K2, ADCY9, DRD1, EGFR, PLCB1, GJA1, GNA11, GUCY1A3, PDGFB, PDGFRA, PRKACB, TJP1
|
0.0002921 |
| Adherens junction |
10 genes: WASF3, EGFR, FER, FGFR1, FYN, SMAD3, PTPRJ, TGFBR2, TJP1, TCF7L1
|
0.00074 |
| Neurotrophin signaling pathway |
13 genes: AKT3, SH2B3, FRS2, CRK, GAB1, RAPGEF1, MAP3K3, NTRK3, PIK3CA, PIK3R1, BCL2, RPS6KA2, RPS6KA5
|
0.002094 |
| Osteoclast differentiation |
13 genes: AKT3, SIRPA, CSF1, CTSK, FHL2, FYN, JAK1, PIK3CA, PIK3R1, PPP3CA, TGFBR2, SQSTM1, MAP3K14
|
0.002246 |
| MAPK signaling pathway |
21 genes: AKT3, MAP3K2, MAP3K8, CRK, DUSP8, EGFR, FGFR1, MAP3K3, TAOK3, PDGFB, PDGFRA, PPP3CA, PRKACB, TAOK1, RASGRF2, RPS6KA2, TGFBR2, MAP3K12, MAP3K14, RPS6KA5, RAPGEF2
|
0.003425 |
| Wnt signaling pathway |
14 genes: NFAT5, PRICKLE1, CSNK1A1, PLCB1, FBXW11, LRP6, SMAD3, PPP3CA, PRKACB, TBL1X, FZD4, TCF7L1, CCND2, ROCK2
|
0.003615 |
| Endocytosis |
17 genes: DAB2, EGFR, IQSEC2, FLT1, RAB11FIP5, LDLR, SMAD3, SMAD7, IQSEC3, PDGFRA, PSD, RAB5B, TGFBR2, EEA1, ZFYVE9, GIT2, IQSEC1
|
0.004141 |
| Hippo signaling pathway |
14 genes: FRMD6, DLG2, FBXW11, TEAD1, TGFBR2, SMAD7, SMAD3, BMP2, BMP7, BMPR2, SMAD1, FZD4, TCF7L1, CCND2
|
0.004313 |
| mTOR signaling pathway |
7 genes: AKT3, HIF1A, PDPK1, PIK3CA, PIK3R1, PRKAA2, RPS6KA2
|
0.00499 |
| Calcium signaling pathway |
15 genes: CHRM2, ADCY9, ADRA1B, DRD1, EGFR, PLCB1, GNA11, ITPKB, PDE1C, PDE1B, PDGFRA, PPP3CA, PRKACB, PTGER3, RYR2
|
0.00613 |
| Adipocytokine signaling pathway |
8 genes: AKT3, CPT1A, ACSL4, PPARA, PRKAA2, SLC2A4, STAT3, TNFRSF1B
|
0.006357 |
| Vasopressin.regulated water reabsorption |
6 genes: ADCY9, DYNC1LI2, PRKACB, RAB5B, CREB3L2, CREB5
|
0.008565 |
| Insulin signaling pathway |
12 genes: AKT3, CRK, RAPGEF1, PDE3B, PDPK1, PIK3CA, PIK3R1, PRKAA2, PRKACB, PRKAR2A, SLC2A4, PPP1R3B
|
0.01106 |
| Phosphatidylinositol signaling system |
8 genes: DGKH, PLCB1, ITPKB, PIK3CA, PIK3R1, PIP4K2A, PTEN, DGKE
|
0.01416 |
| Ras signaling pathway |
17 genes: PDGFB, CSF1, EGFR, FGFR1, PDGFRA, FLT1, GAB1, GNB5, PRKACB, RASGRF2, PIK3CA, PIK3R1, AKT3, SHOC2, RAPGEF5, RGL1, RAB5B
|
0.01722 |
| Glycosphingolipid biosynthesis . ganglio series |
3 genes: ST6GALNAC3, ST6GALNAC6, ST3GAL1
|
0.0214 |
| p53 signaling pathway |
7 genes: CDK6, CDKN1A, SESN3, PTEN, ZMAT3, THBS1, CCND2
|
0.02226 |
| ECM.receptor interaction |
8 genes: COL1A1, COL4A1, ITGA4, ITGB8, SDC2, THBS1, THBS2, SV2B
|
0.02272 |
| Progesterone.mediated oocyte maturation |
8 genes: AKT3, ADCY9, PDE3B, PGR, PIK3CA, PIK3R1, PRKACB, RPS6KA2
|
0.02572 |
| Hedgehog signaling pathway |
6 genes: CSNK1A1, FBXW11, RAB23, PRKACB, BMP2, BMP7
|
0.02617 |
| Inositol phosphate metabolism |
6 genes: PLCB1, IPMK, ITPKB, PIK3CA, PIP4K2A, PTEN
|
0.02827 |
| Apoptosis |
8 genes: AKT3, PIK3CA, PIK3R1, PPP3CA, PRKACB, PRKAR2A, BCL2, MAP3K14
|
0.02898 |
| Regulation of actin cytoskeleton |
15 genes: ARPC2, ABI2, CFL2, CHRM2, CRK, EGFR, FGFR1, ITGA4, ITGB8, PDGFB, PDGFRA, PIK3CA, PIK3R1, PIP4K2A, ROCK2
|
0.02995 |
| Fc gamma R.mediated phagocytosis |
8 genes: AKT3, ARPC2, CFL2, WASF3, CRK, PIK3CA, PIK3R1, VASP
|
0.04046 |
| Axon guidance |
10 genes: NFAT5, CFL2, DPYSL2, EPHA7, NTNG1, FYN, PPP3CA, NTN4, NTN1, ROCK2
|
0.04053 |
| Vascular smooth muscle contraction |
9 genes: ADCY9, ADRA1B, PLCB1, GNA11, GUCY1A3, KCNMA1, PRKACB, CALD1, ROCK2
|
0.04813 |