| Enriched cancer pathway | Genes under regulation | P value |
|---|
| MAPK signaling pathway |
23 genes: AKT3, MAP3K2, MAP3K8, ATF2, FGF2, FGF9, FOS, KRAS, MAPT, MAP3K3, NFATC4, NTRK2, PDGFRA, PLA2G4A, PPM1B, PRKCA, TAOK1, RPS6KA3, SOS1, CACNA2D1, CACNB2, CACNB4, PLA2G12A
|
7.844e-06 |
| Ras signaling pathway |
20 genes: FGF2, FGF9, IGF1, KITLG, HGF, NTRK2, INSR, PDGFRA, GAB2, PTPN11, SOS1, CALM1, KRAS, RASA4, PIK3R3, AKT3, SHOC2, PLA2G12A, PLA2G4A, PRKCA
|
3.627e-05 |
| PI3K AKT signaling pathway |
25 genes: FGF2, FGF9, IGF1, KITLG, HGF, NTRK2, INSR, PDGFRA, SOS1, KRAS, THBS1, ITGA1, ITGA9, PIK3R3, PRKAA2, RPS6KB1, PRKCA, AKT3, PTEN, PPP2R3A, PPP2R5E, BCL2, CREB1, ATF2, CREB3L2
|
7.505e-05 |
| Neurotrophin signaling pathway |
13 genes: AKT3, FRS2, KRAS, MAP3K3, NTRK2, PTPN11, BCL2, RPS6KA3, SOS1, CALM1, CAMK2G, PIK3R3, IRS2
|
0.0001288 |
| Insulin signaling pathway |
13 genes: AKT3, INSR, KRAS, PDE3A, PRKAG2, PPP1CB, PRKAA2, RPS6KB1, SOS1, CALM1, PIK3R3, IRS2, CBLB
|
0.0002952 |
| Fc epsilon RI signaling pathway |
9 genes: AKT3, KRAS, PLA2G4A, PRKCA, PRKCE, SOS1, PLA2G12A, PIK3R3, GAB2
|
0.0006319 |
| Vascular smooth muscle contraction |
11 genes: CALCRL, ADCY9, EDNRA, KCNMA1, PPP1R12B, PLA2G4A, PPP1CB, PRKCA, PRKCE, CALM1, PLA2G12A
|
0.0008003 |
| mTOR signaling pathway |
7 genes: AKT3, RICTOR, IGF1, PRKAA2, RPS6KA3, RPS6KB1, PIK3R3
|
0.0009279 |
| GnRH signaling pathway |
10 genes: MAP3K2, ADCY9, KRAS, MAP3K3, PLA2G4A, PRKCA, SOS1, CALM1, PLA2G12A, CAMK2G
|
0.0009804 |
| Aldosterone.regulated sodium reabsorption |
6 genes: IGF1, INSR, KRAS, PRKCA, PIK3R3, IRS2
|
0.001565 |
| Oocyte meiosis |
10 genes: ADCY9, IGF1, AR, PPP1CB, PPP2R5E, RPS6KA3, CALM1, CAMK2G, SMC1A, SLK
|
0.00245 |
| Phosphatidylinositol signaling system |
8 genes: DGKB, DGKH, INPP5A, PIK3C2A, PRKCA, PTEN, CALM1, PIK3R3
|
0.002469 |
| Focal adhesion |
14 genes: AKT3, HGF, IGF1, ITGA1, ITGA9, ARHGAP5, PDGFRA, PPP1CB, PRKCA, PTEN, BCL2, SOS1, THBS1, PIK3R3
|
0.003217 |
| Adipocytokine signaling pathway |
7 genes: AKT3, ACSL1, PRKAG2, PPARA, PRKAA2, PTPN11, IRS2
|
0.00444 |
| Circadian rhythm . mammal |
4 genes: RORA, PER3, PER2, CLOCK
|
0.004672 |
| ErbB signaling pathway |
8 genes: AKT3, KRAS, PRKCA, RPS6KB1, SOS1, CAMK2G, PIK3R3, CBLB
|
0.004859 |
| VEGF signaling pathway |
7 genes: AKT3, KRAS, NFATC4, PLA2G4A, PRKCA, PLA2G12A, PIK3R3
|
0.008146 |
| Fc gamma R.mediated phagocytosis |
8 genes: AKT3, PLA2G4A, PRKCA, PRKCE, RPS6KB1, PIK3R3, WASL, GAB2
|
0.008201 |
| Melanogenesis |
8 genes: ADCY9, CREB1, KRAS, KITLG, PRKCA, CREB3L2, CALM1, CAMK2G
|
0.01166 |
| TGF.beta signaling pathway |
7 genes: DCN, SMAD2, RPS6KB1, BMPR2, SP1, THBS1, ACVR2A
|
0.0146 |
| Progesterone.mediated oocyte maturation |
7 genes: AKT3, ADCY9, IGF1, KRAS, PDE3A, RPS6KA3, PIK3R3
|
0.01642 |
| T cell receptor signaling pathway |
8 genes: AKT3, MAP3K8, FOS, KRAS, NFATC4, SOS1, PIK3R3, CBLB
|
0.01694 |
| p53 signaling pathway |
6 genes: SESN3, IGF1, ATM, PTEN, THBS1, CCNG1
|
0.01806 |
| Long.term potentiation |
6 genes: KRAS, PPP1CB, PRKCA, RPS6KA3, CALM1, CAMK2G
|
0.01926 |
| Endocytosis |
12 genes: PDCD6IP, VPS37A, EPS15, RAB11FIP2, ACAP2, SMAD2, VPS36, SH3GLB1, PDGFRA, EEA1, CBLB, GIT2
|
0.02125 |
| Ether lipid metabolism |
4 genes: PAFAH1B2, PLA2G4A, LPCAT2, PLA2G12A
|
0.02283 |
| Ubiquitin mediated proteolysis |
9 genes: HUWE1, BIRC6, UBE2B, CUL5, CUL3, CBLB, HERC3, PIAS2, UBE3C
|
0.02581 |
| B cell receptor signaling pathway |
6 genes: AKT3, FOS, KRAS, NFATC4, SOS1, PIK3R3
|
0.02611 |
| Regulation of actin cytoskeleton |
12 genes: ABI2, FGF2, FGF9, ITGA1, ITGA9, KRAS, PDGFRA, PPP1CB, ENAH, SOS1, PIK3R3, WASL
|
0.03037 |
| Glycerophospholipid metabolism |
6 genes: DGKB, DGKH, GPD1L, PLA2G4A, LPCAT2, PLA2G12A
|
0.0344 |
| Dorso.ventral axis formation |
3 genes: KRAS, NOTCH2, SOS1
|
0.03882 |
| Wnt signaling pathway |
9 genes: PRICKLE2, DAAM1, LRP6, SMAD2, NFATC4, PPP2R5E, PRKCA, TBL1X, CAMK2G
|
0.04067 |
| Vasopressin.regulated water reabsorption |
4 genes: ADCY9, CREB1, DYNC1LI2, CREB3L2
|
0.04362 |
| Tight junction |
8 genes: AKT3, CTNNA1, MAGI3, KRAS, PRKCA, PRKCE, PTEN, MPP5
|
0.04957 |