| Enriched cancer pathway | Genes under regulation | P value |
|---|
| Long.term potentiation |
11 genes: PLCB1, GNAQ, ITPR1, PPP1R12A, PRKACB, MAPK1, RAP1A, RAP1B, RPS6KA2, CACNA1C, CALM1
|
6.592e-06 |
| Focal adhesion |
19 genes: COL1A2, FLNC, FLT1, XIAP, IGF1, IGF1R, ARHGAP5, PPP1R12A, MAPK1, MAPK10, PTEN, RAP1A, RAP1B, CCND1, THBS1, TLN2, PIK3R3, ACTN1, CCND2
|
9.113e-06 |
| Vascular smooth muscle contraction |
13 genes: ADCY9, PLCB1, ARHGEF12, GNAQ, ITPR1, MYH11, PPP1R12A, PPP1R12B, PRKACB, PRKCE, MAPK1, CACNA1C, CALM1
|
4.254e-05 |
| Progesterone.mediated oocyte maturation |
11 genes: ADCY9, MAPK14, GNAI1, IGF1, IGF1R, PDE3B, PRKACB, MAPK1, MAPK10, RPS6KA2, PIK3R3
|
5.403e-05 |
| Gastric acid secretion |
10 genes: ADCY9, PLCB1, GNAI1, GNAQ, ITPR1, KCNJ2, KCNK2, ATP1A2, PRKACB, CALM1
|
6.617e-05 |
| Oocyte meiosis |
12 genes: ADCY9, FBXW11, IGF1, IGF1R, AR, ITPR1, PPP2R5C, PPP2R5E, PRKACB, MAPK1, RPS6KA2, CALM1
|
0.0001526 |
| Wnt signaling pathway |
14 genes: CSNK1A1, PRICKLE2, DAAM1, PLCB1, FBXW11, SMAD4, NFATC2, PPP2R5C, PPP2R5E, PRKACB, MAPK10, CCND1, TBL1X, CCND2
|
0.0001743 |
| GnRH signaling pathway |
11 genes: MAP3K2, ADCY9, MAPK14, PLCB1, GNAQ, ITPR1, PRKACB, MAPK1, MAPK10, CACNA1C, CALM1
|
0.0002107 |
| Ras signaling pathway |
18 genes: IGF1, IGF2, KITLG, IGF1R, KIT, FLT1, PTPN11, PRKACB, CALM1, PIK3R3, MAPK1, RAPGEF5, RAP1A, RAP1B, RGL1, MAPK10, ABL1, RAB5B
|
0.0002677 |
| Neurotrophin signaling pathway |
12 genes: MAPK14, ABL1, NTRK3, MAPK1, MAPK10, PTPN11, RAP1A, RAP1B, RPS6KA2, CALM1, PIK3R3, RPS6KA5
|
0.0004188 |
| Axon guidance |
12 genes: PLXNC1, SEMA6B, CFL2, DPYSL2, ARHGEF12, ABL1, GNAI1, NFATC2, SEMA4C, MAPK1, ROBO2, SEMA6D
|
0.0005179 |
| TGF.beta signaling pathway |
9 genes: ID2, INHBB, SMAD4, SMAD5, MAPK1, BMPR2, TGFBR2, THBS1, ZFYVE9
|
0.0009588 |
| MAPK signaling pathway |
18 genes: MAP3K2, ATF2, MAPK14, FLNC, MEF2C, NFATC2, PRKACB, MAPK1, MAPK10, TAOK1, RAP1A, RAP1B, RPS6KA2, TGFBR2, CACNA1C, MAP3K12, RPS6KA5, RAPGEF2
|
0.001193 |
| Gap junction |
9 genes: MAP3K2, ADCY9, PLCB1, GJA1, GNAI1, GNAQ, ITPR1, PRKACB, MAPK1
|
0.001443 |
| Vasopressin.regulated water reabsorption |
6 genes: ADCY9, DYNLL2, DYNC1LI2, PRKACB, RAB5B, CREB5
|
0.00184 |
| Phosphatidylinositol signaling system |
8 genes: PLCB1, ITPKB, ITPR1, OCRL, PTEN, CALM1, PIK3R3, DGKE
|
0.002227 |
| Jak.STAT signaling pathway |
12 genes: CSF2RB, IL6ST, LIF, LIFR, PTPN11, CCND1, STAT3, TPO, PIK3R3, SOCS2, CCND2, SOCS3
|
0.002389 |
| Leukocyte transendothelial migration |
10 genes: RAPGEF4, MAPK14, GNAI1, ARHGAP5, PTPN11, JAM2, RAP1A, RAP1B, PIK3R3, ACTN1
|
0.002631 |
| Insulin signaling pathway |
11 genes: PPARGC1A, PDE3B, PPP1R3C, PRKAA2, PRKACB, MAPK1, MAPK10, CALM1, PIK3R3, SOCS2, SOCS3
|
0.002849 |
| Melanogenesis |
9 genes: ADCY9, PLCB1, GNAI1, GNAQ, KIT, KITLG, PRKACB, MAPK1, CALM1
|
0.003201 |
| Adipocytokine signaling pathway |
7 genes: PPARGC1A, PPARA, PRKAA2, MAPK10, PTPN11, STAT3, SOCS3
|
0.004056 |
| mTOR signaling pathway |
6 genes: IGF1, CAB39, PRKAA2, MAPK1, RPS6KA2, PIK3R3
|
0.004344 |
| Long.term depression |
7 genes: PLCB1, GNAI1, GNAQ, IGF1, IGF1R, ITPR1, MAPK1
|
0.004767 |
| Adherens junction |
7 genes: WASF3, IGF1R, SMAD4, MAPK1, TGFBR2, ACTN1, WASL
|
0.006004 |
| Endocytosis |
13 genes: WWP1, VPS37A, EPS15, EPN2, FLT1, IGF1R, KIT, PSD, RAB5B, TGFBR2, EEA1, ZFYVE9, GIT2
|
0.008042 |
| PI3K AKT signaling pathway |
19 genes: IGF1, IGF2, KITLG, IGF1R, KIT, FLT1, MAPK1, COL1A2, THBS1, PIK3R3, PRKAA2, PTEN, PPP2R5C, PPP2R5E, PHLPP2, CCND1, CCND2, ATF2, CREB5
|
0.009379 |
| p53 signaling pathway |
6 genes: IGF1, PTEN, CCND1, ZMAT3, THBS1, CCND2
|
0.01678 |
| Salivary secretion |
7 genes: ADCY9, PLCB1, GNAQ, ITPR1, ATP1A2, PRKACB, CALM1
|
0.01696 |
| Hippo signaling pathway |
10 genes: DLG2, FBXW11, TEAD1, CTGF, TGFBR2, SMAD4, BMPR2, ID2, CCND1, CCND2
|
0.0172 |
| Circadian rhythm . mammal |
3 genes: FBXW11, RORA, CLOCK
|
0.02994 |
| NOD.like receptor signaling pathway |
5 genes: MAPK14, XIAP, MAPK1, MAPK10, TNFAIP3
|
0.03093 |
| Pancreatic secretion |
7 genes: ADCY9, PLCB1, GNAQ, ITPR1, ATP1A2, RAP1A, RAP1B
|
0.03135 |
| Aldosterone.regulated sodium reabsorption |
4 genes: IGF1, ATP1A2, MAPK1, PIK3R3
|
0.03578 |
| Osteoclast differentiation |
8 genes: MAPK14, CYLD, NFATC2, MAPK1, MAPK10, TGFBR2, PIK3R3, SOCS3
|
0.03788 |
| Apoptosis |
6 genes: CSF2RB, ENDOD1, XIAP, PRKACB, CASP10, PIK3R3
|
0.04984 |