| Enriched cancer pathway | Genes under regulation | P value |
|---|
| Vascular smooth muscle contraction |
16 genes: MRVI1, ADCY2, ADCY9, GNAQ, GUCY1A3, ITPR1, ITPR2, RHOA, MYLK, PPP1R12B, PRKACB, PRKCA, PRKCB, PRKG1, CACNA1C, ROCK2
|
1.623e-07 |
| Focal adhesion |
20 genes: FN1, FYN, RAPGEF1, ITGA1, ITGA9, JUN, KDR, RHOA, LAMC1, MYLK, PAK3, PRKCA, PRKCB, RELN, PTEN, BCL2, SHC1, TLN1, TLN2, ROCK2
|
1.017e-06 |
| Gap junction |
13 genes: ADCY2, ADCY9, LPAR1, GNAQ, GRM5, GUCY1A3, ITPR1, ITPR2, PRKACB, PRKCA, PRKCB, PRKG1, TUBB2A
|
1.373e-06 |
| Long.term potentiation |
11 genes: GNAQ, GRIN2A, GRM5, ITPR1, ITPR2, PRKACB, PRKCA, PRKCB, RPS6KA2, CACNA1C, CAMK2D
|
3.836e-06 |
| Ras signaling pathway |
20 genes: FGF2, FGF18, KDR, GAB1, SHC1, PTPN11, GNG4, PRKACB, GRIN2A, RASAL2, PAK3, RHOA, ETS1, ETS2, KSR1, RGL1, RALB, PRKCA, PRKCB, ABL2
|
1.272e-05 |
| Gastric acid secretion |
10 genes: ADCY2, ADCY9, GNAQ, ITPR1, ITPR2, MYLK, PRKACB, PRKCA, PRKCB, CAMK2D
|
4.107e-05 |
| Hippo signaling pathway |
14 genes: YAP1, FRMD6, PPP2R2C, LATS2, FBXW11, TEAD1, TGFBR1, SMAD7, GDF6, FZD4, YWHAQ, TCF7L1, SNAI2, NKD1
|
0.0001189 |
| Regulation of actin cytoskeleton |
17 genes: ABI2, CFL2, DIAPH2, FGD1, FGF2, FN1, ITGA1, ITGA9, RHOA, MSN, MYLK, PAK3, PIP4K2A, FGF18, WASF1, ARHGEF6, ROCK2
|
0.0001246 |
| GnRH signaling pathway |
11 genes: ADCY2, ADCY9, GNAQ, ITPR1, ITPR2, JUN, PRKACB, PRKCA, PRKCB, CACNA1C, CAMK2D
|
0.0001285 |
| ErbB signaling pathway |
10 genes: GAB1, ABL2, NRG1, JUN, PAK3, PRKCA, PRKCB, SHC1, CAMK2D, CBL
|
0.000165 |
| Salivary secretion |
10 genes: ADCY2, ADCY9, GNAQ, GUCY1A3, ITPR1, ITPR2, PRKACB, PRKCA, PRKCB, PRKG1
|
0.0001995 |
| PI3K AKT signaling pathway |
22 genes: FGF2, FGF18, KDR, PRLR, OSMR, COL4A3, LAMC1, RELN, FN1, ITGA1, ITGA9, LPAR1, GNG4, PRKAA2, DDIT4, PRKCA, PTEN, PPP2R2C, CDK6, YWHAQ, BCL2, CREB5
|
0.0004255 |
| Calcium signaling pathway |
14 genes: ADCY2, ADCY9, GNAQ, GRIN2A, GRM5, ITPR1, ITPR2, MYLK, ATP2A2, PRKACB, PRKCA, PRKCB, CACNA1C, CAMK2D
|
0.0005029 |
| Long.term depression |
8 genes: GNAQ, GRM5, GUCY1A3, ITPR1, ITPR2, PRKCA, PRKCB, PRKG1
|
0.0007642 |
| Melanogenesis |
9 genes: ADCY2, ADCY9, GNAQ, PRKACB, PRKCA, PRKCB, CAMK2D, FZD4, TCF7L1
|
0.002189 |
| Pancreatic secretion |
9 genes: ADCY2, ADCY9, GNAQ, ITPR1, ITPR2, RHOA, ATP2A2, PRKCA, PRKCB
|
0.002189 |
| Neurotrophin signaling pathway |
10 genes: YWHAQ, GAB1, RAPGEF1, JUN, RHOA, PTPN11, BCL2, RPS6KA2, SHC1, CAMK2D
|
0.003181 |
| Wnt signaling pathway |
11 genes: FBXW11, JUN, RHOA, PRKACB, PRKCA, PRKCB, CAMK2D, FZD4, TCF7L1, NKD1, ROCK2
|
0.0037 |
| Adherens junction |
7 genes: WASF3, FYN, RHOA, SNAI2, TGFBR1, TCF7L1, WASF1
|
0.004421 |
| Oocyte meiosis |
9 genes: ADCY2, YWHAQ, ADCY9, FBXW11, ITPR1, ITPR2, PRKACB, RPS6KA2, CAMK2D
|
0.004937 |
| TGF.beta signaling pathway |
7 genes: INHBA, RHOA, GDF6, SMAD7, TGFBR1, NOG, ROCK2
|
0.01006 |
| ECM.receptor interaction |
7 genes: FN1, ITGA1, ITGA9, LAMC1, RELN, SDC2, SV2B
|
0.01006 |
| mTOR signaling pathway |
5 genes: CAB39, DDIT4, PRKAA2, RPS6KA2, ULK2
|
0.01521 |
| Fc gamma R.mediated phagocytosis |
7 genes: CFL2, WASF3, DNM3, ASAP1, PRKCA, PRKCB, WASF1
|
0.01776 |
| MAPK signaling pathway |
14 genes: DUSP1, DUSP7, FGF2, JUN, PRKACB, PRKCA, PRKCB, RPS6KA2, SRF, TGFBR1, CACNA1C, CACNA2D1, FGF18, MAP4K4
|
0.02009 |
| Phosphatidylinositol signaling system |
6 genes: ITPR1, ITPR2, PIP4K2A, PRKCA, PRKCB, PTEN
|
0.02259 |
| Glycosaminoglycan biosynthesis . chondroitin sulfate |
3 genes: CHSY1, CHSY3, CHST11
|
0.02295 |
| Axon guidance |
8 genes: PLXNC1, CFL2, FYN, RHOA, PAK3, SEMA6D, SLIT2, ROCK2
|
0.0308 |
| Glycosaminoglycan biosynthesis . heparan sulfate |
3 genes: EXT1, NDST1, HS3ST3A1
|
0.03569 |
| Cell adhesion molecules .CAMs. |
8 genes: CNTN1, NLGN1, NFASC, NEGR1, GLG1, ITGA9, NCAM1, SDC2
|
0.03868 |