| Enriched cancer pathway | Genes under regulation | P value |
|---|
| PI3K AKT signaling pathway |
29 genes: FGF7, CSF1, FGFR1, PDGFRA, KIT, FLT1, SOS1, IL6R, JAK1, COL1A1, COL4A3, THBS1, THBS2, ITGB8, PIK3R1, PDPK1, PRKAA2, AKT3, PTEN, PPP2R3A, PHLPP2, CDKN1A, CDK6, CCND2, RBL2, BCL2, CREB3L2, CREB5, MCL1
|
4.55e-06 |
| Circadian rhythm . mammal |
6 genes: CRY2, FBXW11, FBXL3, RORA, PER2, CLOCK
|
7.243e-05 |
| TGF.beta signaling pathway |
11 genes: EP300, SMAD5, SMAD7, SMAD9, RBL2, BMP2, BMPR2, TGFBR2, THBS1, THBS2, ZFYVE9
|
9.438e-05 |
| Focal adhesion |
18 genes: AKT3, COL1A1, CRK, FLNA, FLT1, FYN, ITGB8, PDGFRA, PDPK1, PIK3R1, PTEN, BCL2, SOS1, THBS1, THBS2, CAV1, CAV2, CCND2
|
9.815e-05 |
| MAPK signaling pathway |
21 genes: AKT3, MAP3K2, MAP3K8, CRK, DUSP8, FGF7, FGFR1, FLNA, MAP3K3, TAOK3, PDGFRA, PPP3CA, TAOK1, RASGRF2, RPS6KA3, SOS1, TGFBR2, MAP3K12, MAP3K14, RPS6KA5, RAPGEF2
|
0.0001933 |
| Endocytosis |
17 genes: DAB2, IQSEC2, FLT1, RAB11FIP5, KIT, LDLR, SMAD7, SH3GLB1, PDGFRA, PSD, RAB5B, TGFBR2, EEA1, CAV1, CAV2, RABEP1, ZFYVE9
|
0.0003574 |
| Neurotrophin signaling pathway |
12 genes: AKT3, SH2B3, FRS2, CRK, GAB1, MAP3K3, NTRK3, PIK3R1, BCL2, RPS6KA3, SOS1, RPS6KA5
|
0.000897 |
| Osteoclast differentiation |
12 genes: AKT3, SIRPA, CSF1, CTSK, FHL2, FYN, JAK1, PIK3R1, PPP3CA, TGFBR2, SQSTM1, MAP3K14
|
0.0009612 |
| Adipocytokine signaling pathway |
8 genes: AKT3, CPT1A, ACSL4, PPARA, PRKAA2, SLC2A4, STAT3, TNFRSF1B
|
0.001582 |
| Hippo signaling pathway |
12 genes: FRMD6, DLG2, FBXW11, TEAD1, TGFBR2, SMAD7, BMP2, BMPR2, FZD7, FZD4, TCF7L1, CCND2
|
0.004542 |
| Insulin signaling pathway |
11 genes: AKT3, CRK, PDE3B, PDPK1, PIK3R1, PRKAA2, PRKAR2A, PYGB, SLC2A4, SOS1, PPP1R3B
|
0.005448 |
| Melanogenesis |
9 genes: ADCY9, EP300, PLCB1, GNAQ, KIT, CREB3L2, FZD4, FZD7, TCF7L1
|
0.005619 |
| mTOR signaling pathway |
6 genes: AKT3, HIF1A, PDPK1, PIK3R1, PRKAA2, RPS6KA3
|
0.006586 |
| p53 signaling pathway |
7 genes: CDK6, CDKN1A, SESN3, PTEN, ZMAT3, THBS1, CCND2
|
0.006999 |
| T cell receptor signaling pathway |
9 genes: AKT3, NFAT5, MAP3K8, FYN, PIK3R1, PPP3CA, SOS1, MAP3K14, CD28
|
0.008631 |
| Wnt signaling pathway |
11 genes: NFAT5, EP300, PLCB1, FBXW11, LRP6, PPP3CA, TBL1X, FZD4, FZD7, TCF7L1, CCND2
|
0.01046 |
| Ras signaling pathway |
15 genes: FGF7, CSF1, FGFR1, PDGFRA, KIT, FLT1, GAB1, SOS1, RASGRF2, PIK3R1, AKT3, SHOC2, RGL1, ABL2, RAB5B
|
0.01056 |
| Vasopressin.regulated water reabsorption |
5 genes: ADCY9, DYNC1LI2, RAB5B, CREB3L2, CREB5
|
0.01363 |
| ErbB signaling pathway |
7 genes: AKT3, CDKN1A, CRK, GAB1, ABL2, PIK3R1, SOS1
|
0.0231 |
| Axon guidance |
9 genes: NFAT5, CFL2, DPYSL2, EPHA4, EPHA7, FYN, PPP3CA, NTN4, NTN1
|
0.02615 |
| Gap junction |
7 genes: MAP3K2, ADCY9, PLCB1, GNA11, GNAQ, PDGFRA, SOS1
|
0.02722 |
| Jak.STAT signaling pathway |
10 genes: AKT3, SPRED1, EP300, IL6R, JAK1, LIF, PIK3R1, SOS1, STAT3, CCND2
|
0.03024 |
| Adherens junction |
6 genes: WASF2, EP300, FGFR1, FYN, TGFBR2, TCF7L1
|
0.03126 |
| Sphingolipid metabolism |
4 genes: KDSR, SGMS1, ACER3, CERK
|
0.04013 |
| GnRH signaling pathway |
7 genes: MAP3K2, ADCY9, PLCB1, GNA11, GNAQ, MAP3K3, SOS1
|
0.04646 |