| Enriched cancer pathway | Genes under regulation | P value |
|---|
| TGF.beta signaling pathway |
9 genes: INHBB, MAPK1, SKP1, BMP6, BMPR2, TGFB2, TGFBR1, TGFBR2, ACVR1
|
8.772e-05 |
| Hippo signaling pathway |
12 genes: FRMD6, FBXW11, TEAD1, TGFB2, TGFBR1, TGFBR2, SERPINE1, BMP6, BMPR2, WNT2B, FZD4, CCND2
|
0.0001282 |
| PI3K AKT signaling pathway |
19 genes: IGF1, CSF1, FGFR1, NTRK2, PDGFRA, KIT, SOS2, MAPK1, IL6R, COL4A4, LAMC3, ITGA2, ITGA8, ITGB8, PRKAA2, PTEN, CCND2, FOXO3, CREB5
|
0.0002329 |
| p53 signaling pathway |
7 genes: SESN3, GADD45A, IGF1, SERPINE1, PTEN, ZMAT3, CCND2
|
0.0006923 |
| Gap junction |
8 genes: ADCY2, PLCB1, GJA1, ITPR1, PDGFRA, PRKG1, MAPK1, SOS2
|
0.000712 |
| Oocyte meiosis |
9 genes: ADCY2, FBXW11, IGF1, AR, ITPR1, PGR, MAPK1, CPEB1, SKP1
|
0.0008001 |
| Osteoclast differentiation |
9 genes: CSF1, CTSK, CYLD, MAPK1, TGFB2, TGFBR1, TGFBR2, FOSL1, CAMK4
|
0.00181 |
| Axon guidance |
9 genes: CFL2, DPYSL2, ARHGEF12, MAPK1, ROBO1, CXCL12, SLIT3, UNC5C, NRP1
|
0.002014 |
| Focal adhesion |
11 genes: LAMC3, COL4A4, IGF1, ITGA2, ITGB8, PDGFRA, MAPK1, PTEN, SOS2, ITGA8, CCND2
|
0.004131 |
| Melanogenesis |
7 genes: ADCY2, EDN1, PLCB1, KIT, MAPK1, WNT2B, FZD4
|
0.006155 |
| Regulation of actin cytoskeleton |
11 genes: CFL2, DIAPH2, FGFR1, ARHGEF12, ITGA2, ITGB8, PDGFRA, SSH1, MAPK1, SOS2, ITGA8
|
0.006801 |
| Progesterone.mediated oocyte maturation |
6 genes: ADCY2, IGF1, PDE3B, PGR, MAPK1, CPEB1
|
0.01116 |
| Vascular smooth muscle contraction |
7 genes: ADCY2, PLCB1, ARHGEF12, ITPR1, PPP1R12B, PRKG1, MAPK1
|
0.01272 |
| MAPK signaling pathway |
12 genes: GADD45A, FGFR1, NTRK2, PDGFRA, MAPK1, TAOK1, SOS2, TGFB2, TGFBR1, TGFBR2, MAP3K12, RPS6KA5
|
0.01361 |
| Dorso.ventral axis formation |
3 genes: MAPK1, CPEB1, SOS2
|
0.01598 |
| Wnt signaling pathway |
8 genes: DAAM1, PLCB1, FBXW11, SKP1, WNT2B, FOSL1, FZD4, CCND2
|
0.01658 |
| Long.term potentiation |
5 genes: RAPGEF3, PLCB1, ITPR1, MAPK1, CAMK4
|
0.01734 |
| Long.term depression |
5 genes: PLCB1, IGF1, ITPR1, PRKG1, MAPK1
|
0.01734 |
| Phosphatidylinositol signaling system |
5 genes: PLCB1, ITPK1, ITPR1, PIK3C2A, PTEN
|
0.02636 |
| Endocytosis |
9 genes: VPS37A, DNM3, KIT, LDLR, PDGFRA, PSD, TGFB2, TGFBR1, TGFBR2
|
0.03193 |
| Inositol phosphate metabolism |
4 genes: PLCB1, ITPK1, PIK3C2A, PTEN
|
0.03407 |
| ECM.receptor interaction |
5 genes: LAMC3, COL4A4, ITGA2, ITGB8, ITGA8
|
0.03633 |
| Lysosome |
6 genes: TPP1, CTSK, IDS, LAMP2, LIPA, PSAP
|
0.0467 |