| Enriched cancer pathway | Genes under regulation | P value |
|---|
| PI3K AKT signaling pathway |
29 genes: FGF13, BDNF, IGF1, KITLG, ANGPT1, FGFR1, NTRK2, PDGFRA, KIT, FLT1, GHR, IL6R, IL7R, JAK3, COL4A1, THBS1, ITGA1, ITGA9, PIK3R1, PIK3R3, CHRM2, GNB4, GNG2, EIF4B, AKT3, CDK6, CCND2, BCL2, CREB5
|
4.549e-07 |
| Ras signaling pathway |
21 genes: FGF13, BDNF, IGF1, KITLG, ANGPT1, FGFR1, NTRK2, PDGFRA, KIT, FLT1, GNB4, GNG2, PRKACB, RASGRF2, MRAS, PIK3R1, PIK3R3, AKT3, SHOC2, ETS1, RAPGEF5
|
5.583e-06 |
| Vascular smooth muscle contraction |
14 genes: CALCRL, MRVI1, EDNRA, PLCB1, GUCY1A2, ITPR2, KCNMA1, PPP1R12A, PPP1R12B, PLCB2, PRKACB, PRKG1, ROCK1, CALD1
|
6.674e-06 |
| Wnt signaling pathway |
16 genes: NFAT5, PRICKLE1, PRICKLE2, PLCB1, FBXW11, LEF1, PLCB2, PPP3CA, PPP3CB, PRKACB, ROCK1, TBL1X, CAMK2D, FZD4, FZD7, CCND2
|
8.214e-06 |
| Calcium signaling pathway |
17 genes: CHRM2, DRD1, EDNRA, PLCB1, ITPR2, ATP2B4, PDE1A, PDE1C, PDGFRA, PLCB2, PPP3CA, PPP3CB, PRKACB, PTGFR, RYR3, SLC8A1, CAMK2D
|
1.603e-05 |
| Long.term potentiation |
10 genes: RAPGEF3, PLCB1, ITPR2, PPP1R12A, PLCB2, PPP3CA, PPP3CB, PRKACB, RPS6KA2, CAMK2D
|
3.183e-05 |
| Melanogenesis |
11 genes: PLCB1, GNAI1, KIT, KITLG, MITF, LEF1, PLCB2, PRKACB, CAMK2D, FZD4, FZD7
|
0.0001641 |
| Progesterone.mediated oocyte maturation |
10 genes: AKT3, GNAI1, IGF1, PDE3A, PDE3B, PGR, PIK3R1, PRKACB, RPS6KA2, PIK3R3
|
0.0002069 |
| Focal adhesion |
16 genes: AKT3, COL4A1, COL5A2, FLT1, IGF1, ITGA1, ITGA9, PPP1R12A, PDGFRA, PIK3R1, BCL2, ROCK1, THBS1, PIK3R3, ACTN1, CCND2
|
0.0002468 |
| Axon guidance |
12 genes: PLXNC1, NFAT5, CFL2, DPYSL2, NTNG1, GNAI1, PPP3CA, PPP3CB, ROBO1, ROCK1, UNC5C, SLIT2
|
0.0004004 |
| Hippo signaling pathway |
13 genes: WWTR1, DLG2, FBXW11, TEAD1, CTGF, TGFBR1, SMAD7, BMP2, BMPR2, FZD7, FZD4, LEF1, CCND2
|
0.0005537 |
| Jak.STAT signaling pathway |
13 genes: AKT3, SPRED1, GHR, IL6R, IL6ST, IL7R, IL15, JAK3, LIFR, PIK3R1, STAT5B, PIK3R3, CCND2
|
0.0005888 |
| mTOR signaling pathway |
7 genes: AKT3, EIF4B, IGF1, CAB39, PIK3R1, RPS6KA2, PIK3R3
|
0.0007103 |
| MAPK signaling pathway |
18 genes: AKT3, DUSP4, FGF13, FGFR1, MRAS, MEF2C, NTRK2, PDGFRA, PPP3CA, PPP3CB, PRKACB, RASGRF2, RPS6KA2, BDNF, TGFBR1, CACNA2D1, CACNB4, RAPGEF2
|
0.0008612 |
| Long.term depression |
8 genes: PLCB1, GNAI1, GRIA3, GUCY1A2, IGF1, ITPR2, PLCB2, PRKG1
|
0.0009161 |
| Apoptosis |
9 genes: AKT3, NFKBIA, PIK3R1, PPP3CA, PPP3CB, PRKACB, PRKAR2B, BCL2, PIK3R3
|
0.00109 |
| Salivary secretion |
9 genes: PLCB1, GUCY1A2, ITPR2, KCNMA1, ATP2B4, PLCB2, PRKACB, PRKG1, RYR3
|
0.00109 |
| Gap junction |
9 genes: DRD1, PLCB1, GNAI1, GUCY1A2, ITPR2, PDGFRA, PLCB2, PRKACB, PRKG1
|
0.001181 |
| Gastric acid secretion |
8 genes: PLCB1, GNAI1, ITPR2, KCNJ2, KCNJ10, PLCB2, PRKACB, CAMK2D
|
0.001322 |
| Oocyte meiosis |
10 genes: FBXW11, IGF1, AR, ITPR2, PGR, PPP3CA, PPP3CB, PRKACB, RPS6KA2, CAMK2D
|
0.001759 |
| TGF.beta signaling pathway |
8 genes: DCN, SMAD7, SMAD9, ROCK1, BMP2, BMPR2, TGFBR1, THBS1
|
0.003204 |
| Chemokine signaling pathway |
13 genes: AKT3, PLCB1, GNAI1, JAK3, NFKBIA, PIK3R1, PLCB2, GNG2, PRKACB, GNB4, ROCK1, STAT5B, PIK3R3
|
0.003517 |
| Neurotrophin signaling pathway |
10 genes: AKT3, NFKBIA, NTRK2, NTRK3, PIK3R1, BCL2, RPS6KA2, BDNF, CAMK2D, PIK3R3
|
0.003877 |
| Circadian rhythm . mammal |
4 genes: FBXW11, RORA, PER3, PER2
|
0.003972 |
| Osteoclast differentiation |
10 genes: AKT3, SIRPA, CYBB, MITF, NFKBIA, PIK3R1, PPP3CA, PPP3CB, TGFBR1, PIK3R3
|
0.0041 |
| Adherens junction |
7 genes: SORBS1, WASF3, FGFR1, LEF1, PTPRB, TGFBR1, ACTN1
|
0.005143 |
| B cell receptor signaling pathway |
7 genes: AKT3, NFAT5, NFKBIA, PIK3R1, PPP3CA, PPP3CB, PIK3R3
|
0.005964 |
| Cell adhesion molecules .CAMs. |
10 genes: CDH2, CADM1, NEGR1, HLA-DOA, ITGA9, NCAM1, NCAM2, NLGN3, SELE, CNTNAP1
|
0.006267 |
| VEGF signaling pathway |
7 genes: AKT3, NFAT5, PIK3R1, PPP3CA, PPP3CB, PTGS2, PIK3R3
|
0.00641 |
| Insulin signaling pathway |
10 genes: AKT3, SORBS1, RHOQ, PDE3A, PDE3B, PIK3R1, PRKACB, PRKAR2B, PPP1R3B, PIK3R3
|
0.006927 |
| Phosphatidylinositol signaling system |
7 genes: DGKB, PLCB1, ITPR2, PIK3R1, PLCB2, PIK3R3, DGKI
|
0.007374 |
| Regulation of actin cytoskeleton |
13 genes: CFL2, CHRM2, FGF13, FGFR1, MRAS, ITGA1, ITGA9, PPP1R12A, PDGFRA, PIK3R1, ROCK1, PIK3R3, ACTN1
|
0.009735 |
| ECM.receptor interaction |
6 genes: COL4A1, COL5A2, ITGA1, ITGA9, THBS1, SV2B
|
0.03673 |
| T cell receptor signaling pathway |
7 genes: AKT3, NFAT5, NFKBIA, PIK3R1, PPP3CA, PPP3CB, PIK3R3
|
0.03748 |
| ABC transporters |
4 genes: ABCC9, ABCC4, ABCD2, ABCA6
|
0.0379 |
| Carbohydrate digestion and absorption |
4 genes: AKT3, PIK3R1, PLCB2, PIK3R3
|
0.0379 |
| Glycosaminoglycan biosynthesis . heparan sulfate |
3 genes: XYLT1, HS3ST3B1, HS3ST1
|
0.0383 |
| ErbB signaling pathway |
6 genes: AKT3, HBEGF, PIK3R1, STAT5B, CAMK2D, PIK3R3
|
0.04045 |
| Purine metabolism |
9 genes: PDE7B, GUCY1A2, PDE1A, PDE1C, PDE3A, PDE3B, PDE4D, PDE5A, ENTPD1
|
0.04644 |