| Enriched cancer pathway | Genes under regulation | P value |
|---|
| Axon guidance |
18 genes: PLXNC1, SEMA6B, CFL2, DPYSL2, SEMA3D, NTNG1, ABL1, FYN, GNAI2, PLXNA1, PPP3CA, PPP3CB, PPP3R1, MAPK1, SRGAP1, CXCL12, UNC5C, NRP1
|
2.137e-08 |
| Long.term potentiation |
10 genes: GRM5, PPP1R12A, PPP3CA, PPP3CB, PPP3R1, PRKCB, MAPK1, CACNA1C, CAMK4, CAMK2A
|
2.254e-05 |
| PI3K AKT signaling pathway |
22 genes: FGF5, BDNF, KITLG, HGF, NTRK2, IGF1R, MAPK1, IL6R, JAK1, ITGA2, ITGA5, ITGB3, PIK3CD, PRKAA2, DDIT4, PTEN, PPP2R5E, CDK6, FOXO3, YWHAG, ATF2, MCL1
|
0.0003593 |
| Neurotrophin signaling pathway |
11 genes: SH2B3, FOXO3, ABL1, NTRK2, NTRK3, PIK3CD, MAPK1, BDNF, YWHAG, CAMK4, CAMK2A
|
0.0008443 |
| Regulation of actin cytoskeleton |
14 genes: ARPC5, CFL2, FGF5, RRAS2, ITGA2, ITGA5, ITGB3, MYH9, MYH10, PPP1R12A, PIK3CD, PIP4K2A, MAPK1, ACTN1
|
0.002747 |
| Long.term depression |
7 genes: GNAI2, GRM5, GUCY1A3, IGF1R, LYN, PRKCB, MAPK1
|
0.003263 |
| Protein export |
4 genes: SEC63, HSPA5, SPCS3, SEC62
|
0.003436 |
| Circadian rhythm . mammal |
4 genes: RORA, PER3, PER2, CLOCK
|
0.003436 |
| Calcium signaling pathway |
12 genes: ADRA1D, EDNRA, GRM5, ATP2A2, PPP3CA, PPP3CB, PPP3R1, PRKCB, PTGER3, CACNA1C, CAMK4, CAMK2A
|
0.004035 |
| Oocyte meiosis |
9 genes: IGF1R, PGR, PPP2R5E, PPP3CA, PPP3CB, PPP3R1, MAPK1, YWHAG, CAMK2A
|
0.004555 |
| B cell receptor signaling pathway |
7 genes: LYN, PIK3CD, PPP3CA, PPP3CB, PPP3R1, PRKCB, MAPK1
|
0.0048 |
| Fc gamma R.mediated phagocytosis |
8 genes: ARPC5, CFL2, DNM3, LYN, ASAP1, PIK3CD, PRKCB, MAPK1
|
0.004969 |
| Ras signaling pathway |
14 genes: FGF5, BDNF, KITLG, HGF, NTRK2, IGF1R, RRAS2, PIK3CD, MAPK1, KSR1, RGL1, PRKCB, ABL1, ABL2
|
0.006501 |
| Protein processing in endoplasmic reticulum |
11 genes: SEC23A, SEC24A, SEC63, MAN1B1, HSPA5, UBE2J1, EIF2AK2, RAD23B, RPN2, SEC62, TXNDC5
|
0.00745 |
| Osteoclast differentiation |
9 genes: CYLD, FYN, ITGB3, JAK1, PIK3CD, PPP3CA, PPP3CB, MAPK1, CAMK4
|
0.009552 |
| Focal adhesion |
12 genes: FYN, HGF, IGF1R, ITGA2, ITGA5, ITGB3, PPP1R12A, PIK3CD, PRKCB, MAPK1, PTEN, ACTN1
|
0.01036 |
| Progesterone.mediated oocyte maturation |
7 genes: GNAI2, IGF1R, PDE3A, PGR, PIK3CD, MAPK1, CCNA1
|
0.01065 |
| Renin.angiotensin system |
3 genes: LNPEP, MME, NLN
|
0.01087 |
| Tight junction |
9 genes: AMOTL1, RRAS2, GNAI2, MYH9, MYH10, PRKCB, PTEN, ACTN1, VAPA
|
0.01209 |
| Gap junction |
7 genes: MAP3K2, GJA1, GNAI2, GRM5, GUCY1A3, PRKCB, MAPK1
|
0.01269 |
| Purine metabolism |
10 genes: POLR3G, GUCY1A3, NT5E, PDE3A, PDE4D, ENPP1, PGM1, POLR2D, PDE5A, ENTPD1
|
0.01533 |
| VEGF signaling pathway |
6 genes: PIK3CD, PPP3CA, PPP3CB, PPP3R1, PRKCB, MAPK1
|
0.01906 |
| Aldosterone.regulated sodium reabsorption |
4 genes: ATP1A1, PIK3CD, PRKCB, MAPK1
|
0.02875 |
| TGF.beta signaling pathway |
6 genes: INHBA, SMAD1, MAPK1, BMPR2, TFDP1, ACVR1
|
0.03104 |
| T cell receptor signaling pathway |
7 genes: FYN, ICOS, PIK3CD, PPP3CA, PPP3CB, PPP3R1, MAPK1
|
0.03112 |
| ErbB signaling pathway |
6 genes: ABL1, ABL2, PIK3CD, PRKCB, MAPK1, CAMK2A
|
0.03425 |
| Hematopoietic cell lineage |
6 genes: IL6R, ITGA2, ITGA5, ITGB3, KITLG, MME
|
0.03593 |
| Vascular smooth muscle contraction |
7 genes: ADRA1D, EDNRA, GUCY1A3, PPP1R12A, PRKCB, MAPK1, CACNA1C
|
0.04324 |