Enriched cancer pathwayGenes under regulationP value
Axon guidance
18 genes: PLXNC1, SEMA6B, CFL2, DPYSL2, SEMA3D, NTNG1, ABL1, FYN, GNAI2, PLXNA1, PPP3CA, PPP3CB, PPP3R1, MAPK1, SRGAP1, CXCL12, UNC5C, NRP1
2.137e-08
Long.term potentiation
10 genes: GRM5, PPP1R12A, PPP3CA, PPP3CB, PPP3R1, PRKCB, MAPK1, CACNA1C, CAMK4, CAMK2A
2.254e-05
PI3K AKT signaling pathway
22 genes: FGF5, BDNF, KITLG, HGF, NTRK2, IGF1R, MAPK1, IL6R, JAK1, ITGA2, ITGA5, ITGB3, PIK3CD, PRKAA2, DDIT4, PTEN, PPP2R5E, CDK6, FOXO3, YWHAG, ATF2, MCL1
0.0003593
Neurotrophin signaling pathway
11 genes: SH2B3, FOXO3, ABL1, NTRK2, NTRK3, PIK3CD, MAPK1, BDNF, YWHAG, CAMK4, CAMK2A
0.0008443
Regulation of actin cytoskeleton
14 genes: ARPC5, CFL2, FGF5, RRAS2, ITGA2, ITGA5, ITGB3, MYH9, MYH10, PPP1R12A, PIK3CD, PIP4K2A, MAPK1, ACTN1
0.002747
Long.term depression
7 genes: GNAI2, GRM5, GUCY1A3, IGF1R, LYN, PRKCB, MAPK1
0.003263
Protein export
4 genes: SEC63, HSPA5, SPCS3, SEC62
0.003436
Circadian rhythm . mammal
4 genes: RORA, PER3, PER2, CLOCK
0.003436
Calcium signaling pathway
12 genes: ADRA1D, EDNRA, GRM5, ATP2A2, PPP3CA, PPP3CB, PPP3R1, PRKCB, PTGER3, CACNA1C, CAMK4, CAMK2A
0.004035
Oocyte meiosis
9 genes: IGF1R, PGR, PPP2R5E, PPP3CA, PPP3CB, PPP3R1, MAPK1, YWHAG, CAMK2A
0.004555
B cell receptor signaling pathway
7 genes: LYN, PIK3CD, PPP3CA, PPP3CB, PPP3R1, PRKCB, MAPK1
0.0048
Fc gamma R.mediated phagocytosis
8 genes: ARPC5, CFL2, DNM3, LYN, ASAP1, PIK3CD, PRKCB, MAPK1
0.004969
Ras signaling pathway
14 genes: FGF5, BDNF, KITLG, HGF, NTRK2, IGF1R, RRAS2, PIK3CD, MAPK1, KSR1, RGL1, PRKCB, ABL1, ABL2
0.006501
Protein processing in endoplasmic reticulum
11 genes: SEC23A, SEC24A, SEC63, MAN1B1, HSPA5, UBE2J1, EIF2AK2, RAD23B, RPN2, SEC62, TXNDC5
0.00745
Osteoclast differentiation
9 genes: CYLD, FYN, ITGB3, JAK1, PIK3CD, PPP3CA, PPP3CB, MAPK1, CAMK4
0.009552
Focal adhesion
12 genes: FYN, HGF, IGF1R, ITGA2, ITGA5, ITGB3, PPP1R12A, PIK3CD, PRKCB, MAPK1, PTEN, ACTN1
0.01036
Progesterone.mediated oocyte maturation
7 genes: GNAI2, IGF1R, PDE3A, PGR, PIK3CD, MAPK1, CCNA1
0.01065
Renin.angiotensin system
3 genes: LNPEP, MME, NLN
0.01087
Tight junction
9 genes: AMOTL1, RRAS2, GNAI2, MYH9, MYH10, PRKCB, PTEN, ACTN1, VAPA
0.01209
Gap junction
7 genes: MAP3K2, GJA1, GNAI2, GRM5, GUCY1A3, PRKCB, MAPK1
0.01269
Purine metabolism
10 genes: POLR3G, GUCY1A3, NT5E, PDE3A, PDE4D, ENPP1, PGM1, POLR2D, PDE5A, ENTPD1
0.01533
VEGF signaling pathway
6 genes: PIK3CD, PPP3CA, PPP3CB, PPP3R1, PRKCB, MAPK1
0.01906
Aldosterone.regulated sodium reabsorption
4 genes: ATP1A1, PIK3CD, PRKCB, MAPK1
0.02875
TGF.beta signaling pathway
6 genes: INHBA, SMAD1, MAPK1, BMPR2, TFDP1, ACVR1
0.03104
T cell receptor signaling pathway
7 genes: FYN, ICOS, PIK3CD, PPP3CA, PPP3CB, PPP3R1, MAPK1
0.03112
ErbB signaling pathway
6 genes: ABL1, ABL2, PIK3CD, PRKCB, MAPK1, CAMK2A
0.03425
Hematopoietic cell lineage
6 genes: IL6R, ITGA2, ITGA5, ITGB3, KITLG, MME
0.03593
Vascular smooth muscle contraction
7 genes: ADRA1D, EDNRA, GUCY1A3, PPP1R12A, PRKCB, MAPK1, CACNA1C
0.04324