| Enriched cancer pathway | Genes under regulation | P value |
|---|
| Focal adhesion |
40 genes: AKT3, MYL12A, COL4A1, COL6A3, CTNNB1, EGFR, FLNC, FN1, GRB2, RAPGEF1, IGF1, ITGA1, ITGA4, ITGB1, ITGB3, RHOA, LAMC1, LAMC2, MYLK, PPP1R12A, PDGFRA, PIK3CA, PIK3CD, PPP1CB, PARVA, MAPK1, MAPK9, RAP1A, RASGRF1, ACTB, ROCK1, THBS2, THBS4, VCL, ACTN4, CAPN2, CAV1, CAV2, CCND2, CCND3
|
6.301e-10 |
| MAPK signaling pathway |
45 genes: AKT3, RASGRP1, MAP3K2, GADD45G, DUSP14, ATF2, MAPK14, DUSP3, DUSP8, EGFR, FGF1, FGF7, RRAS2, FLNC, GNA12, GRB2, HSPA8, MAPT, MEF2C, MYC, NFATC2, NFATC4, NGF, NTRK2, PDGFRA, PPP3CA, PPP3CB, PPP3R1, MAPK1, MAPK9, DUSP22, TAOK1, RAP1A, RASA1, RASGRF1, RASGRF2, RPS6KA3, SRF, TGFB2, TGFBR1, TGFBR2, TNF, CACNA1C, CACNB4, MAPKAPK2
|
1.778e-08 |
| T cell receptor signaling pathway |
23 genes: AKT3, RASGRP1, MAPK14, GRB2, ICOS, ITK, RHOA, NCK1, NFATC2, NFATC4, PIK3CA, PIK3CD, PPP3CA, PPP3CB, PPP3R1, MAPK1, MAPK9, TNF, NCK2, CBL, CD3E, CD247, CD4
|
8.464e-07 |
| Vascular smooth muscle contraction |
24 genes: MRVI1, ADCY5, ADRA1D, ADRA1B, EDNRA, KCNMB4, GNA12, GNAQ, GUCY1B3, KCNMA1, RHOA, MYLK, PPP1R12A, PPP1R12B, NPR1, PPP1CB, AVPR1A, PRKG1, MAPK1, ROCK1, CACNA1C, CALD1, CALM3, PPP1R14A
|
8.583e-07 |
| Hippo signaling pathway |
28 genes: AMOT, WWTR1, SAV1, PPP2R2C, LATS1, PPP1CB, FBXW11, TEAD1, GLI2, FGF1, TGFB2, TGFBR1, TGFBR2, BMP6, BMPR1A, BMPR2, WNT10B, WNT11, YWHAQ, YWHAH, YWHAG, CTNNB1, APC, LEF1, MYC, CCND2, CCND3, ACTB
|
1.718e-06 |
| Axon guidance |
25 genes: PLXNC1, SEMA3A, CFL2, DPYSL2, EPHA7, SEMA3D, SRGAP2, GNAI3, EPHA6, ITGB1, RHOA, NCK1, NFATC2, NFATC4, PPP3CA, PPP3CB, PPP3R1, MAPK1, SRGAP1, RASA1, ROCK1, CXCL12, NCK2, NRP1, UNC5A
|
2.121e-06 |
| Neurotrophin signaling pathway |
22 genes: AKT3, SH2B3, YWHAQ, IRAK3, MAPK14, GRB2, RAPGEF1, RHOA, NGF, NTRK2, NTRK3, PIK3CA, PIK3CD, MAPK1, MAPK9, PTPN11, RAP1A, RPS6KA3, YWHAG, YWHAH, CALM3, MAPKAPK2
|
4.655e-05 |
| Cell adhesion molecules .CAMs. |
23 genes: CDH2, CD226, CNTN1, NLGN1, NFASC, NEGR1, CD274, ICOS, HLA-DOA, HLA-DPA1, HLA-DQB1, HLA-DRB1, HLA-DRB5, ITGA4, ITGB1, NCAM1, NCAM2, CADM3, JAM3, CD2, CD4, CD22, SDC3
|
4.672e-05 |
| Regulation of actin cytoskeleton |
30 genes: WASF2, MYL12A, CFL2, EGFR, FGF1, FGF7, RRAS2, FN1, GNA12, APC, ITGA1, ITGA4, ITGB1, ITGB3, RHOA, MYH10, MYLK, PPP1R12A, PDGFRA, PIK3CA, PIK3CD, PPP1CB, ENAH, MAPK1, ACTB, ROCK1, VCL, ACTN4, PIP5K1B, SSH2
|
0.0001385 |
| PI3K AKT signaling pathway |
43 genes: FGF1, FGF7, NGF, IGF1, KITLG, EGFR, NTRK2, PDGFRA, GRB2, MAPK1, OSM, JAK2, COL4A1, COL6A3, LAMC1, LAMC2, THBS2, THBS4, FN1, ITGA1, ITGA4, ITGB1, ITGB3, PIK3CA, PIK3CD, GNB3, GNG11, AKT3, PPP2R2C, PPP2R3A, PPP2R5B, BRCA1, MYC, CDK6, CCND2, CCND3, YWHAQ, YWHAH, YWHAG, ATF2, CREB3L1, CREB5, MCL1
|
0.0001438 |
| TGF.beta signaling pathway |
16 genes: DCN, RHOA, MYC, PITX2, MAPK1, ROCK1, BMP6, BMPR1A, BMPR2, TGFB2, TGFBR1, TGFBR2, THBS2, THBS4, TNF, ACVR1
|
0.0001813 |
| Osteoclast differentiation |
20 genes: AKT3, SIRPA, MAPK14, CYLD, GRB2, ITGB3, MITF, NFATC2, TNFRSF11B, PIK3CA, PIK3CD, PPP3CA, PPP3CB, MAPK1, MAPK9, TGFB2, TGFBR1, TGFBR2, TNF, FCGR2C
|
0.0004219 |
| ECM.receptor interaction |
15 genes: COL4A1, COL6A3, FN1, ITGA1, ITGA4, ITGB1, ITGB3, LAMC1, LAMC2, THBS2, THBS4, CD44, CD47, SDC3, SV2B
|
0.0005871 |
| Ras signaling pathway |
30 genes: FGF1, FGF7, NGF, IGF1, KITLG, EGFR, NTRK2, PDGFRA, GRB2, PTPN11, RASGRP1, GNB3, GNG11, RASGRF1, RASGRF2, GRIN2A, CALM3, RRAS2, RASA1, RASAL3, RHOA, PIK3CA, PIK3CD, AKT3, MAPK1, KSR1, RAPGEF5, RAP1A, RALA, MAPK9
|
0.0007518 |
| Progesterone.mediated oocyte maturation |
15 genes: AKT3, ADCY5, MAPK14, GNAI3, IGF1, PDE3A, PDE3B, PIK3CA, PIK3CD, MAPK1, MAPK9, RPS6KA3, CPEB1, CCNA1, CDC27
|
0.000756 |
| Hematopoietic cell lineage |
15 genes: CR1, CR2, HLA-DRB1, HLA-DRB5, ITGA1, ITGA4, ITGB3, KITLG, TNF, CD2, CD3E, CD4, MS4A1, CD22, CD44
|
0.0008548 |
| Phagosome |
22 genes: TUBA1B, DYNC1I1, DYNC1I2, HLA-DOA, HLA-DPA1, HLA-DQB1, HLA-DRB1, HLA-DRB5, ITGB1, ITGB3, LAMP2, OLR1, ATP6V1D, ACTB, TAP2, THBS2, THBS4, COLEC12, CANX, TUBB6, FCGR2C, SEC22B
|
0.0009412 |
| Leukocyte transendothelial migration |
18 genes: MYL12A, MAPK14, CTNNB1, GNAI3, ITGA4, ITGB1, ITK, RHOA, PIK3CA, PIK3CD, PTPN11, RAP1A, ACTB, ROCK1, CXCL12, VCL, ACTN4, JAM3
|
0.0009646 |
| Wnt signaling pathway |
21 genes: CTNNB1, PRICKLE2, DAAM1, FBXW11, APC, RHOA, MYC, NFATC2, NFATC4, LEF1, PPP2R5B, PPP3CA, PPP3CB, PPP3R1, MAPK9, ROCK1, WNT10B, WNT11, VANGL1, CCND2, CCND3
|
0.001453 |
| B cell receptor signaling pathway |
13 genes: AKT3, CR2, GRB2, LYN, NFATC2, NFATC4, PIK3CA, PIK3CD, PPP3CA, PPP3CB, PPP3R1, MAPK1, CD22
|
0.00158 |
| Oocyte meiosis |
17 genes: YWHAQ, ADCY5, FBXW11, IGF1, PPP1CB, PPP2R5B, PPP3CA, PPP3CB, PPP3R1, MAPK1, RPS6KA3, CPEB1, YWHAG, YWHAH, CALM3, SMC1A, CDC27
|
0.001865 |
| Adipocytokine signaling pathway |
12 genes: AKT3, CAMKK2, PPARGC1A, ACSL4, JAK2, LEPR, PRKAG2, MAPK9, PTPN11, STAT3, TNF, ADIPOQ
|
0.002014 |
| Long.term potentiation |
12 genes: GNAQ, GRIN2A, PPP1R12A, PPP1CB, PPP3CA, PPP3CB, PPP3R1, MAPK1, RAP1A, RPS6KA3, CACNA1C, CALM3
|
0.002595 |
| Adherens junction |
12 genes: WASF2, SORBS1, CTNNB1, EGFR, RHOA, LEF1, MAPK1, ACTB, TGFBR1, TGFBR2, VCL, ACTN4
|
0.003715 |
| Chemokine signaling pathway |
23 genes: AKT3, ADCY5, CCR1, CCR4, DOCK2, GNAI3, GNB3, GNG11, GRB2, CXCL3, ITK, JAK2, RHOA, LYN, CXCL9, PIK3CA, PIK3CD, MAPK1, RAP1A, ROCK1, CCL7, CXCL12, STAT3
|
0.005066 |
| Intestinal immune network for IgA production |
9 genes: ICOS, HLA-DOA, HLA-DPA1, HLA-DQB1, HLA-DRB1, HLA-DRB5, ITGA4, TNFRSF17, CXCL12
|
0.005397 |
| Antigen processing and presentation |
12 genes: CTSB, HLA-DOA, HLA-DPA1, HLA-DQB1, HLA-DRB1, HLA-DRB5, HSPA8, TAP2, TNF, CANX, CD4, CD74
|
0.006418 |
| Apoptosis |
13 genes: AKT3, IRAK3, IL1RAP, NGF, PIK3CA, PIK3CD, PPP3CA, PPP3CB, PPP3R1, PRKAR2A, TNF, CAPN2, CFLAR
|
0.00726 |
| Jak.STAT signaling pathway |
19 genes: AKT3, GRB2, SOCS7, IL10RA, JAK2, LEPR, LIF, LIFR, MYC, OSM, PIK3CA, PIK3CD, PTPN11, STAT3, STAT4, PIAS1, CBL, CCND2, CCND3
|
0.009479 |
| Biosynthesis of unsaturated fatty acids |
5 genes: ACOT7, FADS1, ELOVL2, SCD5, FADS2
|
0.01195 |
| Cell cycle |
16 genes: CDK6, STAG1, GADD45G, YWHAQ, MCM6, MYC, PRKDC, RAD21, TGFB2, YWHAG, YWHAH, SMC1A, CCNA1, CCND2, CCND3, CDC27
|
0.01376 |
| VEGF signaling pathway |
11 genes: AKT3, MAPK14, NFATC2, NFATC4, PIK3CA, PIK3CD, PPP3CA, PPP3CB, PPP3R1, MAPK1, MAPKAPK2
|
0.01381 |
| ErbB signaling pathway |
12 genes: AKT3, EGFR, EREG, GRB2, MYC, NCK1, PIK3CA, PIK3CD, MAPK1, MAPK9, NCK2, CBL
|
0.01497 |
| Circadian rhythm . mammal |
5 genes: FBXW11, ARNTL, BHLHE40, PER3, CLOCK
|
0.01765 |
| Gap junction |
12 genes: TUBA1B, MAP3K2, ADCY5, EGFR, GNAI3, GNAQ, GRB2, GUCY1B3, PDGFRA, PRKG1, MAPK1, TUBB6
|
0.01919 |
| Protein processing in endoplasmic reticulum |
19 genes: SEC24A, HSPA4L, ATF6, UBQLN1, HSPA8, MAN1A1, DNAJC10, NPLOC4, MAPK9, EIF2AK2, DNAJC3, RAD23B, SEL1L, UBE2G1, TXNDC5, CANX, CAPN2, DNAJC5B, SEC24D
|
0.02094 |
| Endocytosis |
22 genes: STAMBP, DAB2, EGFR, EPS15, RAB11FIP2, ACAP2, RAB11FIP5, SH3KBP1, HSPA8, RHOA, ASAP1, PDGFRA, SMAP2, TGFB2, TGFBR1, TGFBR2, CLTCL1, PIP5K1B, CAV1, CAV2, CBL, GIT2
|
0.02148 |
| Dorso.ventral axis formation |
5 genes: PIWIL4, EGFR, GRB2, MAPK1, CPEB1
|
0.0249 |
| Insulin signaling pathway |
16 genes: AKT3, SORBS1, PPARGC1A, GRB2, RAPGEF1, PDE3A, PDE3B, PRKAG2, PIK3CA, PIK3CD, PPP1CB, PRKAR2A, MAPK1, MAPK9, CALM3, CBL
|
0.02626 |
| Fc gamma R.mediated phagocytosis |
12 genes: AKT3, WASF2, CFL2, DOCK2, AMPH, LYN, ASAP1, PIK3CA, PIK3CD, MAPK1, PIP5K1B, FCGR2C
|
0.02812 |
| Calcium signaling pathway |
19 genes: ADRA1D, ADRA1B, EDNRA, EGFR, GNAL, GNAQ, GRIN2A, HRH1, MYLK, ATP2A2, PDGFRA, AVPR1A, PPP3CA, PPP3CB, PPP3R1, PTGER3, RYR3, CACNA1C, CALM3
|
0.03368 |
| Melanogenesis |
12 genes: ADCY5, CTNNB1, GNAI3, GNAQ, KITLG, MITF, LEF1, MAPK1, WNT10B, WNT11, CALM3, CREB3L1
|
0.04241 |
| Complement and coagulation cascades |
9 genes: CR1, CR2, F3, F13A1, PROS1, TFPI, SERPING1, C5AR1, C6
|
0.04444 |
| Long.term depression |
9 genes: GNA12, GNAI3, GNAQ, GNAZ, GUCY1B3, IGF1, LYN, PRKG1, MAPK1
|
0.04804 |